Sordina IORT Technologies S.p.A. Liac The mobile electron accelerator that revolutionizes IORT

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1 Sordina IORT Technologies S.p.A. Liac The mobile electron accelerator that revolutionizes IORT

2 Intra-Operative Radiation Therapy (IORT) is a treatment which allows radiation to be applied directly to the tumor bed in the operating room during surgery. It is now well-accepted technique, and its efficacy is proven by a large number of clinical studies. The patient is treated immediately following surgical removal of the tumor with either a single fraction of 21 Gy or a boost of 8-18 Gy. The radiation treatment is completed in less than two minutes. The total time including set up is less than 10 minutes. Single fraction patients do not require any external beam radiation therapy, while boost patients have a greatly reduced number of external beam radiation therapy sessions. Beyond IORT, Electron intra-operative Radiation Therapy IORT. Liac is the smallest, lightest and most manueverable miniaturized electron-beam linear accelerator available today. It provides homogeneous dose distributions throughout the target volume, thus providing a true tumoricidal dose to the entire area at risk. Treatments are easily administered and fast. Liac is positioned over the surgical table, thus eliminating the cumbersome procedure of moving the surgical table with the patient on board. Liac has clear clinical, operational, social and economic benefits.

3 PROVEN EFFICACY DIRECT VISUALIZATION OF THE TUMOR BED COLLABORATION BETWEEN SURGICAL AND RADIATION ONCOLOGISTS FAST TREATMENT TIMES FEWER COMPLICATIONS Liac : Leading-edge technology for better quality of life!

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5 Sordina IORT Technologies, through its Liac, has raised e-iort to new levels of effectiveness and convenience. Liac mobile electron accelerator is the first choice among clinicians throughout the world! Liac can easily be used for treatment of most cancers. The wide range of electron beam energies and the extreme versatility of Liac movement are fundamental for success in the most demanding applications. The time needed for a radiation treatment delivered by Liac is the same regardless of the complexity of the surgical procedure, and the entire radiation procedure takes an experienced team no more than 10 minutes. Its light weight and small size make Liac able to function in any operating room with no need for structural changes. Its motorized transport facilitates movement between operating rooms and its storage. High power and certified safety. A state-of-the-art design, Liac is FDA approved and 1936 certified. With a maximum electron energy of 12 MeV, Liac is able to perform any type of IORT treatment, even those at greater depths, for cancers located on any part of the anatomy. The position of the mobile beam stopper is interlocked with the operation of Liac, so its operation is disabled in the event of a misalignment.

6 Liac Mobile e-iort Linear Accelerator Smallest Footprint Available Quick & Intuitive Hard Docking Short Treatment Times ( seconds) Effective for Broad Tumor Size & Depth Easy QA & Automatic Monitor Unit Calculation Wide Range of Applicator Sizes & Bevel Angles Light Weight, Highly Mobile & Easily Maneuvered Monte Carlo Beam Simulation Facilitates Commissioning Liac Dimensions 76 cm 210 cm 180 cm

7 Liac Technical features

8 _2-BR Rev. B, March 2015 Cancers Treated: Brain Breast Colorectal Esophagus Gastric Genitourinary Gynecological Head & Neck Hepatobiliary Lung Pancreas Pediatric Renal Sarcomas (Bone, Extremity, Retroperitoneal) Registered Office: Galleria del Pozzo Rosso, 13 V.A.T. Number Vicenza (VI), Italy Tel.: Fax: Operative Headquarter and Main Factory premises: Via dell Industria, 1/A Aprilia (LT), Italy Tel.: Fax: Sordina IORT Technologies S.p.A. info@soiort.com