Next generation modeling of omics, exposures and social determinants in health inequities
|
|
- Abel Webster
- 5 years ago
- Views:
Transcription
1 Next generation modeling of omics, exposures and social determinants in health inequities Terry Hyslop, PhD Professor, Duke University Department of Biostatistics & Bioinformatics Director of Biostatistics Duke Cancer Institute
2 Conflict of interest Funding sources: NIH, NCI, Breast Cancer Research Foundation, Komen Foundation Consultant to AbbVie 1
3 The importance of measurement But in the past year I have been struck again and again by how important measurement is to improving the human condition. You can achieve amazing progress if you set a clear goal and find a measure that will drive progress toward that goal Bill Gates 2013 Annual Letter 2
4 Human Genome timeline The Human Genome Project Timeline contains major milestones in genomics from 1865 to More: Darryl Leja, NHGRI. 3
5 Human genome evidence? Cystic fibrosis CFTR (G551D) Pharmacogenomic for ivacaftor Tier 1 HIV HLA-B*5701 Pharmacogenomic for abacavir Tier 1 Lipid disorders, cholesterol, dyslipidemia Familial hypercholesterolemia (FH) Unresectable or metastatic melanoma Unresectable or metastatic melanoma Unresectable or metastatic melanoma Family history of cardiovascular disease before age 50 years in male relatives and age 60 years in female relatives DNA testing and LDL-C concentration measurement Risk factor (for coronary heart disease) to inform cholesterol screening Tier 1 Cascade testing of relatives of people Tier 1 diagnosed with FH BRAF V600E Pharmacogenomic for vemurafenib Tier 1 BRAF V600E Pharmacogenomic for dabrafenib Tier 1 BRAF V600E/K Pharmacogenomic for trametinib Tier 1 Non-small cell lung cancer ALK gene rearrangement Pharmacogenomic for crizotinib Tier 1 Locally advanced or metastatic nonsmall-cell lung cancer Metastatic non-small-cell lung cancer Transfusion-dependent anemia due to low-or intermediate-1-risk myelodysplastic syndromes associated with a deletion 5q Leukemia, lymphoma, solid tumor malignancies EGFR (exon 19 deletions and exon 21 (L858R) substitution mutations) EGFR (exon 19 deletions and exon 21 (L858R) substitution mutations) Pharmacogenomic for erlotinib Tier 1 Pharmacogenomic for afatinib Tier 1 Chromosome 5q deletion Pharmacogenomic for lenalidomide Tier 1 G6PD Pharmacogenomic for rasburicase Tier genetic tests with Level 1 evidence, most for therapeutic selection CDC, Office of Public Health Genomics
6 5
7 Open cohort of all Medicare beneficiaries (60,925,443 persons) 460,310,521 person-years of follow-up from 2000 to 2012 PM2.5 and ozone measured at zip code of participant Significant evidence of adverse mortality effects related to exposure to PM2.5 and ozone at concentrations below current national standards Most pronounced among self-identified racial minorities and people with low income 6
8 Variation of average PM2.5 over regions, years, and months within year 7
9 Lancet, participants aged years enrolled in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) in six metropolitan areas in the USA. Residence-specific spatio-temporal pollution concentration models, incorporating community specific measurements, agency monitoring data, and geographical predictors, estimated concentrations of PM2.5 and nitrogen oxides (NOX) In analysis adjusted for potential confounders, a 5 μg/m. higher PM2.5 concentration was associated with 4.1 units per year (95% CI ) increased rate of coronary artery calcium progression. 8
10 20 17 En vi ro nm en ta lh ea l th Sc ho l ar s Fa ll Fo ru m PM2.5 and NOx in cohort locations, points are study participants 9
11 10
12 11
13 Racial (or other) discrimination stress SES Low physical activity nutrition smoking Lack of open space PM2.5 Access to nutritional foods trust 12 Insurance and coverage Other financial access burdens Drug responsiveness biomarkers Inherited or acquired risk
14 Health Behaviors Environmental Exposures Social Determinants Built Environment Race 13 Socioeconomic Status Biology
15 Health Behaviors Environmental Exposures Social Determinants Built Environment Race 14 Socioeconomic Status Biology
16 How do we measure socioeconomic status? No consistency/standards in implementation racial differences in models often disappear after adjusting for SES in standard modeling approaches REAL problems: Lack of SES-based information in many studies Lack of characterization/measurement of SES Differential healthcare resources, may not be measured well Current standard modeling approaches introduce collinearity due to association of measures, utilize simplistic assumptions 15
