LOCAL AND INTERNATIONAL COMMITTEES

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LOCAL AND INTERNATIONAL COMMITTEES Chairs: Eduardo Richardet and Norma Pilnik International Chair: Christian Rolfo (Belgium) Educational & IASLC School of Medicine Chair: Luis E.

1 LOCAL AND INTERNATIONAL COMMITTEES Chairs: Eduardo Richardet and Norma Pilnik International Chair: Christian Rolfo (Belgium) Educational & IASLC School of Medicine Chair: Luis E. Raez (USA) Scientific Chair: Edgardo S. Santos (USA) SPONSORED BY: INTERNATIONAL ASSOCIATION FOR THE STUDY OF LUNG CANCER FACULTAD DE MEDICINA/UNIVERSIDAD CATOLICA DE CORDOBA (FLASCA) International Committee Paul Bunn (USA) David Gandara (USA) Fred Hirsch (USA) Giorgio V. Scagliotti (Italy) Marileila Varella-Garcia (USA) Ignacio Wistuba (USA) Local Committee-Argentina Santiago Bella Nestor Bustamante Eduardo Cazap Liliana Darluzo Gustavo Ferraris Diego Kaen Daniel Maldonado Claudio Martin Ignacio Magri Claudia Polleri Martin Paradelo Martin Richardet Gonzalo Recondo Silvia Zunino David Smith Latin American Committee: Alfredo Aguilar (Peru) Osvaldo Aren (CHI) Oscar Arrieta (Mexico) Carlos Barrios (Brasil) Monica Campos (Chile) Andres Cardona (Colombia) Luis Corrales (Costa Rica) Mauricio Cuello (Uruguay) Jaime De La Garza (Mexico) Lucia Delgado (Uruguay) Christian Caglevic (Chile) Graciela Gomez Roberto Ivan Lopez (Panama) Jorge Madrid (Chile) Manuel Magallanes (Mexico) Luis Mas (Peru) Clarissa Mathias (Brazil) Francisco Orlandi Moises Russo (CHI) Ricardo Santos (Brazil) Luis Ubillos (Uruguay) Carlos Vallejos (Peru) Mario Varangot (Uruguay) Tatiana Vidaurre Rojas (Peru) Nise Yamagushi (Brazil)

2 Wednesday, August 15, 2018 IASLC School of Thoracic Oncology Program Agenda Chairs: Luis E. Raez (USA), Eduardo Richardet (Argentina) 7:30 a.m. Breakfast and Registration 8:15 a.m. Welcome and Introductions Luis E. Raez (USA) Eduardo Richardet (Argentina) 8:20 a.m. Pre-Meeting Test 8:45-9:15 a.m. Pulmonary Medicine Miriam Lasanosky (Argentina) 9:15-9:45 a.m. 9:45-10:15 a.m. 10:15-10:30 a.m. Pathology Thoracic Surgery Break Fred R. Hirsch (USA) Marileila Varella-Garcia (USA) Francisco Tarrazzi (USA) 10:30-11:00 a.m. Radiation Oncology Ana Botero (USA) 11:00-11:30 a.m. Medical Oncology Christian Rolfo (USA) 11:30-11:45 a.m. 11:45 a.m. - 12:45 p.m. Question and Answers Working Lunch: Biostatistics Norma Pilnik (Argentina) Eduardo Cuestas (Argentina) 2

3 Wednesday, August 15, 2018 Participants will be divided into five groups and each group will rotate through each working station 12:45-1:15 p.m. Workstation 1 (Pulmonary) Miriam Lasanosky (Argentina) 1:15-1:45 p.m. Workstation 2 (Pathology) Ignacio Wistuba (USA) 1:45-2:15 p.m. Workstation 3 (Thoracic Surgery) Daniel Maldonado (Argentina) 2:15-2:30 p.m. Break 2:30-3:00 p.m. Workstation 4 (Radiation Oncology) Ana Botero (USA) Gustavo Ferraris (Argentina) 3:00-3:30 p.m. Workstation 5 (Medical Oncology) Luis E. Raez (USA) Eduardo Richardet (Argentina) 3:30-4:00 p.m. Post-Meeting Test 4:00 p.m. Wrap Up and Adjourn TO BE ANNOUNCED Workshop LATAM Molecular Pathology Working Group 3

