CLINICAL PATTERNS AMONG INVASIVE PULMONARY ASPERGILLOSIS PATIENTS WITH AND WITHOUT RECENT INTENSIVE IMMUNOSUPPRESSIVE THERAPY
|
|
- Cuthbert Bishop
- 5 years ago
- Views:
Transcription
1 CLINICAL PATTERNS AMONG INVASIVE PULMONARY ASPERGILLOSIS PATIENTS WITH AND WITHOUT RECENT INTENSIVE IMMUNOSUPPRESSIVE THERAPY Gee-Chen Chang, 1,2 Kai-Ming Chang, 1,2 Chieh-Liang Wu, 1 and Chi-Der Chiang 1 Background and Purpose: Invasive pulmonary aspergillosis (IPA) is usually an acute life-threatening infection in cancer patients receiving chemotherapy and in organ transplant recipients receiving immunosuppressive therapy. In some immunocompetent patients, IPA has a chronic and indolent clinical course. We compared the clinical patterns among IPA patients who had received recent intensive immunosuppressive therapy (RIIT) and those who had not (N-RIIT). Methods: We reviewed the medical records of patients with a diagnosis of IPA made between 1992 and RIIT was defined as chemotherapy or high-dose corticosteroid therapy (at least 500 mg/d methylprednisolone, or equivalent, for at least 3 d) within 2 weeks before the onset of symptoms. RIIT patients were divided into those with and without malignancy. We compared clinical characteristics including age, sex, chest image patterns, diagnostic methods, culture results, treatment conditions, mortality, and recurrence rate in IPA patients: RIIT versus N-RIIT, and RIIT with and without malignancy. Results: A total of 24 patients with IPA, 17 patients who had received RIIT and seven patients who had not (N-RIIT), were included. In the RIIT group, 11 patients had malignancy and six did not. No significant differences in gender, chest image patterns, diagnostic methods, and culture results were found between the RIIT and N-RIIT groups. The N-RIIT group was older and was treated significantly later after the onset of symptoms than the RIIT group (mean ± standard deviation, SD, ± vs 9.70 ± 9.33 d, p = 0.018). Only one of the seven N-RIIT patients died, while nine of the 17 RIIT patients died (p = 0.08). Among the RIIT patients, five of the six without malignancy died, while four of the 11 patients with malignancy died. IPA recurred in seven of the eight RIIT patients, all of whom had malignancy, but in none of the six N-RIIT patients during a similar follow-up period (mean ± SD, 16.3 ± 18.9 vs 27.0 ± 54.5 mo, p = 0.505). Conclusions: No differences were noted in image and culture studies between RIIT and N-RIIT IPA patients. RIIT IPA patients had acute and fulminant clinical courses, especially patients without malignancy, even though they received treatment with a mean duration of about 10 days starting from the onset of symptoms. All patients with malignancy undergoing further chemotherapy had recurrence of IPA. N-RIIT IPA patients had chronic clinical courses, a trend of lower mortality rate even with delayed diagnosis, and no recurrence. (J Formos Med Assoc 2001;100:762 6) Key words: invasive pulmonary aspergillosis immunosuppressive therapy Aspergillus-related pulmonary disorders may be classified into allergic reactions, colonization, or invasive types. The types of disease caused by Aspergillus species are determined by the host immune activity and struc- tural abnormalities of the lung [1 3]. Invasive pulmonary aspergillosis (IPA) has become an increasingly important cause of morbidity and mortality in immunocompromised patients [1]. IPA is character- 1 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, and 2 Chung Shan Medical University, Taichung. Received: 28 December Revised: 29 January Accepted: 4 September Reprint requests and correspondence to: Dr. Gee-Chen Chang, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, 160 Chung-Kang Road, Section 3, Taichung, Taiwan. 762
2 Clinical Patterns of Invasive Pulmonary Aspergillosis ized by a proliferation of fungal hyphae in the lung parenchyma. Major factors predisposing to the development of IPA are neutropenia of any cause, and immunosuppression by corticosteroids or other immunosuppressive agents [2, 3]. Invasive fungal infections are an acute life-threatening illness in cancer patients and are usually treated empirically. Some invasive fungal infections are diagnosed by lung resection when the disease becomes localized after treatment. However, recurrence of the disease is frequent during neutropenic periods in further courses of chemotherapy in cancer patients. IPA interferes with the treatment of the underlying diseases and may cause morbidity and mortality. IPA has been reported in patients without malignancy but taking corticosteroids [4], diabetes mellitus (DM), influenza, alcoholism [5], underlying chest diseases, and organ transplantation [6]. Some patients with IPA have acute clinical courses, especially organ transplant patients receiving intensive immunosuppressive agents. Others, such as DM or asthma patients, have chronic and indolent clinical courses. The purpose of this study was to compare the clinical patterns of IPA between patients who had received recent intensive immunosuppressive therapy (RIIT) and those who had not (N-RIIT). Patients and Methods The CxRs and CT scans were read independently by one pulmonologist and one radiologist. We divided the findings of the CxRs and CT scans into four patterns: multiple bilateral pulmonary nodules, broncho-pneumonia, bronchopneumonia with pleural effusion, and bronchopneumonia with halo signs. A halo sign was defined as the appearance of groundglass attenuation surrounding the nodule. Patients with bronchopneumonia-type IPA showed an acute onset of an alveolar patch on CxR. RIIT was defined as administration of chemotherapy or high-dose corticosteroid therapy (at least 500 mg/d methylprednisolone, or equivalent, for at least 3 d) within 2 weeks before the onset of pulmonary symptoms. Recurrence of IPA was defined as development of IPA after resolution of the first episode by an anti-fungus regimen and/or surgical resection. Statistical analysis Statistical analysis was performed using the Statistical Package for Social Sciences statistical software (SPSS standard version 8.0, SPSS, Inc., Chicago, IL, USA). We compared characteristics, including sex, CxR, CT scans, diagnostic methods, culture results, and mortality rate, between the RIIT and N-RIIT groups with Fisher s exact test. The differences in age and the interval from the onset of pulmonary symptoms to the start of antifungal therapy were determined