Gynecologic Cancers. What is Gynecologic Cancer. Who is at risk for GYN cancer? 3/1/2018 1
|
|
- Ethan Summers
- 6 years ago
- Views:
Transcription
1 What is Gynecologic Cancer Gynecologic Cancers Marge Ramsdell RN, MN, OCN Madigan Army Medical Center Any cancer that starts in a woman s reproductive organs Each GYN cancer is unique 5 main types Cervical Ovarian Uterine Vaginal Vulvar 3/1/ /1/ Who is at risk for GYN cancer? All women are at risk Risk generally increases with age Incidence estimated ,470 new cases 31,600 death (ACS, 2017) 3/1/ /1/
2 Cervical Cancer - Facts 3 rd most common GYN cancer in women in the U.S Estimated cases New 12,820 Deaths 4,210 Rates are decreasing in the U.S. Incidence remains high among Hispanic/Latino, Black, Asian women Persistent human papillomavirus (HPV) infection Most important risk factor The only GYN cancer that can be prevented with screening tests and routine follow-up 3/1/ Cervical Cancer Risk Factors Human Papilloma virus Smoking Carcinogens concentrate in cervical mucosa Immunosuppression STI s Chlamydia Genital herpes Multiple sexual partners Early onset of sexual activity Long term use of contraceptives Multiple full term pregnancies 3/1/ Human Papillomavirus (HPV) & Cervical Cancer Most significant risk factor Most common STI >100 types - most benign ~ 40 affect the genital tract Low-risk HPVs benign lesions/warts do not cause cancer HPV 6 & 11 90% of all genital warts High-risk HPVs can cause cancer HPV 16 & 18 Most infections occur without symptoms and go away HPV Vaccine 9-valent HPV vaccine HPV 6, 11, 16 & 18 Also covers HPV 31, 33, 45, 52 & 58 Cause ~ 15% of cervical cancers Recommendations Males 11 or yrs Females 11 or yrs May start at age 9 2 doses before 15 th birthday 3 doses after 15 th birthday Not recommended for women > 26 yrs (CDC.gov) 3/1/ /1/
3 Screening Recommendations Age 21 Method and interval Cytology alone every 3 years HPV co-test every 5 years Discontinue screening Age 65 Adequate negative prior screening No history of CIN2 or > Not at high risk for cervical cancer Recommendation intended for general population Cervical Cancer - Pathophysiology Anatomy of the Cervix Endocervix Columnar epithelium Exocervix Squamous epithelium Squamo-columnar junction (SCJ) Transformation Zone Meeting point between endo & exo cervix Glandular cells replaced by squamous cells Response to hormonal changes Metaplasia 3/1/ /1/ Cervical Cancer -Pathophysiology Major histological types Squamous 80% Adenocarcinoma 20% Premalignant changes Cervical intraepithelial neoplasia (CIN) Low grade CIN1 High grade CIN 2/3 Cervical Cancer Signs/Symptoms Frequently asymptomatic Most common Irregular/heavy vaginal bleeding Post-coital bleeding Advanced Pelvic/low back pain Bowel/urinary symptoms 3/1/ /1/
4 Cervical Cancer Diagnosis Physical exam Visualization of the cervix Cervical cytology HPV testing Cervical biopsy and colposcopy With or without visible lesions Symptomatic without visible lesions Abnormal cervical cytology Cervical conization Cervical Cancer Staging Clinical vs surgical staging More accessible in low-resource settings Better for locally advanced disease Avoids surgery Procedure Physical exam Cervical biopsy Endoscopy Hysteroscopy, Cystoscopy, Proctoscopy Imaging studies 3/1/ /1/ Invasive Cervical Cancer Staging Two system in use Federation of Gynecology and Obstetrics (FIGO) Most commonly used Stages - I IVA American Joint Committee on Cancer (AJCC) TNM Stages - T0 T4 In both systems the stages mean the same thing Cervical Cancer Treatment CIN 1 HPV/Cytology co-testing in 12 months CIN persisting at least 2 years Continued f/u or may treat Loop electrosurgical excision procedure (LEEP) CIN 2/3 Treatment required Excisional procedure (LEEP) or Ablation Cotesting at 12, 24 months Any abnormal test Colposcopy 3/1/ /1/
5 Invasive Cervical Cancer - Treatment Choice of treatment will depend on Patient age Tumor volume Desire to maintain fertility Modes of treatment Surgery Radiation therapy Chemotherapy Invasive Cervical Cancer - Treatment Fertility sparing IA1 no lymphovascular space invasion (LVSI) Cone biopsy Trachelectomy IA1 with LVSI & IA2 Cone biopsy Trachelectomy + pelvic LND Consider sentinel lymph node mapping IB1 Radical trachelectomy + pelvic LND 3/1/ /1/ Invasive Cervical Cancer - Treatment Early stage IA1/2 IB1 Non-Fertility Sparing IA1 no (LVSI) Cone biopsy Hysterectomy IA1 with LVSI & IA2 Modified radical hysterectomy + pelvic LND Consider sentinel lymph node mapping OR Pelvic External Beam Radiation (EBRT) + brachytherapy IB1 & IIA1 Radical hysterectomy + pelvic LND OR Pelvic EBRT + brachytherapy 3/1/ Invasive Cervical Cancer - Treatment Advanced Disease IB2 IVA IB2 & IIA2 Radical Hysterectomy + pelvic LND Majority treated with definitive chemoradiation Cisplatin-based regimen as single agent Combined with 5-FU External Beam RT Brachytherapy 3/1/