17 Index domains Poverty % Poverty % Female-headed % Income <$30k % Public Assistance % No Vehicle % No Telephone Employment % Unemployed % Males not in Workforce Education % No HS Education Residential Stability % In Same Residence Since 1995 Occupation Messer LC, Laraia RA, Kaufman JS, et al. The Development of a Standardized Neighborhood Deprivation Index. Journal of Urban Health. 2006; 83(6): % Management (M) % Management (F) %Professional Occup. (M) % Professional Occup. (F) Housing % Crowded Housing % Rented Housing % Vacant Housing % Median Household Value % Renter/Owner Costs in Excess of 50% of Income Residential Composition % Non-Hispanic Black % Older than 65 Years % Single/Unmarried % Single with Dependents
18 A Latent Class Model of SES High Advantage Low Disadvantage High Advantage High Disadvantage Low Advantage Low Disadvantage Low Advantage High Disadvantage Palumbo A, Michael Y, Hyslop T. Latent class model characterization of neighborhood socioeconomic status. Cancer Causes & Control. 2016;27(3):
19 20 17 En vi ro nm en ta lh ea l th Sc ho l ar s Fa ll Fo ru m Socio-economic burden differences and complexity of correlation 18
20 lh ea l ro nm en ta En vi th ar s Sc ho l Fa ll Fo ru m
21 Strong correlation of race and biology 20
22 Strong correlation of race and SES measures 21
23 Outcomes of biology stratified by SES 22
24 Fa ll Fo ru m Extending modeling to food availability, environmental burden, and insulin resistance ro nm en ta lh ea l th Sc ho l ar s Bayesian Hierarchical Distributed Lag models En vi Within the rings, include food access, environmental burdens, SES And at individual level measure behaviors, biomarkers, other factors R01CA , Epigenetic damage in women living in LA food-desert zip codes, Seewaldt, Anh, Shones, Hyslop, co-pis 23
25 17 20 lh ea l ro nm en ta En vi th ar s Sc ho l Fa ll Fo ru m Environmental exposures 24
26 Food vulnerability and health Low-income census tracts where a significant number or share of residents is more than 1 mile (urban) or 10 miles (rural) from the nearest supermarket. 25
27 lh ea l ro nm en ta En vi th ar s Sc ho l Fa ll Fo ru m
28 17 20 Environmental exposure and health 27 lh ea l ro nm en ta En vi th ar s Sc ho l Fa ll Fo ru m
29 Zwickl, K., Ash, M. & Boyce, J.K., Regional Variation in Environmental Inequality: Industrial Air Toxics expsure in U.S. cities. Ecological Economics, (107), pp
30 Project in development Hot spots of breast cancer incidence in NC 29
31 20 17 En vi ro nm en ta lh ea l th Sc ho l ar s Fa ll Fo ru m Environmental Exposure in NC Diesel exposure from EJSCREEN 30
32 Characteristics of models Area level heterogeneity Relative distances in area-specific way Measures association pertinent to areas, and determines whether there is uniformity of association or lack thereof For example if BMI is associated with presence of convenience stores; is that always the case, or not? Our role: to extend the models to incorporate area level exposures i.e. environmental exposures, as well as individual level exposures such as biomarkers, epigenetic markers, behaviors, and SES 31
33 Summary There is an underlying complexity to the drivers of disease initiation, progression, and prognosis Many drivers differ in sub-populations, such that personalized interventions may be required. Modeling approaches should incorporate the complexity The ultimate goal is to identify modifiable factors and sub-populations most at risk! 32
34 Acknowledgements Ladies of Port Richmond A grass-roots organization of working-class women in Philadelphia who raise funds for breast cancer research, and provided my first funding in breast cancer disparities Komen Foundation Provided funding that established much of this work and solidified my thinking on disparities NCI Funding our new grant to study food deserts, epigenetics 33
35 Thank you! With four parameters I can fit an elephant and with five I can make him wiggle his trunk. John von Neumann. 34
Cancer Deaths and the Environment in North Carolina
Cancer Deaths and the Environment in North Carolina H. Kim Lyerly, M.D. Julia Kravchenko, M.D., Ph.D. Sung Han Rhew, Ph.D. Duke University Introduction Environmental risk of cancer recognized by President
More informationBig data vs. the individual liver from a regulatory perspective
Big data vs. the individual liver from a regulatory perspective Robert Schuck, Pharm.D., Ph.D. Genomics and Targeted Therapy Office of Clinical Pharmacology Center for Drug Evaluation and Research Food
More informationHealth Disparities Research
Health Disparities Research Kyu Rhee, MD, MPP, FAAP, FACP Chief Public Health Officer Health Resources and Services Administration Outline on Health Disparities Research What is a health disparity? (DETECT)
More informationLung Cancer Genetics: Common Mutations and How to Treat Them David J. Kwiatkowski, MD, PhD. Mount Carrigain 2/4/17