by Mann-Whitney U test. A p value of less than 0.05 was considered statistically significant. We reviewed the medical records of patients with the diagnosis of IPA who were admitted to Taichung Veterans General Hospital from January 1992 through December All patients had a positive culture of Aspergillus spp. from open lung biopsy transbronchosc-opic lung biopsy, necropsy, percutaneous transthoracic needle lung aspiration, or pleural effusion aspiration. The surgical specimens and the lung aspiration samples were cultured on Sabouraud s agar and species were identified by their morphology under microscopic examination. Patients were excluded if they: had previous pulmonary mycetoma suggested by chest roentgenogram (CxR) or computerized tomography (CT) scan of the chest; only had compatible tissue morphology without positive fungus culture; or only had positive sputum Aspergillus cultures. We collected clinical data including sex, age, underlying diseases, the number of days of neutropenia (absolute neutrophil count < 500 x 10 6 /L), corticosteroid use, the interval from the onset of pulmonary symptoms to the administration of antifungal treatment, mortality attributed to IPA, and recurrence after resolution of IPA. The diagnostic methods were also recorded. Results The medical records of 31 patients with IPA were studied. Seven of these patients without a positive culture were excluded although they had compatible histopathologic findings. A total of 24 patients were included. There were 17 patients in the RIIT group, 11 of whom had malignancy. Ten of the 11 patients with malignancy had leukemia and one had breast cancer. Two patients without malignancy who had received RIIT had systemic lupus erythematosus (SLE) and four were renal transplant patients. The seven patients in the N-RIIT group had the following underlying diseases: DM (n = 4), asthma (n = 1), osteoarthritis (n = 1), and none (n = 1). The clinical, radiologic, and microbiologic characteristics of patients are listed in the Table. The radiographic patterns in 17 patients revealed bronchopneumonia with or without pleural effusion. Seven cases showed an angioinvasive IPA with bilateral multiple pulmonary nodules (Figure). No significant differences were found between the RIIT and N-RIIT 763
3 Table. Clinical, radiologic, and microbiologic characteristics of patients with invasive pulmonary aspergillosis (IPA) Variable Malignancy with RIIT Non-malignancy with RIIT N-RIIT p value* (n = 11) (n = 6) (n = 7) Sex (M/F) 5/6 3/3 5/ Age (yr) Chest roentgenogram pattern 0.96 Bronchopneumonia ± pleural effusion Bilateral pulmonary nodules Computerized tomography scan 0.77 Bronchopneumonia ± pleural effusion 7 3 Bilateral pulmonary nodules Bronchopneumonia + halo sign 2 2 Diagnostic method 0.23 Open lung biopsy or wedge resection Transthoracic needle lung aspiration Transbronchoscopic biopsy Culture results 0.63 Aspergillus fumigatus Aspergillus versicolor 1 Aspergillus flavus 1 S-Tx (d) 7.55 ± ± ± Mortality 4/11 5/6 1/ Recurrence 7/7 0/1 0/6 RIIT = recent intensive immunosuppressive therapy; N-RIIT = non-riit; S-Tx = time from symptom onset to treatment. *RIIT group (± malignancy) vs N-RIIT group; mean ± standard deviation. groups in radiographic patterns, diagnostic methods or microbiologic data. IPA was diagnosed by transthoracic needle aspiration in 13 cases and by transbronchoscopic biopsy in three cases. Eight patients underwent open lung biopsy for diagnosis or curative treatment. All patients with malignancy received chemotherapy and developed neutropenia. The median duration of neutropenia was 15 days (range d). There was a significant difference in the time from the onset of symptoms to treatment between RIIT and N-RIIT groups (mean ± standard deviation, SD, 9.70 ± 9.33 vs ± d, Figure. Angioinvasive invasive pulmonary aspergillosis. Bilateral pulmonary nodules are seen on computerized tomography scan of the chest. Several nodules show signs of cavitation with air-crescence. 764 p = 0.018). The difference in time from the onset of symptoms to the initiation of treatment between RIIT patients with and without malignancy, even though longer in patients without malignancy, was not significant (mean ± SD, 7.55 ± 5.30 vs ± d, p = 0.26). The amount of amphotericin B (AmB) administered ranged from 1,680 to 2,550 mg in the surviving patients and from 5 to 1,280 mg in patients who died during treatment. The AmB was given at a daily dose of 1 mg/kg after a test dose of 1 mg for most patients. Overall, nine of the 17 RIIT patients died and only one of the seven N-RIIT patients died (p = 0.08). Five of six patients without malignancy died, and four of 11 with malignancy who received RIIT died. Sputum cultures were positive for Aspergillus in eight patients in the RIIT group, but six were positive after the definite diagnosis of IPA had been made. In the N-RIIT group, two patients had positive sputum cultures obtained before diagnosis of IPA and those were considered to indicate colonization. After resolution of IPA, seven of the eight RIIT patients and none of the six N-RIIT patients had recurrence of IPA with similar follow-up periods (mean ± SD, 16.3 ± 18.9 vs 27.0 ± 54.5 mo, p = 0.505). All recurrence was in patients with malignancy. Five of these seven patients underwent percutaneous transthoracic needle lung aspiration and two underwent bronchoalveolar
4 Clinical Patterns of Invasive Pulmonary Aspergillosis lavage (BAL) by fiberoptic bronchoscopy with positive Aspergillus cultures. One of the leukemia patients had recurrence, but was treated and survived. She did not have another recurrence during 3 years follow-up after successful bone marrow transplantation. Three RIIT patients had histologic evidence of extrapulmonary involvement including the brain, maxillary sinus, and liver. Discussion Chemotherapeutic agents and corticosteroids have a major impact on the immune system s defense against fungal infection. The first immunologic line of defense against Aspergillus in the lungs is the macrophages, which are capable of ingesting and killing spores [7]. The second line of defense is the neutrophils, which primarily kill the hyphae [8]. Corticosteroids substantially impair the ability of macrophages to kill Aspergillus spores and the ability of neutrophils and mononuclear cells to kill Aspergillus hyphae [9, 10]. In this series, the clinical courses were mainly determined by the immune status