WEDNESDAY, AUGUST 24, 2016

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1 WEDNESDAY, AUGUST 24, :30-16:00 Location: Madrid (Level 2) IASLC School of Thoracic Oncology *30 USD registration fee applies Location: Madrid Chairs: Suresh Ramalingam, USA & Luis E. Raez, USA 07:30 Breakfast and registration 08:15 Welcome and Introductions 08:20 Pre-meeting Test 08:45-09:15 Pulmonary Medicine, Robert Keith, USA 09:15-09:45 Pathology, Fred Hirsch, USA & Marileila Varella-Garcia, USA 09: Thoracic Surgery, Harvey Pass, USA :30 Break 10:30-11:00 Radiation Oncology, Ana Botero, USA 11:00-11:30 Medical Oncology, Christian Rolfo, Belgium 11:30-11:45 Question and Answers 11:45-12:45 Biostatistics, Suzanne Dahlberg, USA Lunch (Participants will be divided into 5 groups and each group will rotate through each working station 12:45-13:15 Workstation 1, Pulmonary, Robert Keith, USA 13:15-13:45 Workstation 2, Pathology, Ignacio Wistuba, USA 12:45-14:15 Workstation 3, Thoracic Surgery, Harvey Pass, USA 14:15-14:30 Break 14:30-15:00 Workstation 4, Radiation Oncology, Ana Botero, USA Workstation 5, Medical Oncology, Luis E. Raez, USA :00 Post-meeting Test 16:00 Wrap up and Adjourn Wednesday, August 24 th,

2 THURSDAY, AUGUST 25, :00 11:45 PATIENT ADVOCACY SESSION Chair: Dr. Nise Yamaguchi, Brasil 10:30 10:35 Chair Welcome, Nise Yamaguchi, Brasil 10:35 10:45 Tumor Molecular Profile: a new challenge Christian Rolfo, Belgium 10:45 10:55 Learning from patients: The story of... 10:55 11:05 Our body helping to cure cancer: Immunotherapy, Roberto Lopez, Panama 11:05 11:15 Celebrating the survivors: The story of... 11:15 11:25 Is easy to get new drugs in Latin America?, Nise Yamaguchi, Brasil 11:25 11:45 Open discussion Moderated by: Christian Rolfo, Belgium 11:40 11:45 Closing Remarks, Nise Yamaguchi, Brasil 12:00-13:00 OPENING CEREMONY Chairs: Roberto I. Lopez, Panama & Edgardo S. Santos, USA Welcome and Introduction to LALCA 2016, Edgardo S. Santos, USA The future of lung cancer management in Panama, Roberto I. Lopez, Panama Welcome from IASLC, Fred R. Hirsch, IASLC CEO, USA Welcome from President of Republic of Panama Welcome from the Panamanian Minister of Health Thursday, August 25 th,

3 13:00-14:00 Cancer Control Program and Tobacco Forum Chairs: Nise Yamaguchi, Brazil & Erick Arauz, Panama 13:00-13:20 Early Detection in Heavy Smoker, Ricardo Sales do Santos, Brazil 13:20-13:40 Importance of Smoking Cessation in the Treatment of Lung Cancer Patient, Carolyn Dresler, USA 13:40-14:00 Tobacco Control in Youth, Nise Yamaguchi, Brazil 14:15-15:15 INDUSTRY SYMPOSIUM SUPPORTED BY Caris 15:30-16:30 Lung Cancer Screening Chairs: Ignacio Gil-Bazo, Spain & Luis Herrera, USA 15:30-15:50 Lung Cancer Computer Tomography Screening, Claudia I. Henschke, USA 15:50-16:10 Lung Cancer Screening: Impact in Survival and Economics, Luis Corrales-Rodriguez, Costa Rica 16:10-16:30 Lung Cancer Screening in Latin America: Challenges and Progress, Carlos Barrios, Brazil 16:45-17:45 Thursday, August 25 th,

