A case of pulmonary adenocarcinoma showing rapid progression of peritoneal dissemination after immune checkpoint inhibitor therapy

Size: px
Start display at page:

Download "A case of pulmonary adenocarcinoma showing rapid progression of peritoneal dissemination after immune checkpoint inhibitor therapy"

Transcription

1 Shinozki et l. BMC Cncer (2018) 18:620 CASE REPORT A cse of pulmonry denocrcinom showing rpid progression of peritonel dissemintion fter immune checkpoint inhiitor therpy Open Access Tro Shinozki 1, Eri Iwmi 1, Shinnosuke Ikemur 1, Ttsu Mtsuzki 1, Tkhiro Nkjim 1, Kzuhiko Hshimoto 2 nd Tkeshi Tershim 1* Astrct Bckground: Immune checkpoint inhiitors re stndrd tretments for non-smll cell lung cncer. Unique cses with prdoxicl ccelertion of the disese fter immunotherpy hve een reported. These hve een descried s cses of hyperprogressive disese. Cse presenttion: A 76-yer-old mn ws dignosed with pulmonry denocrcinom with pleurl dissemintion nd liver nd drenl metstses. Genomic nlysis reveled neither EGFR muttions nor ALK trnsloctions. Immunohistochemicl nlysis reveled progrmmed deth-lignd 1 tumor proportion score of 23%. Chemotherpy with cropltin, pclitxel, nd evcizum resulted in Grde 3 skin eruption nd disese progression. Pemrolizum ws initited s second-line tretment. However, peritonel dissemintion nd scites developed. The ptient died 2 weeks lter. The utopsy reveled widespred peritonel dissemintion nd n extensive hemorrhgic infrction. Conclusion: This ws rre cse of hyperprogressive disese with rpid progression of peritonel dissemintion fter pemrolizum tretment. Keywords: Adenocrcinom, Hyperprogressive disese, Immune checkpoint inhiitor, Lung cncer, Pemrolizum, Peritonel dissemintion Bckground Immune checkpoint inhiitors (ICIs) re currently stndrd tretments for non-smll cell lung cncer (NSCLC) [1, 2]. The unique dverse events tht cn rise fter tretment with ICIs, including pneumonitis, colitis, nd thyroiditis, re known s immune-relted dverse events [3]. Recently, unique cses with prdoxicl ccelertion of the disese fter immunotherpy hve een reported [4, 5]. These hve een descried s cses of hyperprogressive disese. In one study, hyperprogressive disese ws oserved in 9% of ptients treted with ICIs [4]. * Correspondence: 1 Deprtment of Respirtory Medicine, Tokyo Dentl College Ichikw Generl Hospitl, Sugno, Ichikw, Chi , Jpn Full list of uthor informtion is ville t the end of the rticle Herein, we report on cse of hyperprogressive disese fter tretment with pemrolizum, n ICI currently used in the tretment of NSCLC. The clinicl course in this cse ws highly unusul s it exhiited rpid progression of peritonel dissemintion shortly fter single dministrtion of pemrolizum. Moreover, this is one of the first reports to document hyperprogressive disese y utopsy. Cse presenttion A 76-yer-old mn with no history of smoking presented with n norml shdow on chest X-ry. He hd medicl history of hypertension, dyslipidemi, reflux esophgitis, nd enign prosttic hyperplsi. He hd mild dyspne on exertion. Physicl exmintion did not revel ny norml findings nd the results of the The Author(s) Open Access This rticle is distriuted under the terms of the Cretive Commons Attriution 4.0 Interntionl License ( which permits unrestricted use, distriution, nd reproduction in ny medium, provided you give pproprite credit to the originl uthor(s) nd the source, provide link to the Cretive Commons license, nd indicte if chnges were mde. The Cretive Commons Pulic Domin Dediction wiver ( pplies to the dt mde ville in this rticle, unless otherwise stted.

2 Shinozki et l. BMC Cncer (2018) 18:620 Pge 2 of 5 lortory tests were within norml limits. The ptient hd n Estern Coopertive Oncology Group performnce sttus (ECOG PS) score of 1. Chest X-ry reveled tumor in the left hilr region nd left pleurl effusion. This ws confirmed y enhnced computed tomogrphy (CT) scn, which showed 40 mm tumor in the left lower loe with left pleurl effusion. Enhnced CT scn of the domen reveled liver nd drenl metstses. Tissue specimens otined y ronchoscopy reveled well-differentited denocrcinom (Fig. 1). Genomic nlysis ws performed to identify whether there were ny driver muttions present. This reveled tht there were no sensitizing muttions in the epiderml growth fctor receptor (EGFR) gene, nor were there trnsloctions in the nplstic lymphom kinse (ALK) gene. Immunohistochemicl nlysis of progrmmed deth-lignd 1 (PD-L1) expression using the murine 22C-3 ntiody, expressed s the tumor proportion score (TPS), reveled TPS of 23% (Fig. 1). Furthermore, there were no increses in the serum levels of vrious tumor mrkers. First-line chemotherpy with cropltin (re under the curve, 6), pclitxel (200 mg/m 2 ), nd evcizum (15 mg/kg) ws initited for pulmonry denocrcinom ct3n1m1c (Stge IVB). However, skin eruption developed during the week following dministrtion nd spred to his whole ody. The size of the liver metstsis in the S4 region lso incresed from 1.0 to 1.3 cm nd new liver metstses were detected (Fig. 2). The ECOG PS score of the ptient ws 1. Since the ptient s skin eruption ws clssified s Grde 3 dverse event (Common Terminology Criteri for Adverse Events, version 4.0) nd the disese ws progressive, tretment ws switched to n ICI. Pemrolizum (200 mg/ody) ws dministered s second-line tretment. Following dministrtion, the ptient egn to experience grdul loss of ppetite nd dominl distension, followed y worsening of his generl condition. On Dy 13 fter pemrolizum dministrtion, n enhnced CT scn showed progression of the liver metstses (Fig. 3). There ws lso lrge mount of scites nd widespred peritonel dissemintion (Fig. 3, c). These were novel findings tht hd not een oserved prior to pemrolizum tretment. The ptient died suddenly due to rpid progression of respirtory filure on Dy 14 fter pemrolizum dministrtion. An utopsy reveled extensive Stge IV lung denocrcinom originting from the left lower loe with metstses in the lungs, left pleur, liver, drenl glnds, kidneys, pncres, stomch, smll intestine, colon, one mrrow, nd lymph nodes of the ilterl hilr nd pr-ortic lesions. Dissemintion to the peritoneum (Fig. 4), omentum, nd diphrgm ws lso documented y utopsy. Microscopic exmintion of the peritonel Fig. 1 Histopthologicl findings of tissue specimens otined under ronchoscopy. Hemtoxylin nd eosin stining showing well-differentited denocrcinom (200 mgnifiction). 22C-3 ntiody stining ginst progrmmed deth-lignd 1. Tumor proportion score, 23% Fig. 2 Enhnced computed tomogrphy (CT) imging. CT ws performed fter single course of cytotoxic chemotherpy. The size of the liver metstsis in the S4 region incresed from 1.0 to 1.3 cm (rrow)