of the patients. The most immunocompromised patients had the fastest progression (7 14 d from onset to death). This finding is in agreement with previous studies, which have found that immunocompetent and less immunocompromised patients, such as those with DM, usually have indolent symptoms and slow progression (2 3 mo) [11, 12]. IPA is a life-threatening infection occurring mainly in cancer patients and is associated with a mortality rate of 40 to 80% [13]. In many instances, mortality is traceable to a delay in the diagnosis. However, our patients with malignancy were treated empirically with AmB when febrile neutropenia persisted for more than 1 week in spite of broad-spectrum antibiotic therapy. IPA was seldom suspected in RIIT patients without malignancy. All six such patients presented with acute illness, and five died. Only one patient, with SLE, survived after early empirical antifungal treatment, because pulmonary nodules with a halo sign were noted on the CT scan of the chest. In RIIT patients without malignancy, treatment was initiated later and the mortality rate was higher, though not significantly compared with RIIT patients with malignancy. However, these findings might have been due to small patient numbers. Seven N-RIIT patients had subacute or chronic courses with mild fever, cough, or generalized malaise. Underlying conditions reported in patients with IPA have included chronic granulomatous disease [14], DM, alcoholism [5], and patients receiving corticosteroid therapy for chronic pulmonary disease, such as sarcoidosis and chronic obstructive pulmonary disease [4]. In vitro studies in patients with DM have shown decreased leukocyte bactericidal activity and impaired macrophage mobility and phagocytic capacity [15]. However, some patients with IPA did not have any immunocompromising factors [16, 17]. IPA is divided into six distinct clinicopathologic forms of disease, which include acute bronchopneumonia, angioinvasive aspergillosis, acute tracheobronchitis, miliary aspergillosis, pleural aspergillosis, and chronic necrotizing aspergillosis. The first two forms are the most common [11]. The bronchopneumonia form presents a clinical picture that resembles bacterial pneumonia. The lung lesion begins with a patchy infiltration, and then progresses to dense consolidation involving one or both lungs. Angioinvasive aspergillosis often presents with bilateral pulmonary nodules and usually spreads by vascular dissemination to cause thrombosis and necrosis. About one-third of patients initially have normal CxRs at the onset of fever, and later quickly progress to bilateral multiple pulmonary septic emboli lesions [11]. Angioinvasive aspergillosis is usually mistreated as bacterial infection and the mortality rate is very high. Previous studies have shown that CT scans are helpful in detecting early changes in IPA which are not visible on CxRs [18 20]. The pulmonary lesion appears early in the course of IPA infection. Primack et al reported that CT halo signs could indicate an infectious process, including invasive aspergillosis, candidiasis, cytomegalovirus, herpes simplex virus, and coccidioidomycosis, and could also indicate a noninfectious cause including Wegener s granulomatosis, metastatic angiosarcoma, and Kaposi s sarcoma [20]. Thus, CT halo signs can only be used as evidence of pulmonary nodules. A diagnosis of IPA requires the demonstration of septated mycelia, morphologically consistent with aspergillosis, invading the lung parenchyma, in addition to a positive fungal culture. Invasive procedures are often impractical in patients with acute leukemia or in cancer patients undergoing chemotherapy, owing to borderline respiratory status and thrombocytopenia. Empirical treatment should never be withheld in an immunocompromised patient in whom IPA is suspected. BAL could be performed in these patients, but its sensitivity has been reported to be very low in immunocompromised patients [21]. The initial treatment results in RIIT patients with malignancy were much better than in those without malignancy because of early empirical treatment with AmB. However, a previous study reported that the long-term results in RIIT patients with malignancy were not good because of a substantial risk of recur- 765
5 rence during subsequent drug-induced granulocytopenia [22]. Surgical management of IPA can be diagnostic or curative in patients with localized disease. Robinson et al performed pulmonary resection in 16 immunocompromised patients with IPA when localized disease developed after systemic antifungal therapy. At a median of 8 months follow-up, 11 of the 16 patients had survived without evidence of recurrence [23]. The clinical patterns among patients with IPA are determined by the immune status of the patient. In RIIT patients without malignancy, the diagnosis of IPA is seldom considered, which leads to high mortality. A high index of suspicion, early invasive diagnostic procedures, and early empirical AmB treatment after the failure of broad-spectrum antibiotic therapy, as in RIIT patients with malignancy, might rescue these patients. In RIIT patients with malignancy, recurrence of IPA should be suspected in further courses of chemotherapy. However, in N-RIIT IPA patients, chronic IPA can be cured by AmB after diagnosis with little risk of recurrence. References 1. Aslam PA, Eastridge CE, Huges FA Jr: Aspergillosis of the lung an eighteen-year experience. Chest 1971;59: Greene R: The pulmonary aspergillosis: three distinct entities or spectrum of disease. Radiology 1981;140: Turner-Warwick M: Aspergillus fumigatus and lung disease. Postgrad Med 1979;55: Palmer LB, Greenberg HE, Schiff MJ: Corticosteroid treatment as a risk factor for invasive aspergillosis in patients with lung disease. Thorax 1991;46: Denning DW, Stevens DA: Antifungal and surgical treatment of invasive aspergillosis: review of 2121 published cases. Rev Infect Dis 1990;12: Gustafson TL, Schaffner W, Lavely GB, et al: Invasive aspergillosis in renal transplant recipients: correlation with corticosteroid therapy. J Infect Dis 1983;148: Schaffner A, Douglas H, Braude A: Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes. J Clin Invest 1982;69: Diamond RD, Krzesicki R, Epstein B, et al: Damage to hyphal forms of fungi by human leukocytes in vitro: a possible host defense mechanism in aspergillosis and mucormycosis. Am J Pathol 1978;91: Roilides E, Unlig K, Venzon D, et al: Prevention of corticosteroid-induced suppression of human polymorphonuclear leukocyte-induced damage of Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon. Infect Immun 1993;61: Roilides E, Blake C, Holmes A, et al: Granulocyte-macrophage colony-stimulating factor and interferon-gamma prevent dexamethasone-induced immunosuppression of antifungal monocyte activity against Aspergillus fumigatus hyphae. J Med Vet Mycol 1996;34: Young RC, Bennett JE, Vogel CL, et al: Aspergillosis; the spectrum of the disease in 98 patients. Medicine (Baltimore) 1970;49: Degregorio MW, Lee WMF, Linkera CA, et al: Fungal infections in patients with acute leukemia. Am J Med 1982; 73: Denning DW: Therapeutic outcome in invasive aspergillosis. Clin Infect Dis 1996;23: Mouty R, Fischer A, Vilmer E, et al: Incidence, severity, and prevention of infections in chronic granulomatous disease. J Pediatr 1989;114: D Silva H, Burtle JF, Cho SY: Disseminated aspergillosis in an apparently immunocompetent host. JAMA 1982; 248: Karam GH, Griffin FM Jr: Invasive pulmonary aspergillosis in nonimmunocompromised, nonneutropenic hosts. Rev Infect Dis 1986;8: Karim M, Alam M, Shah AA, et al: Chronic invasive aspergillosis in apparently immunocompetent hosts. Clin Infect Dis 1997;24: Kuhlman JE, Fishman EK, Siegelman SS: Invasive pulmonary aspergillosis in acute leukemia: characteristic findings on CT, the CT halo sign, and the role of CT in early diagnosis. Radiology 1985;157: Blum U, Windfuhr M, Buitrago-Tellez C, et al: Invasive pulmonary aspergillosis. MRI, CT, and plain radiographic findings and their contribution for early diagnosis. Chest 1994;106: Primack SL, Hartman TE, Lee KS, et al: Pulmonary nodules and the CT halo sign. Radiology 1994;190: Kahn FW, Jones JM, England DM: The role of bronchoalveolar lavage in the diagnosis of invasive pulmonary aspergillosis. Am J Clin Pathol 1986;86: Moreau P, Zahar JR, Milpied N, et al: Localized invasive pulmonary aspergillosis in patients with neutropenia. Effectiveness of surgical resection. Cancer 1993; 72: Robinson LA, Reed EC, Galbraith TA, et al: Pulmonary resection for invasive Aspergillus infections in immunocompromised patients. J Thorac Cardiovasc Surg 1995; 109:
Successful treatment of larynxtracheobronchial-pulmonary
Case Report Successful treatment of larynxtracheobronchial-pulmonary aspergillosis in an immunocompetent host W.X. Qu, X.W. Feng and L. Zhao The First Respiratory Department of Shengjing Hospital, China
More informationInvasive Pulmonary Aspergillosis in
Infection & Sepsis Symposium Porto, April 1-3, 2009 Invasive Pulmonary Aspergillosis in Non-Immunocompromised Patients Stijn BLOT, PhD General Internal Medicine & Infectious Diseases Ghent University Hospital,
More informationImmunocompromised patients. Immunocompromised patients. Immunocompromised patients
Value of CT in Early Pneumonia in Immunocompromised Patients Nantaka Kiranantawat, PSU Preventative Factors Phagocyts Cellular immunity Humoral immunity Predisposing Factors Infection, Stress, Poor nutrition,
More informationSurgical Therapy for Pulmonary Aspergillosis in Immunocompromised Patients
Surgical Therapy for Pulmonary Aspergillosis in Immunocompromised Patients Christopher T. Salerno, MD, David W. Ouyang, BS, Timothy S. Pederson, BA, David M. Larson, MD, Jay P. Shake, MD, Eric M. Johnson,
More informationPulmonary Aspergillosis
May 2005 Pulmonary Aspergillosis Nancy Wei, Harvard Medical School, Year III Overview Pulmonary aspergillosis background information Patient presentations Common radiographic findings for each type of
More information2046: Fungal Infection Pre-Infusion Data
2046: Fungal Infection Pre-Infusion Data Fungal infections are significant opportunistic infections affecting transplant patients. Because these infections are quite serious, it is important to collect
More informationThe prognosis of invasive pulmonary aspergillosis
Surgical Management of Invasive Pulmonary Aspergillosis in Neutropenic s Alain Bernard, MD, Denis Caillot, MD, Jean François Couaillier, MD, Olivier Casasnovas, MD, Henri Guy, MD, and Jean Pierre Favre,
More informationAspergillus species. The clinical spectrum of pulmonary aspergillosis
Pentalfa 3 maart 2016 The clinical spectrum of pulmonary aspergillosis Pascal Van Bleyenbergh, Pneumologie UZ Leuven Aspergillus species First described in 1729 * >250 species * ubiquitous Inhalation of
More informationSurgical indications: Non-malignant pulmonary diseases. Punnarerk Thongcharoen
Surgical indications: Non-malignant pulmonary diseases Punnarerk Thongcharoen Non-malignant Malignant as a pathological term: Cancer Non-malignant = not cancer Malignant as an adjective: Disposed to cause
More informationECMM Excellence Centers Quality Audit
ECMM Excellence Centers Quality Audit Person in charge: Department: Head of Department: Laboratory is accredited according to ISO 15189 (Medical Laboratories Requirements for quality and competence) Inspected
More informationHospital-acquired Pneumonia
Hospital-acquired Pneumonia Hospital-acquired pneumonia (HAP) Pneumonia that occurs at least 2 days after hospital admission. The second most common and the leading cause of death due to hospital-acquired
More informationInvasive Aspergillosis in India: Unique Challenges. Dr Rajeev Soman Consultant Physician PD Hinduja Hospital Mumbai
Invasive Aspergillosis in India: Unique Challenges Dr Rajeev Soman Consultant Physician PD Hinduja Hospital Mumbai Aspergillus Challenges Capable of surviving & thriving in all the diverse environmental
More informationIntroduction. Study of fungi called mycology.
Fungi Introduction Study of fungi called mycology. Some fungi are beneficial: ex a) Important in production of some foods, ex: cheeses, bread. b) Important in production of some antibiotics, ex: penicillin
More informationASPERGILLOSIS IN THE NON-NEUTROPENIC HOST
ASPERGILLOSIS IN THE NON-NEUTROPENIC HOST Dr J Garbino University Hospital Geneva ASPERGILLOSIS IN THE NON-NEUTROPENIC HOST INTRODUCTION SWISS ASPERGILLOSIS SURVEY IN THE NON-NEUTROPENIC HOST Introduction
More informationCase 1. Background. Presenting Symptoms. Schecter Case1 Differential Diagnosis of TB 1
TB or Not TB? Case 1 Gisela Schecter, M.D., M.P.H. California Department of Public Health Background 26 year old African American male Born and raised in Bay Area of California Convicted of cocaine trafficking
More informationLung Abscess due to Clostridium barati in a Patient with Invasive Pulmonary Aspergillosis ACCEPTED