4 Young Investigator s Session Chairs: Maria Lim, Panama & Belisario Arango, USA 16:45-17:05 How to Write a Manuscript and a Research Grant?, Gilberto Lopes, Brazil 17:05-17:25 How to Incorporate Research in Panama and Latin America?, Roberto I. Lopez, Panama 17:25-17:45 The Role of Medical School to Promote Basic and Clinical Research: Obstacles, Resources and Policies, Enrique Mendoza, Panama 16:45-17:45 Diagnostic Imaging Innovations Chairs: Luis Leonardo Rojas, Colombia & Hector Tapia, Panama 16:45-17:00 PET CT Scan as a Tool for Lung Cancer Management: Utility, Yariela Herrera Malo, Panama 17:00-17:15 EBUS and Navigation System to Yield a Diagnosis, Jonathan Waxman, USA 17:15-17:30 Stereotactic Body Radiotherapy in NSCLC with Oligometastic Disease, Ana Botero, USA 17:30-17:45 Role of Interventional Radiology in the Modern era of Lung Cancer, Ligia Cardona, Dominican Republic 18:00-19:00 Industry Symposium Supported by Merck 18:00-19:00 Thursday, August 25 th,

5 Industry Symposium Supported by AstraZeneca 19:00-20:30 WELCOME RECEPTION Location: Panama 3 & 4 (Level 4) Thursday, August 25 th,

6 FRIDAY, AUGUST 26, :30-17:00 Location: Foyer 3 (Level 4) Registration Open 10:30-17:00 EXHIBITS OPEN/ POSTERS ON DISPLAY Location: Panama 3 & 4 07:00 08:00 IASCL BUSINESS METTING (by invitation only) 08:00-09:15 PRESIDENTIAL SYMPOSIUM Presentation & Discussion of Top 3 Rated Abstracts Chairs: Roberto I. Lopez, Panama, Edgardo S. Santos, USA & David Carbone, USA Discussant: Roy Herbst, USA 09:30-10:30 GENERAL SESSION 1 Innovative Clinical Trial Designs for NSCLC. Friday, August 26 th,

7 Chairs: Carlos Vallejos, Peru & Robert Pirker, Austria 09:30-09:45 Bringing Opportunities in Clinical Research for Latin America, Christian Caglevic, Chile 09:45-10:00 Master Protocols, David Gandara, USA 10:00-10:15 Lung MAP, Roy Herbst, USA 10:15-10:30 Bringing Research to the Patient: Remote Consenting for a Novel Trial- Genomics of Young Lung Cancer, Barbara Gitlitz, USA 10:30-11:00 NETWORKING BREAK AND POSTER VIEWING Location: Panama 3 & 4 (Level 4) 11:00-12:00 GENERAL SESSION 2 Lung Cancer Pathology in the Era of Targeted Therapy Chairs: Marileila Varella-Garcia, USA & Ruth Vergara, Panama 11:00-11:15 The Importance of Histologic Diagnosis in Lung: Clinical Implications, Robert Pirker, Austria 11:15-11:30 Tissue Quality Control for Molecular Testing, Ignacio I. Wistuba, USA 11:30-11:45 Gene Expression Profile for Carcinoma of Unknown Primary, Carlos Barrios, Brazil 11:45-12:00 Questions and Answers 11:00-12:00 GENERAL SESSION 3 Friday, August 26 th,

8 Diagnostic and Staging Issues in the Contemporary Pulmonary Medicine Chairs: Francisco Tarrazzi, USA & Carlomagno Castillero, Panama 11:00-11:15 Assessment of the Pulmonary Nodule, Mark Block, USA 11:15-11:30 Potential and Limitations of EBUS for Diagnosis and Staging, Francisco Tarrazzi, USA 11:30-11:45 Optimization of Bronchoscopic Samples in the Era of Molecular Pathology, Johan Vansteenkiste, Belgium 11:45-12:00 Roadmap for Liquid Biopsy in Lung Cancer, Christian Rolfo, Belgium 12:15-13:15 GENERAL SESSION 4 Molecular Markers in Lung Cancer Chairs: Jaime De La Garza, Mexico & Bruno Bastos, USA 12:15-12:30 Molecular Markers in Lung Adenocarcinomas, Marileila Varella-Garcia, USA 12:30-12:45 Molecular Markers in Squamous Cell Carcinoma, Luis E. Raez, USA 12:45-13:00 Molecular Diagnosis Guidelines Recommended Internationally, Fred R. Hirsch, USA 13:00-13:15 Molecular Testing in Lung Cancer: Efforts and Perspectives in Latin America, Tatiana Vidaurre, Peru GENERAL SESSION 5 New Developments in Surgery Chairs: Mark Block, USA & Rafael Andrade, Panama 12:15-12:30 Invasive Mediastinal Staging: Mediastinoscopy, EBUS and EUS, Jonathan Waxman, USA Friday, August 26 th,