3 Shinozki et l. BMC Cncer (2018) 18:620 Pge 3 of 5 Fig. 4 Mcroscopic exmintion of the utopsy specimens reveled widespred peritonel dissemintion (rrows) c Fig. 3 Enhnced computed tomogrphy (CT) imging. After single dministrtion of pemrolizum, the size of the liver metstsis incresed from 1.3 to 1.6 cm (rrow). nd c Widespred peritonel dissemintion (rrows) nd lrge mount of scites were visile fter pemrolizum tretment tissue confirmed the presence of well-differentited invsive denocrcinom (Fig. 5). Immunohistochemicl nlysis of the peritonel tissue reveled tht the PD-L1 TPS of the tumor cells ws 12% (Fig. 5), which is similr to the score for the tumor tissue otined y ronchoscopy. Overexpression of the MDM2 gene ws not detected y immunohistochemistry. In ddition to these findings, n extensive hemorrhgic infrction due to Fig. 5 Histopthologicl findings of peritonel utopsy specimens. Hemtoxylin nd eosin stining of the peritonel tissue reveled n invsive, well-differentited denocrcinom (100 mgnifiction). 22C-3 ntiody stining ginst progrmmed deth-lignd 1. Tumor proportion score, 12%

4 Shinozki et l. BMC Cncer (2018) 18:620 Pge 4 of 5 tumor emolism ws oserved in the right lung (Fig. 6, ). This ws recorded s the cuse of deth sed on the utopsy. Discussion nd conclusions To the est of our knowledge, this is the first cse of lung cncer with hyperprogressive disese showing rpid progression of peritonel dissemintion fter ICI tretment. Moreover, this is the first cse where hyperprogressive disese ws documented y utopsy. Hyperprogressive disese hs recently een descried in cses treted with immunotherpy [4, 5]. In current tretment strtegies for dvnced NSCLC, the ICI pemrolizum is recommended s first-line therpy in cses where the TPS is 50% nd s second-line therpy in cses where the TPS is 1 49% [1, 2]. It is criticl to determine whether the progression oserved in this cse ws hyperprogressive disese, pseudoprogression, or nturl progression, s is often oserved in the terminl stges of mlignnt diseses. ICIs re sometimes known to result in unique response ptterns, such s pseudoprogression [6]. However, the utopsy findings in Fig. 6 Histopthologicl findings of utopsy specimens from the right lung. Hemtoxylin nd eosin stining (100 mgnifiction). Verhoeff-Vn Gieson elstic stining. An extensive hemorrhgic infrction due to tumor emolism ws oserved (rrow) the present cse ruled out the possiility of pseudoprogression. Chmpit et l. proposed tht hyperprogressive disese should e defined s > 2.0-fold increse in tumor growth rte fter immunotherpy [4]. Kto et l. defined hyperprogressive disese s time-to-tretment filure of < 2 months, > 50.0% increse in tumor urden, nd > 2.0-fold increse in tumor growth rte [5]. In our cse, the scle mesurle region ws the liver metstses. The time elpsed etween the 1.0 to 1.3 cm nd 1.3 to 1.6 cm enlrgement of the trget lesion of the liver ws 51 nd 19 dys, respectively. The volume douling time efore nd fter pemrolizum tretment ws 45 nd 21 dys, respectively (volume douling time = [(T1 T0) log2]/[3log(d1/d0)],where D1 nd D0 re the dimeters t T1 nd T0, respectively) [7]. There ws > 2.0-fold increse in tumor growth rte since tumor growth rte is the inverse of the volume douling time (i.e., tumor growth rte = 1 / volume douling time) [8]. In previous study, the medin time from dignosis of Stge IV disese to peritonel metstsis ws 16.5 (rnge, ) months mong 410 ptients with metsttic NSCLC [9], which is notly longer thn the 2.3 months in this cse. Moreover, the time from pemrolizum dministrtion to peritonel metstsis ws just 0.4 months (13 dys). The novel ppernce of widespred peritonel dissemintion nd lrge mount of scites within 13 dys met the criteri of time-to-tretment filure of < 2 months nd suggested tht the clinicl course of our cse ws much more rpid thn the nturl terminl course. Finlly, utopsy findings reveled greter progression of the metstses thn CT scn imges tken 1 dy prior to the ptient s deth. Together, these indicte tht this ws cse of hyperprogressive disese. The clinicl course of our cse ws highly unique due to the presence of widespred peritonel dissemintion. Peritonel dissemintion is rre clinicl event in lung cncer ptients, with utopsy results indicting n incidence of % [10, 11]. It is even rrer tht peritonel dissemintion develops during the clinicl course. A 26-yer study of 1024 lung cncer ptients reported tht only 12 ptients (1.2%) developed cliniclly detectle peritonel dissemintion [12]. Another study found tht in 410 ptients with metsttic NSCLC, 33 ptients (8%) developed peritonel dissemintion nd tht this ws highly ssocited with pleurl dissemintion [9]. In our cse, it is possile tht pleurl dissemintion nd hyperprogressive disese contriuted to peritonel dissemintion. The mechnisms of hyperprogressive disese re not yet understood. Tumor profiles nd ptient chrcteristics re thought to e importnt fctors. The finding tht the PD-L1 TPS ws similr efore nd fter the

