Cancer in North America: Volume One: Combined Cancer Incidence for the United States, Canada, and North America

Transcription

1 Cancer in North America: Volume One: Combined Cancer Incidence for the United States, Canada, and North America Seattle / Puget Sound Greater Bay Area Metro Detroit Washington D.C. Los Angeles Metro Atlanta North American Association of Central Cancer Registries, Inc.

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3 EXECUTIVE SUMMARY Members of the North American Association of Central Cancer Registries, Inc. (NAACCR) participate voluntarily in an annual call for data to develop a multi-registry, aggregated data resource for cancer surveillance and research. In June 2012, NAACCR released the three volume monograph, Cancer in North America (CINA): This release of cancer incidence statistics for the United States is the 22nd publication in the series and the 20 th release that includes statistics for both Canada and the United States. The monograph is organized into three volumes. Volume One presents the aggregated cancer incidence data representing North America including data from the high quality registries in the United States and Canada. The cancer incidence statistics for the Canadian and United States populations are provided. The combined United States data are presented by race and for Hispanic/Latino ethnicity. Age-adjusted rates using the world population standard are provided, as well, to enable international comparisons. Volume One also includes combined pediatric cancer data. Volume Two describes the registry-specific cancer incidence rates by cancer site, sex, race, and ethnicity for all NAACCR members in good standing that submit data and elect to be included in the monograph. Volume Three presents the registry-specific cancer death rates by cancer site, sex, race, and ethnicity. Volumes One through Three, along with population data, supporting appendices, and cancer rates age-adjusted to the US, Canadian and World population standards are available free of charge from the NAACCR website. This is the second year that the publication provides cancer incidence data for all 50 states, Washington DC, Puerto Rico, all 5 SEER urban registries, and all 13 Canadian registries. A new feature of this edition is the inclusion of data on benign tumors of the brain and central nervous system, which became reportable conditions for most member registries in Note that this publication utilizes population estimates that are not based upon the 2010 census as these data will not be available until sometime after this release. Note also that Volume Three, on cancer mortality includes mortality data only for the United States. For Canadian cancer mortality in 2004 through 2008, please refer to the 2011 CINA publication. A revised CINA publication will be released in the summer of 2012 that will incorporate 2010 census based population figures and will include Canadian cancer mortality data for the years This revision is planned to assure the most timely and accurate cancer incidence and mortality rates possible. In addition to publication of cancer statistics for the most recent five-year period, the CINA data resource is used to create CINA+ Online database and NAACCR FastStats (graphic and tables by cancer sites, race/sex, race/ethnicity, age at diagnosis, sex, registry, and data type) for public queries regarding cancer incidence for the most recent five years. The CINA data is also used to develop a discretionary research data set (CINA Deluxe), including data from 1995 to 2009, to facilitate analytic studies conducted by epidemiologists and other qualified researchers. The data within this report are also available as an electronic reproduction of all cancer statistics reported in the CINA monograph for use in SAS analytic software and a discretionary data set of the data in CINA+ Online (named CINA Plus in SEER*Stat) in SEER*Stat software for approved uses by NAACCR members. These preeminent cancer data resources are unparalleled in geographic scope, timeliness of statistics, and assurance of standardization of information and data quality across all contributors, with standard data quality metrics reported for all contributors. We hope that Cancer in North America: , with the companion CINA products and resources, facilitate studies of cancer burden, so that we are better able to identify and understand appropriate and important measures to control the myriad diseases within the cancer rubric. The cancer surveillance infrastructure in the U.S. and Canada has been orchestrated to meet these objectives. We gratefully acknowledge the voluntary cooperation and recognize the commitment of all member registries to the achievement of high quality standardized cancer incidence data so that aggregation of information from all states, provinces, territories, and regions in North America is practical and provides meaningful information on our regions and countries. The Editors June 2012 EXECUTIVE SUMMARY i

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5 CANCER IN NORTH AMERICA: VOLUME ONE: COMBINED CANCER INCIDENCE FOR THE UNITED STATES, CANADA AND NORTH AMERICA A Publication of the North American Association of Central Cancer Registries, Inc. (NAACCR) Editors: Glenn Copeland, Michigan Cancer Surveillance Program Andrew Lake, Information Management Services, Inc. Rick Firth, Information Management Services, Inc. Brad Wohler, Florida Cancer Data System Xiao-Cheng Wu, Louisiana Tumor Registry Antoinette Stroup, Utah Cancer Registry Carol Russell, Alberta Cancer Registry Kimberley Boyuk, Statistics Canada Maria J. Schymura, New York State Cancer Registry Jim Hofferkamp, NAACCR, Inc. Betsy Kohler, NAACCR, Inc. June 2012 The Editorial Subcommittee of the NAACCR Standing Committee, Data Use and Research Committee publishes this monograph. We are grateful to the National Cancer Institute, National Institutes of Health (NCI/NIH) for providing support for the production under Contract No. HHSN C/ADB Contract No. PC We acknowledge partial support of NAACCR staff by cooperative agreement U75/CCU from the Centers for Disease Control and Prevention (CDC) and by the NCI/NIH Contract No. HHSN C/ADB Contract No. PC Its contents are solely the responsibility of the editors and do not necessarily represent the official view of CDC. iii

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7 CINA PARTICIPANTS Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries SUGGESTED CITATION: Copeland G, Lake A, Firth R, Wohler B,Wu XC, Stroup A, Russell C, Boyuk K, Schymura M, Hofferkamp J, Kohler B (eds). Cancer in North America: Volume One: Combined Cancer Incidence for the United States, Canada and North America. Springfield, IL: North American Association of Central Cancer Registries, Inc. June v

8 TABLE OF CONTENTS SECTION I: Introduction and Technical Notes... I-1 SECTION II: Top Five Most Commonly Diagnosed Cancers in the North America Top Five Most Commonly Diagnosed Cancers in the North America...II-1 Top Five Most Commonly Diagnosed Cancers in the U.S. by Race/Ethnicity Males...II-2 Females...II-3 SECTION III: Average-annual Age-adjusted NAACCR Combined Cancer Incidence Rates for the United States, Canada and North America Data Quality Indicators for the United States... III-1 Map: Registries included in U.S. Combined Incidence for All Races... III-3 Combined Registries, All Races (2000 U.S. and 1996 Canadian populations)... III-4 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, All Races, Males (2000 U.S. population)... III-5 All Races, Males (1996 Canadian population)... III-7 All Races, Females (2000 U.S. population)... III-9 All Races, Females (1996 Canadian population)... III-11 Map: Registries included in U.S. Combined Incidence for White... III-13 Combined Registries, White (2000 U.S. and 1996 Canadian populations)... III-14 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, White, Males (2000 U.S. population)... III-15 White, Males (1996 Canadian population)... III-17 White, Females (2000 U.S. population)... III-19 White, Females (1996 Canadian population)... III-21 Map: Registries included in U.S. Combined Incidence for Black... III-23 Combined Registries, Black (2000 U.S. and 1996 Canadian populations)... III-24 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, Black, Males (2000 U.S. population)... III-25 Black, Males (1996 Canadian population)... III-27 Black, Females (2000 U.S. population)... III-29 Black, Females (1996 Canadian population)... III-31 Map: Registries included in U.S. Combined Incidence for Asian/Pacific Islander... III-33 Combined Registries, Asian/Pacific Islander (2000 U.S. and 1996 Canadian populations)... III-34 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, Asian/Pacific Islander, Males (2000 U.S. population)... III-35 Asian/Pacific Islander, Males (1996 Canadian population)... III-37 Asian/Pacific Islander, Females (2000 U.S. population)... III-39 Asian/Pacific Islander, Females (1996 Canadian population)... III-41 Map: Selected CHSDA Counties included in U.S. Combined Incidence for American Indian/Alaskan Native... III-43 Combined Registries, American Indian/Alaskan Native (2000 U.S. and 1996 Canadian populations)... III-44 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, American Indian/Alaskan Native, Males (2000 U.S. population)... III-45 American Indian/Alaskan Native, Males (1996 Canadian population)... III-47 American Indian/Alaskan Native, Females (2000 U.S. population)... III-49 American Indian/Alaskan Native, Females (1996 Canadian population)... III-51 Most Frequent Cancer Sites by IHS Region, American Indian/Alaskan Native, Males (2000 U.S. population)... III-53 American Indian/Alaskan Native, Females (2000 U.S. population)... III-55 Map: Registries included in U.S. Combined Incidence for Hispanic/Latino, All Races... III-57 Combined Registries, Hispanic/Latino, All Races (2000 U.S. and 1996 Canadian populations)... III-58 Ten Most Commonly Diagnosed Cancers, Incidence Rates by Registry, Hispanic/Latino, All Races, Males (2000 U.S. population)... III-59 Hispanic/Latina, All Races, Females (2000 U.S. population)... III-63 vi TABLE OF CONTENTS

9 Contents Map: Registries included in U.S. Combined Incidence for Non-Hispanic White...III-67 Combined Registries, Non-Hispanic White (2000 U.S. and 1996 Canadian populations)...iii-68 Ten Most Commonly Diagnosed Cancers, Incidence Rates by Registry, Non-Hispanic White, Males (2000 U.S. population)...iii-69 Non-Hispanic White, Females (2000 U.S. population)...iii-73 Map: Registries included in U.S. Combined Incidence for Non-Hispanic Black...III-77 Combined Registries, Non-Hispanic Black (2000 U.S. and 1996 Canadian populations)...iii-78 Ten Most Commonly Diagnosed Cancers, Incidence Rates by Registry, Non-Hispanic Black, Males (2000 U.S. population)...iii-79 Non-Hispanic Black, Females (2000 U.S. population)...iii-83 Data Quality Indicators for Canada...III-88 Map: Registries included in Canadian Combined Incidence for All Races...III-89 Combined Registries, All Races (2000 U.S. and 1996 Canadian populations)...iii-90 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, All Races, Males (2000 U.S. and 1996 Canadian populations)...iii-91 All Races, Females (2000 U.S. and 1996 Canadian populations)...iii-92 Data Quality Indicators for North America...III-94 Map: Registries included in North America Combined Incidence for All Races...III-95 Combined Registries, All Races (2000 U.S. and 1996 Canadian populations)...iii-96 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, All Races, Males (2000 U.S. population)...iii-97 All Races, Males (1996 Canadian population)...iii-99 All Races, Females (2000 U.S. population)...iii-101 All Races, Females (1996 Canadian population)...iii-103 Map: Registries included in U.S. Pediatric Cancer Incidence...III-106 Age-specific Rates for the United States All Races, Males...III-107 All Races, Females...III-108 White, Males...III-109 White, Females...III-110 Black, Males...III-111 Black, Females...III-112 Asian/Pacific Islander, Males...III-113 Asian/Pacific Islander, Females...III-114 American Indian/Alaskan Native, Males...III-115 American Indian/Alaskan Native, Females...III-116 Hispanic/Latino, All Races, Males...III-117 Hispanic/Latina, All Races, Females...III-118 Non-Hispanic White, Males... III-119 Non-Hispanic White, Females...III-120 Non-Hispanic Black, Males...III-121 Non-Hispanic Black, Females...III-122 Age-adjusted Rates (2000 U.S. and 1996 Canadian population) (Ages 0-14, Ages 0-19) All Races, Males...III-123 All Races, Females...III-124 White, Males...III-125 White, Females...III-126 Black, Males...III-127 Black, Females...III-128 Asian/Pacific Islander, Males...III-129 Asian/Pacific Islander, Females...III-130 American Indian/Alaskan Native, Males...III-131 American Indian/Alaskan Native, Females...III-132 Hispanic/Latino, All Races, Males...III-133 Hispanic/Latina, All Races, Females...III-134 Non-Hispanic White, Males...III-135 Non-Hispanic White, Females...III-136 Non-Hispanic Black, Males...III-137 Non-Hispanic Black, Females...III-138 Map: Registries included in Canadian Pediatric Cancer Incidence...III-140 Age-specific Rates for Canada All Races, Males...III-141 All Races, Females...III-142 TABLE OF CONTENTS vii

10 Contents Age-adjusted Rates (2000 U.S. and 1996 Canadian population) (Ages 0-14, Ages 0-19) All Races, Males... III-143 All Races, Females... III-144 Map: Registries included in North American Pediatric Cancer Incidence... III-146 Age-specific Rates for North America All Races, Males... III-147 All Races, Females... III-148 Age-adjusted Rates (2000 U.S. and 1996 Canadian population) (Ages 0-14, Ages 0-19) All Races, Males... III-149 All Races, Females... III-150 All Appendices are available on the NAACCR website: viii TABLE OF CONTENTS

11 Section I Introduction and Technical Notes Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries

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13 CANCER IN NORTH AMERICA: INTRODUCTION The North American Association of Central Cancer Registries, Inc. (NAACCR) is a professional organization that develops and promotes uniform data standards for cancer registration; provides education and training; certifies population based registries; aggregates and publishes data from central cancer registries; and promotes the use of cancer surveillance data and systems for cancer control and epidemiologic research, public health programs, and patient care to reduce the burden of cancer in North America. NAACCR annually produces this statistical monograph on cancer in North America to provide cancer incidence and mortality statistics for the United States and Canada. This year marks the 22nd annual release of the series of Cancer in North America (CINA) monographs. The 2012 monograph includes data from 70 central population-based registries: 57 from the United States (50 states, the District of Columbia, Puerto Rico and 5 metropolitan areas) and 13 from Canada (10 provinces and 3 territories). The submitted data reflect 100% population coverage of Canada and the United States. Combined, five-year average annual incidence statistics for the United States, for Canada and for North America created from registries that met or exceeded the NAACCR standards of fitness for use in aggregated incidence data for all years, The combined statistics presented in Volume One reflect 93% of the U.S. population (47 states). Volume One includes statistics from the 8 Canadian registries that met the CINA inclusion requirements, reflecting 38% of the Canadian population. This year Volume One presents the combined U.S. and Canadian statistics for cancer incidence rates across North America. This monograph would not be possible without the commitment by population-based cancer registries throughout the United States and Canada to collect timely, complete, and accurate data. The NAACCR standing committee, Data Use and Research (DURC), is charged with the annual call for data from member registries to create the CINA monograph and other useful CINA products for data analyses and cancer incidence information (e.g., CINA+ Online, NAACCR FastStats, CINA in SEER*Stat, CINA Plus in SEER*Stat, CINA Monograph data in SAS Data set and CINA Deluxe). An Editorial Board of member volunteers, with support from NAACCR staff and staff from Information Management Services, takes on the responsibility to oversee the call for data, evaluate all submissions, and make all editorial decisions and activities in production of the monograph. Our efforts are to provide timely and useful information on cancer incidence and mortality for all geographic areas and race/ethnic groups in the United States and Canada. The publication includes U.S. cancer incidence and mortality for white, black, Hispanic/Latino and Asian/Pacific Islander as combined and registry specific rates and American Indian and Alaskan Native populations presented for U.S. counties located in Indian Health Service Contract Health Service Delivery Areas (CHSDA) of the United States (excepting only for Kansas). This year we are pleased to provide, for the first time, registry specific statistics and combined data for benign tumors of the brain and central nervous system. CONTENTS OF THE CINA MONOGRAPH The CINA monograph is comprised of three volumes as described below. Rates are presented as averageannual, age-adjusted rates using three different standard million populations: the 2000 U.S., the 1996 Canadian, and the World standard populations. We believe that presenting cancer rates adjusted to all three standards enhances the meaning and utility of the rates for users in the United States, Canada, and international settings. All volumes of the CINA publication, including sections containing incidence rates standardized to the World Standard, and the population counts used in the calculation of cancer rates are available for download on the NAACCR website, Note that U.S. population data reflecting 2010 U.S. census figures were not available at publication. A revised CINA monograph for 2012 will be released in the summer of 2012 that will present statistics based on 2012 population figures and will also include Canadian mortality data for which was not available at publication. INTRODUCTION AND TECHNICAL NOTES I-1