9 12:30-12:45 VATS, Robot-Assisted or Thoracotomy for Lung Cancer Surgery, Mark Block, USA 12:45-13:00 Sublobar Resection for Stage I NSCLC, Harvey Pass, USA 13:00-13:15 Endosonography and Navigation System to Secure Tissue Diagnosis, Johan Vansteenkiste, Belgium 13:30-14:30 Industry Symposium Supported by Boehringer Ingelheim 14:45-16:00 GENERAL SESION 6 Adjuvant Therapy in the Molecular Era Chairs: Barbara Gilitz, USA & Clarissa Mathias, Brazil 14:45-15:00 Adjuvant Chemotherapy for NSCLC: Where Are We Now?, Norma Pilnik, Argentina 15:00-15:15 Role of Targeted Agents in the Adjuvant Setting, Raja Mudad, USA 15:15-15:30 Is There a Role for Immunotherapy in Lung Cancer Adjuvant Setting?, Luis Paz-Ares, Spain 15:30-15:45 Prognostic and Predictive Makers for Adjuvant Therapy NSCLC, Gilberto Lopes, Brazil 15:45-16:00 Question and Answer Period 16:00-16:30 NETWORKING BREAK AND POSTER VIEWING Location: Panama 3 & 4 (Level 4) Friday, August 26 th,

10 16:30-17:30 GENERAL SESION 7 Stage IIIA/B Non-Small Cell Lung Cancer Chairs: Jorge Gomez, USA & Carlos Barrios, Brazil 16:30-16:45 Optimal Radiation Dose and Schedule, Puneeth Lyengar, USA 16:45-17:00 Optimal Combined Modality Therapy for LA-NSCLC, Alberto Chiappori, USA 17:00-17:15 Is There a Role of Neoadjuvant Therapy for N2 Disease, Harvey Pass, USA 17:15-17:30 Integration of Molecular Imaging and Agents in LA-NSCLC, Johan Vansteenkiste, Belgium GENERAL SESION 8 Squamous Cell Carcinoma Chairs: Jhanelle Gray, USA & Alejandro Crissmatt, Panama 16:30-16:45 Biological insights of Squamous Cell Carcinoma Novel Targets, Suresh Ramalingam, USA 16:45-17:00 Maintenance Therapy in Squamous Cell Carcinoma, Luis Leonardo Rojas, Colombia 17:00-17:15 Checkpoint Inhibitors and Vaccine in Squamous Cell Carcinoma, Glenwood Goss, Canada 17:15-17:30 How to Approach Second-Line in Squamous Cell Carcinoma, David Gandara, USA Friday, August 26 th,

11 17:45-18:45 INDUSTRY SUPPORTED SYMPOSIUM By Pfizer 19:00-20:00 Industry Supported Symposium by Guardant Health 20:15-23:00 Faculty Dinner - By Invitation Only Friday, August 26 th,

12 SATURDAY, AUGUST 27, :30-17:00 Location: Foyer 3 (Level 4) Registration Open 10:30 17:00 EXHIBIT HALL OPEN / POSTERS ON DISPLAY Location: Panama 3 & 4 08:00-09:15 POSTER DISCUSSION SESSION- TOPIC 1 Chairs: Roberto I. Lopez, Panama and Edgardo S. Santos, USA Discussant: Roy Herbst, USA POSTER DISCUSSION SESSION- TOPIC 2 Chairs: Luis E. Raez, USA & David Carbone, USA Discussant: Antoinette Wozniak, USA 09:30-10:30 GENERAL SESSION 9 Management of Advanced Stage Non Squamous-NSCLC Saturday, August 27 th,