5 Shinozki et l. BMC Cncer (2018) 18:620 Pge 5 of 5 dministrtion of pemrolizum in our cse ws in greement with the finding tht hyperprogressive disese ws not ssocited with the PD-L1 sttus of tumors [4]. Kto et l. showed tht cncer ptients with MDM2 gene mplifiction or EGFR muttions hd incresed rtes of tumor growth fter tretment with ICIs [5]. However, in our cse, EGFR ws wild-type nd there ws no overexpression of the MDM2 gene. In terms of ptient chrcteristics, ge > 65 yers ws identified s the only ssocited fctor for hyperprogressive disese [4]. Although there my e other unknown risk fctors, it is likely tht old ge ws the primry risk fctor for progressive disese in our cse. Our report hs severl limittions. Firstly, there is the potentil tht the rpid progression seen in our ptient ws due to the nturl course or intrinsic cncer iology rther thn pemrolizum therpy. In fct, the disese ws chemoresistnt nd progressive prior to pemrolizum tretment. The widespred peritonel dissemintion, however, suggested ccelerted progression fter pemrolizum tretment. Secondly, the tumor growth rte is not stndrdized model for response nd the definition of hyperprogressive disese proposed y Chmpit et l. hs not een widely ccepted y the roder oncology community [13]. In our cse, the rpid growth of the tumor ws shown y shortening of the douling time of the trget lesion of the liver. The strength of our cse is the fct tht true progression ws documented y utopsy nd tht utopsy specimens will e useful for elucidting the mechnisms of hyperprogressive disese in the future. In this report, we descrie cse of pulmonry denocrcinom showing rpid progression of peritonel dissemintion soon fter single dministrtion of pemrolizum. It is likely tht old ge ws risk fctor for progressive disese fter ICI tretment. Clinicins should consider the possiility of hyperprogressive disese in smll suset of ptients fter ICI tretment. Further studies re needed to elucidte the risk fctors nd mechnisms of hyperprogressive disese following immunotherpy. Arevitions ALK: Anplstic lymphom kinse; CT: Computed tomogrphy; ECOG PS: Estern Coopertive Oncology Group performnce sttus; EGFR: Epiderml growth fctor receptor; ICI: Immune checkpoint inhiitor; NSCLC: Non-smll cell lung cncer; PD-L1: Progrmmed deth-lignd 1; TPS: Tumor proportion score Ethics pprovl nd consent to prticipte Not pplicle. Consent for puliction Written informed consent ws otined from the ptient s fmily for puliction of this cse report nd ny ccompnying imges. Competing interests The uthors declre tht they hve no competing interests. Pulisher s Note Springer Nture remins neutrl with regrd to jurisdictionl clims in pulished mps nd institutionl ffilitions. Author detils 1 Deprtment of Respirtory Medicine, Tokyo Dentl College Ichikw Generl Hospitl, Sugno, Ichikw, Chi , Jpn. 2 Deprtment of Pthology nd Lortory Medicine, Tokyo Dentl College Ichikw Generl Hospitl, Sugno, Ichikw, Chi , Jpn. Received: 28 Jnury 2018 Accepted: 23 My 2018 References 1. Herst RS, Bs P, Kim DW, Felip E, Pérez-Grci JL, Hn JY, et l. Pemrolizum versus docetxel for previously treted, PD-L1-positive, dvnced non-smll-cell lung cncer (KEYNOTE-010): rndomised controlled tril. Lncet. 2016;387: Reck M, Rodríguez-Areu D, Roinson AG, Hui R, Csőszi T, Fülöp A, et l. Pemrolizum versus chemotherpy for PD-L1-positive non-smll-cell lung Cncer. N Engl J Med. 2016;375: Michot JM, Bigenwld C, Chmpit S, Collins M, Cronnel F, Postel-Viny S, et l. Immune-relted dverse events with immune checkpoint lockde: comprehensive review. Eur J Cncer. 2016;54: Chmpit S, Dercle L, Ammri S, Mssrd C, Holleecque A, Postel-Viny S, et l. Hyperprogressive disese is new pttern of progression in Cncer ptients treted y nti-pd-1/pd-l1. Clin Cncer Res. 2017;23: Kto S, Goodmn A, Wlvlkr V, Brkusks DA, Shri A, Kurzrock R. Hyperprogressors fter immunotherpy: nlysis of genomic ltertions ssocited with ccelerted growth rte. Clin Cncer Res. 2017;23: Chiou VL, Burotto M. Pseudoprogression nd immune-relted response in solid tumors. J Clin Oncol. 2015;33: Schwrtz M. A iomthemticl pproch to clinicl tumor growth. Cncer. 1961;14: Mckintosh JA, Mrshll HM, Yng IA, Bowmn RV, Fong KM. A retrospective study of volume douling time in surgiclly resected non-smll cell lung cncer. Respirol. 2014;19: Ptil T, Aisner DL, Noonn SA, Bunn PA, Purcell WT, Crr LL, et l. Mlignnt pleurl disese is highly ssocited with susequent peritonel metstsis in ptients with stge IV non-smll cell lung cncer independent of oncogene sttus. Lung Cncer. 2016;96: Arms HL, Spiro R, Goldstein N. Metstses in crcinom; nlysis of 1000 utopsied cses. Cncer. 1950;3: McNeill PM, Wgmn LD, Neifeld JP. Smll owel metstses from primry crcinom of the lung. Cncer. 1987;59: Stoh H, Ishikw H, Ymshit YT, Kurishim K, Ohtsuk M, Sekizw K. Peritonel crcinomtosis in lung cncer ptients. Oncol Rep. 2001;8: Shron E. Cn n immune checkpoint inhiitor (sometimes) mke things worse? Clin Cncer Res. 2017;23: Avilility of dt nd mterils All dt generted or nlyzed during this study re included in this pulished rticle. Authors contriutions TS contriuted to tretment decisions, the collection of clinicl dt, dt nlysis, nd writing the mnuscript. EI, SI, TM, TN, nd TT contriuted to the interprettion of the clinicl dt nd chest imges. KH contriuted to the utopsies, pthologicl exmintions, nd immunohistochemicl nlysis. All uthors hve red nd pproved the finl mnuscript.

Efficacy of Pembrolizumab in Patients With Advanced Melanoma With Stable Brain Metastases at Baseline: A Pooled Retrospective Analysis

Efficacy of Pembrolizumab in Patients With Advanced Melanoma With Stable Brain Metastases at Baseline: A Pooled Retrospective Analysis Efficcy of Pembrolizumb in Ptients With Advnced Melnom With Stble Brin Metstses t Bseline: A Pooled Retrospective Anlysis Abstrct 1248PD Hmid O, Ribs A, Dud A, Butler MO, Crlino MS, Hwu WJ, Long GV, Ancell

More information

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer CheckMte 53: Rndomized Results of Continuous vs -Yer Fixed-Durtion Nivolumb in Ptients With Advnced Non-Smll Cell Lung Cncer Abstrct 297O Spigel DR, McCleod M, Hussein MA, Wterhouse DM, Einhorn L, Horn

More information

SYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT

SYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT Finl Arevited Clinicl Study Report Nme of Sponsor/Compny: Bristol-Myers Squi Ipilimum Individul Study Tle Referring to the Dossier (For Ntionl Authority Use Only) Nme of Finished Product: Yervoy Nme of

More information

Lung cancer is the leading cause of cancer death worldwide, EGFR Mutation and Brain Metastasis in Pulmonary Adenocarcinomas

Lung cancer is the leading cause of cancer death worldwide, EGFR Mutation and Brain Metastasis in Pulmonary Adenocarcinomas Originl Article EGFR Muttion nd Brin Metstsis in Pulmonry Adenocrcinoms Dong-Yeop Shin, MD,* Im Il N, MD,* Cheol Hyeon Kim, MD, PhD, Sunhoo Prk, MD, PhD, HeeJong Bek, MD, PhD, nd Sung Hyun Yng, MD, PhD*

More information

CHEST. Thyroid transcription factor 1 (TTF-1) is an important. Original Research

CHEST. Thyroid transcription factor 1 (TTF-1) is an important. Original Research CHEST Originl Reserch Clinicl Significnce of Thyroid Trnscription Fctor-1 in Advnced Lung Adenocrcinom Under Epiderml Growth Fctor Receptor Tyrosine Kinse Inhibitor Tretment Kuei-Pin Chung, MD; Yen-Tsung

More information

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 :

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 : PNEUMOVAX 23 is recommended y the CDC for ll your pproprite dult ptients t incresed risk for pneumococcl disese 1,2 : Adults ged

More information

A rare case of a spontaneously ruptured secondary hepatic malignant lymphoma

A rare case of a spontaneously ruptured secondary hepatic malignant lymphoma Oshit et l. Surgicl Cse Reports (2018) 4:44 https://doi.org/10.1186/s40792-018-0451-2 CASE REPORT Open Access A rre cse of spontneously ruptured secondry heptic mlignnt lymphom Ko Oshit 1, Toshiyuki Itmoto

More information

University of Texas Health Science Center, San Antonio, San Antonio, Texas, USA

University of Texas Health Science Center, San Antonio, San Antonio, Texas, USA Lung Cncer Chemotherpy Given Ner the End of Life by Community Oncologists for Advnced Non-Smll Cell Lung Cncer Jose R. Murillo, Jr., Jim Koeller b,c Methodist Hospitl, Houston, Texs, USA; b University

More information

Efficacy of Sonidegib in Patients With Metastatic BCC (mbcc)

Efficacy of Sonidegib in Patients With Metastatic BCC (mbcc) AAD 216 eposter 3368 Efficcy of Sonidegib in Ptients With Metsttic BCC (mbcc) Colin Morton, 1 Michel Migden, 2 Tingting Yi, 3 Mnish Mone, 3 Dlil Sellmi, 3 Reinhrd Dummer 4 1 Stirling Community Hospitl,

More information

Case Report Surgical Resection of a Leiomyosarcoma of the Inferior Vena Cava Mimicking Hepatic Tumor