6 Cervical Cancer - Surveillance Interaval H&P 3-6 mo for 2 years 6-12 mo for 5 year Cervical/vaginal cytology annually Imaging Laboratory assessment Patient education Symptoms of recurrence Lifestyle Sexual health vaginal dilators & lubricants Long/late term effects of treatment 3/1/ /1/ Ovarian Cancer - Facts Leading cause of death from GYN cancer. 5 th most common cause of cancer mortality Lifetime risk 1 in 75 New 22,240 Deaths 14,070 < 40% are cured Incidence increases with age Median age at diagnosis 63 > 60% present with advanced disease 5 yr. survival 64.5% 3/1/ Ovarian Cancer Risk Factors Patient Characteristics Age > 63 Personal hx breast Ca Reproductive factors Nulligravity Early menarche Late menopause Infertility Polycystic ovarian syndrome Endometriosis Genetic Family Hx ovarian Ca BRCA1/2 mutations Lynch syndrome Environmental factors Obesity Talc exposure Cigarette smoking 3/1/
7 Ovarian Cancer Decreased Risk Reproductive factors Use of oral contraceptives Pregnancy/nuliparity Breastfeeding Gynecologic surgery Salpingo-oophorectomy Tubal ligation Ovarian Cancer Screening Literature does not support routine screening UK Collaborative Trial of Ovarian Cancer Screening Prostate, Lung, Colorectal & Ovarian trial No significant reduction in mortality Women with high risk factors will be followed more closely Pelvic exam CA125 TransvaginalUltrasound 3/1/ /1/ Ovarian Cancer Types Epithelial 90% Serous Endometrioid Mucinous Clear cell Germ Cell 3% Stromal 7% Ovarian Cancer Symptoms Gastrointestinal Bloating Urinary symptoms Difficulty eating/early satiety/ dyspepsia Nausea Constipation/Diarrhea Fatigue Back Pain Gynecologic Abdominal distention/increased abdominal girth Pelvic pain Menstrual irregularities Vaginal bleeding Watery discharge 3/1/ /1/
8 Ovarian Cancer Symptoms 95% symptoms prior to diagnosis 89% symptoms with early stage disease Symptoms that persist daily > a few weeks Ovarian Cancer Diagnosis Hx of present illness Symptoms Family history HBOC Lynch syndrome GYN history Labwork Full panels plus CA-125 (consider HE4) B-HCG AFP Imaging Transvaginal ultrasound CT abd/pelvis MRI Chest x-ray Barium enema 3/1/ /1/ Ovarian Cancer Treatment Risk-reducing surgery Primary treatment Surgical staging and debulking Laparotomy hysterectomy with BSO, omentectomy and lymphadenectomy Comprehensive staging Fluid sampling Pathologic assessment of the abdomen Goal optimal debulking Residual tumor < 1cm Improved response rates Longer disease free survival & overall survival 3/1/ Ovarian Cancer Treatment Chemotherapy Neoadjuvant benefit remains controversial Adjuvant therapy IV with or without intraperitoneal IV/IP regiment recommended for Stage III optimally debulked patients IV drugs - Paclitaxel, Doecetaxel, Carboplatin IP drugs Paclitexel, Cisplatin Number of cycles will vary with stage of disease 6 cycles total 3/1/
9 Ovarian Cancer Treatment Anti-Angiogenesis inhibitors Bevacizumab Question as to benefit in progression free survival Preferred option in pts with recurrent disease and ascities Ovarian Cancer Recurrence 50%-75% relapse with advanced disease Poor prognosis Pts who progress after 2 consecutive chemo regimens Those whose disease recurs in less than 6 mo. Considered platinum resistant Patient who relapse 6 mo or more Platinum sensitive Will often be treated with multiple courses 3/1/ /1/ Ovarian Cancer Recurrence PARP Inhibitors BRCA gene mutation Typically used after 2 or more lines of therapy Oral agents Olaparib Rucaparib preferred for plantinum resistant pt Niraparib without germline BRCA mutation Ovarian Cancer Surveillance Follow up with physical exam Every 2-4 mo. for 2 yr Every 3-6 mo. for 3 yr Annually after 5 yr Other tests Imaging, lab work to include CA-125 Genetic risk evaluation Long term wellness care Physical symptoms/ treatment side effects Psychological issues Threat of recurrence 3/1/ /1/
What is Gynecologic Cancer? Gynecologic Cancers. Who is at risk for GYN Cancer? Case Study 3/21/2017
What is Gynecologic Cancer? Gynecologic Cancers Marge Ramsdell MN, RN, OCN Madigan Army Medical Center Any cancer that starts in a woman s reproductive organs Each GYN cancer is unique 5 main types Cervical
