長庚大學生命科學研究課程師資資訊. anergic patient with pulmonary tuberculosis. Thoracic Med. 20:

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1 長庚大學生命科學研究課程師資資訊 姓名 : 郭漢彬 科別 : 內科部胸腔內科 英文名字 :Han-Pin Kuo 連絡方式 : 請向系上詢問 職稱 : 長庚大學醫學系教授 長庚醫院內科部副部長 研究領域 : 臨床研究 基礎研究 1. Airway remodeling 2. Airway inflammation 3. Nitric oxide 4. Intracellular signal transduction pathway 5. Transcriptional and translation level modulation 近五年發表論文 : 1. Chen.H.-H., Kuo, H.-P. (2005) Recombinant interferon-alpha2b therapy in an anergic patient with pulmonary tuberculosis. Thoracic Med. 20: Wang C.-H, Liu C.-Y, Wan Y.-L, Chou C.-L, Huang K.-H, Lin H.-C, Lin S.-M, Lin T.-Y, Chung K.-F, Kuo H-P*.(2005) Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Respir Res. May 11; 6(1):42 (SCI) 3. Huang C.-D., Wang C.-H., Liu C.-Y., Lin S-M., Chou C.-L., Liu W.-T. Lin H.-C., Kuo H.-P*. (2005). Eosinophils from Asthmatics Release IL-5 in an Autocrine Fashion to Prevent Apoptosis Through Upregulation of Bcl-2 Expression. J. Asthma 42: (SCI). 4. Hsieh M..-H., Lo Y.-L,.Fang Y.-F,., Huang, P.-Y., Kuo H..-P, Lin H..-C.(2005) Late-onset central alveolar hypoventilation syndrome in a patient with hemorrhagic brainstem lesion: improvement after medroxyprogesterone treatment Thoracic Med. 20:

2 5. Huang C.-D., Alaina J. Ammit, Omar Tliba, Kuo HP, Raymond B. Penn, Reynold A. Panettieri Jr., Yassine Amrani. (2005). G-Protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-r-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells. J. Biomed. Sci. 12: (SCI) 6. Chiou H.-E., Liu C.-L., Buttry M.J., Kuo H.-P., Liu H.-W., Kuo H.-T., Lu Y.-T. (2005). Adverse reaction of ribavirin and outcome in SARS: experience in two medical centers. Chest 128(1): (SCI) 7. Chen H.-C, Wang C-J, Chou C-L, Lin S-M, Huang C-D, Lin T-Y, Wang C-H, Lin H-C, Yu C-T, Kuo H-P, Liu CY. (2006). Tumor necrosis factor- [Formula: see text] induces caspase-independent cell death in human neutrophils via reactive oxidants and associated with calpain activity. J Biomed Sci Mar;13(2): (SCI) 8. Wang Y.-M.., Lin S-M., Wang C.-J., Lin T.-Y., Kuo H.-P, Lin H.-C.,(2006). The diagnosis and clinical outcomes of patients with sepsis-induced disseminated intravascular coagulation in a medical intensive care unit. Thoracic Med. 21: Chiang L.-L., Yu, C.-T., Liu,C-Y., Lo Y.-L, Kuo H.-P., Lin H.-C.,(2006). Six-month nocturnal nansal positive pressure ventilation improves respiratory muscle capacity and exercise endurance in patients with chronic hypercapneic respiratory failure. Formosa Med. Assoc. 105: (SCI) 10. Lee K-Y, Ho S-C, Lin H-C, Lin S-M, Liu C-Y, Huang C-D, Wang C-H, Chung K-F, Kuo H-P* (2006). Neutrophil-derived elastase induces TGF-{beta}1 secretion in human airway smooth muscle via NF-{kappa}B pathway. Am J Respir Cell Mol Biol. 35: (SCI) 11. Hsieh M-H, Fang Y-F, Chang W-C, Kuo H-P, Lin S-Y, Lin H-P, Liu C-L, Chen H-C, Ku Y-C, Chen Y-T, Chang Y-H, Chen Y-T, Hsi B-L, Tsai S-F, Huang S-F. (2006). Complex mutation patterns of epidermal growth factor receptor gene associated with