Case Report Surgical Resection of a Leiomyosarcoma of the Inferior Vena Cava Mimicking Hepatic Tumor Cse Reports in Medicine Volume 2013, Article ID 235698, 5 pges http://dx.doi.org/10.1155/2013/235698 Cse Report Surgicl Resection of Leiomyosrcom of the Inferior Ven Cv Mimicking Heptic Tumor Junji Ued,

More information

Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors

Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors Originl Article Impct of Positive Nodl Metstses in Ptients with Thymic Crcinom nd Thymic Neuroendocrine Tumors Benny Weksler, MD, Anthony Holden, MD, nd Jennifer L. Sullivn, MD Introduction: Thymic crcinoms

More information

IMpower133: Primary PFS, OS, and safety in a Ph1/3 study of 1L atezolizumab + carboplatin + etoposide in extensive-stage SCLC

IMpower133: Primary PFS, OS, and safety in a Ph1/3 study of 1L atezolizumab + carboplatin + etoposide in extensive-stage SCLC IMpower133: Primry PFS, OS, nd sfety in Ph1/3 study of 1L tezolizumb + crbopltin + etoposide in extensive-stge SCLC S. V. Liu, 1 A. S. Mnsfield, 2 A. Szczesn, 3 L. Hvel, 4 M. Krzkowski, 5 M. J. Hochmir,

More information

For Adults With Previously Treated Advanced Non-Small Cell Lung Cancer (NSCLC)

For Adults With Previously Treated Advanced Non-Small Cell Lung Cancer (NSCLC) For Adults With Previously Treted Advnced Non-Smll Cell Lung Cncer (NSCLC) individuls depicted re models used for illustrtive purposes only. It cn be overwhelming to lern tht your previously treted dvnced

More information

Primary extramedullary plasmacytoma of the sigmoid colon with perforation: a case report

Primary extramedullary plasmacytoma of the sigmoid colon with perforation: a case report Kitmur et l. Surgicl Cse Reports (2018) 4:28 https://doi.org/10.1186/s40792-018-0437-0 CASE REPORT Open Access Primry extrmedullry plsmcytom of the sigmoid colon with perfortion: cse report Fumims Kitmur

More information

A Rare Manifestation of Solitary Primary Bone Lymphoma of the Finger: a Case Report

A Rare Manifestation of Solitary Primary Bone Lymphoma of the Finger: a Case Report pissn 2384-1095 eissn 2384-1109 imri 2018;22:240-244 A Rre Mnifesttion of Solitry Primry Bone Lymphom of the Finger: Cse Report Jeong A Yeom 2, You Seon Song 1 *, In Sook Lee 1, Kyung Un Choi 3, Jeung

More information

CASE REPORT. Abstract. Introduction. Case Report

CASE REPORT. Abstract. Introduction. Case Report CASE REPORT Pulmonry Tumor Thromotic Microngiopthy Cused y Urothelil Crcinom Expressing Vsculr Endothelil Growth Fctor, Pltelet-derived Growth Fctor, nd Osteopontin Ysushi Wkyshi 1, Mi Iwy 2, Myo Akit

More information

A case of long-term survival after surgical resection for solitary adrenal recurrence of esophageal squamous carcinoma

A case of long-term survival after surgical resection for solitary adrenal recurrence of esophageal squamous carcinoma Kny et l. Surgicl Cse Reports (2017) 3:61 DOI 10.1186/s40792-017-0337-8 CASE REPORT Open Access A cse of long-term survivl fter surgicl resection for solitry drenl recurrence of esophgel squmous crcinom

More information

Supplementary Online Content

Supplementary Online Content Supplementry Online Content Zulmn DM, Pl Chee C, Ezeji-Okoye SC, et l. Effect of n intensive outptient progrm to ugment primry cre for high-need Veterns Affirs ptients: rndomized clinicl tril. JAMA Intern

More information

Using Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids

Using Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids Using Pcloutrzol to Suppress Inflorescence Height of Potted Phlenopsis Orchids A REPORT SUBMITTED TO FINE AMERICAS Linsey Newton nd Erik Runkle Deprtment of Horticulture Spring 28 Using Pcloutrzol to Suppress

More information

Case Report INTRODUCTION CASE REPORT. pissn eissn X

Case Report INTRODUCTION CASE REPORT. pissn eissn X pissn 2287-2728 eissn 2287-285X Cse Report Clinicl nd Moleculr Heptology 2018;24:424-429 Complete cure of dvnced heptocellulr crcinom with right drenl glnd metstsis nd portl vein thrombosis by multiple

More information

BENIGN ulceration along the greater curvature of the pars media of the

BENIGN ulceration along the greater curvature of the pars media of the BENIGN ULCERS OF THE GREATER CURVATURE OF THE STOMACH Report of Two Cses CHARLES H. BROWN, M.D. Deprtment of Gstroenterology nd ANTHONY D. INTRIERE, M.D.* BENIGN ulcertion long the greter curvture of the

More information

Bright Futures Medical Screening Reference Table 2 to 5 Day (First Week) Visit

Bright Futures Medical Screening Reference Table 2 to 5 Day (First Week) Visit Bright Futures Medicl Reference Tle 2 to 5 Dy (First Week) Visit Universl Action Metolic nd Verify documenttion of neworn metolic screening results, pproprite rescreening, nd needed follow-up. Document

More information

Invasive Pneumococcal Disease Quarterly Report July September 2018

Invasive Pneumococcal Disease Quarterly Report July September 2018 Invsive Pneumococcl Disese Qurterly Report July Septemer Introduction Since 17 Octoer 2008, invsive pneumococcl disese (IPD) hs een notifile to the locl Medicl Officer of Helth under the Helth Act 1956.

More information

Esophageal carcinoma is the eighth most common cancer

Esophageal carcinoma is the eighth most common cancer ORIGINAL ARTICLE Tumor-Strom Rtio Is n Independent Predictor for Survivl in Esophgel Squmous Cell Crcinom Ki Wng, MD,* Wei M, MD,* Jinbo Wng, MD,* Ling Yu, MD, Xiomei Zhng, MD, Zhenbo Wng, MD, Bingxu Tn,

More information

Copy Number ID2 MYCN ID2 MYCN. Copy Number MYCN DDX1 ID2 KIDINS220 MBOAT2 ID2

Copy Number ID2 MYCN ID2 MYCN. Copy Number MYCN DDX1 ID2 KIDINS220 MBOAT2 ID2 Copy Numer Copy Numer Copy Numer Copy Numer DIPG38 DIPG49 ID2 MYCN ID2 MYCN c DIPG01 d DIPG29 ID2 MYCN ID2 MYCN e STNG2 f MYCN DIPG01 Chr. 2 DIPG29 Chr. 1 MYCN DDX1 Chr. 2 ID2 KIDINS220 MBOAT2 ID2 Supplementry

More information

A review of the patterns of docetaxel use for hormone-resistant prostate cancer at the Princess Margaret Hospital

A review of the patterns of docetaxel use for hormone-resistant prostate cancer at the Princess Margaret Hospital MEDICAL ONCOLOGY A review of the ptterns of docetxel use for hormone-resistnt prostte cncer t the Princess Mrgret Hospitl S.N. Chin MD,* L. Wng MSc, M. Moore MD,* nd S.S. Sridhr MD MSc* ABSTRACT Bckground

More information

Case Report Acute Zonal Occult Outer Retinopathy with Atypical Findings

Case Report Acute Zonal Occult Outer Retinopathy with Atypical Findings Cse Reports in Medicine Volume 24, Article ID 29696, 7 pges http://dx.doi.org/.55/24/29696 Cse Report Acute Zonl Occult Outer Retinopthy with Atypicl Findings Dimitrios Krginnis, Georgios A. Kontdkis,