14 Volume One, Combined Cancer Incidence for the United States, Canada, and North America presents cancer incidence data that have been combined to create five-year, average-annual data for cancers occurring in all persons and for children, aged 0 to 14, and 0 to 19. Registries submitting the data must meet the NAACCR criteria of high quality incidence data that are fit for use at the time of data submission. The criteria for the standard are described in detail below in the Data Quality Indicator section. In the United States, cancer counts and incidence rates are presented for all races combined, black, white Asian/Pacific Islander, American Indian/Alaskan Native populations and for Hispanic/Latino, non-hispanic white, non-hispanic black. Also, due to the large migration of both cancer patients and populations from Louisiana into Texas, Alabama, and Mississippi in the aftermath of Hurricane Katrina in September 2005, and some hospital closures and loss of many patient records in affected areas, data for the four states (Alabama, Louisiana, Mississippi and Texas) are presented in 4.5 years, from January through June 2005 and all of 2006 through 2009 to avoid miscalculation of cancer rates due to the impact of these unavoidable events on the accuracy of the cancer rates. Volume One is comprised of two major sections: section two includes the five most common types of cancer by sex, race and ethnicity, based on the combined United States data by race and ethnicity. Section three provides cancer incidence rates for the United States, Canada and North America. The rates for the United States are presented for all races combined, white, black, Asian or Pacific Islander, American Indian/Alaska Native, Hispanic, non-hispanic white and non-hispanic black populations for all ages. The rates for Canada and North America are presented for all races and for all ages. Also included in section three are tables of cancer rates for children, aged 0-14 and 0-19 for the United States, Canada and North America. As with the tables for all ages, the pediatric tables are presented by race and ethnicity for the United States and for all races combined for Canada and North America. Volume Two, Registry-specific Cancer Incidence in the United States and Canada presents cancer incidence data for NAACCR-member, population-based central cancer registries in Canada and the United States that have agreed to participate in the CINA monograph. For most cancer registries, five-year averages of data are presented for the years 2005 to If all five years of data were not available, an average of all available years is presented. Finally, due to the large migration of both cancer patients and populations from Louisiana into Texas, Alabama, and Mississippi in the aftermath of Hurricane Katrina in September 2005, and some hospital closures and loss of many patient records in affected areas, data for these four states are presented in 4.5 years, from January through June 2005 and all of 2006 through 2009 to avoid miscalculation of cancer rates due to the impact of these unavoidable events on the accuracy of the cancer rates. Each set of data tables includes demographic and data quality information and registry descriptions to help interpret the statistics reported. In the United States, cancer incidence rates are calculated for the following race/ethnic populations: all races combined, white, black, Asian or Pacific Islander, American Indian/Alaskan Native for CHSDA counties, Hispanic/Latino (all races), non-hispanic white, and non-hispanic black. Race and ethnicity information is not collected in Canada, and thus is not presented here. Volume Three, Registry-specific Cancer Mortality in the United States and Canada presents cancer mortality data for fifty states, the District of Columbia, five SEER metropolitan areas, Puerto Rico, ten Canadian provinces and three Canadian territories. The United States combined mortality data are presented as well. Unlike the incidence statistics, mortality statistics from Louisiana into Texas, Alabama and Mississippi are presented for the full five-year period, 2005 to Canadian cancer mortality for the years 2005 through 2009 was not available at publication. Please refer to the CINA 2011 publication for these data. A revised CINA 2012 publication will be released in the summer of 2012 that is planned to include Canadian mortality data for SOURCES OF DATA Cancer Incidence. A cancer registry must be population-based and a NAACCR member in good standing to be included in NAACCR data publications. All cancer registries in the United States and Canada are NAACCR members, including the three territories in Canada and three U.S. territories. An annual request is sent to all I-2 INTRODUCTION AND TECHNICAL NOTES

15 members to submit voluntarily a data file for use in CINA, CINA research and data information products, the U.S. Annual Report to the Nation, and the American Cancer Society s Cancer Facts and Figures annual publication. All NAACCR member registries receive support from the state, province or territory. In the U.S., they also participate in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program or the Centers for Disease Control and Prevention's National Program of Cancer Registries (NPCR) or both. In Canada, all registries submit data to the Canadian Cancer Registry maintained by Statistics Canada. Mortality Data. Mortality data for 2005 to 2009 for United States registries were obtained from the National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention (CDC), as provided to the National Cancer Institute (NCI). Mortality data for Puerto Rico were provided by Puerto Rico. Canadian cancer mortality for the years 2005 through 2009 were pending release at publication. Population Estimates. To assist the reader, all population estimates by age, sex, and race/ethnicity (where relevant) used in the calculation of rates in the monograph are available for each central registry and for the United States. These are available for download from the NAACCR website at Population estimates for 2005 through 2009 for the United States, individual states, and SEER metropolitan areas were obtained from the SEER program. These estimates were based on United States Census Bureau population estimates for these years and represent a modification of the annual time series population estimates produced by the Population Estimates Program of the Census Bureau with support from the NCI. The population estimates incorporate bridged, single race estimates that are derived from the original multiple race categories in the 2000 Census. These bridged estimates are consistent with the four race groups enumerated in the 1990 Census and were produced under a collaborative arrangement between the National Center for Health Statistics (NCHS) and the Census Bureau. The methodology implemented by the Census Bureau to develop these county estimates is comparable to that used to produce national and state intercensal estimates and is described on the Census Bureau s website (National Center for Health Statistics 2003). In 2007, the U.S. Census revised their methodology for population estimation. This revision impacts all population denominators for 2005 to The main effect of this approach was on specific age groups, particularly, two of the oldest age groups, ages and 75 and older. In many states, the new method results in a larger increase in the younger age category and fewer in the older age category than estimated in previous years. Subsequently, this revision contributed to a larger decrease in age-adjusted cancer mortality rates in some states than what was expected based on statistics from last year. The NCI modifies the Census data for the population estimates for the State of Hawaii. The Epidemiology Program of the Hawaii Cancer Research Center has developed its own set of population estimates, based on sample survey data collected by the Hawaii Department of Health. This effort grew out of a concern that the native Hawaiian population had been vastly undercounted in previous censuses. The Hawaii adjustment to the Census Bureau estimates has the net result of reducing the estimated white population and increasing the Asian and Pacific Islander population for the state. The Census Bureau estimates for the total population, black population, and American Indian and Alaska Native populations in Hawaii are unaffected. Refer to the SEER Cancer Statistics Review, and its methodologies for specific documentation regarding modifications made by the NCI to the Census Bureau estimates (Horner 2009). Finally, the NCI applied an algorithm to the 2005 population estimates to account for the massive out-migration from Louisiana following Hurricane Katrina and the subsequent unprecedented in-migration into specific counties in neighboring and other states (Texas, Alabama, Mississippi, and Louisiana). However, one-half of the unadjusted annual estimates were used in the calculation of rates since the incidence data excluded cases reported from July 2005 through December 2005 for these four states. For Canada, Statistics Canada provided the estimates of the Canadian population for all Canadian provinces and territories, adjusted for census under coverage and non-permanent residents. Race and ethnicity information is not collected in Canada, and thus is not presented here. INTRODUCTION AND TECHNICAL NOTES I-3

16 CANCER SITE CODING, Incidence Data. All cancer registries use the International Classification of Diseases for Oncology, third edition (ICD-O-3) to code the anatomic site and morphology. Cancer incidence statistics include invasive cancers only, with the exception of in situ cancer of the bladder. Although tables include incidence statistics for breast cancer in situ and benign tumors of the brain and central nervous system, these cases are not included in any counts or rates of total cancer incidence. The SEER program site recode groups were used for classifying types of cancer, using anatomic site and morphology. Using this standard ontology, only squamous and basal cell carcinomas of the lip and genital organs are included in the data reported. All categories used to present pediatric cancer rates in Volume One are based on the International Classification of Childhood Cancer, third edition (ICCC-3) (Steliarova-Foucher 2005). Summary tables of all codes and site groups for incidence can be found in the electronic copy of the CINA Monograph Appendices on the NAACCR website, Mortality Data. Underlying cause of death was coded using the International Classification of Diseases (ICD). In the United States, ICD-10 was used for all deaths from 1999 and later. In Canada, ICD-9 was used through 2000, and ICD-10 was used for 2001 and later. Cancer deaths were defined as those coded through in ICD-9 and C00 through C97 in ICD-10. The SEER mortality recode scheme was used to classify cancer deaths into the groupings used in the volume (see Appendix B on the NAACCR website, Multiple Primary Determination Rules. During 2007 a significant revision was made to the decision rules followed to determine when a multiple primary cancer is present. These new rules may have an effect on the number of subsequent primaries identified with these effects varying by cancer site and type. Preliminary data suggest that overall incidence rates will vary only marginally for most cancer sites. This new rule will affect data for incidence years 2007 through 2009 within the current publication. For more information on these new rules please see Hispanic/Latino Ethnicity Identification. The ethnicity available in medical records and reported to cancer registries is enhanced by the use of the NAACCR Hispanic Identification Algorithm, version 2 (NHIAv2). NHIAv2 uses a combination of NAACCR variables including direct identification of ethnicity from the Spanish/Hispanic Origin variable (NAACCR data element 190 values 1-6), and information indirectly derived based on an evaluation of the strength of the birthplace, race, and surname (including maiden name when available) associations with Hispanic ethnicity status. After applying NHIAv2, cases not ultimately classified as Hispanic are classified as non-hispanic, leaving no cases with unknown Hispanic status. The NHIAv2 algorithm allows the user to run the program using one of three possible options: 1) All Records: Surname portion is run on 0 (non-hispanic), 7 (surname only), and 9 (unknown) for all counties. After the algorithm, item 190 codes (0, 7, 9 ) are either NHIA - Hispanic or non-hispanic. 2) Option 1: (The default) For counties with 5% or more Hispanics - as for all records option. For counties with < than 5% Hispanic, surname portion is run on 7 (surname only) and 9 (unknown). After the algorithm, item 190 codes (7, 9 ) are either NHIA - Hispanic or non-hispanic. 3) Option 2: For counties with 5% or more Hispanics - as for all records option. For counties with < than 5% Hispanic, surname portion is run on 7 (surname only). These become either NHIA - Hispanic or non-hispanic. All cases coded to 9 on item 190 are converted to NHIA - non-hispanic. A comparison of the direct and indirect categorization of Hispanic ethnicity is provided in the Appendix F available from the NAACCR Website, I-4 INTRODUCTION AND TECHNICAL NOTES

17 The NHIAv2 method is described in detail elsewhere. (NAACCR Race and Ethnicity Work Group, 2011; NAACCR Guideline for Enhancing Hispanic-Latino Identification: Revised NAACCR Hispanic/Latino Identification Algorithm [NHIA v2.2.1], Revised September 12, 2011.) [URL: Last Accessed, June 6, 2012] Asian/Pacific Islander Identification The information on Asian and Pacific Islander populations is also enhanced by submitting registries using a NAACCR developed algorithm (NAACCR, 2010). The NAACCR Asian Pacific Islander Identification Algorithm version 1 (NAPIIA v1.2.1) uses a combination of NAACCR variables to classify cases directly or indirectly as Asian/Pacific Islander for analytic purposes. It is focused on coding cases with a race code of Asian NOS (race code 96) or Pacific Islander NOS (race code 97) to a more specific Asian or Pacific Islander race category, using the birthplace and name fields (first, last, and maiden names). Birthplace can be used to indirectly assign a specific race to one of eight Asian groups (Chinese, Japanese, Vietnamese, Korean, Asian Indian, Filipino, Thai, and Cambodian) and three Pacific Islander groups (Samoan, Micronesian, and Polynesian). Names can be used to indirectly assign a specific race to one of seven Asian groups (Chinese, Japanese, Vietnamese, Korean, Asian Indian, Filipino, and Hmong) and three Pacific Islander groups (Hawaiian, Guamanian, and Samoan). The algorithm uses the following NAACCR standard variables: Race 1 through Race 5 (NAACCR Items 160 through 164), Name Last (NAACCR Item 2230), Name First (NAACCR Item 2240), Name Maiden (NAACCR Item 2390), Birthplace (NAACCR Item 250), Sex (NAACCR Item 220) Misclassification of American Indian and Alaskan Native Populations. The collection of accurate information on the cancer incidence in American Indian and Alaskan Native populations is hampered by misclassification of this population within cancer case reports. In order to address this problem, cancer registries in the United States coordinate with the Centers for Disease Control and the Bureau of Indian Affairs to link their case files to the enrollment files of the Indian Health Service (Espey, et al., 2008). This process identifies significant numbers of American Indians and Alaskan Natives that were otherwise classified within the cancer case report. The improved information on this population enables calculation of much more accurate cancer incidence rates. As presented in the incidence volumes, the data on American Indians and Alaskan natives are restricted to those counties where Indian Health Service Clinics are located, namely Contract Health Service Delivery Area (CHSDA) counties. This restriction assures that the incidence data presented is the best available data for this population. DATA QUALITY INDICATORS NAACCR assesses the quality of cancer incidence data from individual registries for a number of data quality indicators, which are described in detail below. Results for these indicators can be found in the Cancer in North America, Appendices on the NAACCR website. A dash in the tables indicates that data were not submitted for the year or were not able to be calculated. In order to be included in the NAACCR Combined rates presented in Volume One, the data had to meet the criteria for high quality incidence data. These criteria were applied to each year of data individually, except for the estimate of duplicate reports, which was calculated for the years 2005 to 2009 as a whole. _ Data for 2005 through 2009 had to be submitted to NAACCR by December 1, _ The estimate of duplicate case reports had to be less than 2 duplicate reports per 1000 cases. _ All cases had to pass the edits on variables needed to compute cancer incidence rates by site, sex, race, and tumor descriptions on the NAACCR Call for Data EDITS metafile. _ Fewer than 3% of cases had missing information for sex, county of residence at diagnosis, and age at diagnosis, and fewer than 5% of the cases had an unknown race. _ Death clearance must be completed for 2005 through 2009 mortality with the percent of all cases derived from death certificates only (DCOs) of less than 5%. _ The NAACCR method to estimate completeness of case ascertainment yielded an estimate of 90% or higher. _ All cases had to pass the inter-record edits on cases reporting multiple primary cancers, as determined by the standard Inter-record EDITS program developed for the NAACCR Call for Data submissions. INTRODUCTION AND TECHNICAL NOTES I-5

18 Duplicate Case Records. Most central cancer registries rely on multiple reporting sources for cancer case reports. At the central cancer registry, multiple reports for the same patient must then be matched and the information from all records consolidated. In addition to determining whether multiple reports refer to the same individual, central cancer registry staff must also determine whether the tumor represents a new primary tumor or a duplicate report for a tumor already recorded. Failure to eliminate duplicate cases and duplicate tumors results in over-counting cancer cases. As a part of routine cancer registry operations, a variety of tools are used to ensure accurate case linkage and case consolidation. As part of the preparation of the data submission to NAACCR, each registry uses the NAACCR protocol to determine the adequacy of case linkage and consolidation operations in identifying duplicate records. The NAACCR protocol for assessing duplicate cases can be found on the NAACCR website, Completeness of Case Ascertainment. In order to evaluate case completeness for all geographic areas included in this monograph, the NAACCR Method to Estimate Completeness is used. The method is described in detail elsewhere (Wu, et al., 2002; Howe, 2007). A data analysis tool is available on the NAACCR website, that documents and calculates sex-, race-, and sitespecific estimates based on observed incidence counts and rates, observed local cancer death rates, and a standard rate ratio of incidence to mortality. In addition, adjustments are made to the calculations to account for some variation in sex-, race- and site-specific variation in case fatality. The method assumes that the relationship between incidence rates and mortality rates are stable. However, with the recent annual decreases in cancer death rates, and the awareness that the decreases are not the same in all parts of the United States and Canada, it appears that this assumption is being challenged with a noticeable bias in an upward migration of completeness estimates for many locales. The completeness estimates provided in this publication used mortality data for the years to determine completeness in U.S. registries and for for Canadian registries. The percent completeness presented for each registry and used to determine inclusion of individual registry data in the combined rates presented in Volume One were based upon rate ratios of SEER 11 incidence rates divided by U.S. mortality rates. Missing Case Information. NAACCR has developed standards for completeness of data on key data items that are needed to produce meaningful cancer incidence statistics. These key data items include race, sex, county of residence at diagnosis, and age at diagnosis. Cases with unknown sex or age are omitted from all calculations. Cases with unknown race and county of residence were included in the cancer counts and rates for all races and/or all counties combined. Death Certificate Only Cases. The proportion of cases identified by death certificate only (DCO) is an indicator of data quality and completeness. Central cancer registries use death certificates to identify potentially missed cases and to conduct follow back on cases that have cancer on the death certificate but who are not incident cases in the registry. Cases without follow back information are considered to be DCO cases and may have incomplete or missing information, including date and stage of diagnosis. For DCO cases, the date of death is used as the date of diagnosis. Registries that did not use death certificates as a source of case ascertainment have na listed in the death certificate only row on the registry description page. Data Reliability and Accuracy. All data submitted to NAACCR are evaluated for reliability and accuracy using the EDITS program and a specific set of edits incorporated into a Call for Data Edits Metafile. An edit reviews the internal consistency between and among data elements, such as anatomic site and morphology. Cases that are identified as having errors are reviewed by registry staff and resolved prior to their NAACCR submission. The NAACCR Call for Data EDITS metafile is available on the NAACCR website. [URL Last accessed April 24, 2012]. An inter-record edits program, developed by the Centers for Disease Control and Prevention, is used to identify errors among the records reported for persons who have had multiple tumors diagnosed. For example, an inter-record edit will identify whether birthplace is the same on all reports of multiple tumors that are reported for one individual. I-6 INTRODUCTION AND TECHNICAL NOTES