JCM Accepts, published online ahead of print on 3 January 2008 J. Clin. Microbiol. doi:10.1128/jcm.02446-07 Copyright 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All
More informationPneumothorax: A Rare Presentation of. Pulmonary Mycetoma. Prem Parkash Gupta* Sanjay Fotedar* Dipti Agarwal** Kuldeep Saini* Sarita Magu***
Pneumothorax: A Rare Presentation of Pulmonary Mycetoma Prem Parkash Gupta* Sanjay Fotedar* Dipti Agarwal** Kuldeep Saini* Sarita Magu*** Departments of *Respiratory Medicine, **Physiology, and ***Radiodiagnosis,
More informationAntimicrobial Management of Febrile Neutropenic Sepsis
Antimicrobial Management of Febrile Neutropenic Sepsis Written by: Dr J Joseph, Consultant Haematologist Dr K Gajee, Consultant Microbiologist Amended by: Larissa Claybourn, Antimicrobial Pharmacist Date:
More informationMycological Profile of Bronchial Wash Specimens in Patients with Lower Respiratory Tract Infections
International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 11 (2017) pp. 176-182 Journal homepage: http://www.ijcmas.com Original Research Article https://doi.org/10.20546/ijcmas.2017.611.022
More informationby author The Interaction Between Influenza and Aspergillus Carolina Garcia-Vidal Infectious Diseases Department Hospital Clínic Barcelona
The Interaction Between Influenza and Aspergillus Carolina Garcia-Vidal Infectious Diseases Department Hospital Clínic Barcelona Influenza-associated aspergillosis-eccmid 2018 23 April 2018 Relationship
More informationCase Studies in Fungal Infections and Antifungal Therapy
Case Studies in Fungal Infections and Antifungal Therapy Wayne L. Gold MD, FRCPC Annual Meeting of the Canadian Society of Internal Medicine November 4, 2017 Disclosures No financial disclosures or industry
More informationReverse Halo Sign in Pulmonary Mucormyosis
QJM Advance Access published February 6, 2014 Reverse Halo Sign in Pulmonary Mucormyosis Yu-Hsiang Juan MD 1,2, Sachin S Saboo, MD FRCR 1, Yu-Ching Lin MD 2, James R. Conner MD, Ph.D 3, Francine L. Jacobson
More informationTOWARDS PRE-EMPTIVE? TRADITIONAL DIAGNOSIS. GALACTOMANNAN Sensitivity 61% Specificity 93% Neg Predict Value >95% β-d-glucan Neg Predict Value 100% PCR
TOWARDS PRE-EMPTIVE? GALACTOMANNAN Sensitivity 61% Specificity 93% Neg Predict Value >95% TRADITIONAL DIAGNOSIS β-d-glucan Neg Predict Value 100% PCR diagnostics FUNGAL BURDEN FIRST TEST POSITIVE FOR ASPERGILLOSIS
More informationOpen Forum Infectious Diseases Advance Access published February 11, 2016
Open Forum Infectious Diseases Advance Access published February 11, 2016 1 A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis Michael S. Abers 1,2, Musie
More information(CT), and pathologic findings in invasive aspergillosis of the airways. MATERIALS AND METHODS
P. Mark Logan, FFRRCSI #{149} Steven L. Primack, MD #{149} Roberta R. Miller, MD Nestor L. MUller, MD, PhD Invasive Aspergillosis ofthe Airways: Radiographic, CT, and Pathologic Findings PURPOSE: To assess
More informationDiagnostic Procedures for Pulmonary Infiltrates in the Compromised Host
Diagnostic Procedures for Pulmonary Infiltrates in the Compromised Host Michael Douvas, MD Heme/Onc Gerald Donowitz, MD - ID Eric Davis, MD - Pulmonary Disclosure Drs. Davis, Donowitz, and Douvas do not
More informationThin-Section CT Findings in 32 Immunocompromised Patients with Cytomegalovirus Pneumonia Who Do Not Have AIDS
Tomás Franquet 1,2 Kyung S. Lee 3 Nestor L. Müller 1 Received January 27, 2003; accepted after revision April 21, 2003. 1 Department of Radiology, Vancouver Hospital and Health Sciences Center and University
More informationESCMID Online Lecture Library. by author. CASE PRESENTATION ECCMID clinical grand round May Anat Stern, MD Rambam medical center Haifa, Israel
CASE PRESENTATION ECCMID clinical grand round May 2014 Anat Stern, MD Rambam medical center Haifa, Israel An 18 years old Female, from Ukraine, diagnosed with acute lymphoblastic leukemia (ALL) in 2003.
More informationDAYTON CHILDREN S HOSPITAL CLINICAL PRACTICE GUIDELINES
DAYTON CHILDREN S HOSPITAL CLINICAL PRACTICE GUIDELINES DISCLAIMER: This Clinical Practice Guideline (CPG) generally describes a recommended course of treatment for patients with the identified health
More informationAspergillosis in the critically ill patient
Aspergillosis in the critically ill patient José Artur Paiva Director of Emergency and Intensive Care Department Centro Hospitalar São João Porto Associate Professor of Medicine University of Porto Infection
More informationPneumonia. Definition of pneumonia Infection of the lung parenchyma Usually bacterial
Pneumonia Definition of pneumonia Infection of the lung parenchyma Usually bacterial Epidemiology of pneumonia Commonest infectious cause of death in the UK and USA Incidence - 5-11 per 1000 per year Worse
More informationChronic pulmonary aspergillosis diagnosis and management in resource-limited setting
Chronic pulmonary aspergillosis diagnosis and management in resource-limited setting Professor Retno Wahyuningsih Professor of Medical Mycology Department of Parasitology, Faculty of Medicine Universitas
More informationDAYTON CHILDREN S HOSPITAL CLINICAL PRACTICE GUIDELINES
DAYTON CHILDREN S HOSPITAL CLINICAL PRACTICE GUIDELINES DISCLAIMER: This Clinical Practice Guideline (CPG) generally describes a recommended course of treatment for patients with the identified health
More informationJudith A. Aberg, MD; Linda M. Mundy, MD; and William G. Powderly, MD
Pulmonary Cryptococcosis in Patients Without HIV Infection* Judith A. Aberg, MD; Linda M. Mundy, MD; and William G. Powderly, MD Purpose: To further elucidate the diagnostic and therapeutic approaches
More informationTreatment of Coccidioidomycosis-associated Eosinophilic Pneumonia with Corticosteroids
Treatment of Coccidioidomycosis-associated Eosinophilic Pneumonia with Corticosteroids Joshua Malo, MD Yuval Raz, MD Linda Snyder, MD Kenneth Knox, MD University of Arizona Medical Center Department of
More informationPulmonary Aspergillosis: Radiographic findings from immunosuppressed patient to hyperreactive host.
Pulmonary Aspergillosis: Radiographic findings from immunosuppressed patient to hyperreactive host. Poster No.: C-1442 Congress: ECR 2013 Type: Educational Exhibit Authors: C. P. Fernandez Ruiz, S. Isarria,
More informationPulmonary Aspergillosis: Radiographic findings from immunosuppressed patient to hyperreactive host.
