Table E1. Standardized Mortality Ratios for Total and Specific Causes of Death Parameter Radiologists Psychiatrists No. of Deaths

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1 RSNA, /radiol Table E1. Standardized Mortality Ratios for Total and Specific Causes of Death Parameter Radiologists Psychiatrists No. of Deaths Observed/Expected No. of Deaths Observed/Expected All causes of death All malignant neoplasms ( , 238.6)/(C00-C97) Lip, oral cavity, pharynx ( )/(C00-C14) Digestive organs ( )/(C15-C26) Esophagus (150/C15) Stomach (151/C16) Colon excluding rectum (153)/(C18) Rectum and rectosigmoid junction (154)/(C19-C21) Liver and intrahepatic bile duct (155)/(C22) Pancreas (157/C25) Respiratory and intrathoracic organs ( )/(C30 39) Lung and bronchus (162)/(C34) Bone (170)/(C40-C41) Skin ( )/(C43 44) Melanoma (172)/(C43) Other nonepithelial skin (173)/(C44) Soft tissue (171)/(C45-C49) Breast ( )/C50) Genitourinary organs ( )/(C51-C68) Prostate (185)/(C61) Urinary bladder (188)/(C67) Kidney and renal pelvis (189)/(C64-C65) Brain and central nervous system (including benign) ( , 225)/(C70-C72, D32-D33, D35.2-D35.3, D42-D43) Brain and central nervous system ( )(C70-C72) Thyroid (193)/(C73) All lymphoid and hematopoetic ( , , , , , , , , )/(C81-C88, C90.0, C90.2, C91.0-C91.9, C95-C96) Total leukemia (204, 0, 204.1, 204.2, 204.8, 204.9, 205.0, , 206.0, 207.0, 207.2, 208.0, 208.1, 208.2, 208.8, 208.9; C , C92.0,C92.1, C92.4, C92.5, C93.0, C94.0, C94.2, C95) Leukemia excluding chronic lymphocytic leukemia (204.0, , 206.0, 207.0, 207.2)/(C91.0, C92.0-C92.1, C92.4- C92.5, C93.0, C94.0, C94.2) Total lymphoma ( , , , )/(C C8182-C88); All myeloid (205.0, 205.3, , , , , 238.7, 285.0)/(C92.0-C92.5, C92.7, C92.9, C93.0-C93.2, C93.7, C93.9, C94.0-C94.5, D45-D47.3) Acute myeloid leukemia and myelodysplastic syndrome (MDS) (205.0, , 207.0, 207.2, 238.7, 285.0)/(C92.0, C92.4-C92.5, C93.0, C94.0, C94.2, D46)* Page 1 of 5

2 Acute myeloid and monocytic leukemia (205.0, , 207.0, 207.2)/(C92.0, C92.4-C92.5, C93.0, C94.0, C94.2) MDS (238.7, 285.0)/(D46) Myeloproliferative disorders (202.6, , )/(C92.1-C92.2, D45, D47.0-D47.1, D47.3) Chronic myeloid leukemia (205.1)/(C92.1) Other myeloid leukemia (205.3, )/(C92.3, C92.7, C92.9, C94.1) Other myeloid malignancies ( , 207.1)/(C C93.2, C93.7, C93.9, C94.2-C94.5) All lymphoid ( , , , , , , )/(C81- C88, C90.0, C90.2, C91.0-C91.9) NHL ( , , )/(C82-C88) Chronic lymphocytic leukemia (204.1, 204.2)/(C C91.3) Acute lyphocytic leukemia (204.0)/(C91.0) Other lymphoid leukemia ( )/(C91.4-C91.9) Multiple myeloma ( )/(C90.0, C90.2) Hodgkin lymphoma ( )/(C81) Other leukemias of unspecific cell type ( , )/(C95) Other and unspecific malignant neoplasms of lymphoid, hematopoietic and related tissue (202.5, )/(C96) Infectious diseases ( )/(A00-B99) Human immunodeficiency virus ( )/(B20-B24) Septicemia (038)/(A40-A41) Diseases of blood-forming tissue ( )/(D50-D89) Aplastic anemia (284.8, 284.9)/(D61.3, D61.8, D61.9) All endocrine disorders ( )/(E00-E90) Disorders of the thyroid gland ( )/(E00-E90) Diabetes mellitus (250)/(E10-E14) All mental and behavioral disorders ( )/(F00-F99) Neurologic and mental conditions ( )/(G00-G99) Alzheimers (331.0)/(G30) Other degenerative diseases of the nervous system ( )/(G31-G32) All circulatory diseases ( )/(I00-I99) Hypertension without heart disease (401)/(I10) Ischemic heart disease ( )/(I20-I25) Other diseases of heart ( )/(I30-I52) Cerebrovascular diseases ( )/(I60-I69) Atherosclerosis (440)/(I70) Aortic aneurysm and dissection (441)/(I71) All diseases of the respiratory system ( )/(J00-J99) Pneumonia and influenza ( )/(J10-J18) Chronic obstructive pulmonary disease and allied conditions ( )/(J40-J47) All gastrointestinal diseases ( )/(K00-K93) Chronic liver disease and cirrhosis (571)/(K70-K77) All genitourinary diseases ( )/(N00-N99) Nephritis, nephrotic syndrome/glomerular disease ( )/(N00-N08) Page 2 of 5