19 Timeliness of Data. The NAACCR standard defines timely data as data that are available for use in incidence statistics within 23 months of the close of a diagnostic year (i.e., December 1, 2011 for all cases diagnosed in 2009). Site-Specific Microscopic Confirmation. This criterion is not used by NAACCR to determine high quality for the purposes of this publication. However, it is a useful indicator of quality of data collection. A proportion of microscopically confirmed cases that is higher or lower may suggest problems in case ascertainment or abstracting. However, this proportion varies by cancer site. For sites that are more likely to rely on a clinical or radiological diagnosis, e.g., cancers of the pancreas and brain, confirmation rates that are too high may suggest that some clinically diagnosed cases are missing. Also, registries that do not use death certificates for case finding have an artificially high proportion of microscopically confirmed cases, because DCO cases by definition do not have information on whether the tumor was microscopically confirmed. While no NAACCR standard has been determined for microscopic confirmation, the guideline we use is that the proportion should fall between 92 and 96 percent of all cancer cases, based on the experience of the SEER program. CALCULATION OF STATISTICS Rates. Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age (Ries, et al. 2005), the 1996 Canadian population standard (Statistics Canada, 2003), and to the World population standard (Parkin, et al., 2002). Rates for childhood and adolescents in Volume One were expressed per million population. The incidence and death rates in this monograph are annual averages for the period 2005 through (Note: Not all registries submitted incidence data for all five years; their rates are annual averages for the years submitted. Further, rates for Alabama, Louisiana, Mississippi, and Texas are truncated at June 2005, including data for January through June 2005 and all of 2006 through 2009 to avoid potential misclassification of cancer rates, as noted above). The age distributions of the three population standards are as follows: AGE GROUP 2000 U.S CDN. WORLD 00 years 3,794,901 12,342 24, years 15,191,619 53,893 96, years 19,919,840 67, , years 20,056,779 67,716 90, years 19,819,518 67,841 90, years 18,257,225 67,761 80, years 17,722,067 72,914 80, years 19,511,370 87,030 60, years 22,179,956 88,510 60, years 22,479,229 80,055 60, years 19,805,793 71,847 60, years 17,224,359 55,812 50, years 13,307,234 44,869 40, years 10,654,272 40,705 40, years 9,409,940 37,858 30, years 8,725,574 32,589 20, years 7,414,559 23,232 10, years 4,900,234 15,424 5, years 4,259,173 11,617 5,000 Total 274,633,642 1,000,000 1,000,000 INTRODUCTION AND TECHNICAL NOTES I-7

20 Standard Errors. Standard errors (S.E.) of the rates were calculated using the formula: 2 2 ( S. E. + S. E ) w j n S.E. = 2 p where w j = the fraction of the standard population in age group j, n j = number of cases or deaths in that age group, and p j = person years denominator (Breslow and Day, 1987). For many registries, the standard errors of the rates are small, as the population covered is large. However, for registries that cover a small population, the standard error may be substantial. Confidence Intervals. Although not reproduced in the printed monograph, bar charts of the registry-specific, age-adjusted rates with 95 percent confidence intervals (Tiwari, et al., 2006) are available on the NAACCR website ( The confidence intervals allow the user to assess the precision of the estimate and is an approximate and conservative indicator of whether a registry s rate is statistically higher or lower than the rate for the combined United States, based on whether or not the upper or lower limit of the confidence interval overlaps the 95% confidence interval for the United States. Comparison of Rates. In addition to true regional variation in cancer risk, differences in cancer incidence or mortality rates between areas may be due to either differences in the demographic makeup of the population or differences in data quality. In making valid comparisons of cancer incidence rates among registries, it is important to review the data quality indicators for each registry before attributing rate differences to regional variation. In addition to data quality, it is important to consider differences in the racial composition of the populations being compared before conclusions are drawn about variations in regional rates. Interpretation without consideration of these factors may contribute to misleading or inaccurate conclusions. The standard error of adjusted rates can be used to evaluate the statistical significance of rate differences among comparable populations. For example, if the adjusted rates in two populations are R 1 and R 2 and their standard errors are S.E. 1 and S.E. 2, an approximate confidence interval for the rate ratio can be calculated using the following formula: 2 (R 1 /R 2 ) 1 ± z/x where x = (R 1 B R 2 ) / 1. 2 and z = 1.96 for 95% limits (Parkin, et al., 1992). If this interval does not include one, the two rates are statistically significantly different at a p value of This test can be inaccurate for rates based on fewer than 16 cases or deaths, and it should not be used for rates based on fewer than six cases or deaths. It should be emphasized that this kind of comparison of adjusted rates must be undertaken with caution as misleading conclusions may be drawn if the ratios of the age specific rates in the two populations are not constant in all age groups. In these circumstances, the ratios of the adjusted rates will vary according to the standard populations used (Esteve, et al., 1994). Cell Suppression. Counts and rates were suppressed (indicated by - ) in the tables if the race, gender, and site-specific number of cases or deaths was less than six. These counts are included in the calculation of all sites combined. A dash is also used to indicate not applicable, as in the gender specific cancers. If the rate was less than 0.05 per 100,000 then the rate is listed as 0.0. REFERENCES Anderson RN, Minino AM, Hoyert DL, Rosenberg HM. Comparability of cause of death between ICD-9 and ICD-10: Preliminary estimates. National Vital Statistics Reports 2001;49:1-32. Breslow NE and Day NE. Statistical Methods in Cancer Research. Vol. II International Agency for Research on Cancer: Lyon, France. j j I-8 INTRODUCTION AND TECHNICAL NOTES

21 Espey DK, Wiggins CL, Jim MA, Miller BA, Johnson CJ, Becker TM. Methods for improving cancer surveillance data in American Indian and Alaska Native populations. Cancer Sep 1;113(5 Suppl): Espey DK, Wu XC, Swan J, Wiggins C, Jim MA, Ward E, Wingo PA, Howe HL, Ries LA, Miller BA, Jemal A, Ahmed F, Cobb N, Kaur JS, Edwards BK. Annual report to the nation on the status of cancer, , featuring cancer in American Indians and Alaska Natives. Cancer Nov 15;110(10): Esteve J, Benhamou E, and Raymond L. Statistical Methods in Cancer Research. Vol. V International Agency for Research on Cancer: Lyon, France. Horner MJ, Ries LAG, Krapcho M, Neyman N, Aminou R, Howlader N, Altekruse SF, Feuer EJ, Huang L, Mariotto A, Miller BA, Lewis DR, Eisner MP, Stinchcomb DG, Edwards BK (eds). SEER Cancer Statistics Review, , National Cancer Institute. Bethesda, MD [URL: based on November 2008 SEER data submission, posted to the SEER web site, 2009.] Howe HL, Carozza S, O Malley C, Dolecek TA, Finch JL, Kohler B, Wet D, Liu L, Schymura MJ, Williams M, Abe T, Agovino P, Chen VW, Firth R, Harkins D, Hotes, J, Lake A, Roney D, Suarez L (eds). Cancer in U.S. Hispanics/Latinos, Springfield (IL): North American Association of Central Cancer Registries, December Johnson CH, Peace S, Adamo P, Fritz A, Percy-Laurry A, Edwards BK. The 2007 Multiple Primary and Histology Coding Rules. National Cancer Institute, Surveillance, Epidemiology and End Results Program. Bethesda, MD, NAACCR Expert Panel in Hispanic Identification. Report of the NAACCR Expert Panel on Hispanic Identification Springfield (IL): North American Association of Central Cancer Registries, October NAACCR Latino Research Work Group. NAACCR Guideline for Enhancing Hispanic/Latino Identification: Revised NAACCR Hispanic/Latino Identification Algorithm [NHIA v2]. Springfield (IL): North American Association of Central Cancer Registries. September [URL: Last accessed April 24, 2012]. NAACCR Method to Estimate Completeness. A Data Analysis Tool for Calculations. [URL: Last accessed April 24, 2012]. NAACCR Race and Ethnicity Work Group. NAACCR Asian Pacific Islander Identification Algorithm [NAPIIA v1.2.1]. Springfield, IL: North American Association of Central Cancer Registries, September National Center for Health Statistics. U.S. Census Populations with Bridged Race Categories. September [URL: Last Accessed, June 6, 2012]. Parkin D.M., Whelan S.L., Ferlay J., Teppo L., Thomas D., Thomas D.B. Cancer Incidence in Five Continents. Vol. VIII International Agency for Research on Cancer: Lyon, France. Statistics Canada Annual Demographic Statistics. Statistics Canada Catalogue no XIB Ottawa: Minister of Industry. [URL: SEER U.S. Standard Population vs. Standard Million. 13 December Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. International Classification of Childhood Cancer, third edition. Cancer 2005;103: INTRODUCTION AND TECHNICAL NOTES I-9

22 Tiwari RC, Clegg LX, Zou Z. Efficient interval estimation for age-adjusted cancer rates. Stat Methods Med Res 2006;15: Wu XC, Hotes J, Fulton JP, Cormier M, Correa C, McLaughlin CC, Kosary C, Howe HL, Chen VW (Eds.) Cancer in North America, , Volume One: Introduction and Technical Notes, Incidence. April [URL: Last accessed April 24, 2012]. I-10 INTRODUCTION AND TECHNICAL NOTES

23 Section II Top Five Most Commonly Diagnosed Cancers in North America Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries

24 Top Five Most Commonly Diagnosed Cancers 1 in North America by Sex, All Races Males/All Races United States Canada North America Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 3,612, All Sites 159, All Sites 3,772, Prostate 1,014, Prostate 44, Prostate 1,058, Lung & Bronchus 530, Lung & Bronchus 21, Lung & Bronchus 552, Colon & Rectum 349, Colon & Rectum 21, Colon & Rectum 370, Bladder 233, Bladder 10, Bladder 243, Melanomas of the Skin 161, Non-Hodgkin Lymphoma 6, Melanomas of the Skin 167, Females/All Races United States Canada North America Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 3,356, All Sites 142, All Sites 3,499, Breast 968, Breast 40, Breast 1,008, Lung & Bronchus 454, Lung & Bronchus 19, Lung & Bronchus 473, Colon & Rectum 333, Colon & Rectum 17, Colon & Rectum 351, Uterus Corpus & Uterus NOS 197, Uterus Corpus & Uterus NOS 8, Uterus Corpus & Uterus NOS 205, Non-Hodgkin Lymphoma 131, Non-Hodgkin Lymphoma 5, Non-Hodgkin Lymphoma 136, Compiled by the North American Association of Central Cancer Registries, based on cases included in the combined incidence for the United States. TOP 5 CANCERS Combined Incidence II-1

25 Top Five Most Commonly Diagnosed Cancers 1 in the U.S. by Race/Ethnicity, Males Hispanic/Latino, All Races White Black Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 230, All Sites 3,076, All Sites 366, Prostate 62, Prostate 819, Prostate 135, Colon & Rectum 24, Lung & Bronchus 459, Lung & Bronchus 55, Lung & Bronchus 21, Colon & Rectum 295, Colon & Rectum 37, Non-Hodgkin Lymphoma 11, Bladder 215, Kidney and Renal Pelvis 14, Kidney and Renal Pelvis 11, Melanomas of the Skin 154, Non-Hodgkin Lymphoma 11, American Indian/Alaskan Native 2 Chinese Japanese Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 11, All Sites 18, All Sites 8, Prostate 2, Prostate 3, Prostate 2, Lung & Bronchus 1, Lung & Bronchus 2, Colon & Rectum 1, Colon & Rectum 1, Colon & Rectum 2, Lung & Bronchus 1, Kidney and Renal Pelvis Liver and Intrahepatic Bile Duct Liver and Intrahepatic Bile Duct 1, Stomach Stomach 1, Bladder Filipino Vietnamese Korean Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 14, All Sites 7, All Sites 6, Prostate 3, Lung & Bronchus 1, Colon & Rectum Lung & Bronchus 2, Liver and Intrahepatic Bile Duct 1, Prostate Colon & Rectum 1, Prostate 1, Lung & Bronchus Liver and Intrahepatic Bile Duct Non-Hodgkin Lymphoma Colon & Rectum Stomach Non-Hodgkin Lymphoma Liver and Intrahepatic Bile Duct Compiled by the North American Association of Central Cancer Registries, based on cases included in the combined incidence for the United States. 2 Counts and percentages are based upon cancer cases diagnosed among the AI/AN population in CHSDA counties. See Introduction for more information. TOP 5 CANCERS II-2 Combined Incidence

26 Top Five Most Commonly Diagnosed Cancers 1 in the U.S. by Race/Ethnicity, Females Hispanic/Latino, All Races White Black Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 234, All Sites 2,871, All Sites 331, Breast 67, Breast 822, Breast 101, Colon & Rectum 21, Lung & Bronchus 400, Lung & Bronchus 41, Lung & Bronchus 16, Colon & Rectum 279, Colon & Rectum 39, Thyroid 14, Uterus Corpus & Uterus NOS 14, Uterus Corpus & Uterus NOS Non-Hodgkin Lymphoma 169, Uterus Corpus & Uterus NOS 18, , Pancreas 10, American Indian/Alaskan Native 2 Chinese Japanese Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 12, All Sites 18, All Sites 10, Breast 3, Breast 5, Breast 3, Lung & Bronchus 1, Colon & Rectum 2, Colon & Rectum 1, Colon & Rectum 1, Lung & Bronchus 2, Lung & Bronchus 1, Uterus Corpus & Uterus NOS Kidney and Renal Pelvis Thyroid 1, Uterus Corpus & Uterus NOS Uterus Corpus & Uterus NOS Stomach Filipino Vietnamese Korean Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 18, All Sites 6, All Sites 7, Breast 6, Breast 1, Breast 2, Colon & Rectum 1, Colon & Rectum Colon & Rectum Lung & Bronchus 1, Lung & Bronchus Lung & Bronchus Thyroid 1, Thyroid Stomach Uterus Corpus & Uterus NOS 1, Liver and Intrahepatic Bile Duct Thyroid Compiled by the North American Association of Central Cancer Registries, based on cases included in the combined incidence for the United States. 2 Counts and percentages are based upon cancer cases diagnosed among the AI/AN population in CHSDA counties. See Introduction for more information. TOP 5 CANCERS Combined Incidence II-3

27

28 Section III Average-annual Age-adjusted NAACCR Combined Cancer Incidence Rates for the United States, Canada and North America Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries

29 COMBINED CANCER INCIDENCE RATES UNITED STATES Race-Specific Population Counts by Year Race 2005 * All Races 261,917, ,975, ,829, ,493, ,980,079 White 212,852, ,149, ,042, ,771, ,364,668 Black 33,037,480 36,750,390 37,264,446 37,755,795 38,219,436 American Indian/Alaskan Native (AI/AN) 3,010,391 3,192,696 3,255,213 3,316,328 3,376,074 Asian/Pacific Islander (API) 13,016,505 13,882,969 14,267,967 14,650,091 15,019,901 All Races Population : 1,406,196,649 Distribution of Population by Race Black 13.0% AI/AN 1.1% White 80.8% API 5.0% Hispanic/Latino Population Counts by Year Ethnicity 2005 * Hispanic/Latino, All Races 37,505,515 43,057,569 44,499,092 45,920,578 47,309,511 Non-Hispanic White 178,194, ,207, ,787, ,226, ,558,579 Non-Hispanic Black 31,361,125 34,920,424 35,355,157 35,765,993 36,150,953 Hispanic/Latino Population, Census 2000: Distribution of U.S. Combined Hispanic/Latino Populations % Hispanic/Latino of U.S. Combined Population By Census Year Census Year * Statistics exclude data for AL, LA, and TX from July 2005 through December See Introduction. UNITED STATES III-1 Combined Incidence

30 Race-Specific Population Indicators ( * ) Combined Population: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander 1,406,196,649 1,136,180, ,027,547 16,150,702 70,837,433 COMBINED CANCER INCIDENCE RATES UNITED STATES Percentage of U.S. Population Reflected in the Combined Cancer Statistics: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander 93.3% 93.4% 91.6% 95.7% 95.4% Hispanic/All Races Non-Hispanic White Non-Hispanic Black 218,292, ,975, ,553,652 Number of Cases in Combined Cancer Statistics: All Races 6,969,606 White 5,948,155 Black 697,706 American Indian/Alaskan Native 32,835 Asian/Pacific Islander 178,292 Hispanic/All Races Non-Hispanic White Non-Hispanic Black 96.0% 92.9% 91.3% Hispanic/All Races Non-Hispanic White Non-Hispanic Black 464,718 5,514, ,897 Data Quality Indicators ( ) Indicators (%) 2005 * Missing Race Missing Sex Missing County Missing Age Death Certificate Only Cases Site-Specific Microscopic Confirmation ( * ) Cancer Site % Micro. Confirm Cancer Site % Micro. Confirm All Sites 93.4 Prostate 97.1 Oral Cavity & Pharynx 97.6 Testis 99.1 Esophagus 95.0 Bladder (incl. in situ) 98.0 Stomach 96.0 Kidney & Renal Pelvis 90.1 Colon & Rectum 96.5 Brain & Other Nervous System 84.4 Liver 68.5 Thyroid Gland 99.4 Pancreas 78.7 Hodgkin Lymphoma 98.5 Lung & Bronchus 88.2 Non-Hodgkin Lymphoma 96.6 Melanomas of the Skin 99.1 Multiple Myeloma 87.5 Female Breast (excl. in situ) 98.2 Leukemias 88.4 Cervix uteri 97.5 Brain & ONS 1 benign/borderline 51.0 Uterus Corpus & Uterus NOS 98.5 Breast in situ Ovary 91.4 * Statistics exclude data for AL, LA, and TX from July 2005 through December See Introduction. UNITED STATES Combined Incidence III-2

31 NAACCR U.S. Combined Incidence , All Races Combined Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-3 Combined Incidence All Races

32 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , All Races MALES (ALL RACES) FEMALES (ALL RACES) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 3,612, ,356, Oral Cavity & Pharynx 113, , Lip 6, , Tongue 32, , Major salivary gland 10, , Floor of mouth 6, , Gum & other mouth 12, , Nasopharynx 5, , Oropharynx 5, , Hypopharynx 8, , Digestive System 676, , Esophagus 57, , Stomach 60, , Small intestine 16, , Colon excl. rectum 240, , Rectum & rectosigmoid 108, , Anus, anal canal & anorectum 9, , Liver 66, , Gallbladder 5, , Pancreas 87, , Respiratory System 584, , Larynx 46, , Lung & bronchus 530, , Bones & Joints 7, , Soft Tissue (incl. heart) 25, , Skin (excl. basal & sq.) 175, , Melanomas of the skin 161, , Breast (excl. in situ) 8, , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 1,059, Prostate 1,014, Testis 37, Penis 5, Urinary System 383, , Bladder (incl. in situ) 233, , Kidney & renal pelvis 142, , Ureter 5, , Eye & Orbit 6, , Brain & Other Nervous System 53, , Brain 50, , Endocrine System 47, , Thyroid gland 41, , Lymphomas 173, , Hodgkin Lymphoma 21, , Non-Hodgkin Lymphoma 152, , Multiple Myeloma 46, , Leukemias 103, , Acute lymphocytic 12, , Chronic lymphocytic 36, , Acute myeloid 27, , Chronic myeloid 12, , Other leukemias 13, , Mesothelioma 11, , Kaposi Sarcoma 5, Ill-defined & Unknown 130, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 48, , Breast (in situ) 1, , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System UNITED STATES Combined Incidence All Races III-4

33 UNITED STATES III-5 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,612, ,014, , , , , Alabama 59, , , , , , Alaska 6, , Arizona 66, , , , , , California 389, , , , , , CA: Greater Bay Area 76, , , , , , CA: Los Angeles 94, , , , , , Colorado 50, , , , , , Connecticut 50, , , , , , Delaware 13, , , , Florida 276, , , , , , Georgia 107, , , , , , GA: Metropolitan Atlanta 31, , , , , , Hawaii 16, , , , Idaho 18, , , , , , Illinois 162, , , , , , Indiana 78, , , , , , Iowa 43, , , , , , Kansas 36, , , , , , Kentucky 62, , , , , , Louisiana 55, , , , , , Maine 21, , , , , Maryland 67, , , , , , Massachusetts 90, , , , , , Michigan 139, , , , , , MI: Metropolitan Detroit 57, , , , , , Minnesota 69, , , , , , Mississippi 36, , , , , , Missouri 78, , , , , , Montana 13, , , ,

34 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 23, , , , , Nevada 30, , , , , , New Hampshire 19, , , , , , New Jersey 121, , , , , , New Mexico 22, , , , , , New York 266, , , , , , North Carolina 120, , , , , , North Dakota 9, , , , Ohio 152, , , , , , Oklahoma 49, , , , , , Oregon 48, , , , , , Pennsylvania 191, , , , , , Rhode Island 15, , , , , South Carolina 59, , , , , , South Dakota 10, , , , Tennessee 83, , , , , , Texas 227, , , , , , Utah 22, , , , , , Vermont 9, , , Washington 83, , , , , , WA: Seattle/Puget Sound 58, , , , , , West Virginia 28, , , , , , Wyoming 6, , UNITED STATES Combined Incidence All Races III-6 1. Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

35 UNITED STATES III-7 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,612, ,014, , , , , Alabama 59, , , , , , Alaska 6, , Arizona 66, , , , , , California 389, , , , , , CA: Greater Bay Area 76, , , , , , CA: Los Angeles 94, , , , , , Colorado 50, , , , , , Connecticut 50, , , , , , Delaware 13, , , , Florida 276, , , , , , Georgia 107, , , , , , GA: Metropolitan Atlanta 31, , , , , , Hawaii 16, , , , Idaho 18, , , , , , Illinois 162, , , , , , Indiana 78, , , , , , Iowa 43, , , , , , Kansas 36, , , , , , Kentucky 62, , , , , , Louisiana 55, , , , , , Maine 21, , , , , Maryland 67, , , , , , Massachusetts 90, , , , , , Michigan 139, , , , , , MI: Metropolitan Detroit 57, , , , , , Minnesota 69, , , , , , Mississippi 36, , , , , , Missouri 78, , , , , , Montana 13, , , ,

36 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 23, , , , , Nevada 30, , , , , , New Hampshire 19, , , , , , New Jersey 121, , , , , , New Mexico 22, , , , , , New York 266, , , , , , North Carolina 120, , , , , , North Dakota 9, , , , Ohio 152, , , , , , Oklahoma 49, , , , , , Oregon 48, , , , , , Pennsylvania 191, , , , , , Rhode Island 15, , , , , South Carolina 59, , , , , , South Dakota 10, , , , Tennessee 83, , , , , , Texas 227, , , , , , Utah 22, , , , , , Vermont 9, , , Washington 83, , , , , , WA: Seattle/Puget Sound 58, , , , , , West Virginia 28, , , , , , Wyoming 6, , UNITED STATES Combined Incidence All Races III-8 1. Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

37 UNITED STATES III-9 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,356, , , , , , Alabama 49, , , , , , Alaska 5, , Arizona 62, , , , , , California 371, , , , , , CA: Greater Bay Area 73, , , , , , CA: Los Angeles 93, , , , , , Colorado 48, , , , , , Connecticut 49, , , , , , Delaware 11, , , , Florida 241, , , , , , Georgia 95, , , , , , GA: Metropolitan Atlanta 30, , , , , , Hawaii 15, , , , , Idaho 15, , , , Illinois 156, , , , , , Indiana 76, , , , , , Iowa 40, , , , , , Kansas 33, , , , , , Kentucky 57, , , , , , Louisiana 45, , , , , , Maine 20, , , , , Maryland 65, , , , , , Massachusetts 91, , , , , , Michigan 126, , , , , , MI: Metropolitan Detroit 53, , , , , , Minnesota 61, , , , , , Mississippi 29, , , , , , Missouri 74, , , , , , Montana 12, , , ,

38 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 21, , , , , Nevada 25, , , , , New Hampshire 17, , , , , New Jersey 118, , , , , , New Mexico 20, , , , , New York 258, , , , , , North Carolina 108, , , , , , North Dakota 8, , Ohio 147, , , , , , Oklahoma 44, , , , , , Oregon 47, , , , , , Pennsylvania 185, , , , , , Rhode Island 15, , , , South Carolina 52, , , , , , South Dakota 9, , , , Tennessee 74, , , , , , Texas 206, , , , , , Utah 19, , , , , Vermont 8, , , Washington 77, , , , , , WA: Seattle/Puget Sound 55, , , , , , West Virginia 26, , , , , , Wyoming 5, , UNITED STATES Combined Incidence All Races III Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

39 UNITED STATES III-11 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,356, , , , , , Alabama 49, , , , , , Alaska 5, , Arizona 62, , , , , , California 371, , , , , , CA: Greater Bay Area 73, , , , , , CA: Los Angeles 93, , , , , , Colorado 48, , , , , , Connecticut 49, , , , , , Delaware 11, , , , Florida 241, , , , , , Georgia 95, , , , , , GA: Metropolitan Atlanta 30, , , , , , Hawaii 15, , , , , Idaho 15, , , , Illinois 156, , , , , , Indiana 76, , , , , , Iowa 40, , , , , , Kansas 33, , , , , , Kentucky 57, , , , , , Louisiana 45, , , , , , Maine 20, , , , , Maryland 65, , , , , , Massachusetts 91, , , , , , Michigan 126, , , , , , MI: Metropolitan Detroit 53, , , , , , Minnesota 61, , , , , , Mississippi 29, , , , , , Missouri 74, , , , , , Montana 12, , , ,

40 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 21, , , , , Nevada 25, , , , , New Hampshire 17, , , , , New Jersey 118, , , , , , New Mexico 20, , , , , New York 258, , , , , , North Carolina 108, , , , , , North Dakota 8, , Ohio 147, , , , , , Oklahoma 44, , , , , , Oregon 47, , , , , , Pennsylvania 185, , , , , , Rhode Island 15, , , , South Carolina 52, , , , , , South Dakota 9, , , , Tennessee 74, , , , , , Texas 206, , , , , , Utah 19, , , , , Vermont 8, , , Washington 77, , , , , , WA: Seattle/Puget Sound 55, , , , , , West Virginia 26, , , , , , Wyoming 5, , UNITED STATES Combined Incidence All Races III Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

41 NAACCR U.S. Combined Incidence , The White Population Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-13 Combined Incidence White

42 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , White MALES (WHITE) FEMALES (WHITE) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 3,076, ,871, Oral Cavity & Pharynx 98, , Lip 6, , Tongue 29, , Major salivary gland 9, , Floor of mouth 5, , Gum & other mouth 10, , Nasopharynx 3, , Oropharynx 4, , Hypopharynx 6, , Digestive System 564, , Esophagus 50, , Stomach 46, , Small intestine 13, , Colon excl. rectum 203, , Rectum & rectosigmoid 92, , Anus, anal canal & anorectum 7, , Liver 50, , Gallbladder 4, , Pancreas 75, , Respiratory System 504, , Larynx 38, , Lung & bronchus 459, , Bones & Joints 6, , Soft Tissue (incl. heart) 21, , Skin (excl. basal & sq.) 166, , Melanomas of the skin 154, , Breast (excl. in situ) 7, , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 859, Prostate 819, Testis 34, Penis 4, Urinary System 344, , Bladder (incl. in situ) 215, , Kidney & renal pelvis 122, , Ureter 4, , Eye & Orbit 5, , Brain & Other Nervous System 47, , Brain 45, , Endocrine System 41, , Thyroid gland 36, , Lymphomas 152, , Hodgkin Lymphoma 18, , Non-Hodgkin Lymphoma 133, , Multiple Myeloma 36, , Leukemias 90, , Acute lymphocytic 10, , Chronic lymphocytic 32, , Acute myeloid 24, , Chronic myeloid 10, , Other leukemias 12, , Mesothelioma 10, , Kaposi Sarcoma 3, Ill-defined & Unknown 113, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 41, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System UNITED STATES Combined Incidence White III-14

43 UNITED STATES III-15 Combined Incidence White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,076, , , , , , Alabama 45, , , , , , Alaska 5, , Arizona 61, , , , , , California 316, , , , , , CA: Greater Bay Area 58, , , , , , CA: Los Angeles 69, , , , , , Colorado 46, , , , , , Connecticut 45, , , , , , Delaware 10, , , Florida 243, , , , , , Georgia 78, , , , , , GA: Metropolitan Atlanta 20, , , , , , Hawaii 5, , Idaho 17, , , , , Illinois 134, , , , , , Indiana 71, , , , , , Iowa 41, , , , , , Kansas 33, , , , , , Kentucky 57, , , , , , Louisiana 39, , , , , , Maine 21, , , , , Maryland 48, , , , , , Massachusetts 82, , , , , , Michigan 116, , , , , , MI: Metropolitan Detroit 42, , , , , , Minnesota 64, , , , , , Mississippi 25, , , , , , Missouri 70, , , , , , Montana 12, , , ,

44 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 21, , , , , Nevada 26, , , , , , New Hampshire 18, , , , , , New Jersey 101, , , , , , New Mexico 21, , , , , , New York 217, , , , , , North Carolina 95, , , , , , North Dakota 8, , , , Ohio 132, , , , , , Oklahoma 41, , , , , , Oregon 45, , , , , , Pennsylvania 170, , , , , , Rhode Island 14, , , , , South Carolina 44, , , , , , South Dakota 9, , , , Tennessee 72, , , , , , Texas 194, , , , , , Utah 22, , , , , , Vermont 8, , , Washington 75, , , , , , WA: Seattle/Puget Sound 52, , , , , , West Virginia 28, , , , , , Wyoming 6, , UNITED STATES Combined Incidence White III Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

45 UNITED STATES III-17 Combined Incidence White Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,076, , , , , , Alabama 45, , , , , , Alaska 5, , Arizona 61, , , , , , California 316, , , , , , CA: Greater Bay Area 58, , , , , , CA: Los Angeles 69, , , , , , Colorado 46, , , , , , Connecticut 45, , , , , , Delaware 10, , , Florida 243, , , , , , Georgia 78, , , , , , GA: Metropolitan Atlanta 20, , , , , , Hawaii 5, , Idaho 17, , , , , Illinois 134, , , , , , Indiana 71, , , , , , Iowa 41, , , , , , Kansas 33, , , , , , Kentucky 57, , , , , , Louisiana 39, , , , , , Maine 21, , , , , Maryland 48, , , , , , Massachusetts 82, , , , , , Michigan 116, , , , , , MI: Metropolitan Detroit 42, , , , , , Minnesota 64, , , , , , Mississippi 25, , , , , , Missouri 70, , , , , , Montana 12, , , ,