4 Thursday, August 16, :15-11:40 a.m. Patient Advocacy 1 Chairs: Nise Yamaguchi (Brazil), Eduardo Cazap (Argentina) Location: To Be Announced 10:15 a.m. Welcome Nise Yamaguchi (Brazil) 10:20 a.m. Tumor Molecular Profile: A New Challenge Luis Mas (Peru) 10:30 a.m. Learning from Patients: The Story of LALCEC To Be Announced 10:40 a.m. Our Body Helping to Cure Cancer: Immunotherapy Diego Kaen (Argentina) 10:50 a.m. Celebrating the Survivors: The Story of To Be Announced 11:00 a.m. Communication Skills Martin Richardet (Argentina) 11:10 a.m. Is It Easy to Get New Drugs in Latin America? Lucia Delgado (Uruguay) 11:15 a.m. Open Discussion Lucia Delgado (Uruguay) 11:20 a.m. Round Table Nise Yamagushi (Brazil) Guadalupe Pallotta (Argentina) Eduardo Cazap (Argentina) Noon - 1:00 p.m. OPENING CEREMONY Chairs: Eduardo Richardet (Argentina), Norma Pilnik (Argentina), Christian Rolfo (USA) Location: TBA Welcome and Introduction to LALCA 2018 The Future of Lung Cancer Management in Latinoamerica Welcome from IASLC President Eduardo Richardet (Argentina) Norma Pilnik (Argentina) Giorgio V. Scagliotti (Italy) 4

5 Thursday, August 16, :00-2:00 p.m. CANCER CONTROL PROGRAM AND TOBACCO FORUM Chairs: Nise Yamaguchi (Brazil), Lucia Delgado (Uruguay) 1 (4th Floor) 1:00 p.m. Early Detection in Heavy Smoker Lucia Llambi (Uruguay) 1:15 p.m. Importance of Smoking Cessation in the Treatment of Lung Cancer Patient Raquel Pendito (Argentina) 1:30 p.m. Framework Convention in WHO in LATAM Nise Yamaguchi (Brazil) 1:45 p.m. Panel Discussion Eduardo Cazap (Argentina) Jaime de la Garza (Mexico) 2:15-3:15 p.m. Concurrent Industry Supported Symposia Location: Lugones 1 Industry Symposium Supported by To Be Announced 2:15-3:15 p.m. Concurrent Industry Supported Symposia Location: Lugones 2 Industry Symposium Supported by To Be Announced LUNG CANCER SCREENING 3:30-4:30 p.m. 3:30-3:50 p.m. 3:50-4:10 p.m. 4:10-4:30 p.m. Chairs: Edgardo S. Santos (USA), Luis Corrales-Rodriguez (Costa Rica) Location: To Be Announced Lung Cancer Screening in Clinical Practice and Guidelines Lung Cancer Screening: Impact in Survival and Economics Lung Cancer Screening in Latin America: Challenges and Progress Luis Corrales-Rodriguez (Costa Rica) Monica Campos (Argentina) Carlos Barrios (Brazil) 5

6 Thursday, August 16, :45-5:45 p.m. 4:45 p.m. YOUNG INVESTIGATOR S SESSION Chairs: Christian Caglevic (Chile), Martin Richardet (Argentina) Location: Salon Champaqui How to Write a Manuscript and a Research Grant? Carlos Ferreira (Brazil) 5:05 p.m. How to Incorporate Research in Latin America? Roberto I. Lopez (Panama) 5:25 p.m. The Role of Medical School to Promote Basic and Clinical Research Obstacles, Resources and Policies Gabriel Rabinovich (Argentina) DIAGNOSTIC IMAGING INNOVATION 4:45-5:45 p.m. 4:45 p.m. 5:00 p.m. 5:15 p.m. 5:30 p.m. Chairs: Luis Fein (Argentina), Jorge Alatorre (Mexico) PET CT Scan as a Tool for Lung Cancer Management: Utility EBUS and Navigation System to Yield a Diagnosis Stereotactic Body Radiotherapy in NSCLC with Oligometastic Disease Role of Interventional Radiology in the Modern Era of Lung Cancer Marcelo Claria (Argentina) Francisco Tarrazzi (USA) Ana Botero (USA) Carlos Rojas (Peru) 6:00-7:00 p.m. OPPOSED INDUSTRY SUPPORTED SYMPOSIUM Location: Room 1 (TBA) 6:00-7:00 p.m. OPPOSED INDUSTRY SUPPORTED SYMPOSIUM Location: Room 2 (TBA) 6

