Fabienne Warmerdam Zuyderland
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1 GE Fabienne Warmerdam Zuyderland
2 Disclosure ASCO 2017 travelgrant Pfizer
3 CRC ADJUVANT Less is more? More is More!
4 1 Less is more?
5 Perspectief INT-0035 stadium III (niets vs 5-FU) 6.5-jaars OS 46% vs. 60% MOSAIC stadium III (5-FU/LV vs + oxaliplatin) 10-jaars OS 59.0% vs. 67.1%
6 The BIG Problem: Large Proportion of Patients with Residual Neuropathy at 4 yrs Presented By Cathy Eng at 2017 ASCO Annual Meeting
7 Prospective Pooled Analysis of Six Phase III Trials Investigating Duration of Adjuvant Oxaliplatin-based therapy (3 vs. 6 months) for Patients with Stage III Colon Cancer: <br />The IDEA (International Duration Evaluation of Adjuvant Chemotherapy) Collaboration Presented By Qian Shi at 2017 ASCO Annual Meeting
8 Study Schema Presented By Qian Shi at 2017 ASCO Annual Meeting
9 Rationale for Non-inferiority Margin Presented By Qian Shi at 2017 ASCO Annual Meeting
10 DFS Comparison by Stage, cont. Presented By Qian Shi at 2017 ASCO Annual Meeting
11 DFS Comparison by Regimen, cont. Presented By Qian Shi at 2017 ASCO Annual Meeting
12 DFS Comparison by Risk Group and Regimen, cont. Presented By Qian Shi at 2017 ASCO Annual Meeting
13 Adverse Events Presented By Qian Shi at 2017 ASCO Annual Meeting
14
15 <br /><br /><br /> Presented By Timothy Iveson at 2017 ASCO Annual Meeting
16 IDEA Clinical Consensus: Risk-based approach to adjuvant chemotherapy in stage III colon cancer Presented By Qian Shi at 2017 ASCO Annual Meeting
17 Discussie Cathy Eng
18 Findings: Presented By Cathy Eng at 2017 ASCO Annual Meeting
19 Findings: Presented By Cathy Eng at 2017 ASCO Annual Meeting
20 Potential Pitfalls of the Pooled Data: Presented By Cathy Eng at 2017 ASCO Annual Meeting
21 Comments. Presented By Cathy Eng at 2017 ASCO Annual Meeting
22 Conclusions: Presented By Cathy Eng at 2017 ASCO Annual Meeting
23 Voor nu Geen verandering richtlijn Bij T3N1met CAPOX dosisreductie/stop oxaliplatin na 4 cycli bij PNP
24 2 Nuts for Guts or Guts for Nuts
25
26 Nut Consumption and Survival in Stage III Colon Cancer Patients: Results from CALGB (Alliance)
27 CALGB 89803
28 CALGB 89803
29 Results
30 Results
31 Secondary analyses of 89803
32 More is more
33 Voor nu Leefstijl adviezen in richtlijn Post-treatment program (zoals Herstel & Balans) inclusief dieet- en leefstijl adviezen
34 CRC gemetastaseerd Prognostische en predictieve markers
35 1 RECHTS vs LINKS
36 <br />Primary tumor location is an independent prognostic marker from molecular features for overall survival in patients with metastatic colorectal cancer: analysis of CALGB/SWOG (Alliance) <br /> Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
37 CALGB/SWOG Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
38 <br /> 80405: (KRAS WT) Overall Survival by Sidedness Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
39 Factors included in multivariate analysis Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
40 2 Consensus molecular subtyping (CMS)
41 Impact of Consensus Molecular Subtyping (CMS) on overall survival (OS) and Progression Free Survival (PFS) in patients (pts) with metastatic colorectal cancer (mcrc): Analysis of CALGB / SWOG (Alliance). Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
42 Slide 3 Presented By Robert Coffey at 2017 ASCO Annual Meeting
43 CMS Subgroups Presented By Sebastian Stintzing at 2017 ASCO Annual Meeting
44 Relation of Genotype to Phenotype<br />Colorectal Molecular Subtypes Presented By Alan Venook at 2017 ASCO Annual Meeting
45 Slide 32 Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
46 Slide 33 Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
47 Slide 34 Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
48 Slide 35 Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
49 Conclusion Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
50 Consensus molecular subgroups (CMS) of colorectal cancer (CRC) and 1st-line efficacy of FOLFIRI plus cetuximab or bevacizumab Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