46 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 21, , , , , Nevada 26, , , , , , New Hampshire 18, , , , , , New Jersey 101, , , , , , New Mexico 21, , , , , , New York 217, , , , , , North Carolina 95, , , , , , North Dakota 8, , , , Ohio 132, , , , , , Oklahoma 41, , , , , , Oregon 45, , , , , , Pennsylvania 170, , , , , , Rhode Island 14, , , , , South Carolina 44, , , , , , South Dakota 9, , , , Tennessee 72, , , , , , Texas 194, , , , , , Utah 22, , , , , , Vermont 8, , , Washington 75, , , , , , WA: Seattle/Puget Sound 52, , , , , , West Virginia 28, , , , , , Wyoming 6, , UNITED STATES Combined Incidence White III Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

47 UNITED STATES III-19 Combined Incidence White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 2,871, , , , , , Alabama 38, , , , , , Alaska 4, , Arizona 57, , , , , , California 303, , , , , , CA: Greater Bay Area 54, , , , , , CA: Los Angeles 69, , , , , , Colorado 45, , , , , , Connecticut 45, , , , , , Delaware 9, , , Florida 213, , , , , , Georgia 69, , , , , , GA: Metropolitan Atlanta 18, , , , Hawaii 4, , Idaho 15, , , , Illinois 130, , , , , , Indiana 69, , , , , , Iowa 39, , , , , , Kansas 30, , , , , , Kentucky 53, , , , , , Louisiana 32, , , , , , Maine 19, , , , , Maryland 47, , , , , , Massachusetts 84, , , , , , Michigan 107, , , , , , MI: Metropolitan Detroit 40, , , , , , Minnesota 57, , , , , , Mississippi 20, , , , Missouri 66, , , , , , Montana 11, , , ,

48 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 20, , , , , Nevada 22, , , , , New Hampshire 17, , , , , New Jersey 99, , , , , , New Mexico 18, , , , , New York 212, , , , , , North Carolina 86, , , , , , North Dakota 7, , Ohio 129, , , , , , Oklahoma 37, , , , , , Oregon 44, , , , , , Pennsylvania 165, , , , , , Rhode Island 14, , , , South Carolina 39, , , , , , South Dakota 8, , , Tennessee 64, , , , , , Texas 176, , , , , , Utah 18, , , , , Vermont 8, , , Washington 69, , , , , , WA: Seattle/Puget Sound 49, , , , , , West Virginia 25, , , , , Wyoming 5, , UNITED STATES Combined Incidence White III Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

49 UNITED STATES III-21 Combined Incidence White Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 2,871, , , , , , Alabama 38, , , , , , Alaska 4, , Arizona 57, , , , , , California 303, , , , , , CA: Greater Bay Area 54, , , , , , CA: Los Angeles 69, , , , , , Colorado 45, , , , , , Connecticut 45, , , , , , Delaware 9, , , Florida 213, , , , , , Georgia 69, , , , , , GA: Metropolitan Atlanta 18, , , , Hawaii 4, , Idaho 15, , , , Illinois 130, , , , , , Indiana 69, , , , , , Iowa 39, , , , , , Kansas 30, , , , , , Kentucky 53, , , , , , Louisiana 32, , , , , , Maine 19, , , , , Maryland 47, , , , , , Massachusetts 84, , , , , , Michigan 107, , , , , , MI: Metropolitan Detroit 40, , , , , , Minnesota 57, , , , , , Mississippi 20, , , , Missouri 66, , , , , , Montana 11, , , ,

50 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 20, , , , , Nevada 22, , , , , New Hampshire 17, , , , , New Jersey 99, , , , , , New Mexico 18, , , , , New York 212, , , , , , North Carolina 86, , , , , , North Dakota 7, , Ohio 129, , , , , , Oklahoma 37, , , , , , Oregon 44, , , , , , Pennsylvania 165, , , , , , Rhode Island 14, , , , South Carolina 39, , , , , , South Dakota 8, , , Tennessee 64, , , , , , Texas 176, , , , , , Utah 18, , , , , Vermont 8, , , Washington 69, , , , , , WA: Seattle/Puget Sound 49, , , , , , West Virginia 25, , , , , Wyoming 5, , UNITED STATES Combined Incidence White III Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

51 NAACCR U.S. Combined Incidence , The Black Population Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-23 Combined Incidence Black

52 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , Black MALES (BLACK) FEMALES (BLACK) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 366, , Oral Cavity & Pharynx 10, , Lip Tongue 2, Major salivary gland Floor of mouth Gum & other mouth 1, Nasopharynx Oropharynx Hypopharynx 1, Digestive System 76, , Esophagus 5, , Stomach 8, , Small intestine 2, , Colon excl. rectum 27, , Rectum & rectosigmoid 10, , Anus, anal canal & anorectum 1, , Liver 9, , Gallbladder , Pancreas 9, , Respiratory System 62, , Larynx 6, , Lung & bronchus 55, , Bones & Joints Soft Tissue (incl. heart) 2, , Skin (excl. basal & sq.) 1, , Melanomas of the skin Breast (excl. in situ) 1, , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 137, Prostate 135, Testis 1, Penis Urinary System 25, , Bladder (incl. in situ) 9, , Kidney & renal pelvis 14, , Ureter Eye & Orbit Brain & Other Nervous System 3, , Brain 3, , Endocrine System 2, , Thyroid gland 2, , Lymphomas 13, , Hodgkin Lymphoma 2, , Non-Hodgkin Lymphoma 11, , Multiple Myeloma 7, , Leukemias 7, , Acute lymphocytic 1, Chronic lymphocytic 2, , Acute myeloid 2, , Chronic myeloid 1, Other leukemias 1, Mesothelioma Kaposi Sarcoma 1, Ill-defined & Unknown 10, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 4, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System UNITED STATES Combined Incidence Black III-24

53 UNITED STATES III-25 Combined Incidence Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 366, , , , , , Alabama 12, , , , Alaska Arizona 1, California 25, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 10, , , , Colorado 1, Connecticut 3, , Delaware 2, Florida 26, , , , Georgia 26, , , , GA: Metropolitan Atlanta 10, , , Hawaii Idaho Illinois 21, , , , Indiana 5, , , Iowa Kansas 1, Kentucky 3, , Louisiana 14, , , , Maine Maryland 15, , , , Massachusetts 3, , Michigan 16, , , , MI: Metropolitan Detroit 12, , , , Minnesota 1, Mississippi 10, , , , Missouri 7, , , Montana

54 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska Nevada 1, New Hampshire New Jersey 13, , , , New Mexico New York 35, , , , , , North Carolina 22, , , , North Dakota Ohio 14, , , , Oklahoma 2, , Oregon Pennsylvania 15, , , , Rhode Island South Carolina 13, , , , South Dakota Tennessee 9, , , , Texas 24, , , , , Utah Vermont Washington 2, WA: Seattle/Puget Sound 2, West Virginia Wyoming UNITED STATES Combined Incidence Black III Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

55 UNITED STATES III-27 Combined Incidence Black Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 366, , , , , , Alabama 12, , , , Alaska Arizona 1, California 25, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 10, , , , Colorado 1, Connecticut 3, , Delaware 2, Florida 26, , , , Georgia 26, , , , GA: Metropolitan Atlanta 10, , , Hawaii Idaho Illinois 21, , , , Indiana 5, , , Iowa Kansas 1, Kentucky 3, , Louisiana 14, , , , Maine Maryland 15, , , , Massachusetts 3, , Michigan 16, , , , MI: Metropolitan Detroit 12, , , , Minnesota 1, Mississippi 10, , , , Missouri 7, , , Montana

56 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska Nevada 1, New Hampshire New Jersey 13, , , , New Mexico New York 35, , , , , , North Carolina 22, , , , North Dakota Ohio 14, , , , Oklahoma 2, , Oregon Pennsylvania 15, , , , Rhode Island South Carolina 13, , , , South Dakota Tennessee 9, , , , Texas 24, , , , , Utah Vermont Washington 2, WA: Seattle/Puget Sound 2, West Virginia Wyoming UNITED STATES Combined Incidence Black III Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

57 UNITED STATES III-29 Combined Incidence Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 331, , , , , , Alabama 10, , , , Alaska Arizona 1, California 23, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 10, , , , Colorado 1, Connecticut 3, Delaware 1, Florida 23, , , , , Georgia 23, , , , , GA: Metropolitan Atlanta 10, , , Hawaii Idaho Illinois 20, , , , , Indiana 5, , Iowa Kansas 1, Kentucky 3, , Louisiana 12, , , , Maine Maryland 15, , , , Massachusetts 3, , Michigan 15, , , , MI: Metropolitan Detroit 11, , , , Minnesota 1, Mississippi 8, , , , Missouri 7, , , Montana

58 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska Nevada 1, New Hampshire New Jersey 12, , , , New Mexico New York 33, , , , , , North Carolina 19, , , , , North Dakota Ohio 14, , , , Oklahoma 2, Oregon Pennsylvania 15, , , , Rhode Island South Carolina 12, , , , South Dakota Tennessee 9, , , , Texas 22, , , , Utah Vermont Washington 1, WA: Seattle/Puget Sound 1, West Virginia Wyoming UNITED STATES Combined Incidence Black III Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

59 UNITED STATES III-31 Combined Incidence Black Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 331, , , , , , Alabama 10, , , , Alaska Arizona 1, California 23, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 10, , , , Colorado 1, Connecticut 3, Delaware 1, Florida 23, , , , , Georgia 23, , , , , GA: Metropolitan Atlanta 10, , , Hawaii Idaho Illinois 20, , , , , Indiana 5, , Iowa Kansas 1, Kentucky 3, , Louisiana 12, , , , Maine Maryland 15, , , , Massachusetts 3, , Michigan 15, , , , MI: Metropolitan Detroit 11, , , , Minnesota 1, Mississippi 8, , , , Missouri 7, , , Montana

60 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska Nevada 1, New Hampshire New Jersey 12, , , , New Mexico New York 33, , , , , , North Carolina 19, , , , , North Dakota Ohio 14, , , , Oklahoma 2, Oregon Pennsylvania 15, , , , Rhode Island South Carolina 12, , , , South Dakota Tennessee 9, , , , Texas 22, , , , Utah Vermont Washington 1, WA: Seattle/Puget Sound 1, West Virginia Wyoming UNITED STATES Combined Incidence Black III Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

61 NAACCR U.S. Combined Incidence , The Asian/Pacific Islander Population Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-33 Combined Incidence Asian/Pacific Islander

62 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , Asian/Pacific Islander (API) MALES (API) FEMALES (API) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 82, , Oral Cavity & Pharynx 3, , Lip Tongue Major salivary gland Floor of mouth Gum & other mouth Nasopharynx 1, Oropharynx Hypopharynx Digestive System 25, , Esophagus Stomach 3, , Small intestine Colon excl. rectum 6, , Rectum & rectosigmoid 4, , Anus, anal canal & anorectum Liver 5, , Gallbladder Pancreas 2, , Respiratory System 12, , Larynx Lung & bronchus 11, , Bones & Joints Soft Tissue (incl. heart) Skin (excl. basal & sq.) Melanomas of the skin Breast (excl. in situ) , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS Ovary , Male Genital System 19, Prostate 18, Testis Penis Urinary System 6, , Bladder (incl. in situ) 3, , Kidney & renal pelvis 2, , Ureter Eye & Orbit Brain & Other Nervous System 1, , Brain 1, Endocrine System 1, , Thyroid gland 1, , Lymphomas 4, , Hodgkin Lymphoma Non-Hodgkin Lymphoma 3, , Multiple Myeloma 1, Leukemias 2, , Acute lymphocytic Chronic lymphocytic Acute myeloid Chronic myeloid Other leukemias Mesothelioma Kaposi Sarcoma Ill-defined & Unknown 2, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 1, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Statistics exclude data for KS for all years and AL, LA, MS and TX from July 2005 through December See Introduction for more information. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System. UNITED STATES Combined Incidence Asian/Pacific Islander III-34

63 UNITED STATES III-35 Combined Incidence Asian/Pacific Islander Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Males All Sites Prostate Lung & Bronchus Colon & Rectum Liver & IBD 3 Stomach Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 82, , , , , , Alabama Alaska Arizona California 33, , , , , , CA: Greater Bay Area 11, , , , CA: Los Angeles 10, , , , Colorado Connecticut Delaware Florida 1, Georgia 1, GA: Metropolitan Atlanta Hawaii 10, , , , Idaho Illinois 2, Indiana Iowa Kansas Kentucky Louisiana Maine Maryland 1, Massachusetts 1, Michigan MI: Metropolitan Detroit Minnesota Mississippi Missouri Montana

64 UNITED STATES Combined Incidence Asian/Pacific Islander III-36 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Males All Sites Prostate Lung & Bronchus Colon & Rectum Liver & IBD 3 Stomach Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska Nevada New Hampshire New Jersey 3, New Mexico New York 9, , , , North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania 1, Rhode Island South Carolina South Dakota Tennessee Texas 3, Utah Vermont Washington 2, WA: Seattle/Puget Sound 2, West Virginia Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error

65 UNITED STATES III-37 Combined Incidence Asian/Pacific Islander Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Males All Sites Prostate Lung & Bronchus Colon & Rectum Liver & IBD 3 Stomach Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 82, , , , , , Alabama Alaska Arizona California 33, , , , , , CA: Greater Bay Area 11, , , , CA: Los Angeles 10, , , , Colorado Connecticut Delaware Florida 1, Georgia 1, GA: Metropolitan Atlanta Hawaii 10, , , , Idaho Illinois 2, Indiana Iowa Kansas Kentucky Louisiana Maine Maryland 1, Massachusetts 1, Michigan MI: Metropolitan Detroit Minnesota Mississippi Missouri Montana

66 UNITED STATES Combined Incidence Asian/Pacific Islander III-38 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Males All Sites Prostate Lung & Bronchus Colon & Rectum Liver & IBD 3 Stomach Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska Nevada New Hampshire New Jersey 3, New Mexico New York 9, , , , North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania 1, Rhode Island South Carolina South Dakota Tennessee Texas 3, Utah Vermont Washington 2, WA: Seattle/Puget Sound 2, West Virginia Wyoming Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error

67 UNITED STATES III-39 Combined Incidence Asian/Pacific Islander Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Females All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus, NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 95, , , , , , Alabama Alaska Arizona California 38, , , , , , CA: Greater Bay Area 13, , , , CA: Los Angeles 12, , , Colorado Connecticut Delaware Florida 2, Georgia 1, GA: Metropolitan Atlanta Hawaii 10, , , , Idaho Illinois 3, , Indiana Iowa Kansas Kentucky Louisiana Maine Maryland 1, Massachusetts 1, Michigan 1, MI: Metropolitan Detroit Minnesota Mississippi Missouri Montana

68 UNITED STATES Combined Incidence Asian/Pacific Islander III-40 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Females All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus, NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska Nevada 1, New Hampshire New Jersey 3, , New Mexico New York 9, , , North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania 1, Rhode Island South Carolina South Dakota Tennessee Texas 3, , Utah Vermont Washington 3, , WA: Seattle/Puget Sound 3, , West Virginia Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

69 UNITED STATES III-41 Combined Incidence Asian/Pacific Islander Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Females All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus, NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 95, , , , , , Alabama Alaska Arizona California 38, , , , , , CA: Greater Bay Area 13, , , , CA: Los Angeles 12, , , Colorado Connecticut Delaware Florida 2, Georgia 1, GA: Metropolitan Atlanta Hawaii 10, , , , Idaho Illinois 3, , Indiana Iowa Kansas Kentucky Louisiana Maine Maryland 1, Massachusetts 1, Michigan 1, MI: Metropolitan Detroit Minnesota Mississippi Missouri Montana