More informationIndex. B Bilateral salpingo-oophorectomy (BSO), 69
A Advanced stage endometrial cancer diagnosis, 92 lymph node metastasis, 92 multivariate analysis, 92 myometrial invasion, 92 prognostic factors FIGO stage, 94 histological grade, 94, 95 histologic cell
More informationGynecologic Malignancies. Kristen D Starbuck 4/20/18
Gynecologic Malignancies Kristen D Starbuck 4/20/18 Outline Female Cancer Statistics Uterine Cancer Adnexal Cancer Cervical Cancer Vulvar Cancer Uterine Cancer Endometrial Cancer Uterine Sarcoma Endometrial
More informationWhat is Gynecologic Cancer? Gynecologic Cancers. Who is at risk for GYN Cancer? Case Study 2/25/2016
What is Gynecologic Cancer? Gynecologic Cancers Marge Ramsdell MN, RN, OCN Madigan Army Medical Center Any cancer that starts in a woman s reproductive organs Each GYN cancer is unique 5 main types Cervical
More informationPRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES GYNECOLOGIC CANCER CERVIX
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES GYNECOLOGIC CANCER CERVIX Site Group: Gynecology Cervix Author: Dr. Stephane Laframboise 1. INTRODUCTION 3 2. PREVENTION 3 3. SCREENING AND
More informationPrevention, Diagnosis and Treatment of Gynecologic Cancers
Prevention, Diagnosis and Treatment of Gynecologic Cancers Jubilee Brown MD and Pamela T. Soliman MD, MPH Department of Gynecologic Oncology and Reproductive Medicine University of Texas MD Anderson Cancer
More informationCervical Cancer 3/25/2019. Abnormal vaginal bleeding
Cervical Cancer Abnormal vaginal bleeding Postcoital, intermenstrual or postmenopausal Vaginal discharge Pelvic pain or pressure Asymptomatic In most patients who are not sexually active due to symptoms
More informationAppropriate Use of Cytology and HPV Testing in the New Cervical Cancer Screening Guidelines
Appropriate Use of Cytology and HPV Testing in the New Cervical Cancer Screening Guidelines Tim Kremer, MD Ralph Anderson, MD 1 Objectives Describe the natural history of HPV particularly as it relates
More informationMPH Quiz. 1. How many primaries are present based on this pathology report? 2. What rule is this based on?
MPH Quiz Case 1 Surgical Pathology from hysterectomy performed July 11, 2007 Final Diagnosis: Uterus, resection: Endometrioid adenocarcinoma, Grade 1 involving most of endometrium, myometrial invasion
More informationNorth of Scotland Cancer Network Clinical Management Guideline for Carcinoma of the Uterine Cervix
THIS DOCUMENT North of Scotland Cancer Network Carcinoma of the Uterine Cervix UNCONTROLLED WHEN PRINTED DOCUMENT CONTROL Prepared by A Kennedy/AG Macdonald/Others Approved by NOT APPROVED Issue date April
More informationHitting the High Points Gynecologic Oncology Review
Hitting the High Points is designed to cover exam-based material, from preinvasive neoplasms of the female genital tract to the presentation, diagnosis and treatment, including surgery, chemotherapy, and
More information6 Week Course Agenda. Today s Agenda. Ovarian Cancer: Risk Factors. Winning the War 11/30/2016 on Women s Cancer Gynecologic Cancer Prevention
6 Week Course Agenda Winning the War 11/30/2016 on Women s Cancer Gynecologic Cancer Prevention Lee-may Chen, MD Director, Division of Gynecologic Oncology Professor Department of Obstetrics, Gynecology
More informationGynecological Cancers in Primary Care
Gynecological Cancers in Primary Care Nora M. Lersch MSN CRNP AOCNP Division of Gynecological Oncology Objectives Identify the incidence of ovarian, cervical, vulvar and endometrial cancer Identify common
More informationGYNECOLOGIC MALIGNANCIES: Ovarian Cancer
GYNECOLOGIC MALIGNANCIES: Ovarian Cancer KRISTEN STARBUCK, MD ROSWELL PARK CANCER INSTITUTE DEPARTMENT OF SURGERY DIVISION OF GYNECOLOGIC ONCOLOGY APRIL 19 TH, 2018 Objectives Basic Cancer Statistics Discuss
More informationGynecologic Cancers are many diseases. Speaker Disclosure: Gynecologic Cancer Care in the Age of Precision Medicine. Controversies in Women s Health
Gynecologic Cancer Care in the Age of Precision Medicine Gynecologic Cancers in the Age of Precision Medicine Controversies in Women s Health Lee-may Chen, MD Department of Obstetrics, Gynecology & Reproductive
More informationNAACCR Webinar Series /7/17
COLLECTING CANCER DATA: UTERUS 2017 2018 NAACCR WEBINAR SERIES Q&A Please submit all questions concerning webinar content through the Q&A panel. Reminder: If you have participants watching this webinar
More informationGynecologic Cancer InterGroup Cervix Cancer Research Network. Management of Cervical Cancer in Resource Limited Settings.