51 FIRE-3 Design Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
52 OS in RAS wild-type Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
53 CMS4: FOLFIRI cetuximab vs. FOLFIRI bevacizumab Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
54 FOLFIRI cetuximab vs. FOLFIRI bevacizumab Presented By Heinz-Josef Lenz at 2017 ASCO Annual Meeting
55 Voor nu Geen veranderingen behandeling mcrc
56 Immunotherapie in CRC 10-15% MSI 19 ptn >= 2 lijnen Na 3 maanden: DCR 68% CR 5% PR 47% SD 16%
57 Cholangiocarcinoom adjuvant Nieuw!
58 Slide 4 Presented By John Primrose at 2017 ASCO Annual Meeting
59 Slide 6 Presented By Tanios Bekaii-Saab at 2017 ASCO Annual Meeting
60 Outcomes Measures according to ITT and PP analyses*,^ Presented By Tanios Bekaii-Saab at 2017 ASCO Annual Meeting
61 Summary slide : Adjuvant Therapy in Biliary Cancer (BTC) Presented By Tanios Bekaii-Saab at 2017 ASCO Annual Meeting
62 Voor nu 6 maanden adjuvant capecitabine wordt standaard voor cholangiocarcinoom
63 Oesophagus-maag perioperatief taxanen
64 Perioperative chemotherapy with docetaxel, oxaliplatin, and fluorouracil/leucovorin (FLOT) versus epirubicin, cisplatin, and fluorouracil or capecitabine (ECF/ECX) for resectable gastric or gastroesophageal junction (GEJ) adenocarcinoma (FLOT4): A multicenter, randomized phase 3 trial Presented By Salah-Eddin Al-Batran at 2017 ASCO Annual Meeting
65 Perspectief MAGIC Trial niets vs ECC 23% vs 36%
66 FLOT4 Study Design Presented By Salah-Eddin Al-Batran at 2017 ASCO Annual Meeting
67 Histopathology (yptn) Presented By Salah-Eddin Al-Batran at 2017 ASCO Annual Meeting
68 Operative Morbidity/Mortality Presented By Salah-Eddin Al-Batran at 2017 ASCO Annual Meeting
69 Chemo Related Toxicity 1 Presented By Salah-Eddin Al-Batran at 2017 ASCO Annual Meeting
70 Chemo Related Toxicity 2 Presented By Salah-Eddin Al-Batran at 2017 ASCO Annual Meeting
71 FLOT4: Progression-Free Survival Presented By Salah-Eddin Al-Batran at 2017 ASCO Annual Meeting
72 FLOT4: Overall Survival Presented By Salah-Eddin Al-Batran at 2017 ASCO Annual Meeting
73 Voor nu FLOT wordt nieuwe standaard peri-operatieve therapie maagcarcinoom
74 Oesophagus-maag gemetastaseerd Immunotherapie
75 Anti-PD1
76 ATTRACTION 2: Phase III of NIVOLUMAB vs. Placebo in G/GEC Presented By Tanios Bekaii-Saab at 2017 ASCO Annual Meeting
77 KEYNOTE-059 Cohort 1: Efficacy and Safety of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric Cancer Presented By Charles Fuchs at 2017 ASCO Annual Meeting
78 KEYNOTE-059 (NCT ): Phase 2 Multicohort Study of Pembrolizumab for G/GEJ Adenocarcinoma<br /> Presented By Charles Fuchs at 2017 ASCO Annual Meeting
79 KEYNOTE-059 Cohort 1 Eligibility Criteria Presented By Charles Fuchs at 2017 ASCO Annual Meeting
80 Response in All Patients Presented By Charles Fuchs at 2017 ASCO Annual Meeting
81 Maximum Percentage Change From Baseline in<br />Target Lesion Sizea Presented By Charles Fuchs at 2017 ASCO Annual Meeting
82 Treatment Exposurea and Duration of Response Presented By Charles Fuchs at 2017 ASCO Annual Meeting
83 OS in All Patients Presented By Charles Fuchs at 2017 ASCO Annual Meeting
84 Response by MSI Status (n = 174) Presented By Charles Fuchs at 2017 ASCO Annual Meeting
85 Conclusions Presented By Charles Fuchs at 2017 ASCO Annual Meeting
86 Conclusions Presented By Charles Fuchs at 2017 ASCO Annual Meeting
87 Anti-PD1 + anti-ctla-4
88 Nivolumab ± Ipilimumab in Patients With Advanced/Metastatic Chemotherapy-Refractory Gastric, Esophageal, or Gastroesophageal Junction Cancer: CheckMate 032 Study Presented By Yelena Janjigian at 2017 ASCO Annual Meeting
89 Nivolumab ± ipilimumab in patients with advanced/metastatic chemotherapy-refractory gastric, esophageal, or gastroesophageal junction cancer: CheckMate 032 study Presented By Tanios Bekaii-Saab at 2017 ASCO Annual Meeting
90 Overall Survival Presented By Tanios Bekaii-Saab at 2017 ASCO Annual Meeting
91 Summary slide : Immunotherapy in Advanced Gastro-Esophageal Cancer Presented By Tanios Bekaii-Saab at 2017 ASCO Annual Meeting
92 Voor nu Immunotherapie oesophagus/maag nog geen optie in gemetastaseerde setting (PASKWIL criteria?) Onderzoek in adjuvante setting volgt
93 Ergo: Practice-changing in GI CRC adjuvant 6 mnd CAPOX, T3N1 eventueel stop na 3 mnd bij tox Leefstijl- en voedingsadviezen! Cholangiocarcinoom adjuvant capecitabine Maagcarcinoom perioperatief FLOT
94
95 PASKWIL criteria 2016
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