Pulmonary Aspergillosis: Radiographic findings from immunosuppressed patient to hyperreactive host. Poster No.: C-1442 Congress: ECR 2013 Type: Educational Exhibit Authors: C. P. Fernandez Ruiz, S. Isarria,
More informationDiagnosis of Invasive Septate Mold Infections A Correlation of Microbiological Culture and Histologic or Cytologic Examination
Microbiology and Infectious Disease / DIAGNOSIS OF SEPTATE MOLD INFECTIONS Diagnosis of Invasive Septate Mold Infections A Correlation of Microbiological Culture and Histologic or Cytologic Examination
More informationHAEMATOLOGY ANTIFUNGAL POLICY
HAEMATOLOGY ANTIFUNGAL POLICY PROPHYLAXIS Primary Prophylaxis Patient Group Patients receiving intensive remissioninduction chemotherapy for Acute Leukaemia (excluding patients receiving vinca alkaloids)
More informationMANAGEMENT OF FEVER IN PEDIATRIC PATIENTS FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANTATION
MANAGEMENT OF FEVER IN PEDIATRIC PATIENTS FOLLOWING HEMATOPOIETIC STEM CELL TRANSP There are no translations available. MANAGEMENT OF FEVER IN PEDIATRIC PATIENTS FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANTATION
More informationChapter 22. Pulmonary Infections
Chapter 22 Pulmonary Infections Objectives State the incidence of pneumonia in the United States and its economic impact. Discuss the current classification scheme for pneumonia and be able to define hospital-acquired
More informationPROGRESSI NELLA TERAPIA ANTIFUNGINA. A tribute to Piero Martino
PROGRESSI NELLA TERAPIA ANTIFUNGINA A tribute to Piero Martino 1946-2007 ITALIAN ICONS IERI, OGGI, E DOMANI IERI, OGGI, E DOMANI IERI, OGGI, E DOMANI 1961 CAUSES OF DEATH IN PATIENTS WITH MALIGNANCIES
More informationIndre Vengalyte MD¹, Regina Pileckyte MD¹, Laimonas Griskevicius MD PhD 1, 2
ASPERGILLUS GALACTOMANNAN (GM) ANTIGEN IN THE BRONCHOALVEOLAR LAVAGE (BAL) FLUID FOR THE DIAGNOSIS OF INVASIVE PULMONARY ASPERGILLOSIS (IPA) IN HEMATOLOGICAL PATIENTS Indre Vengalyte MD¹, Regina Pileckyte
More informationKey Difference - Pleural Effusion vs Pneumonia
Difference Between Pleural Effusion and Pneumonia www.differencebetween.com Key Difference - Pleural Effusion vs Pneumonia Pleural effusion and pneumonia are two conditions that affect our respiratory
More informationInvasive Aspergillosis in Steroid-Treated Patients
Invasive Aspergillosis in Steroid-Treated Patients Dimitrios P. Kontoyiannis, MD, ScD Professor of Medicine Department of Infectious Diseases Infection Control and Employee Health PMN damaging Aspergillus
More informationEosinophils and effusion: a clinical conundrum
Ruth Sobala, Kevin Conroy, Hilary Tedd, Salem Elarbi kevin.peter.conroy@gmail.com Respiratory Dept, Queen Elizabeth Hospital, Gateshead, UK. Eosinophils and effusion: a clinical conundrum Case report A
More informationPULMONARY MEDICINE BOARD REVIEW. Financial Conflicts of Interest. Question #1: Question #1 (Cont.): None. Christopher H. Fanta, M.D.
PULMONARY MEDICINE BOARD REVIEW Christopher H. Fanta, M.D. Pulmonary and Critical Care Division Brigham and Women s Hospital Partners Asthma Center Harvard Medical School Financial Conflicts of Interest
More informationTop 5 papers in clinical mycology
Top 5 papers in clinical mycology Dirk Vogelaers Department of General Internal Medicine University Hospital Ghent Joint symposium BVIKM/BSIMC and SBMHA/BVMDM Influenza-associated aspergillosis in critically
More informationCommon Fungi. Catherine Diamond MD MPH
Common Fungi Catherine Diamond MD MPH Birth Month and Day & Last Four Digits of Your Cell Phone # BEFORE: http://tinyurl.com/kvfy3ts AFTER: http://tinyurl.com/lc4dzwr Clinically Common Fungi Yeast Mold
More informationUnit II Problem 2 Pathology: Pneumonia
Unit II Problem 2 Pathology: Pneumonia - Definition: pneumonia is the infection of lung parenchyma which occurs especially when normal defenses are impaired such as: Cough reflex. Damage of cilia in respiratory
More informationHistory of Aspergillus. History of Aspergillus. Biology of Aspergillus flavus Fungus Saphrophyte Haploid filamentous fungi Mycelium secrets enzymes
Anthony Fossaceca Anthony Nuzzi Swati Vasireddy History of Aspergillus Pier Antonio Micheli Italian priest and Biologist Discovered the fungi in 1729 Structure Aspergillum (holy water sprinkler) Hence
More informationDr Marie Bruyneel and Deborah Konopnicki. BVIKM/SBMIC November 8th, 2012
Dr Marie Bruyneel and Deborah Konopnicki BVIKM/SBMIC November 8th, 2012 Men, 54 years Emergency room on end october 2009 Sent by his family doctor for Influenza A H1N1? Viral syndrom, cough, fever 39 (7j)
More informationEosinophilic lung diseases - what the radiologist needs to know
Eosinophilic lung diseases - what the radiologist needs to know Poster No.: C-0803 Congress: ECR 2014 Type: Authors: Keywords: DOI: Educational Exhibit E.-M. Heursen, R. Reina Cubero, F. Japon Sola; Cádiz/ES
More informationPNEUMONIA IN A PRESUMED IMMUNOCOMPETENT PATIENT
Dr Marie Bruyneel and Deborah Konopnicki BVIKM/SBMIC November 8th, 2012 PNEUMONIA IN A PRESUMED IMMUNOCOMPETENT PATIENT Men, 54 years Emergency room on end october 2009 Sent by his family doctor for Influenza
More informationAtlas of the Vasculitic Syndromes
CHAPTER e40 Atlas of the Vasculitic Syndromes Carol A. Langford Anthony S. Fauci Diagnosis of the vasculitic syndromes is usually based upon characteristic histologic or arteriographic findings in a patient
More informationPleural effusion as an initial manifestation in a patient with primary pulmonary monoclonal B-cell lymphocyte proliferative disease
Du et al. Respiratory Research (2018) 19:247 https://doi.org/10.1186/s12931-018-0941-6 LETTER TO THE EDITOR Pleural effusion as an initial manifestation in a patient with primary pulmonary monoclonal B-cell
More informationMethods ROLE OF OPEN LUNG BIOPSY IN PATIENTS WITH DIFFUSE LUNG INFILTRATES AND ACUTE RESPIRATORY FAILURE
ROLE OF OPEN LUNG BIOPSY IN PATIENTS WITH DIFFUSE LUNG INFILTRATES AND ACUTE RESPIRATORY FAILURE Li-Hui Soh, Chih-Feng Chian, Wen-Lin Su, Horng-Chin Yan, Wann-Cherng Perng, and Chin-Pyng Wu Background
More informationComplications after HSCT. ICU Fellowship Training Radboudumc
Complications after HSCT ICU Fellowship Training Radboudumc Type of HSCT HSCT Improved outcome due to better HLA matching, conditioning regimens, post transplant supportive care Over one-third have pulmonary
More informationTitle: Author: Speciality / Division: Directorate:
Antifungal guidelines for CANDIDIASIS INFECTIONS (Adults) Proven infection: Targeted antifungal therapy should be prescribed for: o Positive cultures from a sterile site with clinical or radiological abnormality
More informationTuberculosis - clinical forms. Dr. A.Torossian,, M.D., Ph. D. Department of Respiratory Diseases
Tuberculosis - clinical forms Dr. A.Torossian,, M.D., Ph. D. Department of Respiratory Diseases 1 TB DISEASE Primary Post-primary (Secondary) Common primary forms Primary complex Tuberculosis of the intrathoracic
More informationMarc Bazot, MD; Jacques Cadranel, MD; Sylvie Benayoun, MD; Marc Tassart, MD; Jean Michel Bigot, MD; and Marie France Carette, MD
Primary Pulmonary AIDS-Related Lymphoma* Radiographic and CT Findings Marc Bazot, MD; Jacques Cadranel, MD; Sylvie Benayoun, MD; Marc Tassart, MD; Jean Michel Bigot, MD; and Marie France Carette, MD Study
More informationWHICH ANTIFUNGAL AGENT IS THE CHOICE FOR SUSPECTED FUNGAL INFECTIONS?