More information

Clinical Evidence for Second- and Third-Line Treatment Options in Advanced Non-Small Cell Lung Cancer

Clinical Evidence for Second- and Third-Line Treatment Options in Advanced Non-Small Cell Lung Cancer Clinicl Evidence for Second- nd Third-Line Tretment Options in Advnced Non-Smll Cell Lung Cncer Filippo de Mrinis, Frncesco Grossi b Thorcic Oncology Unit I, Deprtment of Lung Diseses, Sn Cmillo nd Forlnini

More information

Tumor-to-tumor metastases in Cowden s disease: an autopsy case report and review of the literature

Tumor-to-tumor metastases in Cowden s disease: an autopsy case report and review of the literature Mtsumoto et l. Dignostic Pthology (2015) 10:172 DOI 10.1186/s13000-015-0408-8 CASE REPORT Tumor-to-tumor metstses in Cowden s disese: n utopsy cse report nd review of the literture Kren Mtsumoto, Kne Nosk,

More information

Localized IgG4-related Cholecystitis Mimicking Gallbladder Cancer

Localized IgG4-related Cholecystitis Mimicking Gallbladder Cancer CASE REPORT Loclized IgG4-relted Cholecystitis Mimicking Gllldder Cncer Tdhis Inoue 1, Fumihiro Okumur 1, Tkshi Mizushim 1, Hirotd Nishie 1, Hiroysu Iwski 1, Kiki Ane 1, Tknori Ozeki 1, Kent Kchi 1, Shigeki

More information

Thallium-201 chloride scintigraphy in soft tissue tumors

Thallium-201 chloride scintigraphy in soft tissue tumors 136 ORIGINAL Thllium-201 chloride scintigrphy in soft tissue tumors Hideki Otsuk, Kori Terzw, Nomi Morit, Yoichi Otomi, Shoichiro Tko, Seiji Iwmoto, Kyosuke Oski, Msfumi Hrd, nd Hiromu Nishitni Deprtment

More information

Introduction. These patients benefit less from conventional chemotherapy than patients identified as MMR proficient or microsatellite stable 3-5

Introduction. These patients benefit less from conventional chemotherapy than patients identified as MMR proficient or microsatellite stable 3-5 Nivolumb + Ipilimumb Combintion in Ptients With DNA Mismtch Repir-Deficient/Microstellite Instbility-High Metsttic Colorectl Cncer: First Report of the Full Cohort From CheckMte-142 Abstrct 553 André T,

More information

Clinical manifestations in patients with alpha-fetoprotein producing gastric cancer

Clinical manifestations in patients with alpha-fetoprotein producing gastric cancer Curr Oncol, Vol. 21, pp. e394-399; doi: http://dx.doi.org/10.3747/co.21.1768 CLINICAL MANIFESTATIONS IN AFP PRODUCING GASTRIC CANCER ORIGINAL ARTICLE Clinicl mnifesttions in ptients with lph-fetoprotein

More information

The Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report

The Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report Hiroshim J. Med. Sci. Vol. 65, No. 1, 13~17, Mrch, 2016 HIJM 65 3 13 The Selective Arteril Clcium Injection Test is Vlid Dignostic Method for Invisile Gstrinom with Duodenl Ulcer Stenosis: A Cse Report

More information

Patient Monitoring Checklist

Patient Monitoring Checklist Ptient Monitoring Checklist Ptient nme Dte This checklist is intended for nurses or other helthcre professionls (HCPs) to use prior to dosing ech ptient nd t ny follow-up visits or clls with the ptient

More information

Seeding Metastasis of Chromophobe Renal Cell Carcinoma after Robot-Assisted Laparoscopic Partial Nephrectomy

Seeding Metastasis of Chromophobe Renal Cell Carcinoma after Robot-Assisted Laparoscopic Partial Nephrectomy pissn 2384-1095 eissn 2384-1109 imri 2017;21:119-124 https://doi.org/10.13104/imri.2017.21.2.119 Seeding Metstsis of Chromophoe Renl Cell Crcinom fter Root-Assisted Lproscopic Prtil Nephrectomy Knghun

More information

Study of Stress Distribution in the Tibia During Stance Phase Running Using the Finite Element Method

Study of Stress Distribution in the Tibia During Stance Phase Running Using the Finite Element Method Ksetsrt J. (Nt. Sci.) 48 : 729-739 (2014) Study of Stress Distriution in the Tii During Stnce Phse Running Using the Finite Element Method Thepwchr Ruchirh 1, Tumrong Puttpitukporn 1, * nd Siriporn Ssimontonkul

More information

27 June Bmnly L. WALTER ET AL.: RESPONSE OF CERVICAL CANCERS TO IRRADIATION

27 June Bmnly L. WALTER ET AL.: RESPONSE OF CERVICAL CANCERS TO IRRADIATION 27 June 1964 Bmnly MEDICAL JOURNAL L. WALTER ET AL.: RESPONSE OF CERVICAL CANCERS TO IRRADIATION x 1,638.) FIG. 2.-Foci of sme tumour s in Fig. 1 contining vible tumour cells with scnty cytoplsm, reltively

More information

The Dynamics of Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus

The Dynamics of Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus Chpter 2 The Dynmics of Vricell-Zoster Virus Epithelil Kertitis in Herpes Zoster Ophthlmicus The morphology of n individul VZV lesion reflects sequence of events triggered y the virus impct on cornel epithelil

More information

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients Effects of physicl exercise on working memory nd prefrontl cortex function in post-stroke ptients M Moriy, C Aoki, K Sktni Grdute School of Helth Sciences Reserch, Mjor of Physicl Therpy, TeikyoHeisei

More information

Giant insulinoma: report of a case and review of published reports

Giant insulinoma: report of a case and review of published reports Ued et l. Surgicl Cse Reports (2016) 2:136 DOI 10.1186/s40792-016-0265-z CASE REPORT Gint insulinom: report of cse nd review of pulished reports Open Access Kzumitsu Ued *, Tetsuro Tir, Hiroyuki Hkod,

More information

Molecular Testing in Anatomic Pathology and Adherence to Guidelines

Molecular Testing in Anatomic Pathology and Adherence to Guidelines Moleculr Testing in Antomic Pthology nd Adherence to Guidelines A College of Americn Pthologists Q-Probes Study of 2230 Testing Events Reported by 26 Institutions Keith E. Volmr, MD; Michel O. Idowu, MD,

More information

A Case of Intraductal Papillary Mucinous Carcinoma in the Head of the Pancreas Associated With Absence of the Duct of Wirsung

A Case of Intraductal Papillary Mucinous Carcinoma in the Head of the Pancreas Associated With Absence of the Duct of Wirsung CASE REPORT A Cse of Intrductl Ppillry Mucinous Crcinom in the Hed of the Pncres Associted With Asence of the Duct of Wirsung Ismu Mkino, Tkhis Ymguchi, Mitsuyoshi Okzki, Tomohru Miyshit, Hidehiro Tjim,

More information

Age related differences in prognosis and prognostic factors among patients with epithelial ovarian cancer

Age related differences in prognosis and prognostic factors among patients with epithelial ovarian cancer MOLECULAR AND CLINICAL ONCOLOGY 9: 329-334, 2018 Age relted differences in prognosis nd prognostic fctors mong ptients with epithelil ovrin cncer KENJI YOSHIKAWA, TAKESHI FUKUDA, RYO UEMURA, HIROAKI MATSUBARA,