Lung Cancer Genetics: Common Mutations and How to Treat Them David J. Kwiatkowski, MD, PhD Mount Carrigain 2/4/17 Histology Adenocarcinoma: Mixed subtype, acinar, papillary, solid, micropapillary, lepidic
More informationHealth Disparities Research. Kyu Rhee, MD, MPP, FAAP, FACP Chief Public Health Officer Health Resources and Services Administration
Health Disparities Research Kyu Rhee, MD, MPP, FAAP, FACP Chief Public Health Officer Health Resources and Services Administration Outline on Health Disparities Research What is a health disparity? (DETECT)
More informationRecinda L. Sherman, CTR Florida Cancer Data System
Relationship of Community Level Socioeconomic Status and Stage at Diagnosis of Colorectal Cancer in Florida Recinda L. Sherman, CTR Florida Cancer Data System 1 Colorectal Cancer Common cancer in industrialized
More informationRacial disparities in health outcomes and factors that affect health: Findings from the 2011 County Health Rankings
Racial disparities in health outcomes and factors that affect health: Findings from the 2011 County Health Rankings Author: Nathan R. Jones, PhD University of Wisconsin Carbone Cancer Center Introduction
More informationTreatment disparities for patients diagnosed with metastatic bladder cancer in California
Treatment disparities for patients diagnosed with metastatic bladder cancer in California Rosemary D. Cress, Dr. PH, Amy Klapheke, MPH Public Health Institute Cancer Registry of Greater California Introduction
More informationIdentifying Geographic & Socioeconomic Disparities in Access to Care for Pediatric Cancer Patients in Texas
Identifying Geographic & Socioeconomic Disparities in Access to Care for Pediatric Cancer Patients in Texas Mary T. Austin, MD, MPH Assistant Professor, Pediatric Surgery University of Texas Health Science
More informationPatient Reported Outcomes: Unpacking Quality Measures Andrew L Brickman, PhD Richard Taaffe, Discussant, CEO WHCHC June 23, 2018
Patient Reported Outcomes: Unpacking Quality Measures Andrew L Brickman, PhD Richard Taaffe, Discussant, CEO WHCHC June 23, 2018 1 Are patient reported outcomes a new thing? Is this the next shiny object?
More informationAIR POLLUTION RISK & VULNERABILITY TO HEALTH IMPACTS: A LOOK AT WEST OAKLAND
AIR POLLUTION RISK & VULNERABILITY TO HEALTH IMPACTS: A LOOK AT WEST OAKLAND AB 617 Community Air Protection Program Consultation Group Meeting March 26, 2018 Muntu Davis, MD, MPH Alameda County Health
More informationCorporate Medical Policy
Corporate Medical Policy Molecular Analysis for Targeted Therapy for Non-Small Cell Lung File Name: Origination: Last CAP Review: Next CAP Review: Last Review: molecular_analysis_for_targeted_therapy_for_non_small_cell_lung_cancer
More informationSocial determinants, health and healthcare outcomes 2017 Intermountain Healthcare Annual Research Meeting
Social determinants, health and healthcare outcomes 2017 Intermountain Healthcare Annual Research Meeting Andrew J Knighton PHD CPA Intermountain Institute for Healthcare Delivery Research Adversity is
More informationHEALTH DISPARITIES AMONG ADULTS IN OHIO
OHIO MEDICAID ASSESSMENT SURVEY 2012 Taking the pulse of health in Ohio HEALTH DISPARITIES AMONG ADULTS IN OHIO Amy K. Ferketich, PhD 1 Ling Wang, MPH 1 Timothy R. Sahr, MPH, MA 2 1The Ohio State University
More informationVariation in Health and Well-Being Across Connecticut: Utilization of The DataHaven Community Wellbeing Survey s Five Connecticuts Measure
Variation in Health and Well-Being Across Connecticut: Utilization of The DataHaven Community Wellbeing Survey s Five Connecticuts Measure Research Brief UNM-RWJF Center for Health Policy Connecticut Study
More informationNation nal Cancer Institute. Prevalence Projections: The US Experience
Nation nal Cancer Institute Prevalence Projections: The US Experience State of Art Methods for the Analysis of Population- Based Cancer Data January 22-23, 2014 Ispra, Italy U.S. DEPARTMENT OF HEALTH AND
More informationGENETIC TESTING FOR TARGETED THERAPY FOR NON-SMALL CELL LUNG CANCER (NSCLC)
CANCER (NSCLC) Non-Discrimination Statement and Multi-Language Interpreter Services information are located at the end of this document. Coverage for services, procedures, medical devices and drugs are
More informationGeography of Lung Cancer for Texas Counties, GEOG 4120 Medical Geography, Dr. Oppong Marie Sato
Geography of Lung Cancer for Texas Counties, 1980-1998 GEOG 4120 Medical Geography, Dr. Oppong Marie Sato Lung Cancer is Degenerative disease Ranked as number 1 leading cancer death in Texas and also US
More informationCharacteristics of Philadelphia Census Tracts with High Prostate Cancer Risk
Characteristics of Philadelphia Census Tracts with High Prostate Cancer Risk Charnita Zeigler-Johnson, PhD, MPH Thomas Jefferson University Philadelphia, PA Using Cancer Registry Data in Disparities Research
More informationInvestigating the Effects of Racial Residential Segregation, Area-level Socioeconomic Status and Physician Composition on Colorectal Cancer Screening
Virginia Commonwealth University VCU Scholars Compass Theses and Dissertations Graduate School 2016 Investigating the Effects of Racial Residential Segregation, Area-level Socioeconomic Status and Physician
More informationPRINCIPLES FOR ELIMINATING DISPARITIES THROUGH HEALTH CARE REFORM. John Z. Ayanian, MD, MPP
PRINCIPLES FOR ELIMINATING DISPARITIES THROUGH HEALTH CARE REFORM John Z. Ayanian, MD, MPP Harvard Medical School Brigham and Women s Hospital Harvard School of Public Health 8 th Annual National Summit
More informationDifferences that occur by gender, race or ethnicity, education or income, disability, geographic location, or sexual orientation. Healthy People 2010
Differences that occur by gender, race or ethnicity, education or income, disability, geographic location, or sexual orientation. Healthy People 2010 Health Inequalities: Measureable differences in health
More information7/6/2015. Cancer Related Deaths: United States. Management of NSCLC TODAY. Emerging mutations as predictive biomarkers in lung cancer: Overview
Emerging mutations as predictive biomarkers in lung cancer: Overview Kirtee Raparia, MD Assistant Professor of Pathology Cancer Related Deaths: United States Men Lung and bronchus 28% Prostate 10% Colon
More informationChanging Patient Base. A Knowledge to Practice Program
Changing Patient Base A Knowledge to Practice Program Learning Objectives By the end of this tutorial, you will: Understand how demographics are changing among patient populations Be aware of the resulting
More informationCanada: Equitable Cancer Care Access and Outcomes? Historic Observational Evidence: Incidence Versus Survival, Canada Versus the United States
Canada: Equitable Cancer Care Access and Outcomes? Historic Observational Evidence: Incidence Versus Survival, Canada Versus the United States This work is funded by the: Canadian Institutes of Health
More informationObjective: To describe a new approach to neighborhood effects studies based on residential mobility and demonstrate this approach in the context of
Objective: To describe a new approach to neighborhood effects studies based on residential mobility and demonstrate this approach in the context of neighborhood deprivation and preterm birth. Key Points:
More informationBad Things and the Heart
Bad Things and the Heart K A T H L E E N M H E I N T Z, D. O., F A C C A S S I S T A N T P R O F E S S O R O F M E D I C I N E D I V I S I O N O F C A R D I O L O G Y C O O P E R M E D I C A L S C H O
More informationCommunity Health Status Assessment
Community Health Status Assessment EXECUTIVE SUMMARY The Community Health Status Assessment (CHSA) is one of four assessments completed as part of the 2015-2016 Lane County Community Health Needs Assessment
More informationBehavioral Health Disparities in Indiana
February 2016 Improving Community Health Through Policy Research 16-H72 Behavioral Health Disparities in Indiana INTRODUCTION The burden of illness, premature death, and disability is distributed unequally
More informationCancer and Demographic COUNTY PROFILE Broward County, Florida
Cancer and Demographic COUNTY PROFILE Broward County, Florida Sylvester Comprehensive Cancer Center Jay Weiss Institute for Health Equity University of Miami Revised Sept. 2016 TABLE OF CONTENTS Page Introduction
More informationCHRONIC DISEASE PREVALENCE AMONG ADULTS IN OHIO
OHIO MEDICAID ASSESSMENT SURVEY 2012 Taking the pulse of health in Ohio CHRONIC DISEASE PREVALENCE AMONG ADULTS IN OHIO Amy Ferketich, PhD Ling Wang, MPH The Ohio State University College of Public Health
More informationCancer Health Disparities in Tarrant County
Cancer Health Disparities in Tarrant County A presentation to the Tarrant County Cancer Disparities Coalition May 3, 07 Marcela Gutierrez, LMSW Assistant Professor in Practice UTA School of Social Work
More informationAPPENDIX AVAILABLE ON THE HEI WEB SITE
APPENDIX AVAILABLE ON THE HEI WEB SITE Research Report 178 National Particle Component Toxicity (NPACT) Initiative Report on Cardiovascular Effects Sverre Vedal et al. Section 1: NPACT Epidemiologic Study
More informationMinority Inclusion in Clinical Trials
Minority Inclusion in Clinical Trials Otis W. Brawley, MD, MACP, FASCO,FACE Chief Medical and Scientific Officer American Cancer Society Professor of Hematology, Medical Oncology, Medicine and Epidemiology
More informationCancer Disparities in Arkansas: An Uneven Distribution. Prepared by: Martha M. Phillips, PhD, MPH, MBA. For the Arkansas Cancer Coalition
Cancer Disparities in Arkansas: An Uneven Distribution Prepared by: Martha M. Phillips, PhD, MPH, MBA For the Arkansas Cancer Coalition Table of Contents Page Burden of Cancer 3 Cancer Disparities 3 Cost
More informationThe Social Determinants of Drug Abuse
The Social Determinants of Drug Abuse Investigation into the Etiology of the Opioid Epidemic Bioethics Symposium South Carolina Medical Association April 28, 2018 Ponder these images Objectives Briefly
More informationAgenda CIAHD Monthly Research Meeting SPH Tower 1, Room 4645 February 3, :30 3:00pm. I. Meeting Overview 5 minutes
Agenda CIAHD Monthly Research Meeting SPH Tower 1, Room 4645 February 3, 2010 1:30 3:00pm I. Meeting Overview 5 minutes II. Project Presentations 2008/2009 Funded Pilot Project: PI Marc Turenne Disparities
More informationCancer Dispari,es in Indiana
Cancer Dispari,es in Indiana Susan M. Rawl, PhD, RN, FAAHB, FAAN Professor, Indiana University School of Nursing Co- Leader, Cancer PrevenEon & Control Program Indiana University Simon Cancer Center Indiana
More informationSupplementary Online Content
Supplementary Online Content Shurraw S, Hemmelgarn B, Lin M, et al. Association between glycemic control and adverse outcomes in people with diabetes mellitus and chronic kidney disease: a population-based
More informationLola Stronach. A thesis submitted in partial fulfillment of the requirements for the degree of. Master of Public Health. University of Washington 2012
Comparing Food Desert and Non-Food Desert Residents by Key Socio-Demographic Variables, Distance to supermarkets, Supermarket Type by Price, Diet Quality and Obesity in King County, Washington Lola Stronach
More informationWorking Towards Addressing Women s Health Disparities in Arizona
Working Towards Addressing Women s Health Disparities in Arizona Suncerria Tillis, MBA Arizona Health Disparities Center December 6, 2006 National Conference of State Legislatures Women s Health Pre-Conference
More informationBaseline Health Data Report: Cambria and Somerset Counties, Pennsylvania
Baseline Health Data Report: Cambria and Somerset Counties, Pennsylvania 2017 2018 Page 1 Table of Contents Executive Summary.4 Demographic and Economic Characteristics 6 Race and Ethnicity (US Census,
More informationRoots of Adult Disease Traced to Early Childhood Adversity
Contact: Millicent Lawton Center on the Developing Child millicent_lawton@harvard.edu (617) 496-0429 Roots of Adult Disease Traced to Early Childhood Adversity Early childhood programs could prevent chronic
More informationSlide 1. Slide 2. Slide 3. Ongoing Disparities in Rural Health. All-Cause Mortality: US vs. Appalachia
Slide 1 Ongoing Disparities in Rural Health 1 Slide 2 Source: Singh and Siahpush, Widening Rural-Urban Disparities in Life Expectancy, U.S., 1969-2009. American Journal of Preventive Medicine, 2014; 46(2):e19-e29.
More informationQuantitative Data: Measuring Breast Cancer Impact in Local Communities
Quantitative Data: Measuring Breast Cancer Impact in Local Communities Quantitative Data Report Introduction The purpose of the quantitative data report for the Southwest Florida Affiliate of Susan G.
More informationPHACS County Profile Report for Searcy County. Presented by: Arkansas Center for Health Disparities and Arkansas Prevention Research Center
PHACS County Profile Report for Searcy County Presented by: Arkansas Center for Health Disparities and Arkansas Prevention Research Center Contents Introduction... Page 2 Demographics...Page 3 Social Environment
More informationHealth Disparities Matter!
/KirwanInstitute www.kirwaninstitute.osu.edu Health Disparities Matter! Kierra Barnett, Research Assistant Alex Mainor, Research Assistant Jason Reece, Director of Research Health disparities are defined
More informationThis is a submitted version of a paper published in Epidemiology.
Umeå University This is a submitted version of a paper published in Epidemiology. Citation for the published paper: Oudin, A., Forsberg, B., Jakobsson, K. (2012) "Air pollution and stroke" Epidemiology,
More informationBaptistHealth_FEB2014 1
Hispanic Health Disparities in Diabetes: Implications for CVD Prevention Neil Schneiderman University of Miami Baptist Health South Florida 12 th Annual CVD Prevention Symposium Miami Beach, Florida February
More informationRacial and Socioeconomic Disparities in Appendicitis
Racial and Socioeconomic Disparities in Appendicitis Steven L. Lee, MD Chief of Pediatric Surgery, Harbor-UCLA Associate Clinical Professor of Surgery and Pediatrics David Geffen School of Medicine at
More informationTargeted therapies for advanced non-small cell lung cancer. Tom Stinchcombe Duke Cancer Insitute
Targeted therapies for advanced non-small cell lung cancer Tom Stinchcombe Duke Cancer Insitute Topics ALK rearranged NSCLC ROS1 rearranged NSCLC EGFR mutation: exon 19/exon 21 L858R and uncommon mutations
More informationWHO CAN OR WILL BE THE POPULATION HEALTH INTEGRATOR?
WHO CAN OR WILL BE THE POPULATION HEALTH INTEGRATOR? David Kindig MD, PhD University of Wisconsin-Madison School of Medicine and Public Health IHI Triple Aim Toronto Ontario February 11, 2010 SUMMARY OF
More informationDemographics and Health Data
Demographics and Health Data Information for Local Planners City of Lakewood, WA Demographic Characteristics Environmental Health Division 3629 South D Street, Tacoma, WA 98418 (253) 798-6470 Table 1 presents
More informationNeighbourhood deprivation and smoking outcomes in South Africa
Neighbourhood deprivation and smoking outcomes in South Africa Lisa Lau, MPH. Department of Epidemiology, School of Public Health, University of Michigan.! Jamie Tam, MPH. Department of Health Management
More informationDiversity, Health Disparities and Population Health
Diversity, Health Disparities and Population Health UAHS Discovery Lunch December 18, 2015 Joe G.N. Skip Garcia, MD Senior Vice President for Health Sciences Dr. Merlin DuVal Professor of Medicine 1 Five
More information2014 Butte County BUTTE COUNTY COMMUNITY HEALTH ASSESSMENT
2014 Butte County BUTTE COUNTY COMMUNITY HEALTH ASSESSMENT EXECUTIVE SUMMARY 2015 2017 EXECUTIVE SUMMARY TOGETHER WE CAN! HEALTHY LIVING IN BUTTE COUNTY Hundreds of local agencies and community members
More informationConceptual framework! Definitions of race and ethnicity Census Questions, Genetics! Social Class, migration, language proficiency!
Conceptual framework! Definitions of race and ethnicity Census Questions, Genetics! Social Class, migration, language proficiency! Patient-physician communication! Clinical Research Examples! Options for
More informationAnnex 1: MINDMAP research teams
Annex 1: MINDMAP research teams The Department of Public Health from the Erasmus MC in Rotterdam is a leading centre of public health research both within the Netherlands, and internationally and it is
More informationA Blueprint for Drug/Diagnostic Development: Facilitating Development and Use of Curated Genetic Databases
A Blueprint for Drug/Diagnostic Development: Facilitating Development and Use of Curated Genetic Databases TABLE OF CONTENTS Forum Goals Summary Terminology and Considerations Proposals o Proposal #1:
More informationNational Cancer Institute
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Trends and patterns of childhood cancer incidence in the US, 1995 2010 Li Zhu National Cancer Institute Linda Pickle StatNet Consulting, LLC Joe Zou Information
More informationBehind the Cascade: Analyzing Spatial Patterns Along the HIV Care Continuum
Behind the Cascade: Analyzing Spatial Patterns Along the HIV Care Continuum Kathleen Brady 1,2, M. Eberhart 1, A. Hillier 2, C. Voytek 2, M. Blank 2, I. Frank 2, D. Metzger, 2 B. Yehia 2 1 Philadelphia
More informationCollaborations to Reduce Health Disparities and Improve Wellness
Collaborations to Reduce Health Disparities and Improve Wellness Congressional Black Caucus Braintrust National Minority Quality Forum 2008 Leadership Summit Washington, DC 14 April 2008 Bryan J. Alsip,
More informationDisparity Data Fact Sheet General Information
Disparity Data Fact Sheet General Information Tobacco use is a well-recognized risk factor for many cancers, respiratory illnesses and cardiovascular diseases within Michigan. rates have continued to decline
More informationPersonalized Genetics
Personalized Genetics Understanding Your Genetic Test Results Tracey Evans, MD September 29, 2017 Genetics 101 Punnett Square Genetic Pedigree 2 Genetics 101 Punnett Square Genetic Pedigree 3 It s not
More informationCommunity Health Advisors- Utilizing Lay Navigators. Michael Bertram, PhD, MBA Associate Director for Administration
Community Health Advisors- Utilizing Lay Navigators Michael Bertram, PhD, MBA Associate Director for Administration Background & History Catchment Area Alabama 90% cancer patients Population 26.2% AA;
More informationAdvancing Health Equity in Lung Cancer Outcomes
Advancing Health Equity in Lung Cancer Outcomes Edwin J Jackson Jr. DO Pulmonary and Critical Care Medicine Disclosures Funding: American Thoracic Society 2 1 Lecture Outline Cancer Disparities Smoking
More informationIn Health Matters, Place Matters - The Health Opportunity Index (HOI) Virginia Department of Health Office of Health Equity
In Health Matters, Place Matters - The Health Opportunity Index (HOI) Virginia Department of Health Office of Health Equity 1 Identifying the Problem America s Health Rankings United Health Foundation
More informationBasket Trials: Features, Examples, and Challenges
: Features, s, and Challenges Lindsay A. Renfro, Ph.D. Associate Professor of Research Division of Biostatistics University of Southern California ASA Biopharm / Regulatory / Industry Statistics Workshop
More informationOverview of the Global Burden of Disease. December 3, 2015 Ali H. Mokdad, PhD Director, Middle Eastern Initiatives Professor, Global Health
Overview of the Global Burden of Disease December 3, 2015 Ali H. Mokdad, PhD Director, Middle Eastern Initiatives Professor, Global Health Outline 1) GBD 2013 2) Key results 3) US work 4) Recommendations
More informationWill Equity Be Achieved Through Health Care Reform?
Will Equity Be Achieved Through Health Care Reform? John Z. Ayanian, MD, MPP Director & Alice Hamilton Professor of Medicine Mass Medical Society Public Health Leadership Forum April 4, 214 OBJECTIVES
More informationRacial Variation In Quality Of Care Among Medicare+Choice Enrollees
Racial Variation In Quality Of Care Among Medicare+Choice Enrollees Black/white patterns of racial disparities in health care do not necessarily apply to Asians, Hispanics, and Native Americans. by Beth
More informationThe Origin, Evolution & Principles of Patient Navigation
The Origin, Evolution & Principles of Patient Navigation 2016 Annual Meeting Michigan Direct Services program Traverse City, MI May 6, 2016 Harold P Freeman, M.D. President & CEO, Harold P. Freeman Patient
More informationThe Heterosexual HIV Epidemic in Chicago: Insights into the Social Determinants of HIV
The Heterosexual HIV Epidemic in Chicago: Insights into the Social Determinants of HIV Nikhil Prachand, MPH Board of Health Meeting January 19, 2011 STI/HIV/AIDS Division Today s Presentation Epidemiology
More informationDefinition of Health/Healthcare disparities. Health/Healthcare. Healthcare Disparities
Healthcare Disparities Darrell M. Gray, II, MD, MPH Assistant Professor Deputy Director, Center for Cancer Health Equity OSU Comprehensive Cancer Center The James Cancer Hospital and Solove Research Institute
More information2014 Healthy Community Study Executive Summary
2014 Healthy Community Study Executive Summary BACKGROUND The Rockford Health Council (RHC) exists to build and improve community health in the region. To address this mission, RHC conducts a Healthy Community
More informationPINELLAS HIGHLIGHTS DIET & EXERCISE
PINELLAS HIGHLIGHTS DIET & EXERCISE DIET & EXERCISE Diet is not simply a matter of discipline. Access and the ability to afford healthy food play a role in food selection. Without enough income or proper
More informationDiabetes Disparities in the African- American Community
Diabetes Disparities in the African- American Community Sherita Hill Golden, MD, MHS Hugh P. McCormick Family Professor of Endocrinology and Metabolism Executive Vice-Chair, Department of Medicine Division
More informationDisparities in Vison Loss and Eye Health
Disparities in Vison Loss and Eye Health Xinzhi Zhang, MD, PhD, FACE, FRSM National Institute on Minority Health and Health Disparities National Institutes of Health Disclaimer The findings and conclusions
More informationPrecision Genetic Testing in Cancer Treatment and Prognosis
Precision Genetic Testing in Cancer Treatment and Prognosis Deborah Cragun, PhD, MS, CGC Genetic Counseling Graduate Program Director University of South Florida Case #1 Diana is a 47 year old cancer patient
More informationELIMINATING HEALTH DISPARITIES IN AN URBAN AREA. VIRGINIA A. CAINE, M.D., DIRECTOR MARION COUNTY HEALTH DEPARTMENT INDIANAPOLIS, INDIANA May 1, 2002
ELIMINATING HEALTH DISPARITIES IN AN URBAN AREA VIRGINIA A. CAINE, M.D., DIRECTOR MARION COUNTY HEALTH DEPARTMENT INDIANAPOLIS, INDIANA May 1, 2002 Racial and ethnic disparities in health care are unacceptable
More informationAssociation between Long-term Exposure to Outdoor Air Pollution and Mortality in China: a Cohort Study
Association between Long-term Exposure to Outdoor Air Pollution and Mortality in China: a Cohort Study Haidong Kan ( 阚海东 ), PhD Fudan University ( 复旦大学 ) A&WMA International Specialty Conference Xi an,
More informationMolecular Testing in Lung Cancer
Molecular Testing in Lung Cancer Pimpin Incharoen, M.D. Assistant Professor, Thoracic Pathology Department of Pathology, Ramathibodi Hospital Genetic alterations in lung cancer Source: Khono et al, Trans
More informationWhy Does Place Matter? Community-level Analysis and CER in Understanding Chronic Disease Disparities
Why Does Place Matter? Community-level Analysis and CER in Understanding Chronic Disease Disparities Arleen F. Brown, MD, PhD UCLA Division of GIM & HSR Comparative Effectiveness Research CTSI Clinical
More informationHousing / Lack of Housing and HIV Prevention and Care
Housing / Lack of Housing and HIV Prevention and Care Evidence and Explanations Angela A. Aidala, PhD Columbia University Mailman School of Public Health Center for Homeless Prevention Studies WOMEN AS
More informationWhat is the Impact of Cancer on African Americans in Indiana? Average number of cases per year. Rate per 100,000. Rate per 100,000 people*
What is the Impact of Cancer on African Americans in Indiana? Table 13. Burden of Cancer among African Americans Indiana, 2008 2012 Average number of cases per year Rate per 100,000 people* Number of cases