13 Chairs: Luis Paz-Ares, Spain & Miguel Villalona, USA 09:30-09:45 Front Line Therapy for EGFR/ALK/ROS-1 Genomic Aberrations, Luis Paz-Ares, Spain 09:45-10:00 How to Deal with ALK Resistance- How Far to Go?, Christian Rolfo, Belgium 10:00-10:15 Selecting Patients for Maintenance Therapy, Giorgio Scagliotti, Italy 10:15-10:30 Molecular Targeted Therapy for Brain Metastases and Leptomeningeal Disease, Jorge Gomez, USA GENERAL SESSION 10 Immunotherapy in Non-Small Cell Lung Cancer Chairs: Ana Oton, USA & Eduardo Richardet, Argentina 09:30-09:40 Immunotherapy: Making it in a Simple Language, Ada Blidner, Argentina 09:40-09:50 Predictive Assays for Immunotherapy, Fred Hirsch, USA 09:50-10:00 Clinical Trials with Anti-PD-1, Luis E. Raez, USA 10:00-10:10 Clinical Trials with Anti-PDL-1 Inhibitors, Clarissa Mathias, Brazil 10:10-10:20 Other Immunotherapy Pathways-- CTL4 and Others, David Carbone, USA 10:20-10:30 Questions and Answers 10:30-11:00 NETWORKING BREAK AND POSTER VIEWING Location: Panama 3 & 4 (Level 4) 11:00-12:30 ROUNDTABLE DISCUSSIONS Location: Berlin 1 & 2 (Level 2) Chairs: Eduardo Richardet, Argentina & Edgardo S. Santos, USA Saturday, August 27 th,

14 Novel Approaches in Surgery: Robotic Surgery, VATS, Navigation System: Luis Herrera, USA & Harvey Pass, USA Palliative Care in Lung Cancer: Erick Arauz, Panama & Luis Mas Lopez, Peru Commentator: Luis Ubillos, Uruguay Treatment of Wild Type Lung Cancer Tumours First and Second Line: Tatiana Vidaurre, Peru Commentator: Diego Kaen, Argentina Therapy of Tumours Carrying EGFR Mutations or ALK Translocations: Commentator: Martin E. Richardet, Argentina How to Study Molecular Biology and Tumour Markers: Ignacio Wistuba, USA & Ruth Vergara, Panama Radiation Therapy in Lung Cancer: Michael Kasper, USA Commentator: Gaspar Perez Jimenez, Panama New Molecules and Therapies for Lung Cancer: Suresh Ramalingam, USA & Luis Leonardo Rojas, Colombia Commentator: Martin Dietrich Diagnosis and Staging in Lung Cancer: Marileila Varella-Garcia, USA & Cesar Perez, USA Commentator: Mauricio Cuello, Uruguay Locally Advanced Non-Small Cell Lung Cancer: Giorgio Scagliotti, Italy & Jhanelle Gray, USA Commentator: Luis Corrales-Rodriguez, Costa Rica Therapy of EGFR/ALK Resistant Lung Cancer Tumours: Bruno Bastos, USA & Roy Herbst, USA Commentator: Claudio Martin, Argentina Saturday, August 27 th,

15 Management of Toxicities from Immunotherapies in Lung Cancer: Christian Rolfo, Belgium & Luis Paz- Ares, Spain Commentator: Belisario Arango, USA Adjuvant therapy in Non-Small Cell Lung Cancer: Raja Mudad, USA & Oscar Arrieta, Mexico Commentator: Norma Pilnik, Argentina Management of Limited and Extensive Small Cell Lung Cancer: Glenwood Goss, Canada & Tarek Mekhail, USA Commentator: Sai-Hong Ou, USA 12:45-13:45 GENERAL SESSION 11 Small Cell Lung Cancer & Neuroendocrine Tumor, NET Chairs: Oscar Arrieta, Mexico & Cesar Perez, USA 12:45-13:00 Small Cell Cancer Biology: Are there new targets?, Maria Pietanza, USA 13:00-13:15 Systemic Chemotherapy for SCLC, Nise Yamaguchi, Brazil 13:15-13:30 Success and Challenges of Radiation Therapy for SCLC, Ignacio Castellon, USA 13:30-13:45 Management of Well-Differentiated NET, Aurelio Castrellon, USA GENERAL SESSION 12 Advanced Radiation Technology Chairs: Puneeth Lyengar, USA & Ana Botero, USA Saturday, August 27 th,