70 UNITED STATES Combined Incidence Asian/Pacific Islander III-42 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Females All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus, NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska Nevada 1, New Hampshire New Jersey 3, , New Mexico New York 9, , , North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania 1, Rhode Island South Carolina South Dakota Tennessee Texas 3, , Utah Vermont Washington 3, , WA: Seattle/Puget Sound 3, , West Virginia Wyoming Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

71 NAACCR U.S. Combined Incidence , The American Indian/Alaskan Native CHSDA Counties Population UNITED STATES III-43 Combined Incidence American Indian/Alaskan Native

72 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , American Indian/Alaskan Native (AI/AN) for CHSDA 1 Counties MALES (AI/AN) FEMALES (AI/AN) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 11, , Oral Cavity & Pharynx Lip Tongue Major salivary gland Floor of mouth Gum & other mouth Nasopharynx Oropharynx Hypopharynx Digestive System 2, , Esophagus Stomach Small intestine Colon excl. rectum Rectum & rectosigmoid Anus, anal canal & anorectum Liver Gallbladder Pancreas Respiratory System 1, , Larynx Lung & bronchus 1, , Bones & Joints Soft Tissue (incl. heart) Skin (excl. basal & sq.) Melanomas of the skin Breast (excl. in situ) , Female Genital System , Cervix uteri Uterus Corpus Uterus, NOS Ovary Male Genital System 2, Prostate 2, Testis Penis Urinary System 1, Bladder (incl. in situ) Kidney & renal pelvis Ureter Eye & Orbit Brain & Other Nervous System Brain Endocrine System Thyroid gland Lymphomas Hodgkin Lymphoma Non-Hodgkin Lymphoma Multiple Myeloma Leukemias Acute lymphocytic Chronic lymphocytic Acute myeloid Chronic myeloid Other leukemias Mesothelioma Kaposi Sarcoma Ill-defined & Unknown Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) Breast (in situ) * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Statistics exclude data for KS and MN for all years and AL, LA, MS and TX from July 2005 through December See Introduction for more information. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 2 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System UNITED STATES Combined Incidence American Indian/Alaskan Native III-44

73 UNITED STATES III-45 Combined Incidence American Indian/Alaskan Native Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver & IBD 4 Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 11, , , , Alabama Alaska Arizona 1, California Colorado Connecticut Florida Idaho Indiana Iowa Louisiana Maine Massachusetts Michigan Mississippi Montana Nebraska Nevada New Mexico New York North Carolina North Dakota Oklahoma 3, Oregon Pennsylvania Rhode Island South Carolina South Dakota

74 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver & IBD 4 Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Texas Utah Washington WA: Seattle/Puget Sound Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error UNITED STATES Combined Incidence American Indian/Alaskan Native III-46

75 UNITED STATES III-47 Combined Incidence American Indian/Alaskan Native Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver & IBD 4 Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 11, , , , Alabama Alaska Arizona 1, California Colorado Connecticut Florida Idaho Indiana Iowa Louisiana Maine Massachusetts Michigan Mississippi Montana Nebraska Nevada New Mexico New York North Carolina North Dakota Oklahoma 3, Oregon Pennsylvania Rhode Island South Carolina South Dakota

76 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver & IBD 4 Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Texas Utah Washington WA: Seattle/Puget Sound Wyoming Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error UNITED STATES Combined Incidence American Indian/Alaskan Native III-48

77 UNITED STATES III-49 Combined Incidence American Indian/Alaskan Native Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Kidney & Renal Pelvis Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 12, , , , Alabama Alaska 1, Arizona 1, California Colorado Connecticut Florida Idaho Indiana Iowa Louisiana Maine Massachusetts Michigan Mississippi Montana Nebraska Nevada New Mexico 1, New York North Carolina North Dakota Oklahoma 3, Oregon Pennsylvania Rhode Island South Carolina South Dakota

78 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Kidney & Renal Pelvis Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Texas Utah Washington WA: Seattle/Puget Sound Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error UNITED STATES Combined Incidence American Indian/Alaskan Native III-50

79 UNITED STATES III-51 Combined Incidence American Indian/Alaskan Native Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Kidney & Renal Pelvis Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 12, , , , Alabama Alaska 1, Arizona 1, California Colorado Connecticut Florida Idaho Indiana Iowa Louisiana Maine Massachusetts Michigan Mississippi Montana Nebraska Nevada New Mexico 1, New York North Carolina North Dakota Oklahoma 3, Oregon Pennsylvania Rhode Island South Carolina South Dakota

80 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Kidney & Renal Pelvis Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Texas Utah Washington WA: Seattle/Puget Sound Wyoming Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error UNITED STATES Combined Incidence American Indian/Alaskan Native III-52

81 Total Cancer Cases and Average Annual Age-Adjusted Cancer Incidence Rates* Most Frequent Cancer Sites by IHS 1 Region, NAACCR U.S. Combined Selected CHSDA 1 Counties , American Indian/Alaskan Native, Males U.S. (CHSDA Counties) 2, 3 Northern Plains Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites 11, , Prostate 1 2, Lung & Bronchus 2 1, Colon & Rectum 3 1, Kidney & Renal Pelvis Liver and Intrahepatic Bile Duct Non-Hodgkin Lymphoma Urinary Bladder Oral Cavity & Pharynx Leukemia Stomach Pancreas Testis Esophagus Brain & Other Nervous System Melanoma of the Skin Myeloma Larynx Thyroid Alaska Southern Plains 2 Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites , Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver and Intrahepatic Bile Duct Non-Hodgkin Lymphoma Urinary Bladder Oral Cavity & Pharynx Leukemia Stomach Pancreas Testis Esophagus Brain & Other Nervous System Melanoma of the Skin ~ ~ ~ ~ ~ Myeloma Larynx Thyroid * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. The rates are based on cases and populations included in the combined incidence for the United States excluding MN and KS. 1 Abbreviations: IHS - Indian Health Services; CHSDA - Contract Health Service Delivery Area 2 Statistics exclude data for TX from July 2005 through December See Introduction. 3 Statistics exclude data for AL, LA and MS from July 2005 through December See Introduction. ~ Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. UNITED STATES III-53 Combined Incidence American Indian/Alaskan Native

82 Total Cancer Cases and Average Annual Age-Adjusted Cancer Incidence Rates* Most Frequent Cancer Sites by IHS 1 Region, NAACCR U.S. Combined Selected CHSDA 1 Counties , American Indian/Alaskan Native, Males Pacific Coast East 3 Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites 2, Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver and Intrahepatic Bile Duct Non-Hodgkin Lymphoma Urinary Bladder Oral Cavity & Pharynx Leukemia Stomach Pancreas Testis Esophagus ~ ~ ~ ~ ~ Brain & Other Nervous System Melanoma of the Skin Myeloma Larynx Thyroid ~ ~ ~ ~ ~ Southwest Cancer site or type Rank Count Rate 95% CI S.E. All Sites 2, Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver and Intrahepatic Bile Duct Non-Hodgkin Lymphoma Urinary Bladder Oral Cavity & Pharynx Leukemia Stomach Pancreas Testis Esophagus Brain & Other Nervous System Melanoma of the Skin Myeloma Larynx Thyroid * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. The rates are based on cases and populations included in the combined incidence for the United States excluding MN and KS. 1 Abbreviations: IHS - Indian Health Services; CHSDA - Contract Health Service Delivery Area 3 Statistics exclude data for AL, LA and MS from July 2005 through December See Introduction. ~ Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. UNITED STATES Combined Incidence American Indian/Alaskan Native III-54

83 Total Cancer Cases and Average Annual Age-Adjusted Cancer Incidence Rates* Most Frequent Cancer Sites by IHS 1 Region, NAACCR U.S. Combined Selected CHSDA 1 Counties , American Indian/Alaskan Native, Females U.S. (CHSDA Counties) 2, 3 Northern Plains Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites 12, , Breast 1 3, Lung & Bronchus 2 1, Colon & Rectum 3 1, Corpus & Uterus, NOS Kidney & Renal Pelvis Thyroid Non-Hodgkin Lymphoma Ovary Cervix Uteri Pancreas Leukemia Liver and Intrahepatic Bile Duct Stomach Melanoma of the Skin Oral Cavity & Pharynx Brain & Other Nervous System Urinary Bladder Gallbladder Alaska Southern Plains 2 Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites 1, , Breast Lung & Bronchus Colon & Rectum Corpus & Uterus, NOS Kidney & Renal Pelvis Thyroid Non-Hodgkin Lymphoma Ovary Cervix Uteri Pancreas Leukemia Liver and Intrahepatic Bile Duct Stomach Melanoma of the Skin ~ ~ ~ ~ ~ Oral Cavity & Pharynx Brain & Other Nervous System Urinary Bladder Gallbladder ~ ~ ~ ~ ~ * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. The rates are based on cases and populations included in the combined incidence for the United States excluding MN and KS. 1 Abbreviations: IHS - Indian Health Services; CHSDA - Contract Health Service Delivery Area 2 Statistics exclude data for TX from July 2005 through December See Introduction 3 Statistics exclude data for AL, LA and MS from July 2005 through December See Introduction. ~ Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. UNITED STATES III-55 Combined Incidence American Indian/Alaskan Native

84 Total Cancer Cases and Average Annual Age-Adjusted Cancer Incidence Rates* Most Frequent Cancer Sites by IHS 1 Region, NAACCR U.S. Combined Selected CHSDA 1 Counties , American Indian/Alaskan Native, Females Pacific Coast East 3 Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites 2, Breast Lung & Bronchus Colon & Rectum Corpus & Uterus, NOS Kidney & Renal Pelvis Thyroid Non-Hodgkin Lymphoma Ovary Cervix Uteri Pancreas Leukemia Liver and Intrahepatic Bile Duct Stomach Melanoma of the Skin ~ ~ ~ ~ ~ Oral Cavity & Pharynx Brain & Other Nervous System Urinary Bladder Gallbladder ~ ~ ~ ~ ~ Southwest Cancer site or type Rank Count Rate 95% CI S.E. All Sites 2, Breast Lung & Bronchus Colon & Rectum Corpus & Uterus, NOS Kidney & Renal Pelvis Thyroid Non-Hodgkin Lymphoma Ovary Cervix Uteri Pancreas Leukemia Liver and Intrahepatic Bile Duct Stomach Melanoma of the Skin Oral Cavity & Pharynx Brain & Other Nervous System Urinary Bladder Gallbladder * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. The rates are based on cases and populations included in the combined incidence for the United States excluding MN and KS. 1 Abbreviations: IHS - Indian Health Services; CHSDA - Contract Health Service Delivery Area 3 Statistics exclude data for AL, LA and MS from July 2005 through December See Introduction. ~ Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. UNITED STATES Combined Incidence American Indian/Alaskan Native III-56

85 NAACCR United States Combined Incidence , Hispanic/Latino, All Races Combined Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-57 Combined Incidence Hispanic/Latino, All Races

86 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , Hispanic/Latino, All Races MALES (HISPANIC/LATINO) FEMALES (HISPANIC/LATINA) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 US. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 230, , Oral Cavity & Pharynx 6, , Lip Tongue 1, Major salivary gland Floor of mouth Gum & other mouth Nasopharynx Oropharynx Hypopharynx Digestive System 55, , Esophagus 2, Stomach 7, , Small intestine 1, Colon excl. rectum 16, , Rectum & rectosigmoid 8, , Anus, anal canal & anorectum , Liver 9, , Gallbladder , Pancreas 5, , Respiratory System 25, , Larynx 2, Lung & bronchus 21, , Bones & Joints 1, Soft Tissue (incl. heart) 2, , Skin (excl. basal & sq.) 3, , Melanomas of the skin 2, , Breast (excl. in situ) , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS Ovary , Male Genital System 68, Prostate 62, Testis 5, Penis Urinary System 21, , Bladder (incl. in situ) 9, , Kidney & renal pelvis 11, , Ureter Eye & Orbit Brain & Other Nervous System 4, , Brain 4, , Endocrine System 4, , Thyroid gland 3, , Lymphomas 14, , Hodgkin Lymphoma 2, , Non-Hodgkin Lymphoma 11, , Multiple Myeloma 3, , Leukemias 8, , Acute lymphocytic 3, , Chronic lymphocytic 1, Acute myeloid 2, , Chronic myeloid 1, Other leukemias 1, Mesothelioma Kaposi Sarcoma 1, Ill-defined & Unknown 8, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 4, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. UNITED STATES Combined Incidence Hispanic/Latino, All Races III-58

87 UNITED STATES III-59 Combined Incidence Hispanic/Latino, All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latino, All Races, Males {Page 1 of 4} All Sites Prostate Colon & Rectum Lung & Bronchus Non-Hodgkin Lymphoma Kidney & Renal Pelvis Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 230, , , , , , Alabama Alaska Arizona 7, , California 61, , , , , , CA: Greater Bay Area 8, , CA: Los Angeles 21, , , , , , Colorado 4, , Connecticut 2, Delaware Florida 33, , , , , , Georgia 1, GA: Metropolitan Atlanta Hawaii Idaho Illinois 7, , Indiana 1, Iowa Kansas Kentucky Louisiana Maine Maryland 1, Massachusetts 2, Michigan 1, MI: Metropolitan Detroit Minnesota Mississippi Missouri

88 UNITED STATES Combined Incidence Hispanic/Latino, All Races III-60 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latino, All Races, Males {Page 2 of 4} All Sites Prostate Colon & Rectum Lung & Bronchus Non-Hodgkin Lymphoma Kidney & Renal Pelvis Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska Nevada 2, New Hampshire New Jersey 8, , New Mexico 6, , New York 23, , , , , North Carolina 1, North Dakota Ohio 1, Oklahoma Oregon 1, Pennsylvania 3, Rhode Island South Carolina South Dakota Tennessee Texas 41, , , , , , Utah 1, Vermont Washington 1, WA: Seattle/Puget Sound 1, West Virginia Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

89 UNITED STATES III-61 Combined Incidence Hispanic/Latino, All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latino, All Races, Males {Page 3 of 4} Liver & IBD 3 Bladder Leukemia Stomach Oral Cavity & Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 10, , , , , , Alabama Alaska Arizona California 2, , , , , , CA: Greater Bay Area CA: Los Angeles Colorado Connecticut Delaware Florida , , , Georgia GA: Metropolitan Atlanta Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan MI: Metropolitan Detroit Minnesota Mississippi Missouri

90 UNITED STATES Combined Incidence Hispanic/Latino, All Races III-62 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latino, All Races, Males {Page 4 of 4} Liver & IBD 3 Bladder Leukemia Stomach Oral Cavity & Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York 1, North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas 2, , , , , , Utah Vermont Washington WA: Seattle/Puget Sound West Virginia Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

91 UNITED STATES III-63 Combined Incidence Hispanic/Latina, All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latina, All Races, Females {Page 1 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 234, , , , , , Alabama Alaska Arizona 7, , California 65, , , , , , CA: Greater Bay Area 8, , CA: Los Angeles 23, , , , , , Colorado 4, , Connecticut 2, Delaware Florida 31, , , , , , Georgia 2, GA: Metropolitan Atlanta 1, Hawaii Idaho Illinois 8, , Indiana 1, Iowa Kansas 1, Kentucky Louisiana Maine Maryland 1, Massachusetts 3, Michigan 1, MI: Metropolitan Detroit 1, Minnesota Mississippi Missouri

92 UNITED STATES Combined Incidence Hispanic/Latina, All Races III-64 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latina, All Races, Females {Page 2 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska Nevada 2, New Hampshire New Jersey 8, , New Mexico 6, , New York 23, , , , , , North Carolina 1, North Dakota Ohio 1, Oklahoma 1, Oregon 1, Pennsylvania 2, Rhode Island South Carolina South Dakota Tennessee Texas 42, , , , , , Utah 1, Vermont Washington 2, WA: Seattle/Puget Sound 1, West Virginia Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

