Rectum and anus cancer Highligths Dott. Domenico Corsi. UOC Oncologia Ospedale San Giovanni Calibita Fatebenefratelli Isola Tiberina

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1 Rectum and anus cancer Highligths Dott. Domenico Corsi UOC Oncologia Ospedale San Giovanni Calibita Fatebenefratelli Isola Tiberina

2 Focus on - Molecular variances between rectal and left-side colon cancer Slide 20 - International Watch and Wait Database in rectal cancer - Management of early low lying rectal cancer - New strategies in anal cancer Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

3 Molecular Variances Between Rectal <br />and Left-Sided Colon Cancers Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

4 Background Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

5 CONSORT Diagram Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

6 Slide 20 Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

7 Frequency of microsatellite instability in left-sided CRC Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

8 Tumor Mutation Load (TML) Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

9 Her2/Neu: Overexpression and Amplification Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

10 Mutation Frequency Comparison Between Rectal and Right-sided Colon Cancers Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

11 Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

12 Her2/Neu : Overexpression and Amplification Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

13 Conclusions Presented By Mohamed Salem at 2017 Gastrointestinal Cancers Symposium

14 The International Watch & Wait Database (IWWD) for Rectal Cancer Presented By Maxime Valk at 2017 Gastrointestinal Cancers Symposium

15 Watch & Wait in Rectal Cancer Presented By Maxime Valk at 2017 Gastrointestinal Cancers Symposium

16 Slide 10 Presented By Maxime Valk at 2017 Gastrointestinal Cancers Symposium

17 Slide 11 Presented By Maxime Valk at 2017 Gastrointestinal Cancers Symposium

18 Slide 14 Presented By Maxime Valk at 2017 Gastrointestinal Cancers Symposium

19 Slide 15 Presented By Maxime Valk at 2017 Gastrointestinal Cancers Symposium

20 Slide 16 Presented By Maxime Valk at 2017 Gastrointestinal Cancers Symposium

21 Cause of death Presented By Maxime Valk at 2017 Gastrointestinal Cancers Symposium

22 Conclusion Presented By Maxime Valk at 2017 Gastrointestinal Cancers Symposium

23 Management of Low-Lying<br />Early Rectal Cancer Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

24 Slide 6 Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

25 Transabdominal Resection (TME) Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

26 Consequences of transabdominal resection (TME) Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

27 Local Excision (LE, TEM, TEO, TAMIS) Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

28 Relative survival after local excision for T1 and T2 rectal cancer (Red Line) Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

29 Nodal involvement by histopathology Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

30 Options after LE: TME or ChemoRT Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

31 Transabdominal resection (Completion TME) after LE<br />Technical Challenges Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

32 Completion TME After LE - Results Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

33 Options after LE: TME or ChemoRT Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

34 ChemoRT before LE Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

35 RCT of endoluminal locoregional resection (ELRR) versus laparoscopic total mesorectal excision (TME)<br />for T2 rectal cancer after neoadjuvant therapy Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

36 ChemoRT and LE for T2N0 Rectal Cancer<br /> ACOSOG Z6041 Trial Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

37 ChemoRT and LE: ACOSOG Z6041 trial<br />Results for 72 Evaluable patients Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

38 SCRT and TEM for early rectal cancer Presented By Julio Garcia-Aguilar at 2017 Gastrointestinal Cancers Symposium

39 New strategies in Anal Cancer

40 Squamous cell carcinoma of the Anus<br />

41 Slide 11 Presented By Robert Glynne-Jones at 2017 Gastrointestinal Cancers Symposium

42 Squamous cell carcinoma of the anus Presented By Robert Glynne-Jones at 2017 Gastrointestinal Cancers Symposium

43 Rationale for Nivolumab in Metastatic SCCA: Presented By Cathy Eng at 2017 Gastrointestinal Cancers Symposium

44 Programmed Cell Death-Ligand 1 (PD-L1) Expression in Anal Cancer <br /> Presented By Robert Glynne-Jones at 2017 Gastrointestinal Cancers Symposium

45 Slide 21 Presented By Robert Glynne-Jones at 2017 Gastrointestinal Cancers Symposium

46 Slide 24 Presented By Robert Glynne-Jones at 2017 Gastrointestinal Cancers Symposium

47 Published Regimens for Met Anal SCCA Presented By Cathy Eng at 2017 Gastrointestinal Cancers Symposium

48 KEYNOTE 028: Phase Ib Expanded cohort of Pembrolizumab Presented By Cathy Eng at 2017 Gastrointestinal Cancers Symposium

49 NCI9673: Phase II Design of Nivolumab in Metastatic SCCA Presented By Cathy Eng at 2017 Gastrointestinal Cancers Symposium

50 Patient Demographics Presented By Cathy Eng at 2017 Gastrointestinal Cancers Symposium

51 Primary Endpoint: Response Rate Presented By Cathy Eng at 2017 Gastrointestinal Cancers Symposium

52 NCI9673 Toxicities of Therapy Presented By Cathy Eng at 2017 Gastrointestinal Cancers Symposium

53 NCI9673: PFS and OS Presented By Cathy Eng at 2017 Gastrointestinal Cancers Symposium

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