Management of Cervical Cancer in Resource Limited Settings Linus Chuang MD Conflict of Interests None Cervical cancer is the fourth most common malignancy in women worldwide 530,000 new cases per year
More informationGynecologic Cancers are many diseases. Gynecologic Cancers in the Age of Precision Medicine Advances in Internal Medicine. Speaker Disclosure:
Gynecologic Cancer Care in the Age of Precision Medicine Gynecologic Cancers in the Age of Precision Medicine Advances in Internal Medicine Lee-may Chen, MD Department of Obstetrics, Gynecology & Reproductive
More informationCervical cancer presentation
Carcinoma of the cervix: Carcinoma of the cervix is the second commonest cancer among women worldwide, with only breast cancer occurring more commonly. Worldwide, cervical cancer accounts for about 500,000
More informationWhat is cervical cancer?
What is cervical cancer? The cervix is the bottom part, or neck, of the uterus. Cervical cancer happens when normal cells in the cervix change into abnormal cells, and grow out of control. Most women whose
More informationEstimated New Cancers Cases 2003
Harvard-MIT Division of Health Sciences and Technology HST.071: Human Reproductive Biology Course Director: Professor Henry Klapholz Estimated New Cancers Cases 2003 Images removed due to copyright reasons.
More informationGynecological Cancers
Gynecological Cancers Outline Ovarian Cancer Uterine (Endometrial) Cancer Cervical Cancer Vulvar Cancer Vaginal Cancer Overian Cancer Ovarian cancer is cancer that forms in the tissue of the ovary and
More informationVaginal intraepithelial neoplasia
Vaginal intraepithelial neoplasia The terminology and pathology of VAIN are analogous to those of CIN (VAIN I-III). The main difference is that vaginal epithelium does not normally have crypts, so the
More informationEndometrial Cancer. Incidence. Types 3/25/2019
Endometrial Cancer J. Anthony Rakowski DO, FACOOG MSU SCS Board Review Coarse Incidence 53,630 new cases yearly 8,590 deaths yearly 4 th most common malignancy in women worldwide Most common GYN malignancy
More informationWhat Causes Cervical Cancer? Symptoms of Cervical Cancer
Cervical Health Awareness Month is a chance to raise awareness about how women can protect themselves from HPV (human papillomavirus) and cervical cancer. HPV is a very common infection that spreads through
More informationIf you do not have time for the entire presentation refer to the following table of contents. To navigate through the slides, right click on your
Welcome This is an online version of a lecture given by Dr Keith Merritt on gyn cancers. Its purpose is to help women become more aware of early symptoms, risk factors, screening strategies and the importance
More information17 th ESO-ESMO Masterclass in clinical Oncology
17 th ESO-ESMO Masterclass in clinical Oncology Cervical and endometrial Cancer Cristiana Sessa IOSI Bellinzona, Switzerland Berlin, March 28 th, 2018 Presenter Disclosures None Cervical Cancer Estimated
More informationJanjira Petsuksiri, M.D
GYN malignancies Janjira Petsuksiri, M.D Outlines Cervical cancer Endometrial cancer Ovarian cancer Vaginal cancer Vulva cancer 2 CA Cervix Epidemiology - Second most common female cancer Risk factors
More informationI have no financial interests in any product I will discuss today.
Cervical Cancer Screening Update and Implications for Annual Exams George F. Sawaya, MD Professor Department of Obstetrics, Gynecology and Reproductive Sciences Department of Epidemiology and Biostatistics
More informationUPDATE IN THE MANAGEMENT OF INVASIVE CERVICAL CANCER
UPDATE IN THE MANAGEMENT OF INVASIVE CERVICAL CANCER Susan Davidson, MD Professor Department of Obstetrics and Gynecology Division of Gynecologic Oncology University of Colorado- Denver Anatomy Review
More informationRitu Salani, M.D., M.B.A. Assistant Professor, Dept. of Obstetrics & Gynecology Division of Gynecologic Oncology The Ohio State University
Cervical Cancer Ritu Salani, M.D., M.B.A. Assistant Professor, Dept. of Obstetrics & Gynecology Division of Gynecologic Oncology The Ohio State University Estimated gynecologic cancer cases United States
More informationProtect & Detect: What Women should Know about cancer. The American College of Obstetricians and Gynecologists
Protect & Detect: What Women should Know about cancer The American College of Obstetricians and Gynecologists A Message From ACOG President Kenneth L. Noller, MD Dr. Noller is the Louis E. Phaneuf professor
More informationStaging and Treatment Update for Gynecologic Malignancies
Staging and Treatment Update for Gynecologic Malignancies Bunja Rungruang, MD Medical College of Georgia No disclosures 4 th most common new cases of cancer in women 5 th and 6 th leading cancer deaths
More informationSarah Burton. Lead Gynae Oncology Nurse Specialist Cancer Care Cymru
Sarah Burton Lead Gynae Oncology Nurse Specialist Cancer Care Cymru Gynaecological Cancers Cervical Cancers Risk factors Presentation Early sexual activity Multiple sexual partners Smoking Human Papiloma
More informationFertility-sparing surgery in young patients with cervical cancer
Fertility-sparing surgery in young patients with cervical cancer Pr Catherine Uzan Chef de service Chirurgie et cancérologie gynécologique et mammaire, Pitié Evaluation BEFORE surgery Cancer: stage, type
More informationCERVICAL CANCER FACTSHEET. What is cervical cancer?