93 UNITED STATES III-65 Combined Incidence Hispanic/Latina, All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latina, All Races, Females {Page 3 of 4} Non-Hodgkin Lymphoma Cervix Ovary Kidney & Renal Pelvis Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 10, , , , , , Alabama Alaska Arizona California 2, , , , , , CA: Greater Bay Area CA: Los Angeles 1, , Colorado Connecticut Delaware Florida 1, , , Georgia GA: Metropolitan Atlanta Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan MI: Metropolitan Detroit Minnesota Mississippi Missouri

94 UNITED STATES Combined Incidence Hispanic/Latina, All Races III-66 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latina, All Races, Females {Page 4 of 4} Non-Hodgkin Lymphoma Cervix Ovary Kidney & Renal Pelvis Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York 1, North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas 1, , , , , , Utah Vermont Virginia Washington WA: Seattle/Puget Sound West Virginia Wyoming 1. Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

95 NAACCR United States Combined Incidence , The Non-Hispanic White Population Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-67 Combined Incidence Non-Hispanic White

96 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , Non-Hispanic White MALES (NON-HISPANIC WHITE) FEMALES (NON-HISPANIC WHITE) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 2,862, ,651, Oral Cavity & Pharynx 92, , Lip 6, , Tongue 27, , Major salivary gland 8, , Floor of mouth 5, , Gum & other mouth 9, , Nasopharynx 3, , Oropharynx 4, , Hypopharynx 6, , Digestive System 512, , Esophagus 47, , Stomach 40, , Small intestine 12, , Colon excl. rectum 188, , Rectum & rectosigmoid 84, , Anus, anal canal & anorectum 7, , Liver 40, , Gallbladder 3, , Pancreas 69, , Respiratory System 480, , Larynx 35, , Lung & bronchus 438, , Bones & Joints 5, , Soft Tissue (incl. heart) 19, , Skin (excl. basal & sq.) 163, , Melanomas of the skin 151, , Breast (excl. in situ) 7, , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 797, Prostate 763, Testis 29, Penis 3, Urinary System 324, , Bladder (incl. in situ) 206, , Kidney & renal pelvis 111, , Ureter 4, , Eye & Orbit 5, , Brain & Other Nervous System 43, , Brain 41, , Endocrine System 37, , Thyroid gland 33, , Lymphomas 138, , Hodgkin Lymphoma 15, , Non-Hodgkin Lymphoma 122, , Multiple Myeloma 33, , Leukemias 82, , Acute lymphocytic 7, , Chronic lymphocytic 31, , Acute myeloid 22, , Chronic myeloid 9, , Other leukemias 11, , Mesothelioma 10, , Kaposi Sarcoma 2, Ill-defined & Unknown 106, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 37, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. UNITED STATES Combined Incidence Non-Hispanic White III-68

97 UNITED STATES III-69 Combined Incidence Non-Hispanic White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Males {Page 1 of 4} All Sites Prostate Colon & Rectum Lung & Bronchus Non-Hodgkin Lymphoma Kidney & Renal Pelvis Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 2,862, , , , , , Alabama 45, , , , , , Alaska 5, , Arizona 54, , , , , , California 256, , , , , , CA: Greater Bay Area 49, , , , , , CA: Los Angeles 48, , , , , , Colorado 41, , , , , , Connecticut 43, , , , , , Delaware 10, , , Florida 212, , , , , , Georgia 77, , , , , , GA: Metropolitan Atlanta 19, , , , Hawaii 5, , Idaho 17, , , , Illinois 126, , , , , , Indiana 70, , , , , , Iowa 41, , , , , , Kansas 32, , , , , , Kentucky 57, , , , , , Louisiana 39, , , , , , Maine 21, , , , Maryland 47, , , , , , Massachusetts 80, , , , , , Michigan 114, , , , , , MI: Metropolitan Detroit 41, , , , , , Minnesota 64, , , , , , Mississippi 25, , , , , , Missouri 69, , , , , ,

98 UNITED STATES Combined Incidence Non-Hispanic White III-70 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Males {Page 2 of 4} All Sites Prostate Colon & Rectum Lung & Bronchus Non-Hodgkin Lymphoma Kidney & Renal Pelvis Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana 12, , , , Nebraska 21, , , , Nevada 24, , , , New Hampshire 18, , , , New Jersey 93, , , , , , New Mexico 14, , , , New York 197, , , , , , North Carolina 93, , , , , , North Dakota 8, , , , Ohio 131, , , , , , Oklahoma 40, , , , , , Oregon 44, , , , , , Pennsylvania 167, , , , , , Rhode Island 13, , , , South Carolina 44, , , , , , South Dakota 9, , , , Tennessee 71, , , , , , Texas 154, , , , , , Utah 21, , , , , Vermont 8, , , Washington 73, , , , , , WA: Seattle/Puget Sound 51, , , , , , West Virginia 27, , , , , , Wyoming 6, , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

99 UNITED STATES III-71 Combined Incidence Non-Hispanic White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Males {Page 3 of 4} Liver & IBD 3 Bladder Leukemia Stomach Oral Cavity & Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 44, , , , , , Alabama , , , , Alaska Arizona , , , , California 4, , , , , , CA: Greater Bay Area , , , , CA: Los Angeles , , , , Colorado , , , Connecticut , , , , Delaware Florida 3, , , , , , Georgia 1, , , , , GA: Metropolitan Atlanta , Hawaii Idaho , Illinois 1, , , , , , Indiana 1, , , , , Iowa , , , Kansas , Kentucky , , , , Louisiana , , , Maine , Maryland , , , , Massachusetts 1, , , , , , Michigan 1, , , , , , MI: Metropolitan Detroit , , , , Minnesota , , , , Mississippi , Missouri 1, , , , ,

100 UNITED STATES Combined Incidence Non-Hispanic White III-72 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Males {Page 4 of 4} Liver & IBD 3 Bladder Leukemia Stomach Oral Cavity & Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska , Nevada , New Hampshire , New Jersey 1, , , , , , New Mexico New York 3, , , , , , North Carolina 1, , , , , , North Dakota Ohio 1, , , , , , Oklahoma , , , Oregon , , , , Pennsylvania 2, , , , , , Rhode Island , South Carolina , , , South Dakota Tennessee 1, , , , , Texas 2, , , , , , Utah , Vermont Washington 1, , , , , , WA: Seattle/Puget Sound , , , , West Virginia , Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

101 UNITED STATES III-73 Combined Incidence Non-Hispanic White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Females {Page 1 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 2,651, , , , , , Alabama 38, , , , , , Alaska 4, , Arizona 49, , , , , , California 239, , , , , , CA: Greater Bay Area 45, , , , , , CA: Los Angeles 46, , , , , , Colorado 40, , , , , , Connecticut 42, , , , , , Delaware 9, , , Florida 183, , , , , , Georgia 68, , , , , , GA: Metropolitan Atlanta 17, , , , Hawaii 3, , Idaho 14, , , , Illinois 123, , , , , , Indiana 68, , , , , , Iowa 38, , , , , , Kansas 29, , , , , , Kentucky 52, , , , , , Louisiana 32, , , , , , Maine 19, , , , , Maryland 46, , , , , , Massachusetts 81, , , , , , Michigan 105, , , , , , MI: Metropolitan Detroit 39, , , , , , Minnesota 57, , , , , , Mississippi 20, , , , Missouri 65, , , , , ,

102 UNITED STATES Combined Incidence Non-Hispanic White III-74 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Females {Page 2 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana 11, , , , Nebraska 20, , , , , Nevada 20, , , , New Hampshire 17, , , , , New Jersey 91, , , , , , New Mexico 12, , , , New York 192, , , , , , North Carolina 84, , , , , , North Dakota 7, , Ohio 128, , , , , , Oklahoma 36, , , , , , Oregon 43, , , , , , Pennsylvania 163, , , , , , Rhode Island 14, , , , South Carolina 38, , , , , , South Dakota 8, , , Tennessee 63, , , , , , Texas 135, , , , , , Utah 17, , , , , , Vermont 8, , , Washington 67, , , , , , WA: Seattle/Puget Sound 47, , , , , , West Virginia 25, , , , , Wyoming 5, , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

103 UNITED STATES III-75 Combined Incidence Non-Hispanic White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Females {Page 3 of 4} Non-Hodgkin Lymphoma Cervix Ovary Kidney & Renal Pelvis Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 105, , , , , , Alabama 1, , , Alaska Arizona 1, , , , California 9, , , , , , CA: Greater Bay Area 1, , , , CA: Los Angeles 1, , , , Colorado 1, , Connecticut 1, , , Delaware Florida 6, , , , , , Georgia 2, , , , , , GA: Metropolitan Atlanta Hawaii Idaho Illinois 4, , , , , , Indiana 2, , , , , , Iowa 1, , , , Kansas 1, Kentucky 2, , , , , Louisiana 1, , Maine Maryland 1, , , , Massachusetts 2, , , , , Michigan 4, , , , , , MI: Metropolitan Detroit 1, , , , Minnesota 2, , , , , Mississippi Missouri 2, , , , , ,

104 UNITED STATES Combined Incidence Non-Hispanic White III-76 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Females {Page 4 of 4} Non-Hodgkin Lymphoma Cervix Ovary Kidney & Renal Pelvis Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska Nevada New Hampshire New Jersey 3, , , , , , New Mexico New York 7, , , , , , North Carolina 3, , , , , , North Dakota Ohio 5, , , , , , Oklahoma 1, , , Oregon 1, , , , Pennsylvania 6, , , , , , Rhode Island South Carolina 1, , , South Dakota Tennessee 2, , , , , , Texas 5, , , , , , Utah Vermont Virginia 2, , , , , Washington 1, , , , , WA: Seattle/Puget Sound West Virginia Wyoming 1. Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

105 NAACCR United States Combined Incidence , The Non-Hispanic Black Population Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-77 Combined Incidence Non-Hispanic Black

106 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , Non-Hispanic Black MALES (NON-HISPANIC BLACK) FEMALES (NON-HISPANIC BLACK) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 360, , Oral Cavity & Pharynx 10, , Lip Tongue 2, Major salivary gland Floor of mouth Gum & other mouth 1, Nasopharynx Oropharynx Hypopharynx 1, Digestive System 75, , Esophagus 5, , Stomach 8, , Small intestine 2, , Colon excl. rectum 26, , Rectum & rectosigmoid 9, , Anus, anal canal & anorectum 1, , Liver 9, , Gallbladder , Pancreas 9, , Respiratory System 61, , Larynx 6, , Lung & bronchus 54, , Bones & Joints Soft Tissue (incl. heart) 2, , Skin (excl. basal & sq.) 1, , Melanomas of the skin Breast (excl. in situ) 1, , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 134, Prostate 133, Testis 1, Penis Urinary System 24, , Bladder (incl. in situ) 9, , Kidney & renal pelvis 14, , Ureter Eye & Orbit Brain & Other Nervous System 3, , Brain 3, , Endocrine System 2, , Thyroid gland 2, , Lymphomas 13, , Hodgkin Lymphoma 2, , Non-Hodgkin Lymphoma 11, , Multiple Myeloma 7, , Leukemias 7, , Acute lymphocytic Chronic lymphocytic 2, , Acute myeloid 2, , Chronic myeloid 1, Other leukemias Mesothelioma Kaposi Sarcoma 1, Ill-defined & Unknown 10, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 4, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. UNITED STATES Combined Incidence Non-Hispanic Black III-78

107 UNITED STATES III-79 Combined Incidence Non-Hispanic Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Males {Page 1 of 4} All Sites Prostate Colon & Rectum Lung & Bronchus Non-Hodgkin Lymphoma Kidney & Renal Pelvis Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 360, , , , , , Alabama 12, , , , Alaska Arizona 1, California 25, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 10, , , , Colorado 1, Connecticut 3, , Delaware 2, Florida 25, , , , Georgia 26, , , , GA: Metropolitan Atlanta 10, , , Hawaii Idaho Illinois 21, , , , Indiana 5, , , Iowa Kansas 1, Kentucky 3, , Louisiana 14, , , , Maine Maryland 15, , , , Massachusetts 3, , Michigan 16, , , , MI: Metropolitan Detroit 12, , , , Minnesota 1, Mississippi 10, , , , Missouri 7, , ,

108 UNITED STATES Combined Incidence Non-Hispanic Black III-80 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Males {Page 2 of 4} All Sites Prostate Colon & Rectum Lung & Bronchus Non-Hodgkin Lymphoma Kidney & Renal Pelvis Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska Nevada 1, New Hampshire New Jersey 12, , , , New Mexico New York 32, , , , , , North Carolina 22, , , , North Dakota Ohio 14, , , , Oklahoma 2, , Oregon Pennsylvania 15, , , , Rhode Island South Carolina 13, , , , South Dakota Tennessee 9, , , , Texas 24, , , , , Utah Vermont Washington 2, WA: Seattle/Puget Sound 2, West Virginia Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

109 UNITED STATES III-81 Combined Incidence Non-Hispanic Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Males {Page 3 of 4} Liver & IBD 3 Bladder Leukemia Stomach Oral Cavity & Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 9, , , , , , Alabama Alaska Arizona California CA: Greater Bay Area CA: Los Angeles Colorado Connecticut Delaware Florida Georgia GA: Metropolitan Atlanta Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan MI: Metropolitan Detroit Minnesota Mississippi Missouri

110 UNITED STATES Combined Incidence Non-Hispanic Black III-82 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Males {Page 4 of 4} Liver & IBD 3 Bladder Leukemia Stomach Oral Cavity & Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York 1, North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Washington WA: Seattle/Puget Sound West Virginia Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

111 UNITED STATES III-83 Combined Incidence Non-Hispanic Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Females {Page 1 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 325, , , , , , Alabama 10, , , , Alaska Arizona 1, California 22, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 10, , , , Colorado 1, Connecticut 3, Delaware 1, Florida 22, , , , , Georgia 23, , , , , GA: Metropolitan Atlanta 9, , , Hawaii Idaho Illinois 20, , , , , Indiana 5, , Iowa Kansas 1, Kentucky 3, Louisiana 12, , , , Maine Maryland 15, , , , Massachusetts 3, , Michigan 15, , , , MI: Metropolitan Detroit 11, , , , Minnesota 1, Mississippi 8, , , , Missouri 7, , ,

112 UNITED STATES Combined Incidence Non-Hispanic Black III-84 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Females {Page 2 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska Nevada 1, New Hampshire New Jersey 12, , , , New Mexico New York 31, , , , , North Carolina 19, , , , , North Dakota Ohio 14, , , , Oklahoma 2, Oregon Pennsylvania 15, , , , Rhode Island South Carolina 11, , , , South Dakota Tennessee 9, , , , Texas 22, , , , Utah Vermont Washington 1, WA: Seattle/Puget Sound 1, West Virginia Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

113 UNITED STATES III-85 Combined Incidence Non-Hispanic Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Females {Page 3 of 4} Non-Hodgkin Lymphoma Cervix Ovary Kidney & Renal Pelvis Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 9, , , , , , Alabama Alaska Arizona California CA: Greater Bay Area CA: Los Angeles Colorado Connecticut Delaware Florida Georgia GA: Metropolitan Atlanta Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan MI: Metropolitan Detroit Minnesota Mississippi Missouri

114 UNITED STATES Combined Incidence Non-Hispanic Black III-86 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Ten Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Females {Page 4 of 4} Non-Hodgkin Lymphoma Cervix Ovary Kidney & Renal Pelvis Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York 1, , North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington WA: Seattle/Puget Sound West Virginia Wyoming 1. Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates.

