Critical Issues in Head and Neck Oncology

Transcription

1 Critical Issues in Head and Neck Oncology

2 Jan B. Vermorken Volker Budach C. René Leemans Jean-Pascal Machiels Piero Nicolai Brian O'Sullivan Editors Critical Issues in Head and Neck Oncology Key Concepts from the Fifth THNO Meeting

3 Editors Jan B. Vermorken Department of Medical Oncology Antwerp University Hospital Edegem, Belgium Volker Budach Departments for Radiation Oncology Charité University Medicine Berlin, Germany C. René Leemans Department of Otolaryngology VU University Medical Center Amsterdam, The Netherlands Jean-Pascal Machiels Department of Medical Oncology Université catholique de Louvain Brussels, Belgium Piero Nicolai Department of Otorhinolarynology University of Brescia Brescia, Italy Brian O'Sullivan Princess Margaret Hospital Toronto, Canada ISBN DOI / ISBN (ebook) Library of Congress Control Number: Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is Gewerbestrasse 11, 6330 Cham, Switzerland

4 Preface Trends in Head and Neck Oncology (THNO) is an educational program that started in 2007, initially under a different name, but recognized as such since Its concept is to promote multidisciplinarity and updated knowledge and, consequently, its leadership has a multidisciplinary signature. The realization of this educational program has been made possible by the support of Pharma and the practical logistical support of CongressCare. The organizers are grateful to our colleagues of Merck KGaA, who were the single sponsor at the commencement of the program in THNO-5 is the first THNO meeting with strong support and input of local colleagues into the case presentations in order to underscore the goals of this meeting. It is also the first time that the Proceedings have made available to the wider medical community. Edegem, Belgium Berlin, Germany Amsterdam, The Netherlands Brussels, Belgium Brescia, Italy Toronto, Canada Jan B. Vermorken Volker Budach C. René Leemans Jean-Pascal Machiels Piero Nicolai Brian O Sullivan v

5 Contents Part I The Make Sense Campaign 1 The Make Sense Campaign : An Initiative of the European Head and Neck Society C. René Leemans and Jan B. Vermorken Part II Head and Neck Cancer: A Changing Disease 2 New Epidemiologic Aspects in Head and Neck Cancers Gemma Gatta and Laura Botta 3 The Biology of Head and Neck Cancer Kevin J. Harrington Part III Diagnostic Challenges 4 The Changing Role of the Pathologist Philip Sloan 5 Molecular Imaging in Head and Neck Squamous Cell Carcinoma Patients Sjoukje F. Oosting, Elisabeth G.E. de Vries, and Max J.H. Witjes Part IV Multidisciplinary Decision Making and Head and Neck Tumor Boards 6 Multidisciplinary Decision Making and Head and Neck Tumor Boards Jan B. Vermorken vii

6 viii Contents Part V Locoregionally Advanced Head and Neck Cancer 7 Pros and Cons of Endoscopic Surgery Francesca Del Bon, Alberto Paderno, Alberto Schreiber, Nausica Montalto, Cesare Piazza, and Piero Nicolai 8 Oncologic Dentistry and Implants Ross O.C. Elledge, Rokhsareh Elledge, Sat Parmar, and Stefan Edmondson 9 Comprehensive Overview: Definitive Radiotherapy and Concurrent Chemoradiation in Locally Advanced Head and Neck Cancer Volker Budach 10 Treatment of Viral-Associated HNC (OPC and NPC) Shao Hui Huang, Melvin L.K. Chua, Francesca Caparrotti, and Brian O Sullivan 11 Patient and Treatment Factors in Concurrent Chemoradiotherapy Jan B. Vermorken Part VI Recurrent/Metastatic Head and Neck Cancer: How and When to Treat 12 Salvage Surgery of Head and Neck Cancer C. René Leemans 13 Recurrent/Metastatic Head and Neck Cancer: When and How to Irradiate Shao Hui Huang, Nadeem Riaz, Nancy Lee, and Brian O Sullivan 14 Systemic Treatments: Chemotherapy and Targeted Therapies Jean-Pascal Machiels and Sandra Schmitz 15 Immunotherapeutic Approaches Petr Szturz and Jan B. Vermorken 16 Treatment in the Elderly Petr Szturz and Jan B. Vermorken 17 Palliative Care in Patients with Head and Neck Cancer Dirk Schrijvers

7 Contents ix Part VII Quality of Life and End of Life Issues 18 Quality of Life Issues Susanne Singer 19 Symptoms at End-of-Life of Head and Neck Cancer Patients Dirk Schrijvers 20 Issues at End of Life Rodger Charlton

8 Contributors Laura Botta Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy Volker Budach, MD, PhD Professor and Chairman, Departments for Radiation Oncology, Charité University Medicine, Berlin, Germany Francesca Caparrotti University of Toronto, Toronto, ON, Canada Rodger Charlton, MD, FRCGP University of Leicester, Nottingham, UK Melvin L. K. Chua University of Toronto, Toronto, ON, Canada Elisabeth G. E. de Vries Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Francesca Del Bon Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Brescia, Italy Stefan Edmondson Department of Oral and Maxillofacial Surgery, Queen Elizabeth Hospital, Birmingham, West Midlands, UK Rokhsareh Elledge St. Peter s Dental Practice, Worcester, Worcestershire, UK Ross O. C. Elledge Department of Oral and Maxillofacial Surgery, Queen Elizabeth Hospital, Birmingham, West Midlands, UK Gemma Gatta Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy Kevin J. Harrington The Institute of Cancer Research/The Royal Marsden NIHR Biomedical Research Centre, Division of Radiotherapy and Imaging, Targeted Therapy Laboratory, London, UK Shao Hui Huang Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada xi

9 xii Contributors Nancy Lee Radiaton Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA C. René Leemans Department of Otolaryngology, VU University Medical Center, Amsterdam, The Netherlands Jean-Pascal Machiels Institut Roi Albert II, Service d Oncologie Médicale, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain, Brussels, Belgium Nausica Montalto Department of Otorhinolaryngology-Head and Neck Surgery, University of BresciaBresciaItaly Piero Nicolai Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Brescia, Italy Brian O Sullivan Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada Sjoukje F. Oosting, MD, PhD Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Alberto Paderno Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Brescia, Italy Sat Parmar Department of Oral and Maxillofacial Surgery, Queen Elizabeth Hospital, Birmingham, West Midlands, UK Cesare Piazza Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Brescia, Italy Nadeem Riaz Radiaton Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA Sandra Schmitz Institut Roi Albert II, Service d Oncologie Médicale, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain, Brussels, Belgium Alberto Schreiber Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Brescia, Italy Dirk Schrijvers Department Medical Oncology, Ziekenhuisnetwerk Antwerpen, Antwerp, Belgium Susanne Singer Division of Epidemiology and Health Services Research, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre Mainz, Mainz, Germany Philip Sloan Newcastle University, NUTH and EPSRC/MRC Molecular Node, Newcastle upon Tyne, UK

10 Contributors xiii Petr Szturz Department of Internal Medicine, Hematology, and Oncology, University Hospital Brno and School of Medicine, Masaryk University, Brno, Czech Republic Jan B. Vermorken, MD, PhD Department of Medical Oncology, Antwerp University Hospital, Edegem, Belgium Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium Max J. H. Witjes Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands