RECENT TRENDS. The Impact of the NCI and NIBIB
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1 The Impact of the NCI and NIBIB James Deye, Ph.D. Program Director on Medical Physics RECENT TRENDS doubling of the NIH budget over last 5 years; appointment of new heads of NIH and NCI; creation of NIBIB; budget set-asides for the war on terrorism; dawning of translational research methods; blurring of boundaries between disciplines; increasing role for industry, NIH ICs Genes and the Environment Goal: To discover genetic, environmental, and lifestyle factors and their interactions that define cancer risk and inform strategies for cancer control. Cancer Imaging Goal: To accelerate discovery and development of imaging methods that will predict clinical course and response to interventions. Defining the Signatures of Cancer Cells: Detection, Diagnosis, and Therapy Goal: To catalog distinguishing molecular signatures of cells to deve lop new diagnostic and therapeutic approaches and predict response. Molecular Targets of Prevention and Treatment Goal: To accelerate discovery, development, and testing of prevention and treatment agents that target the molecular changes of cancer. Research on Tobacco and Tobacco-Related Cancers Goal: To understand the causes of tobacco use, addiction, and related cancers and apply this knowledge to their prevention and treatment. Cancer Communications Goal: To understand and apply the most effective communications approaches to maximize access to and 1
2 Divisions - Extramural Division of Cancer Biology Division of Cancer Control and Population Sciences Division of Cancer Prevention Division of Cancer Treatment and Diagnosis Division of Extramural Activities Divisions and Centers - Intramural Center for Cancer Research Division of Cancer Epidemiology and Genetics WORKSHOPS sponsored by RRP ( ) - TRANSLATIONAL RESEARCH IN RADIATION ONCOLOGY (published) - RESEARCH IN MEDICAL PHYSICS (published) - LATE EFFECTS OF RADIATION THEARAPY (published) - BRACHYTHERAPY (in press) - MONTE CARLO CALCULATIONS IN RADIATION THERAPY (draft) - MOLECULAR and CELLULAR BIOLOGY of MODERATE DOSE (1-10 Sv) RADIATION and POTENTIAL MECHANISMS of RADIATION PROTECTION (published) - OPERATIONS RESEARCH APPLIED TO RADIATION THERAPY (draft) NCI CLINICAL TRIAL GROUPS 1.Cancer and Acute Leukemia Group B (CALGB) 2.Children s Cancer Study Group (CCSG) 3.Eastern Cooperative Oncology Group (ECOG) 4.Gynecologic Oncology Group (GOG) 5.National Surgical Adjuvant Breast and Bowel Project (NSABP) 6.North Central Cancer Treatment Group (NCCTG) 7.Pediatric Oncology Group (POG) 8.Radiation Therapy Oncology Group (RTOG) 9.Southwest Oncology Group (SWOG) 10.Intergroup Rhabdomyosarcoma Study Group (IRSG) 11.National Wilms Tumor Study Group (NWTSG) 12.American College of Surgeons Oncology Group (ACOSOG ) 2
3 National Institute of Biomedical Imaging and Bioengineering (NIBIB) organization chart 3
4 Extramural Programs Reservedfor Small Business SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM The best way to predict the future is to create it. SBIR PROGRAM ELIGIBILITY CHECKPOINTS Organized for- profit U.S. business At least 51% U.S.-ownedand independently operated Small Business located in the U.S. P.I. s primary employment with small business during project 500 or fewer employees STTR PROGRAM FORMAL COOPERATIVE R&D EFFORT Minimum 40% by small business Minimum 30% by research institution U.S. RESEARCH INSTITUTION (RI) College or University; other non-profit research organization; federal R&D center PRINCIPAL INVESTIGATOR FROM SMALL BUSINESS and/or RESEARCH INST. AWARD MADE TO SMALL BUSINESS Faculty Partnership Opportunities Own small firms (assign someone else PI) Principal Investigator (w/ official permission from University) Senior Personnel on SBIR Consultants on SBIR Subcontract on SBIR University facilities can provide analytical and other service support SBIR/STTR 3-Phase Program PHASE I Feasibility study (no preliminary data needed) $100K -- 6 months (SBIR) or 12 months(sttr) PHASE II Full R/R&D 2-Year Award --$750K (SBIR) or $500K (STTR) PHASE III Commercialization Stage Without SBIR/STTR Support funding/sbir.htm Special Announcements (PAs and RFAs) Tools for Insertional Mutagenesis In The Mouse Functional Tissue Engineering for Heart, Vascular, Lung, Blood and Sleep Disorders and Diseases Innovative Toxicology Models for Drug Evaluation Innovations in Biomedical Information Science and Technology Development of Novel Imaging Technologies Bioengineering NanotechnologyInitiative Protein Structure Initiative (Structural Genomics) Innovative Technologies for the Molecular Analysisof Cancer Development of Digital MammographyDisplays and Workstations 4
5 Applications Submitted to NIH Center for Scientific Review Approximately 40,000 grant applications are submitted to NIH each year, of which 25-30% are funded Competing grant applications are received for three review cycles per year 5
6 RADIATION ONCOLOGY PHYSICS EFFORTS IMRT (Intensity Modulated Radiation Therapy) BRACHYTHERAPY RIT (Radio-Immuno-Therapy) MULTI-DISCIPLINARY NCI has funded an Advanced Technology Radiation Therapy QA Consortium (ATC) for Clinical Trials - ITC and RTOG Headquarters (itc.wustl.edu) RPC (rpc.mdanderson.org/rpc/) QARC ( RCET (recet.health.ufl.edu) NCI has also created an Imaging Trials effort along with the ACR: - ACRIN ( RADIATION ONCOLOGY PHYSICS EFFORTS IMRT Questionnaire documentation of institution s s IMRT planning, delivery, and QA capabilities physician s, s, physicist's, IMRT experience IMRT Dry-run run (benchmark) case demonstrate capability and knowledge of the protocol. IMRT DosimetryPhantom Verification Study NCI:Types of Initiatives ( ) Research Centers of Excellence (Molecular Imaging) Small Animal Resource Centers (Molecular Imaging) National Distributed Research Resources Research Interface Software ( Ultrasound). Image Databases for Software Evaluation (Lung CT). Platform Independent Imaging Methods (MRI). NCI/NCRR: Phased Innovation Award (R21/R33). Specifically designed for technology development, with provision of academic/ industry partnerships. NCI Review:Reviewers: Academia and Industry and small business. Applications: 1 st Round 40; 4 funded, 2 nd Round 70 Future: Multiple Prototypes: SB Joint Ventures NCI/NIBIB: Exploring new funding mechanisms tailored for Imaging Technology Development, including IGT/IGS 6
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