7 Thursday, August 16, 2018 WELCOME RECEPTION 7:30-9:00 p.m. Location: Palacio Ferreira Friday, August 17, :00-9:00 a.m. 8:00-9:30 a.m. 8:00 a.m. TBD 8:15 a.m. TBD 8:30 a.m. TBD 8:45 a.m. TBD 9:00 a.m. TBD 9:15 a.m. TBD IASLC Business Meeting (By Invitation Only) Location: Salon Las Sierras PRESIDENTIAL SYMPOSIUM Presentation and Discussion of Top Rated Abstracts Chairs: Eduardo Richardet (Argentina), Norma Pilnik (Argentina), Giorgio V. Scagliotti (Italy) 9:00 a.m. - 6:00 p.m. EXHIBITION OPEN Location: TBA 7

8 Friday, August 17, :30-10:30 a.m. 9:30 a.m. GENERAL SESSION 1 Innovative Clinical Trial Design for NSCLC Chairs: Carlos Vallejos (Peru), Christian Rolfo (USA) Bringing Opportunities in Clinical Research for Latin America Denisse Bretel (Peru) 9:45 a.m. Master Protocols David Gandara (USA) 10:00 a.m. Lung MAP Roy Herbst (USA) 10:15 a.m. Bringing Research to the Patient: Remote Consenting for a Novel Trial: Genomics of Young Lung Cancer Ezequiel Klimosky (Argentina) 10:30-11:00 a.m. NETWORKING BREAK AND POSTER VIEWING [Poster Session 1] Location: Exhibit Hall, Sheraton Hotel Snacks and refreshments provided 11:00 a.m. - noon 11:00 a.m. GENERAL SESSION 2 Lung Cancer Pathology in the Era of Targeted Therapy Chairs: Marileila Varella-Garcia (USA), Liliana Darluzo (Argentina) The Importance of Histologic Diagnosis in Lung: Clinical Implications Martin Paradelo (Argentina) 11:15 a.m. Tissue Quality Control for Molecular Testing Ignacio I. Wistuba (USA) 11:30 a.m. Gene Expression Profile for Role in the Era of Targeted Therapy 11:45 a.m. Question and Answers Maria Arcila (Columbia) 8

9 Friday, August 17, :00 a.m. - noon GENERAL SESSION 3 Diagnostic and Staging Issues in the Contemporary Pulmonary Medicine Chairs: David Smith (Argentina), Claudia Poleri (Argentina) 11:00 a.m. Assessment of the Pulmonary Nodule Sergio Lucino (Argentina) 11:15 a.m. 11:30 a.m. Potential and Limitations of EBUS for Diagnosis and Staging Optimization of Bronchoscopic Samples in the Era of Molecular Pathology Francisco Tarrazi (USA) Mark Block (USA) 11:45 a.m. Roadmap for Liquid Biopsy in Lung Cancer Christian Rolfo (USA) 12:15-1:15 p.m. GENERAL SESSION 4 Molecular Markers in Lung Cancer Chairs: Rafael Rosell (Spain), Mario Varangot (Uruguay) 12:15 p.m. Molecular Markers in Lung Adenocarcinomas Marileila Varella-Garcia (USA) 12:30 p.m. Molecular Markers in Squamous Cell Carcinoma Rafael Rosell (Spain) 12:45 p.m. 1:00 p.m. Molecular Diagnosis Guidelines Recommended Internationally Molecular Testing in Lung Cancer: Efforts and Perspectives in Latin America Fred R. Hirsch (USA) Oscar Arrieta (Mexico) 9