16 12:45-13:00 Radiation Oncology Challenges in Latin America, Ignacio Castellon, USA 13:00-13:15 Role of SBRT in Early Stage NSCLC, Puneeth Lyengar, USA 13:15-13:30 Role of SBRT in Advanced NSCLC, Michael Kasper, USA 13:30-13:45 Role of Proton in Lung Cancer, Ana Botero, USA 14:00-15:00 Industry Symposium Supported by Lilly Oncology 15:15-16:15 GENERAL SESSION 13 Novel Therapies Targeting Lung Cancer Pathways Chairs: Paul Bunn, USA 15:15-15:25 RET/BRAF, Antoinette Wozniak, USA 15:25-15:35 MET and MET Exon 14 Skipping, Paul Bunn, USA 15:35-15:45 Repair Inhibitors, Miguel Villalona, USA 15:45-15:55 NF-1, David Carbone, USA 15:55-16:05 ROS-1, Ignacio Gil-Bazo, Spain 16:05-16:15 Questions and Answer Period GENERAL SESSION 14 Saturday, August 27 th,

17 Mesothelioma, Thymoma, and Thymic Carcinoma Chairs: Jorge Rios, USA & Sai-Hong Ou, USA 15:15-15:30 VATS and Robotic Surgery in Mesothelioma, Francisco Tarrazzi, USA 15:30-15:45 Biological insights and Novel Therapy for Malignant Mesothelioma, Sai-Hong Ou, USA 15:45-16:00 Current Standard of Care for the Treatment of Thymoma: What s New?, Luis Corrales-Rodriguez, Costa Rica 16:00-16:15 Emerging Biology and Therapeutics in Thymic Carcinoma, Jorge Gomez, USA 16:15-16:45 NETWORKING BREAK AND POSTER VIEWING Location: Panama 3 & 4 (Level 4) 16:45-17:45 GENERAL SESSION 15 Epidermal Growth Factor Receptor, EGFR Mutation as Targeted Therapy Chairs: Sai-Hong Ou, USA & Manuel Magallanes Maciel, Mexico 16:45-17:00 Actual Status of First and Second Generation EGFR TKIs in the Treatment of NSCLC, Fred R. Hirsch, USA 17:00-17:15 Targeting T790M in Lung Cancer: Osimertinib and Rociletinib, Suresh Ramalingam, USA 17:15-17:30 New Insights of EGFR Inhibition: EGF816, ASP8273, and AUY922, Pau Bunn, USA 17:30-17:45 EGFR TKIs with Central Nervous System Penetration for Management of Lung Cancers, Sai-Hong Ou, USA Saturday, August 27 th,

18 GENERAL SESSION 16 ALK/EML4 Translocation as Targeted Therapy 18:00-18:45 Chairs: Alfredo Aguilar, Peru & Cesar Perez, USA CLOSING CEREMONY 16:45-17:00 Crizotinib, Ceritinib and Alectinib, the Approved ALK Inhibitors: Where are we now?, Ana Oton, USA 17:00-17:15 Novel Molecular Mechanisms of Resistance to ALK Inhibition, Clarissa Mathias, Brazil 17:15-17:30 ALK inhibitors with Central Nervous System Penetration for Management of Lung Cancers, Jhanelle Gray, USA 17:30-17:45 ALK Inhibitors in Combination with other Targeted Therapies and Radiotherapy in Patients with ALK+ NSCLC, Luis Ubillos, Uruguay Chairs: Roberto Lopez, Panama & Edgardo S. Santos, USA Summary of Top Rated Abstracts Award Presentations, Roberto Lopez, Panama Closing Remarks, Edgardo S. Santos, USA & Fred R. Hirsch, USA Saturday, August 27 th,

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