More information

Successful Diagnosis of a Thymoma by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration: A Report of Two Cases

Successful Diagnosis of a Thymoma by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration: A Report of Two Cases CASE REPORT Successful Dignosis of Thymom y Endoronchil Ultrsound-guided Trnsronchil Needle Aspirtion: A Report of Two Cses Ysushi Yoshid 1, Msto Singyoji 1, Hironori Ashinum 1, Meiji Itkur 1, Toshihiko

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION Prentl doi:.8/nture57 Figure S HPMECs LM Cells Cell lines VEGF (ng/ml) Prentl 7. +/-. LM 7. +/-.99 LM 7. +/-.99 Fold COX induction 5 VEGF: - + + + Bevcizum: - - 5 (µg/ml) Reltive MMP LM mock COX MMP LM+

More information

The effects of diversion of intestinal contents on the progress of Crohn's disease of the large bowel

The effects of diversion of intestinal contents on the progress of Crohn's disease of the large bowel Gut, 1971, 12, 11-15 The effects of diversion of intestinl contents on the progress of Crohn's disese of the lrge owel J. H. BURMAN, H. THOMPSON, W. T. COOKE, AND J. ALEXANDER WILLIAMS From the Nutritionl

More information

Identical twins with borderline lepromatous leprosy mimicking extensive alopecia areata: A rare presentation

Identical twins with borderline lepromatous leprosy mimicking extensive alopecia areata: A rare presentation Lepr Rev (2018) 89, 301 305 CASE REPORT Identicl twins with orderline lepromtous leprosy mimicking extensive lopeci ret: A rre presenttion RUBINA JASSI*, KRISHNA DEB BURMAN**, BHAVYA SWARNKAR** & RADHIKA

More information

Academia Pharma Intersect: Lung Cancer. A. JOHN IAFRATE c

Academia Pharma Intersect: Lung Cancer. A. JOHN IAFRATE c The Oncologist Acdemi Phrm Intersect: Lung Cncer Crizotinib for the Tretment of ALK-Rerrnged Non-Smll Cell Lung Cncer: A Success Story to Usher in the Second Decde of Moleculr Trgeted Therpy in Oncology

More information

Review article. Key words non specific low back pain, exercise therapy, stretching, motor control. Grade D

Review article. Key words non specific low back pain, exercise therapy, stretching, motor control. Grade D Spinl Surgery 31 2 140 144 2017 総説 Review rticle Astrct Exercise therpy is useful for low ck pin. Exercise therpy ims to improve posturl lignment, muscle strength, nd endurnce, nd lso contriutes to pin

More information

Journal of Hainan Medical University.

Journal of Hainan Medical University. 132 Journl of Hinn Medicl University 2017; 23(11): 132-136 Journl of Hinn Medicl University http://www.hnykdxxb.com Assessment of the efficcy nd sfety of bronchil rtery perfusion chemotherpy combined with

More information

Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population

Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population Originl Article Clinicl sttistics nlysis on the chrcteristics of pneumoconiosis of Chinese miner popultion Mei-Fng Wng 1 *, Run-Ze Li 2 *, Ying Li 2, Xue-Qin Cheng 1, Jun Yng 1, Wen Chen 3, Xing-Xing Fn

More information

ORIGINAL ARTICLE ABSTRACT INTRODUCTION

ORIGINAL ARTICLE ABSTRACT INTRODUCTION ORIGINAL ARTICLE LOSS OF EPCAM STAINING CORRELATES WITH POOR OUTCOME IN CRC, Wng et l. Reduction in membrnous immunohistochemicl stining for the intrcellulr domin of epithelil cell dhesion molecule correltes

More information

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE Swine Dy 22 Contents EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE B. J. Johnson, J. P. Kyser, J. D. Dunn, A. T. Wyln, S. S. Dritz 1, J.

More information

Input from external experts and manufacturer on the 2 nd draft project plan Stool DNA testing for early detection of colorectal cancer

Input from external experts and manufacturer on the 2 nd draft project plan Stool DNA testing for early detection of colorectal cancer Input externl experts nd mnufcturer on the 2 nd drft project pln Stool DNA testing for erly detection of colorectl cncer (Project ID:OTJA10) All s nd uthor s replies on the 2nd drft project pln Stool DNA

More information

Hilar cholangiocarcinoma accompanied by pancreaticobiliary maljunction without bile duct dilatation 20 years after cholecystectomy : report of a case

Hilar cholangiocarcinoma accompanied by pancreaticobiliary maljunction without bile duct dilatation 20 years after cholecystectomy : report of a case 169 CASE REPORT Hilr cholngiocrcinom ccompnied y pncreticoiliry mljunction without ile duct dilttion 20 yers fter cholecystectomy : report of cse Shinichiro Ymd, Mitsuo Shimd, Tohru Utsunomiy, Yuji Morine,

More information

See 17 for PATIENT COUNSELING INFORMATION. Revised: 09/2017 FULL PRESCRIBING INFORMATION: CONTENTS*

See 17 for PATIENT COUNSELING INFORMATION. Revised: 09/2017 FULL PRESCRIBING INFORMATION: CONTENTS* HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use Gemzr sfely nd effectively. See full prescriing informtion for Gemzr. GEMZAR (gemcitine for injection),

More information

Natural History and Treatment of Wilms's Tumour : An Analysis of 335 Cases Occurring in England and Wales

Natural History and Treatment of Wilms's Tumour : An Analysis of 335 Cases Occurring in England and Wales 24 October MEDCL JOURNL 15 Ppers nd Originls Nturl History nd Tretment Wilms's Tumour : n nlysis 335 Cses Occurring in Englnd nd Wles 12- E. M. LEDLE,* M.B., B.S., D.M.R.; L. S. MYNORS,* M.B., B.S.; G.

More information

General Microscopic Changes

General Microscopic Changes Generl Microscopic Chnges 2 This chpter covers collection of microscopic chnges tht lck dignostic specificity ut occur in different specific diseses, s will ecome pprent in susequent chpters. Almost ll

More information

Start ORKAMBI today. INDICATIONS AND USAGE IMPORTANT SAFETY INFORMATION. Sydney Age 4

Start ORKAMBI today. INDICATIONS AND USAGE IMPORTANT SAFETY INFORMATION. Sydney Age 4 F O R H E A L T H C A R E P R O F E S S I O N A L S For ptients ge 2 yers nd older who re homozygous for the F508del muttion 1,2 Modify the course. Strt tody. Sydney Age 4 F508del/F508del INDICATIONS AND

More information

Supplementary Materials. Viral delivery of mir-196a ameliorates the SBMA phenotype via the silencing of CELF2

Supplementary Materials. Viral delivery of mir-196a ameliorates the SBMA phenotype via the silencing of CELF2 Supplementry Mterils Virl delivery of mir-96 meliortes the SBMA phenotype vi the silencing of CELF2 Yu Miyzki, Hiroki Adchi, Mshis Ktsuno, Mkoto Minmiym, Yue-Mei Jing, Zhe Hung, Hideki Doi, Shinjiro Mtsumoto,

More information

The potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens

The potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens The potentil future of trgeted rdionuclide therpy: implictions for occuptionl exposure? Introduction: Trgeted Rdionuclide Therpy (TRT) Systemic tretment Molecule lbelled with rdionuclide delivers toxic

More information

Significance of Expression of TGF- in Pulmonary Metastasis in Non-small Cell Lung Cancer Tissues