10 Friday, August 17, :15-1:15 p.m. 12:15 p.m. 12:30 p.m. GENERAL SESSION 5 New Developments in Surgery Chairs: Ricardo Terra (Brazil), Nestor Bustamante (Argentina) Location: Salon Champaqui Invasive Mediastinal Staging: Mediastinoscopy, EBUS and EUS VATS, Robot-Assisted or Thoracotomy for Lung Cancer Surgery William William (Brazil) Ricardo Terra (Brazil) 12:45 p.m. Sublobar Resection for Stage I NSCLC Mark Block (USA) 1:00 p.m. Navigation System to Secure Tissue Diagnosis Gustavo Lyon (Argentina) 1:30-2:30 pm. Industry Symposium Supported By: TBA Treatment Updates in NSCLC: Translating Evidence into Clinical Practice Location: Salon Las Sierras 2:45-4:00 p.m. 2:45 p.m. GENERAL SESSION 6 Adjuvant Therapy in the Molecular Era Chairs: Gonzalo Recondo (Argentina), Edgardo S. Santos (USA) Location: TBA Adjuvant Chemotherapy for NSCLC: Where are We Now? Norma Pilnik (Argentina) 3:00 p.m. Role of Targeted Agents in the Adjuvant Setting Luis E. Raez (Brazil) 3:15 p.m. 3:30 p.m. 3:45 p.m. Is There a Role for Immunotherapy in Lung Cancer Adjuvant Setting? Prognostic and Predictive Makers for Adjuvant Therapy NSCLC Question and Answers Edgardo S. Santos (USA) Osvaldo Aren (Chile) 10

11 Friday, August 17, 2018 NETWORKING BREAK AND POSTER VIEWING [Poster Session 1] 4:00-4:30 p.m. Location: Exhibit Hall 4:30-5:30 p.m. GENERAL SESSION 7 Stage IIIA/B Non-Small Cell Lung Cancer Chairs: Santiago Bella (Argentina), Jorge Gallardo (Chile) 4:30 p.m. Optimal Radiation Dose and Schedule Gustavo Ferraris (Argentina) 4:45 p.m. 5:00 p.m. Optimal Combined Modality Therapy for LA-NSCLC Is There a Role of Neoadjuvant Therapy for N2 disease? Alberto Chiappori (USA) Federico Albrecht (USA) 5:15 p.m. Integration of Molecular Imaging and Agents in LA-NSCLC Luis Mas (Peru) 4:30-5:30 p.m. 4:30 p.m. 4:45 p.m. 5:00 p.m. GENERAL SESSION 8 Squamous Cell Carcinoma Chairs: Claudio Martin (Argentina), Luis Ubillos (Uruguay) Biological Insights of Squamous Cell Carcinoma: Novel Targets Maintenance Therapy in Squamous Cell Carcinoma Checkpoint Inhibitors and Vaccines in Squamous Cell Carcinoma Jorge Gomez (USA) Gilberto Castro (Brazil) Ticiana Leal (USA) 5:15 p.m. How to Approach Second-Line in Squamous Cell Carcinoma Claudio Martin (Argentina) 11

12 Friday, August 17, 2018 Industry Supported Symposium 5:45-6:45 p.m. Location: TBA (TWO ROOMS; 1 SYMPOSIA) 7:00 8:00 p.m. Industry Supported Symposium Location: TBA (TWO ROOMS; 1 SYMPOSIA) 8:15-11:00 p.m. Faculty Dinner - By Invitation Only Location: TBA Saturday, August 18, 2018 Registration Open 8:00 a.m. - 5:00 p.m. Location: Sheraton Hotel Poster Discussion Session 1 8:00-9:15 a.m. Chairs: Giorgio V. Scagliotti (Italy), Eduardo Richardet (Argentina) 1 8:00 a.m. PD :05 a.m. PD :10 a.m. PD :15 a.m. Discussant: TBA 8:30 a.m. Question and Answers 8:35 a.m. PD :40 a.m. PD :45 a.m. PD :50 a.m. Discussant: TBA 9:05 a.m. Question and Answers 12

13 Saturday, August 18, 2018 Poster Discussion Session 2 8:00-9:15 a.m. Chairs: Fred R. Hirsch (USA), Norma Pilnik (Argentina) 2 8:00 a.m. PD :05 a.m. PD :10 a.m. PD :15 a.m. Discussant: TBA 8:30 a.m. Question and Answers 8:35 a.m. PD :40 a.m. PD :45 a.m. PD :50 a.m. Discussant: TBA 9:05 a.m. Question and Answers 13

