TARGETING TREATMENT OF SOFT TISSUE SARCOMAS

Transcription

1 TARGETING TREATMENT OF SOFT TISSUE SARCOMAS

2 Cancer Treatment and Research Steven T. Rosen, M.D., Series Editor Klastersky, J. (ed): Infectious Complications of Cancer ISBN Kurzrock, R., Talpaz, M. (eds): Cytokines: Interleukins and Their Receptors ISBN Sugarbaker, P. (ed): Peritoneal Carcinomatosis: Drugs and Diseases ISBN Sugarbaker, P. (ed): Peritoneal Carcinomatosis: Principles of Management ISBN Dickson, R.B., Lippman, M.E. (eds.): Mammary Tumor Cell Cycle, Differentiation and Metastasis ISBN Freireich, E.J, Kantarjian, H. (eds): Molecular Genetics and Therapy of Leukemia ISBN Cabanillas, F., Rodriguez, M.A. (eds): Advances in Lymphoma Research ISBN Miller, A.B. (ed.): Advances in Cancer Screening ISBN Hait, W.N. (ed.): Drug Resistance ISBN Pienta, K.J. (ed.): Diagnosis and Treatment of Genitourinary Malignancies ISBN Arnold, A.J. (ed.): Endocrine Neoplasms ISBN Pollock, R.E. (ed.): Surgical Oncology ISBN Verweij, J., Pinedo, H.M., Suit, H.D. (eds): Soft Tissue Sarcomas: Present Achievements and Future Prospects ISBN Walterhouse, D.O., Cohn, S. L. (eds.): Diagnostic and Therapeutic Advances in Pediatric Oncology ISBN Mittal, B.B., Purdy, J.A., Ang, K.K. (eds): Radiation Therapy ISBN Foon, K.A., Muss, H.B. (eds): Biological and Hormonal Therapies of Cancer ISBN Ozols, R.F. (ed.): Gynecologic Oncology ISBN Noskin, G. A. (ed.): Management of Infectious Complications in Cancer Patients ISBN Bennett, C. L. (ed.): Cancer Policy ISBN X. Benson, A. B. (ed.): Gastrointestinal Oncology ISBN Tallman, M.S., Gordon, L.I. (eds): Diagnostic and Therapeutic Advances in Hematologic Malignancies ISBN von Gunten, C.F. (ed): Palliative Care and Rehabilitation of Cancer Patients ISBN X Burt, R.K., Brush, M.M. (eds): Advances in Allogeneic Hematopoietic Stem Cell Transplantation ISBN Angelos, P. (ed.): Ethical Issues in Cancer Patient Care ISBN Gradishar, W.J., Wood, W.C. (eds): Advances in Breast Cancer Management ISBN Sparano, Joseph A. (ed.): HIV & HTLV-I Associated Malignancies ISBN Ettinger, David S. (ed.): Thoracic Oncology ISBN Bergan, Raymond C. (ed.): Cancer Chemoprevention ISBN X. Raza, A., Mundle, S.D. (eds): Myelodysplastic Syndromes & Secondary Acute Myelogenous Leukemia ISBN: Talamonti, Mark S. (ed.): Liver Directed Therapy for Primary and Metastatic Liver Tumors ISBN Stack, M.S., Fishman, D.A. (eds): Ovarian Cancer ISBN Bashey, A., Ball, E.D. (eds): Non-Myeloablative Allogeneic Transplantation ISBN Leong, Stanley P.L. (ed.): Atlas of Selective Sentinel Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer ISBN Andersson, B., Murray D. (eds): Clinically Relevant Resistance in Cancer Chemotherapy ISBN Beam, C. (ed.): Biostatistical Applications in Cancer Research ISBN Brockstein, B., Masters, G. (eds): Head and Neck Cancer ISBN Frank, D.A. (ed.): Signal Transduction in Cancer ISBN Figlin, Robert A. (ed.): Kidney Cancer ISBN Kirsch, Matthias; Black, Peter McL. (ed.): Angiogenesis in Brain Tumors ISBN Keller, E.T., Chung, L.W.K. (eds): The Biology of Skeletal Metastases ISBN Kumar, Rakesh (ed.): Molecular Targeting and Signal Transduction ISBN Verweij, J., Pinedo, H.M. (eds): Targeting Treatment of Soft Tissue Sarcomas ISBN Finn, W.G., Peterson, L.C. (eds.): Hematopathology in Oncology ISBN