Significance of Expression of TGF- in Pulmonary Metastasis in Non-small Cell Lung Cancer Tissues Originl Article Significnce of Expression of in Pulmonry Metstsis in Non-smll Cell Lung Cncer Tissues Hisshi Sji, Hruhiko Nkmur, Idiris Awut, Norihito Kwski, Msru Hgiwr, Akihiko Ogt, Mkoto Hosk, Tkmoto

More information

Increased Relative Mortality in Women With Severe Oxygen-Dependent COPD

Increased Relative Mortality in Women With Severe Oxygen-Dependent COPD CHEST Originl Reserch Incresed Reltive Mortlity in Women With Severe Oxygen-Dependent COPD Mgnus Ekström, MD ; Krl A. Frnklin, MD, PhD ; nd Kerstin E. Ström, MD, PhD COPD Bckground: Although the incidence

More information

Colonoscopic decompression of childhood sigmoid and cecal volvulus

Colonoscopic decompression of childhood sigmoid and cecal volvulus CASE REPORT Colonoscopic decompression of childhood sigmoid nd cecl volvulus Irj Shhrmin 1, Ali Bzi 1,2, Dnil Edti 3, Krim Rostmi 3, Mojt Delrmns 1,2 1 Peditric Digestive nd Heptic Reserch Center, Zol

More information

P (RCC) was first done in the late 1930s and reported in

P (RCC) was first done in the late 1930s and reported in Pulmonry Resection of Metsttic Renl Cell Crcinom Robert J. Cerfolio, MD, Mrk S. Allen, MD, Clude Deschmps, MD, Richrd C. Dly, MD, Steven L. Wllrichs, BS, Victor F. Trstek, MD, nd Peter C. Pirolero, MD

More information

Findings in spontaneous intramural intestinal hematoma imaging

Findings in spontaneous intramural intestinal hematoma imaging Brief report Findings in spontneous intrmurl intestinl hemtom imging F. Mirs Azcón, A. Mrtínez Mrtínez, A. Sntigo Chinchill*, A. Medin Benítez, E. Ochndo Pulido nd M.A. Pérez Rosillo Imging deprtment,

More information

IMPORTANT Reminders for Patients. IMPORTANT Information for Doctors/Nurses

IMPORTANT Reminders for Patients. IMPORTANT Information for Doctors/Nurses Monitor Your Signs nd Symptoms (nivolum) is prescription medicine used in comintion with YERVOY (ipilimum) to tret type of skin cncer clled melnom tht hs spred or cnnot e removed y surgery (dvnced melnom).

More information

Severe Gummy Smile with Class II Malocclusion Treated with LeFort I Osteotomy Combined with Horseshoe Osteotomy and Intraoral Vertical Ramus

Severe Gummy Smile with Class II Malocclusion Treated with LeFort I Osteotomy Combined with Horseshoe Osteotomy and Intraoral Vertical Ramus 2013 67 1 5560 Severe Gummy Smile with Clss II Mlocclusion Treted with LeFort I Osteotomy Comined with Horseshoe Osteotomy nd Introrl Verticl Rmus Osteotomy * 56 Shimo et l. Act Med. Okym Vol. 67, No.

More information

Opioid Use and Survival at the End of Life: A Survey of a Hospice Population

Opioid Use and Survival at the End of Life: A Survey of a Hospice Population 532 Journl of Pin nd Symptom Mngement Vol. 32 No. 6 December 2006 NHPCO Originl Article Opioid Use nd Survivl t the End of Life: A Survey of Hospice Popultion Russell K. Portenoy, MD, Un Sibircev, BA,

More information

Dose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: in vitro verification

Dose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: in vitro verification Hshimoto et l. BMC Phrmcology nd Toxicology (2017) 18:74 DOI 10.1186/s40360-017-0180-3 RESEARCH ARTICLE Open Access Dose-dependent effect of dptomycin on the rtificil prolongtion of prothrombin time in

More information

Prosthetic Valve Dysfunction 35 Years after Mitral Valve Replacement with a Starr-Edwards Caged-disc Valve

Prosthetic Valve Dysfunction 35 Years after Mitral Valve Replacement with a Starr-Edwards Caged-disc Valve CASE REPORT Prosthetic Vlve Dysfunction 35 Yers fter Mitrl Vlve Replcement with Strr-Edwrds Cged-disc Vlve Tetsuro Yokokw 1, Tkhiro Ohr 1, Seiji Tkshio 1, Mri Skmoto 1,YukoWd 1, Kenji Nkmur 1, Hiroyuki

More information

Prognostic significance of pretreatment serum levels of albumin, LDH and total bilirubin in patients with nonmetastatic

Prognostic significance of pretreatment serum levels of albumin, LDH and total bilirubin in patients with nonmetastatic Crcinogenesis, 2015, Vol. 36, No. 2, 243 248 doi:10.1093/crcin/bgu247 Advnce Access publiction December 18, 2014 Originl Mnuscript originl mnuscript Prognostic significnce of pretretment serum levels of

More information

Non-invasive Diagnosis of Liver Clinical Condition by Real-time Tissue Elastography and Shear Wave Measurement : Get More Accessible by One Probe

Non-invasive Diagnosis of Liver Clinical Condition by Real-time Tissue Elastography and Shear Wave Measurement : Get More Accessible by One Probe XXXXXXXXXX Non-invsive Dignosis of Liver Clinicl Condition y Rel-time Tissue Elstogrphy nd Sher Wve Mesurement : Get More Accessile y One Proe Norihis Yd Mstoshi Kudo Deprtment of Gstroenterology nd Heptology,

More information

Sphincter-saving resection by cluneal arched skin incision for a gastrointestinal stromal tumor (GIST) of the lower rectum: a case report

Sphincter-saving resection by cluneal arched skin incision for a gastrointestinal stromal tumor (GIST) of the lower rectum: a case report Tzw et l. Surgicl Cse Reports (2017) 3:8 DOI 10.1186/s40792-016-0285-8 CASE REPORT Sphincter-sving resection y clunel rched skin incision for gstrointestinl stroml tumor (GIST) of the lower rectum: cse

More information

Symptomatic Remote Cyst after BCNU Wafer Implantation for Malignant Glioma

Symptomatic Remote Cyst after BCNU Wafer Implantation for Malignant Glioma Cse Report doi: 10.2176/nmc.cr.2017-0218 Neurol Med Chir (Tokyo) 58, 270 276, 2018 Symptomtic Remote Cyst fter BCNU Wfer Implnttion for Mlignnt Gliom Online My 21, 2018 Hideki MATSUMURA, 1 Eiichi ISHIKAWA,

More information

Shinhaeng Cho, Youngmoon Goh, Chankyu Kim, Haksoo Kim, Jong Hwi Jeong, Young Kyung Lim, Se Byeong Lee, Dongho Shin

Shinhaeng Cho, Youngmoon Goh, Chankyu Kim, Haksoo Kim, Jong Hwi Jeong, Young Kyung Lim, Se Byeong Lee, Dongho Shin Originl Article PMP Progress in Medicl Physics 28(4), Decemer 217 https://doi.org/1.14316/pmp.217.28.4.144 pissn 28-444, eissn 28-443 Dosimetric Impct of Ti Mesh on Proton Bem Therpy Shinheng Cho, Youngmoon

More information

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess

More information

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis Supplementry Informtion PDGF-BB secreted y preosteoclsts induces ngiogenesis during coupling with osteogenesis Hui Xie, Zhung Cui, Long Wng, Zhuying Xi, Yin Hu, Lingling Xin, Chngjun Li, Ling Xie, Jnet