14 Saturday, August 18, :30-10:30 a.m. 9:30 a.m. 9:45 a.m. GENERAL SESSION 9 Management of Advanced Stage Non-Squamous NSCLC Chairs: Christian Rolfo (USA), Norma Pilnik (Argentina) Front Line Therapy for EGFR/ALK/ROS-1 Genomic Aberrations How to Deal with ALK Resistance- How Far to Go? Rafael Rosell (Spain) Christian Rolfo (USA) 10:00 a.m. Selecting Patients for Maintenance Therapy Giorgio V. Scagliotti (Italy) 10:15 a.m. Molecular Targeted Therapy for Brain Metastases and Leptomeningeal Disease 10:20 a.m. Question and Answers Ignatious Ou (USA) 9:30-10:30 a.m. GENERAL SESSION 10 Immunotherapy in Non-Small Cell Lung Cancer Chairs: Ana Oton (USA), Eduardo Richardet (Argentina) 9:30 a.m. Immunotherapy: Making It in a Simple Language Gabriel Rabinovich (Argentina) 9:40 a.m. Predictive Assays for Immunotherapy Fred R. Hirsch (USA) 9:50 a.m. Clinical Trials with Anti-PD-1 Inhibitors Luis E. Raez (USA) 10:00 a.m. Clinical Trials with Anti-PDL-1 inhibitors Clarissa Mathias (Brazil) 10:10 a.m. Other Immunotherapy Pathways CTL4 and Others 10:20 a.m. Question and Answers David Carbone (USA) 10:30-11:00 a.m. Networking Break and Poster Viewing [Poster Session 2] Location: Exhibit Hall 14

15 Saturday, August 18, :00 a.m. - 12:30 p.m. ROUND TABLE DISCUSSIONS Chairs: Diego Kaen (Argentina), Martin Richardet (Argentina) Location: TBD Novel Approaches in Surgery: Robotic Surgery, VATS, Navigation System TBA (2) Palliative Care in Lung Cancer TBA (2) Treatment of Wild Type Lung Cancer Tumors First and Second Line Therapy of Tumors Carrying EGFR Mutations or ALK Translocations How to Study Molecular Biology and Tumor Markers TBA (2) TBA (2) TBA (2) Radiation Therapy in Lung Cancer TBA (2) New Molecules and Therapies for Lung Cancer TBA (2) Diagnosis and Staging in Lung Cancer TBA (2) Locally Advanced Non-Small Cell Lung Cancer TBA (2) Therapy of EGFR/ALK Resistant Lung Cancer Tumors Management of Toxicities from Immunotherapies in Lung Cancer TBA (2) TBA (2) 15

16 Saturday, August 18, 2018 Adjuvant Therapy in Non-Small Cell Lung Cancer TBA (2) Management of Limited and Extensive Small Cell Lung Cancer TBA (2) Liquid Biopsy in Lung Cancer TBA (2) TBA (2) Christian Rolfo (USA) David Gandara (USA) 12:45-1:45 p.m. 12:45 p.m. GENERAL SESSION 11 Small Cell Lung Cancer and Neuroendocrine Tumor (Net) Chairs: Oscar Arrieta (Mexico), Nise Yamaguchi (Brazil) Small Cell Cancer Biology: Are There New Targets? Ruben Salanova (Argentina) 1:00 p.m. Systemic Therapy for SCLC Brian Hunis (USA) 1:15 p.m. Success and Challenges of Radiation Therapy for SCLC Berta Roth (Argentina) 1:30 p.m. Management of Well-Differentiated NET Andres F Cardona (Columbia) 12:45-1:45 p.m. GENERAL SESSION 12 Advanced Radiation Technology Chairs: Silvia Zunino (Argentina), Jorge Gonzalez (Chile) 12:45 p.m. Radiation Oncology Challenges in Latin America Hugo Marsiglia (Chile) 1:00 p.m. Role of SBRT in Early Stage NSCLC Moises Russo (Chile) 1:15 p.m. Role of SBRT in Advanced NSCLC Silvia Zunino (Argentina) 1:30 p.m. Role of Proton in Lung Cancer Ana Botero (USA) 16