3 TARGETING TREATMENT OF SOFT TISSUE SARCOMAS edited by Jaap Verweij Department of Medical Oncology Erasmus University Medical Center Rotterdam, The Netherlands and Herbert M. Pinedo Department of Medical Oncology Free University Medical Center Amsterdam, The Netherlands KLUWER ACADEMIC PUBLISHERS NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW

4 ebook ISBN: Print ISBN: Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow Print 2004 Kluwer Academic Publishers Boston All rights reserved No part of this ebook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at: and Kluwer's ebookstore at:

5 Table of Contents Targeted therapy: Ready for prime time? 1 C. Seynaeve and J. Verweij, Erasmus University Medical Center, Rotterdam, The Netherlands Volume-based radiotherapy targeting in soft tissue sarcoma 17 Iain Ward, Tara Haycocks, Michael Sharpe, Anthony Griffin, Charles Catton, David Jaffray, Brian O Sullivan, Princess Margaret Hospital, University of Toronto, Toronto, Canada Preoperative therapy for soft tissue sarcoma 43 Janice N. Cormier, Howard N. Langstein, Peter W. T. Pisters, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA TNF-based isolated limb perfusion: A decade of experience with 65 antivascular therapy in the management of locally advanced extremity soft tissue sarcomas Dirk J Grünhagen, Flavia Brunstein, Timo L.M. ten Hagen, Albertus N. van Geel, Johannes H.W. de Wilt, and Alexander M.M. Eggermont, Erasmus University Medical Center, Rotterdam, The Netherlands Pitfalls in pathology of soft tissue sarcomas Judith V.M.G. Bovée and Pancras C.W. Hogendoorn, Leiden Universtiy Medical Center, Leiden, The Netherlands Molecular biology and cytogenetics of soft tissue sarcomas: Relevance for targeted therapies Jonathan Fletcher, Brighams and Womens Hospital, Boston, MA, USA KIT and PDGF as targets Jaap Verweij, Erasmus UniversityMedical Center, Rotterdam, The Netherlands Targeting mutant kinases in gastrointestinal stromal tumors: A paradigm for molecular therapy of other sarcomas Mike C. Heinrich, Christopher L. Corless, Portland, OR, USA Targeting other abnormal signalling pathways in sarcoma: EGFR in synovial sarcomas, in liposarcoma Jean-Yves Blay, Isabelle Ray-Coquard, Laurent Alberti, Dominique Ranchere, Hospital Edouard Herriot, Lyon, France Angiogenesis: A potential target for therapy of soft tissue sarcomas K. Hoekman and H.M. Pinedo, Free University Medical Center, Amsterdam, The Netherlands Index 181

6 Preface The last decade we have witnessed a major change in the development of new techniques and agents for the treatment of cancer in general, and for soft tissue sarcomas in particular. The important achievements of molecular biology research have changed the landscape markedly. Increasingly subtypes of soft tissue sarcomas are shown to be related to changes in cellular growth factors in the cell signaling pathways. This in theory enabled to development of agents with specific activity against these factors. The presence of the KIT receptor at the surface of the gastrointestinal stroma tumor cell, and the constitutive activation by mutations, has lead to the discovery of the specific KIT tyrosine kinase inhibitor Imatinib, an agent with impressive activity in this disease. Before the era of Imatinib, GIST was an untreatable disease once metastasized. Imatinib clearly is a breakthrough in the approach of soft tissue sarcomas, and will likely serve as a role model for the development of other agents acting towards other receptors. Likewise, soft tissue sarcomas with their specific molecular characteristics, will likely serve as role model diseases for targeted treatment approaches. Whether the future lies in drugs with selective inhibition of only one receptor and one pathway, or multiple receptors and multiple pathways is currently a matter of debate, and again soft tissue sarcomas serve as role model. Fully in line with the more targeted approach in drug use, the changes in the field of radiation therapy and surgery basically also focus on a better targeting of the disease, albeit not based on the molecular characteristics yet. The present volume of this series reflects all of the above mentioned changes. World wide renowned experts have been willing to contribute to this book, and we would like to thank all of them for their efforts. Hopefully this book will contribute to a better understanding of the changes in the field, and will serve our patients in helping getting a better future. Jaap Verweij Herbert M. Pinedo Editors