More information

One of the most important biological mechanisms of

One of the most important biological mechanisms of Brief Report Serum Thymidine Kinse 1 Activity in the Prognosis nd Monitoring of Chemotherpy in Lung Cncer Ptients: A Brief Report Benjmin Nismn, PhD,* Hovv Nechushtn, MD, PhD,* Him Birn, MD, Hds Gntz-Sorotsky,

More information

The incidence of melanoma, the most serious

The incidence of melanoma, the most serious Efectiveness nd sfety of ipilimumb therpy in dvnced melnom: evidence from clinicl prctice sites in the US Kim A Mrgolin, MD, Ahmd Trhini, MD, PhD, b Sumti Ro, PhD, c Monic Ktyl, JD, MPH, d I-Fen Chng,

More information

Metformin and breast cancer stage at diagnosis: a population-based study

Metformin and breast cancer stage at diagnosis: a population-based study ORIGINAL ARTICLE METFORMIN AND BREAST CANCER STAGE AT DIAGNOSIS, Leg et l. Metformin nd brest cncer stge t dignosis: popultion-bsed study I.C. Leg md msc,* K. Fung msc,* P.C. Austin phd, nd L.L. Lipscombe

More information

Anus,Rectum and Colon

Anus,Rectum and Colon JOURNAL OF THE Anus,Rectum nd Colon http://journl-rc.jp CASE REPORT Anl Cnl Dupliction Associted with Prescrl Cyst in n Adult Tkyuki Toyong 1), Hiromitsu Mtsud 1), Ryuichi Miu 1), Yohei Toming 1), Keiji

More information

For Adults with Metastatic Melanoma

For Adults with Metastatic Melanoma For Adults with Metsttic Melnom The + YERVOY Regimen ws shown to reduce the risk of disese progression by nerly 60% compred to YERVOY lone. Hlf of the ptients on + YERVOY were live t 11.5 months without

More information

XII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV

XII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV XII. HIV/AIDS Knowledge bout HIV Trnsmission nd Misconceptions bout HIV One of the most importnt prerequisites for reducing the rte of HIV infection is ccurte knowledge of how HIV is trnsmitted nd strtegies

More information

Supplementary Figure 1

Supplementary Figure 1 Supplementry Figure 1 c d Wistr SHR Wistr AF-353 SHR AF-353 n = 6 n = 6 n = 28 n = 3 n = 12 n = 12 Supplementry Figure 1 Neurophysiologicl properties of petrosl chemoreceptive neurones in Wistr nd SH rts.

More information

Supplementary Online Content

Supplementary Online Content Supplementry Online Content Rieckmnn N, Kronish IM, Shpiro PA, Whng W, Dvidson KW. Serotonin reuptke inhibitor use, depression, nd long-term outcomes fter n cute coronry : prospective cohort study. JAMA

More information

Diagnostic value of ultrasound combined with magnetic resonance imaging in different stages of breast cancer

Diagnostic value of ultrasound combined with magnetic resonance imaging in different stages of breast cancer ONCOLOGY LETTERS Dignostic vlue of ultrsound combined with mgnetic resonnce imging in different stges of brest cncer QIAOHONG PAN 1* nd JIANWU JI 2* Deprtments of 1 Ultrsound nd 2 MRI, Heping Hospitl Affilited

More information

A Study of Serological Markers of Hepatitis B and C Viruses in Istanbul, Turkey

A Study of Serological Markers of Hepatitis B and C Viruses in Istanbul, Turkey Originl Pper Med Princ Prct 2003;12:184 188 DOI: 10.1159/000070757 Received: Decemer 15, 2001 Revised: Decemer 21, 2002 A Study of Serologicl Mrkers of Heptitis B nd C Viruses in Istnul, Turkey S. Erden

More information

Fertility in Norwegian testicular cancer patients

Fertility in Norwegian testicular cancer patients DOI: 0.054/ bjoc.999.0989, vilble online t http://www.idelibrry.com on Fertility in Norwegin testiculr cncer ptients SD Fosså nd Ø Krvdl 2 The Norwegin Rdium Hospitl, Montebello, N-030 Oslo, Norwy; 2 The

More information

Relation of Tumor Size, Lymph Node Status, and Survival in

Relation of Tumor Size, Lymph Node Status, and Survival in Reltion of Tumor Size, Lymph Node Sttus, nd Survivl in 24,74 Brest Cncer Cses CHRISTINE L. CARTER, PHD, MPH,* CAROL ALLEN, PHD,t AND DONALD E. HENSON, MD* Two of the most importnt prognostic indictors

More information

Emerging Options for Thromboprophylaxis After Orthopedic Surgery: A Review of Clinical Data

Emerging Options for Thromboprophylaxis After Orthopedic Surgery: A Review of Clinical Data Emerging Options for Thromboprophylxis After Orthopedic Surgery: A Review of Clinicl Dt Bob L. Lobo, Phrm.D. In four rndomized, controlled studies of ptients undergoing orthopedic surgery, the ntithrombotic

More information

Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma

Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma doi: 10.2169/internlmedicine.0737-18 Intern Med 57: 3249-3254, 2018 http://internmed.jp CASE REPORT Methotrexte-ssocited Lymphoprolifertive Disorder of the Stomch Presumed to Be Mucos-ssocited Lymphoid

More information

MOLECULAR AND CLINICAL ONCOLOGY 7: , 2017

MOLECULAR AND CLINICAL ONCOLOGY 7: , 2017 336 Effect of intrtumorl bscess/necrosis on the outcome for hed nd neck cncer ptients treted by hypofrctionted stereotctic re irrdition using CyberKnife HIDEYA YAMAZAKI 1,2, MIKIO OGITA 3, KENGO HIMEI

More information

Medical Thoracoscopy vs CT Scan-Guided Abrams Pleural Needle Biopsy for Diagnosis of Patients With Pleural Effusions

Medical Thoracoscopy vs CT Scan-Guided Abrams Pleural Needle Biopsy for Diagnosis of Patients With Pleural Effusions CHEST Originl Reserch PLEURAL DISEASE Medicl Thorcoscopy vs CT Scn-Guided Abrms Pleurl Needle Biopsy for Dignosis of Ptients With Pleurl Effusions A Rndomized, Controlled Tril Muzffer Metints, MD; Guntulu

More information

Recombinant human interleukin 6 in metastatic renal cell cancer: a phase II

Recombinant human interleukin 6 in metastatic renal cell cancer: a phase II Britsh Journl of Cncer (1996) 73, 789-793 1996 Stockton Press All rights reserved 7-92/96 $12. $ Recominnt humn interleukin 6 in metsttic renl cell cncer: phse II tril JML Stouthrd', H Goey2, EGE de Vries3,

More information

PROVEN ANTICOCCIDIAL IN NEW FORMULATION

PROVEN ANTICOCCIDIAL IN NEW FORMULATION PROVEN ANTICOCCIDIAL IN NEW FORMULATION Coxidin 100 microgrnulte A coccidiosttic dditive for roilers, chickens rered for lying nd turkeys Contins 100 g of monensin sodium per kg Aville s homogenous grnules

More information

Struma ovarii with follicular thyroid-type carcinoma and neuroendocrine component: case report

Struma ovarii with follicular thyroid-type carcinoma and neuroendocrine component: case report Selvggi et l. World Journl of Surgicl Oncology 2012, 10:93 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Strum ovrii with folliculr thyroid-type crcinom nd neuroendocrine component: cse report

More information