CERVICAL CANCER FACTSHEET What is cervical cancer? ENGAGe is releasing a series of factsheets to raise awareness of gynaecological cancers and to support its network to work at a grassroots level. Take-up
More informationHPV and Cervical Cancer, Screening and Prevention. John Ragsdale, MD July 12, 2018 CME Lecture Series
HPV and Cervical Cancer, Screening and Prevention John Ragsdale, MD July 12, 2018 CME Lecture Series We have come a long Way Prevalence HPV in Young Adults in U.S HPV genotypes 55-60% of All cancers 20%
More informationInvasive Cervical Cancer: Squamous Cell, Adenocarcinoma, Adenosquamous
Note: If available, clinical trials should be considered as preferred treatment options for eligible patients (www.mdanderson.org/gynonctrials). Other co-morbidities are taken into consideration prior
More informationEndometrial cancer. Szabolcs Máté MD. I. St. Department of Obstetrics and Gyneacology.
Endometrial cancer Szabolcs Máté MD. I. St. Department of Obstetrics and Gyneacology dr.mate.szabolcs@gmail.com Epidemiology Developing countries Cervical cancer is the most common gyn. malignant tumor
More informationPassport to Health Preventing and Recognizing Gynecologic Cancers
Passport to Health Preventing and Recognizing Gynecologic Cancers Presented by: Obstetrician/Gynecologist Leigh Bauer, M.D. They can sneak up on you. 2 Gynecologic cancers, that is. Knowing the facts can
More informationMost common cancer Africans & Asians more prone because of poor socioeconomic condition Drastic decline in west as more detection of preinvasive
CANCER CERVIX Most common cancer Africans & Asians more prone because of poor socioeconomic condition Drastic decline in west as more detection of preinvasive leison by PAP Smears. Etiology: Age - 2 peaks
More informationMenopause and Cancer risk; What to do overcome the risks? Fatih DURMUŞOĞLU,M.D
Menopause and Cancer risk; What to do overcome the risks? Fatih DURMUŞOĞLU,M.D Menopause and Cancer How does menopause affect a woman s cancer risk? Ø Menopause does not cause cancer.but risk of developing
More informationJacqui Morgan March 6, 2019
Jacqui Morgan March 6, 2019 Case 1 25yo, G2P1 Here for WWE, no problems, healthy, needs refill on OCPs. Pap- Abnormal Glandular Cells-NOS Now What?? Case 1 Colposcopy What findings? Case 1 ECC Cervical
More informationHIV and AIDS Related Cancers DR GORDON AMBAYO UHS
HIV and AIDS Related Cancers DR GORDON AMBAYO UHS INTRODUCTION People with HIV/AIDS are at high risk for developing certain cancers, such as: Kaposi's sarcoma, non-hodgkin lymphoma, and cervical cancer.
More informationUterus Malignancies /5/15
Collecting Cancer Data: Uterus 2014-2015 NAACCR Webinar Series February 5, 2015 Q&A Please submit all questions concerning webinar content through the Q&A panel. Reminder: If you have participants watching
More informationPORTEC-4. Patient seqnr. Age at inclusion (years) Hospital:
May 2016 Randomisation Checklist Form 1, page 1 of 2 Patient seqnr. Age at inclusion (years) Hospital: Eligible patients should be registered and randomised via the Internet at : https://prod.tenalea.net/fs4/dm/delogin.aspx?refererpath=dehome.aspx
More informationGynecologic Cancers. Marcella Williams, MS, RN, AOCN
This material is protected by U.S. copyright law. Unauthorized reproduction is prohibited. To purchase quantity reprints, please e-mail reprints@ons.org or to request permission to reproduce multiple copies,
More informationOne of the commonest gynecological cancers,especially in white Americans.
Gynaecology Dr. Rozhan Lecture 6 CARCINOMA OF THE ENDOMETRIUM One of the commonest gynecological cancers,especially in white Americans. It is a disease of postmenopausal women with a peak incidence in
More information!"#$%&'(#)*$+&,$-&.#,$/#0()1-$ ),1')$2(%&,2#,%$%(0'#$34567$
!"#$%&'(#)*$+&,$-&.#,$/#0()1-$ ),1')$2(%&,2#,%$%(0'#$34567$ Updated Consensus Guidelines for Managing Abnormal Cervical Cancer Screening Tests and Cancer Precursors American Society for and Cervical Pathology
More informationCervical Cancer Early Detection, Diagnosis, and Staging
Cervical Cancer Early Detection, Diagnosis, and Staging Detection and Diagnosis Catching cancer early often allows for more treatment options. Some early cancers may have signs and symptoms that can be
More informationChapter 2: Initial treatment for endometrial cancer (including histologic variant type)
Chapter 2: Initial treatment for endometrial cancer (including histologic variant type) CQ01 Which surgical techniques for hysterectomy are recommended for patients considered to be stage I preoperatively?