WHICH ANTIFUNGAL AGENT IS THE CHOICE FOR SUSPECTED FUNGAL INFECTIONS? Assoc. Prof. Dr. Serkan SENER Acibadem University Medical School Department of Emergency Medicine, Istanbul Acibadem Ankara Hospital,
More informationCombination Antifungal Therapy for Invasive Pulmonary Aspergillosis in a Heart Transplant Recipient
case report Combination Antifungal Therapy for Invasive Pulmonary Aspergillosis in a Heart Transplant Recipient Andres Beiras-Fernandez, 1 * Amir K. Bigdeli, 1 * Thomas Nickel, 2 Sebastian Michel, 1 Peter
More information4/17/2010 C ini n ca c l a Ev E a v l a ua u t a ion o n of o ILD U dat a e t e i n I LDs
Update in ILDs Diagnosis 101: Clinical Evaluation April 17, 2010 Jay H. Ryu, MD Mayo Clinic, Rochester MN Clinical Evaluation of ILD Outline General aspects of ILDs Classification of ILDs Clinical evaluation
More informationCase Report Rapid Progression of Pulmonary Blastomycosis in an Untreated Patient of Chronic Lymphocytic Leukemia
Case Reports in Medicine, Article ID 514382, 5 pages http://dx.doi.org/10.1155/2014/514382 Case Report Rapid Progression of Pulmonary Blastomycosis in an Untreated Patient of Chronic Lymphocytic Leukemia
More informationPneumocystis. Pneumocystis BIOL Summer Introduction. Mycology. Introduction (cont.) Introduction (cont.)
Introduction Pneumocystis Disclaimer: This lecture slide presentation is intended solely for educational purposes. Many of the images contained herein are the property of the original owner, as indicated
More informationEMERGING FUNGAL INFECTIONS IN IMMUNOCOMPROMISED PATIENTS
EMERGING FUNGAL INFECTIONS IN IMMUNOCOMPROMISED PATIENTS DR LOW CHIAN YONG MBBS, MRCP(UK), MMed(Int Med), FAMS Consultant, Dept of Infectious Diseases, SGH Introduction The incidence of invasive fungal
More informationIs pre-emptive therapy a realistic approach?
Is pre-emptive therapy a realistic approach? J Peter Donnelly PhD, FRCPath Department of Haematology Radboud University Nijmegen Medical Centre Nijmegen, The Netherlands Is pre-emptive therapy a realistic
More informationResearch priorities in medical mycology
Research priorities in medical mycology David W. Denning National Aspergillosis Centre University Hospital of South Manchester The University of Manchester Agenda How many patients are there with serious
More informationInteresting cases in fungal asthma
Interesting cases in fungal asthma Ritesh Agarwal MD, DM Professor of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Chandigarh, India Fungal asthma Broadly defined as the
More informationTherapeutic management. complicated by invasive aspergillosis.
Therapeutic management in a boy with XL-CGD complicated by invasive aspergillosis. Department of Immunology Children s Memorial Health Institute Warsaw POLAND Maja Klaudel-Dreszler & Magdalena Kurenko-Deptuch
More informationProphylaxis versus Diagnostics-driven approaches to treatment of Invasive fungal diseases. Y.L. Kwong Department of Medicine University of Hong Kong
Prophylaxis versus Diagnostics-driven approaches to treatment of Invasive fungal diseases Y.L. Kwong Department of Medicine University of Hong Kong Pathogenic yeast Candida Cryptococcus Trichosporon Pathogenic
More informationP has been described in patients with underlying
SUCCESSFUL CONTROL OF SYSTEMIC ASPERGILLUS NIGER INFECTIONS IN TWO PATIENTS WITH ACUTE LEUKEMIA FELIPE G. GERCOVICH, MD,* STEPHEN P. RICHMAN, MD,+ VICTORIO RODRIGUEZ, MARIO LUNA, MD,~ KENNETH B. MCCREDIE,
More informationPneumonia in immunosuppressed patients
Blackwell Science, LtdOxford, UKRESRespirology1323-77992004 Blackwell Science Asia Pty LtdMarch 20049S1S25S29Original ArticlePneumonia in immunosuppressed patientss Kohno et al. Respirology (2004) 9, S25
More informationARDS during Neutropenia. D Mokart DAR IPC GRRRRROH 2010
ARDS during Neutropenia D Mokart DAR IPC GRRRRROH 2010 Definitions Neutropenia is a decrease in circulating neutrophil white cells in the peripheral blood. neutrophil count of 1,000 1,500 cells/ml = mild
More informationPathology of Pneumonia
Pathology of Pneumonia Dr. Atif Ali Bashir Assistant Professor of Pathology College of Medicine Majma ah University Introduction: 5000 sq meters of area.! (olympic track) Filters >10,000 L of air / day!
More informationExcavated pulmonary nodule: steps to diagnosis?
Excavated pulmonary nodule: steps to diagnosis? Poster No.: C-1044 Congress: ECR 2014 Type: Authors: Keywords: DOI: Educational Exhibit W. Mnari, M. MAATOUK, A. Zrig, B. Hmida, M. GOLLI; Monastir/ TN Metastases,
More informationMANAGEMENT OF HOSPITAL-ACQUIRED FUNGAL INFECTIONS
MANAGEMENT OF HOSPITAL-ACQUIRED FUNGAL INFECTIONS Paul D. Holtom, MD Associate Professor of Medicine and Orthopaedics USC Keck School of Medicine Numbers of Cases of Sepsis in the United States, According
More informationEun-Young Kang, M.D., Jae Wook Lee, M.D., Ji Yung Choo, M.D., Hwan Seok Yong, M.D., Ki Yeol Lee, M.D., Yu-Whan Oh, M.D.