3 Accidents and adverse effects ( )/(V01-X59, Y85-Y86) Suicide and self-inflicted injury (E950-E959)/(U03, X60-X84, Y87.0) Homicide and legal intervention (E960-E969)/(U01-U02, X85- Y09, Y87.1) Note. Except where noted, data are for men and women combined. * Includes all malignant, benign, and uncertain behavior. Page 3 of 5

4 Table E2. RRs and 95% CIs for Deaths from All Causes, All Cancers, Site-specific Cancers, and Circulatory Diseases in All Exposed Radiologists Compared with Male Psychiatrists Who Were Confirmed Alive or Deceased: Sensitivity Analysis Causes of Death (ICD 9 < P Value for Overall and 10 Codes) Trend Deaths* RR Deaths* RR Deaths* RR Deaths* RR Deaths* RR All causes of death 712/ (0.86, 1.03) 2427/ (0.91, 1.00) 973/ (0.76, 0.89) 148/ (0.51, 0.76) < / (0.87, 0.94) All malignant neoplasms 190/ (0.92, 1.32) 745/ (0.88, 1.05) 337/ (0.79, 1.04) 34/ (0.56, 1.34) / (0.90, 1.03) ( , 238.6)/(C00-C97) Brain and central nervous 1/ (0.02, 1.29) 26/ (0.47, 1.20) 24/ (0.52, 1.45) 6/ (0.25, 1.79).33 57/ (0.53, 1.01) system (including benign) ( , 225)/(C70-C72, D32-D33, D35.2-D35.3, D42-D43) Brain and central 1/ (0.02, 1.58) 23/ (0.45, 1.19) 22/ (0.50, 1.46) 6/ (0.26, 1.94).49 52/ (0.52, 1.02) nervous system ( )(C70-C72) Total leukemia (204, 0, 204.1, 204.2, 204.8, 204.9, 205.0, 205.1, 206.0, 207.0, 207.2, 208.0, 208.1, 208.2, 208.8, 208.9; C , C92.0,C92.1, C92.4, C92.5, C93.0, C94.0, C94.2, C95) 11/ (0.82, 4.32) 44/ (0.86, 1.90) 20/ (0.49, 1.49) 2/ (0.16, 9.03).45 77/ (0.88, 1.60) Leukemia excluding CLL (204.0, , 5/ (0.77, 13.45) 23/ (0.72, 2.11) 14/ (0.58, 2.45) 2/ (0.17, 22.0) >.50 44/ (0.90, 2.01) 206.0, 207.0, 207.2)/(C91.0, C92.0-C92.1, C92.4-C92.5, C93.0, C94.0, C94.2) Acute myeloid leukemia and myelodysplastic syndrome (MDS) (205.0, 206.0, 2, 207.0, 207.2, 238.7, 285.0)/(C92.0, C92.4- C92.5, C93.0, C94.0, C94.2, D46) b 4/ (0.67, 20.02) 22/ (0.77, 2.37) 11/ (0.70, 4.09) 3/0 NA.24 40/ (1.05, 2.56) All circulatory diseases ( )/(I00-I99) 364/ (0.80, 1.02) 944/ (0.88, 1.03) 290/ (0.83, 1.12) 22/ (0.37, 1.03) / (0.88, 1.00) Ischemic heart disease 211/ (0.73, 1.02) 563/ (0.84, 1.04) 176/ (0.80, 1.17) 12/ (0.34, 1.33) > / (0.85, 0.99) ( )/(I20-I25) Cerebrovascular diseases ( )/(I60- I69) 77/ (1.08, 1.96) 133/ (0.85, 1.31) 27/ (0.45, 1.13) 2/ (0.09, 2.16) / (0.93, 1.28) Page 4 of 5

5 * Data are numbers of radiologists/numbers of psychiatrists. Stratified according to year of attained age (30 34, 35 39, 40 44, 45 49, 50 54, 55 59, 60 64, 65 69, 70 74, 75 79, 80+), year of birth ( , , , , , , , , ), and year of medical school graduation (< 1940, , , 1980+). Numbers in parentheses are 95% CIs. NA = not applicable. Page 5 of 5

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