More informationI have no financial interests in any product I will discuss today.
Cervical Cancer Prevention: 2012 and Beyond George F. Sawaya, MD Professor Department of Obstetrics, Gynecology and Reproductive Sciences Department of Epidemiology and Biostatistics University of California,
More informationCervical Cancer Guidelines L and SC Network July Introduction:
Cervical Cancer Guidelines L and SC Network July 2018 Introduction: There was a total number of 442 cases of cervix cancer diagnosed in Lancashire and South Cumbria Cancer Network in the period 2005 2009
More informationPRE TEST CERVICAL SCREENING MANAGEMENT COLPOSCOPY PATHOLOGIC DIAGNOSIS AND TREATMENT
PRE TEST CERVICAL SCREENING MANAGEMENT COLPOSCOPY PATHOLOGIC DIAGNOSIS AND TREATMENT QUESTION #1 WHICH OF THE FOLLOWING IS NOT A RISK FACTOR FOR CERVICAL CANCER? A. HIGH RISK HPV B. CIGARETTE SMOKING C.
More informationWhat is endometrial cancer?
Uterine cancer What is endometrial cancer? Endometrial cancer is the growth of abnormal cells in the lining of the uterus. The lining is called the endometrium. Endometrial cancer usually occurs in women
More informationVerbal Disclosure. Endometrial Cancer: Epidemiology
Gynecologic Malignancies: What is the latest? MISTY WHITE WHNP GYNECOLOGIC ONCOLOGY UT MD ANDERSON CANCER CENTER Verbal Disclosure q I have nothing to disclose. Outline q Endometrial Cancer Incidence Presentation
More informationOvarian Cancer Includes Epithelial, Fallopian Tube, Primary Peritoneal Cancer, and Ovarian Germ Cell Tumors
Ovarian Cancer Includes Epithelial, Fallopian Tube, Primary Peritoneal Cancer, and Ovarian Germ Cell Tumors Overview Ovarian epithelial cancer, fallopian tube cancer, and primary peritoneal cancer are
More informationAdjuvant Therapies in Endometrial Cancer. Emma Hudson
Adjuvant Therapies in Endometrial Cancer Emma Hudson Endometrial Cancer Most common gynaecological cancer Incidence increasing in Western world 1-2% cancer deaths 75% patients postmenopausal 97% epithelial
More informationand treating joins with the top of canal). at risk for cervical carcinomas, cervix.
CERVICAL CANCER Worldwide, cervical cancer is twelfth most common and the fifth most deadly cancer in women. It affects about 16 per 100,000 women per year and kills about 9 per 100,000 per year. Cervical
More informationThe society for lower genital tract disorders since 1964.
The society for lower genital tract disorders since 1964. Updated Consensus Guidelines for Managing Abnormal Cervical Cancer Screening Tests and Cancer Precursors American Society for and Cervical Pathology
More informationHuman Papillomavirus (HPV) and Cervical Cancer Prevention
Human Papillomavirus (HPV) and Cervical Cancer Prevention MOA Autumn Convention November 3, 2017 David J Boes, DO, FACOOG (Dist.) Associate Professor, MSU-COM 1 Disclosures None relative to this presentation
More informationDisclosures. Abnormal vaginal bleeding 90% Post menopausal bleeding Pre- or perimenopausal with abnormal bleeding
Disclosures The most common gynecologic cancer in US. 2.8 % of all women diagnoses 2017 new cases: 61,380 3.6% of all new cancer cases Estimated deaths: 10,920 81.3% survive 5 years Types: Endometrial
More informationEndometrial Cancer. Saudi Gynecology Oncology Group (SGOG) Gynecological Cancer Treatment Guidelines
Saudi Gynecology Oncology Group (SGOG) Gynecological Cancer Treatment Guidelines Endometrial Cancer Emad R. Sagr, MBBS, FRCSC Consultant Gynecology Oncology Security forces Hospital, Riyadh Epidemiology
More informationOvarian Cancer. Georgia McCann, MD. Division of Gynecologic Oncology
Ovarian Cancer Georgia McCann, MD Division of Gynecologic Oncology Myth: Ovarian cancer is a silent killer Non-specific Abdominal pain, discomfort Bloating, back pain Urinary urgency Constipation Tiredness
More informationCoversheet for Network Site Specific Group Agreed Documentation
Coversheet for Network Site Specific Group Agreed Documentation This sheet is to accompany all documentation agreed by Pan Birmingham Cancer Network Site Specific Groups. This will assist the Network Governance
More informationAlgorithms for management of Cervical cancer
Algithms f management of Cervical cancer Algithms f management of cervical cancer are based on existing protocols and guidelines within the ESGO comunity and prepared by ESGO Educational Committe as a
More informationMajor tips: The importance of early detection: Hx, risk factors
Cancer Chapter 3 Introduction Cancer ranks 2nd to cardiovascular disease as the leading cause of death in the Gaza Strip. Death rate increased from 10.3% in 2007 to 13.6 in 2012. Some related factors :
More informationCPC on Cervical Pathology
CPC on Cervical Pathology Dr. W.K. Ng Senior Medical Officer Department of Clinical Pathology Pamela Youde Nethersole Eastern Hospital Cervical Smear: High Grade SIL (CIN III) Cervical Smear: High Grade
More informationGynecologic Oncologist. Surgery Chemotherapy Radiation Therapy Hormonal Therapy Immunotherapy. Cervical cancer
Gynecologic Oncology Pre invasive vulvar, vaginal, & cervical disease Vulvar Cervical Endometrial Uterine Sarcoma Fallopian Tube Ovarian GTD Gynecologic Oncologist Surgery Chemotherapy Radiation Therapy
More informationCervical cancer is a disease in which malignant (cancer) cells form in the tissues of the cervix.