Eun-Young Kang, M.D., Jae Wook Lee, M.D., Ji Yung Choo, M.D., Hwan Seok Yong, M.D., Ki Yeol Lee, M.D., Yu-Whan Oh, M.D. Department of Radiology, Korea University Guro Hospital, College of Medicine, Korea
More informationThe Egyptian Journal of Hospital Medicine (July 2017) Vol.68 (2), Page
The Egyptian Journal of Hospital Medicine (July 2017) Vol.68 (2), Page 1135-1140 Role of High Resolution Computed Tomography in Diagnosis of Interstitial Lung Diseases in Patients with Collagen Diseases
More informationOSTEOMYELITIS. If it occurs in adults, then the axial skeleton is the usual site.
OSTEOMYELITIS Introduction Osteomyelitis is an acute or chronic inflammatory process of the bone and its structures secondary to infection with pyogenic organisms. Pathophysiology Osteomyelitis may be
More information11/19/2012. The spectrum of pulmonary diseases in HIV-infected persons is broad.
The spectrum of pulmonary diseases in HIV-infected persons is broad. HIV-associated Opportunistic infections Neoplasms Miscellaneous conditions Non HIV-associated Antiretroviral therapy (ART)-associated
More informationHistoplasma, Coccidioides, Aspergillus, Other Systemic Fungal Pathogens And Paragonimus westermani
Histoplasma, Coccidioides, Aspergillus, Other Systemic Fungal Pathogens And Paragonimus westermani Dr. Sameer Naji, MB, BCh, PhD (UK) Dept. of Basic Medical Sciences Faculty of Medicine The Hashemite University
More informationCondition First line Alternative Comments Candidemia Nonneutropenic adults
Recommendations for the treatment of candidiasis. Clinical Practice Guidelines for the Management of Candidiasis: 2009 Update by the Infectious Diseases Society of America. Condition First line Alternative
More informationComputed Tomography (CT) Scan Features of Pulmonary Drug-Resistant Tuberculosis in Non-HIV-Infected Patients
Cronicon OPEN ACCESS EC BACTERIOLOGY AND VIROLOGY Research Article Computed Tomography (CT) Scan Features of Pulmonary Drug-Resistant Tuberculosis in Non-HIV-Infected Patients Ehsan Shahverdi 1 *, Ashkan
More informationPekka Riikonen. Introduction
Recombinant Human Granulocyte-Macrophage Colony-S timulating Factor in Combination with Antibiotics in the Treatment of Febrile Neutropenia in Children Pekka Riikonen Kuopio University Hospital, Division
More informationSeptember 2014 Imaging Case of the Month. Michael B. Gotway, MD. Department of Radiology Mayo Clinic Arizona Scottsdale, AZ
September 2014 Imaging Case of the Month Michael B. Gotway, MD Department of Radiology Mayo Clinic Arizona Scottsdale, AZ Clinical History: A 57-year-old non-smoking woman presented to her physician as
More informationClinical Management of Pulmonary Aspergillosis
Review Article Clinical Management of Pulmonary Aspergillosis JMAJ 48(12): 601 606, 2005 Tsunehiro Ando,* 1,2 Kazutoshi Shibuya* 2 Abstract Pulmonary aspergillosis is deep seated mycosis that occurs as
More informationLUNG FUNGUS PRESENTED WITH NODULES- A CASE REPORT
LUNG FUNGUS PRESENTED WITH NODULES- A CASE REPORT Dr Ujwal Thakur 1, Prof. Dr Huang Jinbai 2 and Prof. Dr Ren Boxu 3 1Department of radiology, the first affiliated Hospital of Yangtze University, Jingzhou,
More informationEosinophilic lung diseases
Eosinophilic lung diseases Chai Gin Tsen Department of Respiratory and Critical Care Medicine Tan Tock Seng Hospital The eyes do not see what the mind does not know Not very common A high index of suspicion
More informationDepartment of Pediatric Hematology/Oncology, University Children s Hospital Tübingen, Hoppe-Seyler-Strß 1, Tübingen, Germany 2
Case Reports in Transplantation Volume 2012, Article ID 672923, 4 pages doi:10.1155/2012/672923 Case Report Eradication of Pulmonary Aspergillosis in an Adolescent Patient Undergoing Three Allogeneic Stem
More informationDifferential diagnosis
Differential diagnosis Idiopathic pulmonary fibrosis (IPF) is part of a large family of idiopathic interstitial pneumonias (IIP), one of four subgroups of interstitial lung disease (ILD). Differential
More informationDepartment of Anaesthesiology and Pain Medicine, Seonam University College of Medicine, Namwon, Korea
Case Report pissn 1738-2637 http://dx.doi.org/10.3348/jksr.2013.68.6.473 Rapid Progression of Metastatic Pulmonary Calcification and Alveolar Hemorrhage in a Patient with Chronic Renal Failure and Primary
More informationPatients with hematologic malignant diseases necessitating
AGGRESSIVE SURGICAL MANAGEMENT IN LOCALIZED PULMONARY MYCOTIC AND NONMYCOTIC INFECTIONS FOR NEUTROPENIC PATIENTS WITH ACUTE LEUKEMIA: REPORT OF EIGHTEEN CASES O. Baron, MD a B. Guillaumé, MD b P. Moreau,
More informationLung Cancer - Suspected
Lung Cancer - Suspected Shared Decision Making Lung Cancer: http://www.enhertsccg.nhs.uk/ Patient presents with abnormal CXR Lung cancer - clinical presentation History and Examination Incidental finding
More informationMedical Mycology Case Reports
Medical Mycology Case Reports 1 (2012) 107 111 Contents lists available at SciVerse ScienceDirect Medical Mycology Case Reports journal homepage: www.elsevier.com/locate/mmcr Granulomatous invasive fungal
More informationInflammation class 2. Inflammation part 2. Rheumatic fever RF. Rheumatic fever - pathogenesis. Hypersensitivity reactions. Rheumatic fever RF
Inflammation class 2 Inflammation part 2 Rheumatic endocarditis Pneumocystis carinii pneumonia Cytomegalic pneumonia Aspergillosis Actinomycosis Rheumatic fever RF An acute, immunologically mediated multisystem
More informationAspergillus is a ubiquitous fungus belonging. case report
Invasive pulmonary aspergillosis presenting as thoracic mass causing obstruction of the superior and inferior vena cava in an immunocompetent patient: a diagnostic dilemma Moti lal Bunkar, a Rajendra Prasad
More informationLethal pulmonary fungal disease think fungus early
Lethal pulmonary fungal disease think fungus early David W. Denning National Aspergillosis Centre University Hospital of South Manchester The University of Manchester Global Action Fund for Fungal Infections
More information