More informationCanarsie / Flatlands
Keeping Brooklyn Healthy by Assessing Population Health and Driving Innovation 11234, 11236, 11239 Neighborhood at a glance Population: 195,027 TBHC Service Areas: Outside the Service Area for The Brooklyn
More informationAsthma-Related Hospitalization and Emergency Room Visits in Oakland
McNair Research Journal SJSU Volume 13 Spring 2017 Article 12 2017 Asthma-Related Hospitalization and Emergency Room Visits in Oakland Alondra Varela San Jose State University Follow this and additional
More informationNext Generation Sequencing in Clinical Practice: Impact on Therapeutic Decision Making
Next Generation Sequencing in Clinical Practice: Impact on Therapeutic Decision Making November 20, 2014 Capturing Value in Next Generation Sequencing Symposium Douglas Johnson MD, MSCI Vanderbilt-Ingram
More informationWhen Zip Code Matters More Than Genetic Code: The Social Determinants of Health
When Zip Code Matters More Than Genetic Code: The Social Determinants of Health Dave Steward, MD, MPH dsteward@siumed.edu ABC-D Conference Illinois Chapter, American Academy of Pediatrics April 28, 2017
More informationImplementation of nation-wide molecular testing in oncology in the French Health care system : quality assurance issues & challenges
Implementation of nation-wide molecular testing in oncology in the French Health care system : quality assurance issues & challenges Frédérique Nowak - 21 october 2015 "Putting Science into Standards event:
More informationCancer Health Disparities Research Leading to Elimination
COMPREHENSIVE CANCER CENTER Cancer Health Disparities Research Leading to Elimination Edward E. Partridge, MD, Director Comprehensive Cancer Center Professor of Gynecologic Oncology Evalina B. Spencer
More informationHealth Systems Strategies to Reduce Tobacco Disparities. Ryan Reikowsky, MA, MPH Manager, Community Development
Health Systems Strategies to Reduce Tobacco Disparities Ryan Reikowsky, MA, MPH Manager, Community Development Session Overview Goal: Identify health systems strategies to reduce tobacco disparities and
More informationThe Association of Socioeconomic Status and Late Stage Breast Cancer in Florida: A Spatial Analysis using Area-Based Socioeconomic Measures
The Association of Socioeconomic Status and Late Stage Breast Cancer in Florida: A Spatial Analysis using Area-Based Socioeconomic Measures Jill Amlong MacKinnon, PhD Florida Cancer Data System University
More information2017 PRC Community Health Needs Assessment
2017 PRC Community Needs Assessment Obici care Foundation Service Area Western Tidewater, Virginia Prepared for: OBICI HEALTHCARE FOUNDATION By Professional Research Consultants, Inc. The PRC Community
More informationAnnie Wendt Epidemiologist Kalamazoo County Department of Health and Community Services
Kalamazoo County Health Indicators Disaggregated by Race, Place and Socioeconomic Status and Key References for Understanding Health Disparities and for Building Healthier Communities Annie Wendt Epidemiologist
More informationCounty-Level Analysis of U.S. Licensed Psychologists and Health Indicators
County-Level Analysis of U.S. Licensed Psychologists and Health Indicators American Psychological Association Center for Workforce Studies Luona Lin, Karen Stamm and Peggy Christidis March 2016 Recommended
More informationUniversity of Wisconsin School of Medicine and Public Health The County Health Rankings Model of Population Health
University of Wisconsin School of Medicine and Public Health The County Health Rankings Model of Population Health Institute of Medicine January 21, 2010 Washington DC Outline Background and rationale
More informationTheresa Keegan, Ph.D., M.S. Associate Professor Department of Internal Medicine Division of Hematology and Oncology
Impact of treatment and insurance on socioeconomic disparities in survival after adolescent and young adult Hodgkin lymphoma: A population- based study Theresa Keegan, Ph.D., M.S. Associate Professor Department
More informationKENOSHA COUNTY COMMUNITY HEALTH IMPROVEMENT PLAN MID-YEAR ( ) An Initiative Supported Through the Kenosha County Division of Health
KENOSHA COUNTY COMMUNITY HEALTH IMPROVEMENT PLAN MID-YEAR (2016-2020) An Initiative Supported Through the Kenosha County Division of Health Revised June 2016 TABLE OF CONTENTS Contents Steering Committee
More informationNew Developments in Cancer Treatment. Ian Rabinowitz MD
New Developments in Cancer Treatment Ian Rabinowitz MD Treatment Outline Angiogenesis inhibition Targeted therapy Immunotherapy Personalization of therapy Genomics and cancer Stem cells and cancer Angiogenesis
More information