Cervical Cancer Cervical cancer is a disease in which malignant (cancer) cells form in the tissues of the cervix. The cervix is the lower, narrow end of the uterus (the hollow, pear-shaped organ where
More informationObjectives. I have no financial interests in any product I will discuss today. Cervical Cancer Screening Guidelines: Updates and Controversies
Cervical Cancer Screening Guidelines: Updates and Controversies I have no financial interests in any product I will discuss today. Jody Steinauer, MD, MAS University of California, San Francisco Objectives
More informationNorth of Scotland Cancer Network Clinical Management Guideline for Endometrial Cancer
THIS DOCUMENT North of Scotland Cancer Network Clinical Management Guideline for Endometrial Cancer Based on WOSCAN CMG with further extensive consultation within NOSCAN UNCONTROLLED WHEN PRINTED DOCUMENT
More informationDysplasia: layer of the cervical CIN. Intraepithelial Neoplasia. p16 immunostaining. 1, Cervical. Higher-risk, requires CIN.
CLINICAL PRACTICE GUIDELINE Guideline Number: DHMP_DHMC_PG1015 Guideline Subject: Routine Cervical Cancer Screening Effective Date: 9/2018 Revision Date: 9/2019 Pages: 2 of 2 Quality Management Committee
More informationCervical Dysplasia and HPV
Cervical Dysplasia and HPV J. Anthony Rakowski D.O., F.A.C.O.O.G. MSU SCS Board Review Coarse HPV Double stranded DNA virus The HPV infect epithelial cells of the skin and mucous membranes Highest risk
More informationTHE MODERN GYNECOLOGIC EXAMINATION & SCREENING FOR GYNECOLOGIC MALIGNANCIES
THE MODERN GYNECOLOGIC EXAMINATION & SCREENING FOR GYNECOLOGIC MALIGNANCIES Denise Uyar, MD Associate Professor OB/GYN Chief Gynecologic Oncology Medical College of Wisconsin April 12, 2019 NO DISCLOSURES
More informationPRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES GYNECOLOGIC CANCER VULVAR
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES GYNECOLOGIC CANCER VULVAR Last Revision Date July 2015 1 Site Group: Gynecologic Cancer Vulvar Author: Dr. Stephane Laframboise 1. INTRODUCTION
More informationChapter 8 Adenocarcinoma
Page 80 Chapter 8 Adenocarcinoma Overview In Japan, the proportion of squamous cell carcinoma among all cervical cancers has been declining every year. In a recent survey, non-squamous cell carcinoma accounted
More informationOppgave: MED5600_OPPGAVE04_V18_ORD
Side 23 av 63 Oppgave: MED5600_OPPGAVE04_V18_ORD Del 1: Sofie, 38 years, para1, comes to your office complaining about dyspareunia and spotting she has recently observed on several occasions, unrelated
More informationPractice of Medicine-1 Ovarian Cancer Clinical Correlation
Practice of Medicine-1 Ovarian Cancer Clinical Correlation Amir A. Jazaeri, M.D. Assistant Professor, Division of Gynecologic Oncology American Cancer Society Female Cancers 2000 Statistics Reprinted by
More informationTOC NCCN Categories of Evidence and Consensus Category 1: Based upon high-level evidence, there is uniform NCCN consensus that the intervention is appropriate. Category 2A: Based upon lower-level evidence,
More informationGynecology Oncology Rotation
McGill University Obstetrics and Gynecology Residency Program Goals and Objectives Gynecology Oncology Rotation Overview Goal The primary goal of the resident s Gynecology Oncology rotation of 4 weeks
More informationI have no financial interests in any product I will discuss today.
Cervical Cancer Screening Update and Implications for Annual Exams George F. Sawaya, MD Professor Department of Obstetrics, Gynecology and Reproductive Sciences Department of Epidemiology and Biostatistics
More informationFrom Research to Practice: What s New in Gynecologic Cancers?