17 Saturday, August 18, 2018 INDEPENDENT SATELLITE SYMPOSIUM 2:00-3:00 p.m. Location: Salon Las Sierras 3:15-4:15 p.m. GENERAL SESSION 13 Novel Therapies Targeting Lung Cancer Pathways Chairs: Paul A. Bunn, Jr. (USA), Luis E. Raez (USA) 3:15 p.m. RET/BRAF Paul A. Bunn, Jr. (USA 3:25 p.m. MET and MET Exon 14 Skipping Clarissa Mathias (Brazil) 3:35 p.m. DNA Repair Inhibitors David Gandara (USA) 3:45 p.m. NF-1 David Carbone (USA) 3:55 p.m. NTRK Giorgio V. Scagliotti (Italy) 4:05 p.m. Question and Answers 3:15-4:15 p.m. GENERAL SESSION 14 Mesothelioma, Thymoma and Thymic Carcinoma Chairs: Brian Hunis (USA), Jorge Madrid (Chile) 3:15 p.m. VATS and Robotic Surgery in Mesothelioma Ricardo Santos (Brazil) 3:30 p.m. 3:45 p.m. 4:00 p.m. Biological Insights and Novel Therapy for Malignant Mesothelioma Current Standard of Care for the Treatment of Thymoma: What s New? Immunotherapy Rationale in Small Cell and Miscellaneous Luis Corrales-Rodriguez (Costa Rica) Manuel Magallanes (Mexico) Francisco Orlandi (Chile) 4:15-4:45 p.m. Networking Break and Poster Viewing [Poster Session 2] Location: Exhibit Hall 17

18 Saturday, August 18, :45 5:45 p.m. 4:45 p.m. GENERAL SESSION 15 Epidermal Growth Factor Receptor Mutation as Targeted Therapy Chairs: Clarissa Mathias (Brazil), Luis Mas (Peru) Actual Status of First and Second-Generation EGFR TKIs in the Treatment of NSCLC Fred R. Hirsch (USA) 5:00 p.m. Targeting T790M in Lung Cancer Carlos Barrios (Brazil) 5:15 p.m. 5:30 p.m. New Insights of EGFR Inhibition: EGF816, ASP8273 and Others EGFR TKIs with Central Nervous System Penetration for Management of Lung Cancers Rafael Rosell (Spain) Paul A. Bunn, Jr. (USA) 4:45 5:45 p.m. GENERAL SESSION 16 ALK/EML4 Translocation as Targeted Therapy Chairs: Alfredo Aguilar (Peru), Osvaldo Aren (Chile) 5:00 p.m. ALK Inhibitors: Where Are We Now? Ana Oton (USA) 5:15 p.m. 5:30 p.m. 5:45 p.m. Novel Molecular Mechanisms of Resistance to ALK Inhibition ALK Inhibitors with Central Nervous System Penetration for Management of Lung Cancers ALK Inhibitors in Combination with Other Targeted Therapies and Radiotherapy in Patients with ALK+ NSCLC Brian Hunis (USA) Jorge Alatorre (Mexico) Luis Ubillos (Uruguay) 18

Saturday, August 18, 2018 6:00-6:30 p.m.

19 Saturday, August 18, :00-6:30 p.m. Closing Ceremony Chairs: Eduardo Richardet (Argentina), Normal Pilnik (Argentina), Christian Rolfo (USA) Location: TBA Award Presentations Closing Remarks Introducing LALCA 2019 Mexico City, Mexico Norma Pilnik (Argentina) Eduardo Richardet (Argentina) Fred R. Hirsch (USA) 19

Breakfast and Registration. Welcome and Introductions Luis E. Raez (USA), Eduardo Richardet (Argentina) Pre-meeting Test

Breakfast and Registration. Welcome and Introductions Luis E. Raez (USA), Eduardo Richardet (Argentina) Pre-meeting Test Wednesday, August 15, 2018 IASLC School of Thoracic Oncology Program Agenda Chairs: Luis E. Raez (USA), Luis Corrales-Rodriguez (Costa Rica) 7:30 a.m. Breakfast and Registration 8:15 a.m. 8:20 a.m. 8:45-9:15