3 variable responses to gefitinib treatment in patients with non-small cell lung cancer. Lung Cancer. 53: (SCI) 12. Lin S-M, Huang C-D, Lin H-C,Liu C-Y, Wang C-H, Kuo H-P*. (2006). A modified Goal-directed protocol improves clinical outcomes in intensive are unit patients with septic shock: a randomized controlled trial. Shock 26: (SCI) 13. Lo C-Y, Lin S-M, Kuo A-J, Chun F-T, Chang P-J, Kuo C-S, Lin H-C, Kuo H-P (2006). Clinical characteristics and outcome in adult patients with pneumococcal empyema. Thorac.Med. 21: Kuo C-H, Wang C-H, Kuo H-P*. (2007). Pulmonary Arteriovenous Malformation of Osler-Weber-Rendu Syndrome diagnosed by Endobronchial Ultrasound (EBUS). Respirology Mar;12(2): (SCI). 15. Su C-L, Chiang L-L, Chiang T-Y, Yu C-T, Kuo H-P, Lin HC (2007). Domiciliary positive expiratory pressure improves pulmonary function and exercise capacity in patients with chronic obstructive pulmonary disease. J Formos Med Assoc. Mar; 106(3): (SCI) 16. Liu C-Y, Lin H-C, Yu C-T, Lin S-M, Lee K-Y, Chen H-C, Chou C-L, Huang C-D, Chou P-C, Liu W-T, Wang C-H, Kuo H-P*. (2007). The concentration-dependent chemokine release and pro-apoptotic effects of neutrophil-derived alpha-defensin-1 on human bronchial and alveolar epithelial cells. Life Sci. Jan 30;80(8): (SCI) 17. Chang M-L, Liu W-T, Wang C-H, Kuo H-P, 2007 The clinical use of an internet-based asthma teleconsultation system. Thorac.Med. 22: Lin T-Y, Lin S-M, Chen H-C, Wang C-J, Wang Y-M, Chang M-L,Wang C-H, Liu C-Y, Lin H-C, Yu C-T, Hsieh L-L, Kuo H-P, Huang C-D (2007). An open-label, randomized comparison of levofloxacin and amoxicillin/clarithromycin for the treatment of hospitalized patients with community-acquired pneumonia. Chang Gung Med. J. 130:

4 19. Chou C-L, Chang L-L, Yu C-T, Chen H-C, Lee K-Y, Lin S-M, Huang C-D Liu W-T, Chou P-C, Wang C-H, Lin H-C, Kuo H-P, Liu C-Y (2007) Apoptosis dependent and-independent mechanisms mediate the phagocytic recognition/clearance of the HL60-aitransfectants with prolonged survival Inflammation Research 156: (SCI) 20. Kuo C-H, Lin H-C, Yu C-T, Kuo H-P, (2007). Multiple Myeloma Associated with osteosclerotic bone lesion presenting as chest wall masses. Thorac.Med. 22: Kuo C-H, Lin S-M, Chen H-C, Chou C-L, Yu C-T, Kuo H-P*, (2007) Diagnosis of peripheral lung cancer with three echoic features via endobronchial ultrasound Chest 132: (SCI) 22. Lin S-M, Lin H-C, Lee K-Y, Huang C-D, Liu C-Y, Wang C-H, Kuo H-P* (2007). Ventilator-induced injury augments interleukin-1b production and neutrophil sequestration in lipopolysaccharide-treated lungs. Shock 28: (SCI) 23. Wan YL, Tsay PK, Cheung YC, Chiang PC, Wang CH, Tsai YH, Kuo HP, Tsao KC, Lin TY. (2007). A Correlation between the Severity of Lung Lesions on Radiographs and Clinical Findings in Patients with Severe Acute Respiratory Syndrome. Korean J Radiol. (SCI) 28: Kuo HP, Wang YM, Wang CH, He CC, Lin SM, Lin HC, Liu CY, Huang KH, Hsieh LL, Huang CD. (2008). Matrix metalloproteinase-1 polymorphism in Taiwanese patients with endobronchial tuberculosis. Tuberculosis (Edinb). 88: (SCI) 25. Lin S-M, Wang Y-M, Lin H-C, Lee K-Y, Huang C-D, Liu C-Y, Wang C-H, Kuo H-P*. (2008). Serum Thrombomodulin Level Relates to the Clinical Course of Disseminated Intravascular Coagulation, Multi-organ Dysfunction Syndrome and Mortality in Patients with Sepsis. Crit Care Med. 36: (SCI) 26. Wang SY, Tao JL, Tsai CM, Kuo HP, Lin CC. (2008) Sleep quality and its effecting factors in patients with non-small cell lung cancer. New Taipei Journal of Nursing. 10: Lin SM, Lin TY, Chou CL, Chen HC, Wang CH, Liu CY, Lin HC, Yu CT, Lee KY, Kuo