From Research to Practice: What s New in Gynecologic Cancers? David Warshal, M.D. Head, Division of Gynecologic Oncology MD Anderson Cooper Cancer Institute Associate Professor of Obstetrics and Gynecology
More informationENDOMETRIAL CANCER Updated Apr 2017 by: Dr. Jenny Ko (Medical Oncologist, Abbotsford Cancer Centre)
ENDOMETRIAL CANCER Updated Apr 2017 by: Dr. Jenny Ko (Medical Oncologist, Abbotsford Cancer Centre) Source: UpToDate 2017, ASCO/CCO/Alberta provincial guidelines, NCCN Reviewed by: Dr. Sarah Glaze (Gynecologic
More informationARROCase: Locally Advanced Endometrial Cancer
ARROCase: Locally Advanced Endometrial Cancer Charles Vu, MD (PGY-3) Faculty Advisor: Peter Y. Chen, MD, FACR Beaumont Health (Royal Oak, MI) November 2016 Case 62yo female with a 3yr history of vaginal
More informationX-Plain Ovarian Cancer Reference Summary
X-Plain Ovarian Cancer Reference Summary Introduction Ovarian cancer is fairly rare. Ovarian cancer usually occurs in women who are over 50 years old and it may sometimes be hereditary. This reference
More informationEradicating Mortality from Cervical Cancer
Eradicating Mortality from Cervical Cancer Michelle Berlin, MD, MPH Vice Chair, Obstetrics & Gynecology Associate Director, Center for Women s Health June 2, 2009 Overview Prevention Human Papilloma Virus
More informationWhat is Cervical Cancer?
What is Cervical Cancer? Cervical cancer starts in a woman's cervix, the lower narrow part of the uterus. The uterus holds the growing fetus during pregnancy. The cervix connects the lower part of the
More informationECC or Margins Positive?
CLINICAL PRESENTATION This practice algorithm has been specifically developed for M. D. Anderson using a multidisciplinary approach and taking into consideration circumstances particular to M. D. Anderson,
More informationGCIG Rare Tumour Brainstorming Day
GCIG Rare Tumour Brainstorming Day Relatively (Not So) Rare Tumours Adenocarcinoma of Cervix Keiichi Fujiwara, Ros Glasspool Benedicte Votan, Jim Paul Aim of the Day To develop at least one clinical trial
More informationCervical Cancer Screening Update. Melissa Hartman, DO Women s Health
Cervical Cancer Screening Update Melissa Hartman, DO Women s Health Previous Cervical Cancer Screening Organization Recommendation ACS (2011) ACP (2008) NCI (2003) Age 21 or 3 years after first intercourse
More informationNewton Wellesley Hospital 2013
Newton Wellesley Hospital 20 Standard 4.6 Assessment and Evaluation of Treatment Planning Endometrial Cancer Each year a physician member of the cancer committee conducts a study to ensure that diagnostic
More informationCervical Cancer - Suspected
Cervical Cancer - Suspected Presentation for patients Asymptomatic presentation Symptomatic presentation History and examination Consider differential diagnoses RED FLAG! Cervix appears normal after examination
More informationSee the latest estimates for new cases of ovarian cancer and deaths in the US and what research is currently being done.
About Ovarian Cancer Overview and Types If you have been diagnosed with ovarian cancer or are worried about it, you likely have a lot of questions. Learning some basics is a good place to start. What Is
More informationStage IB1 (2-4 cm) Cervical cancer treated with Neoadjuvant chemotherapy followed by fertility Sparing Surgery (CONTESSA) Dre Marie Plante
Stage IB1 (2-4 cm) Cervical cancer treated with Neoadjuvant chemotherapy followed by fertility Sparing Surgery (CONTESSA) Dre Marie Plante Neo-Adjuvant Chemotherapy and Conservative Surgery in Cervical
More informationWhat You Need to Know About Ovarian Cancer
What You Need to Know About Ovarian Cancer About Us The Rhode Island Ovarian Cancer Alliance (RIOCA) was formed in honor and memory of Jessica Morris. Jessica was diagnosed with Stage IIIC Ovarian Cancer
More informationCERVICAL INTRAEPITHELIAL NEOPLASIA (CIN)
CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN) The cervix constitutes the lower third of the uterus. It is in two parts, the endocervix and the ectocervix. Ectocervix is covered with squamous epithelium. Endocervix
More informationPreventing Cervical Cancer 2018 WHAT THIS WILL MEAN FOR PRIMARY CARE
Preventing Cervical Cancer 2018 WHAT THIS WILL MEAN FOR PRIMARY CARE DR GARY FENTIMAN, CLINICAL LEADER COLPOSCOPY, N C S P TAKE-HOME LESSONS Vaccination is Primary Prevention for Cervical Cancer Women
More informationCARCINOMA CERVIX. Dr. PREETHI REDDY. B. M S OBG II yr POST GRADUATE.
CARCINOMA CERVIX Dr. PREETHI REDDY. B M S OBG II yr POST GRADUATE. Introduction Cervical cancer is the second most common female malignancy worldwide. It is responsible for 4,66,000 deaths annually worldwide
More informationNew Cancer Cases By Site Breast 28% Lung 14% Colo-Rectal 10% Uterus 6% Thyroid 5% Lymphoma 4% Ovary 3%
Uterine Malignancy New Cancer Cases By Site 2010 Breast 28% Lung 14% Colo-Rectal 10% Uterus 6% Thyroid 5% Lymphoma 4% Ovary 3% Cancer Deaths By Site 2010 Lung 26% Breast 15% Colo-Rectal 9% Pancreas 7%
More information