5 HP*. (2008). Metallic stent and flexible bronchoscopy without fluoroscopy in acute respiratory failure. Eur Respir. J 31: (SCI) 28. Wang C-H, Huang C-D, Lin, H-C, Lee K-Y, Lin S-M, Liu C-Y, Huang K-H, Ko Y-S, Kuo H-P*. (2008). Increased circulating fibrocytes in asthma with chronic airflow obstruction. Am J Respir Crit Care Med 178(6): (SCI) 29. Chung FT, Lin SM, Chen HC, Chou CL, Yu CT, Liu CY, Wang CH, Lin HC, Huang CD, Kuo HP*. (2008). Factors leading to tracheobronchial self-expandable metallic stent fracture. J Thorac Cardiovasc Surg. 136: (SCI) 30. Tashkin DP, Celli B, Senn S, Burkhart D, Kesten S, Menjoge S, Decramer M; UPLIFT Study Investigators. (2008). A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 9;359: (SCI) 31. Lin SM, Huang CD, Liu CY, Lin HC, Wang CH, Huang PY, Fang YF, Shieh MH, Kuo HP*. (2008). Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients. J Crit Care. 23: (SCI) 32. Liu WT, Wang CH, Lin HC, Lin SM, Lee KY, Lo YL, Hung SH, Chang YM, Chung KF, Kuo HP*. (2008). Efficacy of a cell phone-based exercise programme for COPD. Eur Respir J. 32(3): (SCI) 33. Perng RP, Yang CH, Chen YM, Chang GC, Lin MC, Hsieh RK, Chu NM, Lai RS, Su WC, Tsao CJ, Hsia TC, Chen HC, Chen CH, Huang MS, Wang JL, Ho ML, Chung CY, Yu CJ, Chang WC, Kuo HP, Yu CT, Lin ZZ, Kao WY. (2008). High efficacy of erlotinib in Taiwanese NSCLC patients in an expanded

6 access program study previously treated with chemotherapy. Lung Cancer. 62: (SCI) 34. Busse WW, Pedersen S, Pauwels RA, Tan WC, Chen YZ, Lamm CJ, O'Byrne PM; START Investigators Group. (2008). The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma. J Allergy Clin Immunol. 121: (SCI) 35. Huang CD, Lin SM, Chang PJ, Liu WT, Wang CH, Liu CY, Lin HC, Hsieh LL, Kuo HP*. (2009) Matrix metalloproteinase-1 polymorphism is associated with persistent airway obstruction in asthma in the Taiwanese population J Asthma. 46(1):41-6. (SCI) 36. Lin SM, Chou CL, Chen HC, Wang CH, Lin HC, Yu CT, Lee KY, Kuo HP*. (2009). Diagnostic Value of Endobronchial Ultrasonography for Pulmonary Tuberculosis. The Journal of Thoracic and Cardiovascular Surgery (SCI) 138(1): Liu CY, Wang YM, Wang CL, Feng PH, Ko HW, Liu YH, Wu YC, Chu Y, Chung FT, Kuo CH, Lee KY, Lin SM, Lin HC, Wang CH, Yu CT, Kuo HP*. (2010). J Cancer Res Clin Oncol. (SCI). (in press). Population alterations of L: -arginase- and inducible nitric oxide synthase-expressed CD11b(+)/CD14 (-)/CD15 (+)/CD33 (+) myeloid-derived suppressor cells and CD8 (+) T lymphocytes in patients with advanced-stage non-small cell lung cancer. 38. Ho SC, Lee KY, Chan YF, Kuo LW, Ito K, Adcock IM, Chen BC, Sheu JR, Lin CH, Kuo HP*. (2009). J Immunol. (SCI) 183(1): Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor.

7 39. Decramer M, Celli B, Kesten S, Lystig T, Mehra S, Tashkin DP; UPLIFT investigators. (2009). Lancet. (SCI) 374(9696): Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial. 40. Kuo CH, Lin SM, Lee KY, Chung FT, Hsieh MH, Fang YF, Yu CT, Kuo HP*. (2010). Clin Lung Cancer. (SCI) 11(1):51-6. Subsequent chemotherapy improves survival outcome in advanced non-small-cell lung cancer with acquired tyrosine kinase inhibitor resistance. 41. Tan EH, Ramlau R, Pluzanska A, Kuo HP, Reck M, Milanowski J, Au JS, Felip E, Yang PC, Damyanov D, Orlov S, Akimov M, Delmar P, Essioux L, Hillenbach C, Klughammer B, McLoughlin P, Baselga J. (2010). Ann Oncol. (SCI) 21(2): A multicentre phase II gene expression profiling study of putative relationships between tumour biomarkers and clinical response with erlotinib in non-small-cell lung cancer.