115

116 Race-Specific Population Indicators ( ) Combined Population: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander 61,790, Number of Cases in Combined Cancer Statistics: All Races 302,564 White - Black - American Indian/Alaskan Native - Asian/Pacific Islander - COMBINED CANCER INCIDENCE RATES CANADA Percentage of Canada Population Reflected in the Combined Cancer Statistics: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander 37.5% Race-Specific Population Counts by Year Race All Races 12,029,187 12,172,903 12,341,987 12,525,441 12,720,511 Data Quality Indicators ( ) Indicators (%) Missing Race na na na na na Missing Sex Missing County Missing Age Death Certificate Only Cases Site-Specific Microscopic Confirmation ( ) Cancer Site % Micro. Confirm Cancer Site % Micro. Confirm All Sites 90.7 Prostate 95.1 Oral Cavity & Pharynx 98.1 Testis 98.9 Esophagus 94.3 Bladder (incl. in situ) 96.3 Stomach 95.0 Kidney & Renal Pelvis 83.4 Colon & Rectum 94.5 Brain & Other Nervous System 81.7 Liver 50.3 Thyroid Gland 99.3 Pancreas 57.8 Hodgkin Lymphoma 99.8 Lung & Bronchus 81.2 Non-Hodgkin Lymphoma 96.5 Melanomas of the Skin 99.6 Multiple Myeloma 90.3 Female Breast (excl. in situ) 98.7 Leukemias 92.2 Cervix uteri 98.8 Brain & ONS 1 benign/borderline 63.4 Uterus Corpus & Uterus NOS 98.7 Breast in situ Ovary 89.4 CANADA Combined Incidence III-88

117 NAACCR Canadian Combined Incidence , All Races Combined Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries CANADA III-89 Combined Incidence All Races

118 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR Canadian Combined, , All Races MALES (ALL RACES) FEMALES (ALL RACES) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 159, , Oral Cavity & Pharynx 4, , Lip Tongue 1, Major salivary gland Floor of mouth Gum & other mouth Nasopharynx Oropharynx Hypopharynx Digestive System 35, , Esophagus 2, Stomach 3, , Small intestine Colon excl. rectum 13, , Rectum & rectosigmoid 8, , Anus, anal canal & anorectum Liver 2, Gallbladder Pancreas 3, , Respiratory System 23, , Larynx 1, Lung & bronchus 21, , Bones & Joints Soft Tissue (incl. heart) Skin (excl. basal & sq.) 5, , Melanomas of the skin 5, , Breast (excl. in situ) , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS Ovary , Male Genital System 46, Prostate 44, Testis 1, Penis Urinary System 16, , Bladder (incl. in situ) 10, , Kidney & renal pelvis 5, , Ureter Eye & Orbit Brain & Other Nervous System 2, , Brain 2, , Endocrine System 1, , Thyroid gland 1, , Lymphomas 7, , Hodgkin Lymphoma Non-Hodgkin Lymphoma 6, , Multiple Myeloma 1, , Leukemias 5, , Acute lymphocytic Chronic lymphocytic 2, , Acute myeloid 1, Chronic myeloid Other leukemias Mesothelioma Kaposi Sarcoma Ill-defined & Unknown 5, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System CANADA Combined Incidence All Races III-90

119 CANADA IV-91 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR Canadian Combined 3, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Non-Hodgkin Lymphoma Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR Canadian Combined 159, , , , , , Alberta 37, , , , , , British Columbia 55, , , , , , Manitoba 15, , , , , New Brunswick 12, , , , Newfoundland and Labrador 8, , , , Nova Scotia 15, , , , Prince Edward Island 2, Saskatchewan 14, , , , Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 2 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR Canadian Combined 3, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Non-Hodgkin Lymphoma Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR Canadian Combined 159, , , , , , Alberta 37, , , , , , British Columbia 55, , , , , , Manitoba 15, , , , , New Brunswick 12, , , , Newfoundland and Labrador 8, , , , Nova Scotia 15, , , , Prince Edward Island 2, Saskatchewan 14, , , , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the Canadian combined. 2. Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the Canadian combined. 3. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 4. Abbreviations: S.E. - Standard Error

120 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR Canadian Combined 3, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Non-Hodgkin Lymphoma Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR Canadian Combined 142, , , , , , Alberta 34, , , , , , British Columbia 49, , , , , , Manitoba 14, , , , New Brunswick 10, , , , Newfoundland and Labrador 6, , , Nova Scotia 13, , , , Prince Edward Island 1, Saskatchewan 12, , , , CANADA Combined Incidence All Races IV-92 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 2 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR Canadian Combined 3, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Non-Hodgkin Lymphoma Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR Canadian Combined 142, , , , , , Alberta 34, , , , , , British Columbia 49, , , , , , Manitoba 14, , , , New Brunswick 10, , , , Newfoundland and Labrador 6, , , Nova Scotia 13, , , , Prince Edward Island 1, Saskatchewan 12, , , , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the Canadian combined. 2. Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the Canadian combined. 3. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 4. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

121

122 Race-Specific Population Indicators ( ) Combined Population: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander 1,467,986, Number of Cases in Combined Cancer Statistics: All Races 7,272,170 White - Black - American Indian/Alaskan Native - Asian/Pacific Islander - COMBINED CANCER INCIDENCE RATES NORTH AMERICA Percentage of Canada Population Reflected in the Combined Cancer Statistics: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander 87.8% Race-Specific Population Counts by Year Race All Races 273,946, ,148, ,171, ,019, ,700,590 Data Quality Indicators ( ) Indicators (%) Missing Race na na na na na Missing Sex Missing County Missing Age Death Certificate Only Cases Site-Specific Microscopic Confirmation ( ) Cancer Site % Micro. Confirm Cancer Site % Micro. Confirm All Sites 93.3 Prostate 97.0 Oral Cavity & Pharynx 97.7 Testis 99.1 Esophagus 95.0 Bladder (incl. in situ) 97.9 Stomach 96.0 Kidney & Renal Pelvis 89.9 Colon & Rectum 96.4 Brain & Other Nervous System 84.3 Liver 68.0 Thyroid Gland 99.4 Pancreas 77.9 Hodgkin Lymphoma 98.6 Lung & Bronchus 87.9 Non-Hodgkin Lymphoma 96.6 Melanomas of the Skin 99.1 Multiple Myeloma 87.6 Female Breast (excl. in situ) 98.2 Leukemias 88.6 Cervix uteri 97.5 Brain & ONS 1 benign/borderline 51.2 Uterus Corpus & Uterus NOS 98.5 Breast in situ Ovary 91.3 NORTH AMERICA Combined Incidence III-94

123 NAACCR North America Combined Incidence , All Races Combined Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries NORTH AMERICA III-95 Combined Incidence All Races

124 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR North America Combined, , All Races MALES (ALL RACES) FEMALES (ALL RACES) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 3,772, ,499, Oral Cavity & Pharynx 118, , Lip 7, , Tongue 33, , Major salivary gland 10, , Floor of mouth 6, , Gum & other mouth 12, , Nasopharynx 6, , Oropharynx 5, , Hypopharynx 8, , Digestive System 712, , Esophagus 59, , Stomach 64, , Small intestine 16, , Colon excl. rectum 253, , Rectum & rectosigmoid 116, , Anus, anal canal & anorectum 9, , Liver 68, , Gallbladder 5, , Pancreas 91, , Respiratory System 608, , Larynx 47, , Lung & bronchus 552, , Bones & Joints 7, , Soft Tissue (incl. heart) 26, , Skin (excl. basal & sq.) 181, , Melanomas of the skin 167, , Breast (excl. in situ) 9, ,008, Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 1,105, Prostate 1,058, Testis 39, Penis 5, Urinary System 399, , Bladder (incl. in situ) 243, , Kidney & renal pelvis 147, , Ureter 5, , Eye & Orbit 6, , Brain & Other Nervous System 55, , Brain 52, , Endocrine System 48, , Thyroid gland 42, , Lymphomas 181, , Hodgkin Lymphoma 22, , Non-Hodgkin Lymphoma 158, , Multiple Myeloma 48, , Leukemias 108, , Acute lymphocytic 12, , Chronic lymphocytic 39, , Acute myeloid 29, , Chronic myeloid 13, , Other leukemias 14, , Mesothelioma 12, , Kaposi Sarcoma 5, Ill-defined & Unknown 135, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 49, , Breast (in situ) 1, , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System NORTH AMERICA Combined Incidence All Races III-96

125 NORTH AMERICA III-97 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,612, ,014, , , , , Alabama 59, , , , , , Alaska 6, , Arizona 66, , , , , , California 389, , , , , , CA: Greater Bay Area 76, , , , , , CA: Los Angeles 94, , , , , , Colorado 50, , , , , , Connecticut 50, , , , , , Delaware 13, , , , Florida 276, , , , , , Georgia 107, , , , , , GA: Metropolitan Atlanta 31, , , , , , Hawaii 16, , , , Idaho 18, , , , , , Illinois 162, , , , , , Indiana 78, , , , , , Iowa 43, , , , , , Kansas 36, , , , , , Kentucky 62, , , , , , Louisiana 55, , , , , , Maine 21, , , , , Maryland 67, , , , , , Massachusetts 90, , , , , , Michigan 139, , , , , , MI: Metropolitan Detroit 57, , , , , , Minnesota 69, , , , , , Mississippi 36, , , , , , Missouri 78, , , , , , Montana 13, , , , Nebraska 23, , , , , Nevada 30, , , , , , New Hampshire 19, , , , , , New Jersey 121, , , , , , New Mexico 22, , , , , ,

126 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. New York 266, , , , , , North Carolina 120, , , , , , North Dakota 9, , , , Ohio 152, , , , , , Oklahoma 49, , , , , , Oregon 48, , , , , , Pennsylvania 191, , , , , , Rhode Island 15, , , , , South Carolina 59, , , , , , South Dakota 10, , , , Tennessee 83, , , , , , Texas 227, , , , , , Utah 22, , , , , , Vermont 9, , , Washington 83, , , , , , WA: Seattle/Puget Sound 58, , , , , , West Virginia 28, , , , , , Wyoming 6, , NORTH AMERICA ombined Incidence All Races III-98 NAACCR Canadian Combined 159, , , , , , Alberta 37, , , , , , British Columbia 55, , , , , , Manitoba 15, , , , , New Brunswick 12, , , , Newfoundland and Labrador 8, , , , Nova Scotia 15, , , , Prince Edward Island 2, Saskatchewan 14, , , , NAACCR North American Combined 1. 3,772, ,058, , , , , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

127 NORTH AMERICA III-99 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,612, ,014, , , , , Alabama 59, , , , , , Alaska 6, , Arizona 66, , , , , , California 389, , , , , , CA: Greater Bay Area 76, , , , , , CA: Los Angeles 94, , , , , , Colorado 50, , , , , , Connecticut 50, , , , , , Delaware 13, , , , Florida 276, , , , , , Georgia 107, , , , , , GA: Metropolitan Atlanta 31, , , , , , Hawaii 16, , , , Idaho 18, , , , , , Illinois 162, , , , , , Indiana 78, , , , , , Iowa 43, , , , , , Kansas 36, , , , , , Kentucky 62, , , , , , Louisiana 55, , , , , , Maine 21, , , , , Maryland 67, , , , , , Massachusetts 90, , , , , , Michigan 139, , , , , , MI: Metropolitan Detroit 57, , , , , , Minnesota 69, , , , , , Mississippi 36, , , , , , Missouri 78, , , , , , Montana 13, , , , Nebraska 23, , , , , Nevada 30, , , , , , New Hampshire 19, , , , , , New Jersey 121, , , , , , New Mexico 22, , , , , ,

128 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. New York 266, , , , , , North Carolina 120, , , , , , North Dakota 9, , , , Ohio 152, , , , , , Oklahoma 49, , , , , , Oregon 48, , , , , , Pennsylvania 191, , , , , , Rhode Island 15, , , , , South Carolina 59, , , , , , South Dakota 10, , , , Tennessee 83, , , , , , Texas 227, , , , , , Utah 22, , , , , , Vermont 9, , , Washington 83, , , , , , WA: Seattle/Puget Sound 58, , , , , , West Virginia 28, , , , , , Wyoming 6, , NORTH AMERICA Combined Incidence All Races III-100 NAACCR Canadian Combined 159, , , , , , Alberta 37, , , , , , British Columbia 55, , , , , , Manitoba 15, , , , , New Brunswick 12, , , , Newfoundland and Labrador 8, , , , Nova Scotia 15, , , , Prince Edward Island 2, Saskatchewan 14, , , , NAACCR North American Combined 1. 3,772, ,058, , , , , Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

129 NORTH AMERICA III-101 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,356, , , , , , Alabama 49, , , , , , Alaska 5, , Arizona 62, , , , , , California 371, , , , , , CA: Greater Bay Area 73, , , , , , CA: Los Angeles 93, , , , , , Colorado 48, , , , , , Connecticut 49, , , , , , Delaware 11, , , , Florida 241, , , , , , Georgia 95, , , , , , GA: Metropolitan Atlanta 30, , , , , , Hawaii 15, , , , , Idaho 15, , , , Illinois 156, , , , , , Indiana 76, , , , , , Iowa 40, , , , , , Kansas 33, , , , , , Kentucky 57, , , , , , Louisiana 45, , , , , , Maine 20, , , , , Maryland 65, , , , , , Massachusetts 91, , , , , , Michigan 126, , , , , , MI: Metropolitan Detroit 53, , , , , , Minnesota 61, , , , , , Mississippi 29, , , , , , Missouri 74, , , , , , Montana 12, , , , Nebraska 21, , , , , Nevada 25, , , , , New Hampshire 17, , , , , New Jersey 118, , , , , , New Mexico 20, , , , ,

130 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. New York 258, , , , , , North Carolina 108, , , , , , North Dakota 8, , Ohio 147, , , , , , Oklahoma 44, , , , , , Oregon 47, , , , , , Pennsylvania 185, , , , , , Rhode Island 15, , , , South Carolina 52, , , , , , South Dakota 9, , , , Tennessee 74, , , , , , Texas 206, , , , , , Utah 19, , , , , Vermont 8, , , Washington 77, , , , , , WA: Seattle/Puget Sound 55, , , , , , West Virginia 26, , , , , , Wyoming 5, , NORTH AMERICA Combined Incidence All Races III-102 NAACCR Canadian Combined 142, , , , , , Alberta 34, , , , , , British Columbia 49, , , , , , Manitoba 14, , , , New Brunswick 10, , , , Newfoundland and Labrador 6, , , Nova Scotia 13, , , , Prince Edward Island 1, Saskatchewan 12, , , , NAACCR North American Combined 1. 3,499, ,008, , , , , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

131 NORTH AMERICA III-103 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,356, , , , , , Alabama 49, , , , , , Alaska 5, , Arizona 62, , , , , , California 371, , , , , , CA: Greater Bay Area 73, , , , , , CA: Los Angeles 93, , , , , , Colorado 48, , , , , , Connecticut 49, , , , , , Delaware 11, , , , Florida 241, , , , , , Georgia 95, , , , , , GA: Metropolitan Atlanta 30, , , , , , Hawaii 15, , , , , Idaho 15, , , , Illinois 156, , , , , , Indiana 76, , , , , , Iowa 40, , , , , , Kansas 33, , , , , , Kentucky 57, , , , , , Louisiana 45, , , , , , Maine 20, , , , , Maryland 65, , , , , , Massachusetts 91, , , , , , Michigan 126, , , , , , MI: Metropolitan Detroit 53, , , , , , Minnesota 61, , , , , , Mississippi 29, , , , , , Missouri 74, , , , , , Montana 12, , , , Nebraska 21, , , , , Nevada 25, , , , , New Hampshire 17, , , , , New Jersey 118, , , , , , New Mexico 20, , , , ,

132 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. New York 258, , , , , , North Carolina 108, , , , , , North Dakota 8, , Ohio 147, , , , , , Oklahoma 44, , , , , , Oregon 47, , , , , , Pennsylvania 185, , , , , , Rhode Island 15, , , , South Carolina 52, , , , , , South Dakota 9, , , , Tennessee 74, , , , , , Texas 206, , , , , , Utah 19, , , , , Vermont 8, , , Washington 77, , , , , , WA: Seattle/Puget Sound 55, , , , , , West Virginia 26, , , , , , Wyoming 5, , NORTH AMERICA Combined Incidence All Races III-104 NAACCR Canadian Combined 142, , , , , , Alberta 34, , , , , , British Columbia 49, , , , , , Manitoba 14, , , , New Brunswick 10, , , , Newfoundland and Labrador 6, , , Nova Scotia 13, , , , Prince Edward Island 1, Saskatchewan 12, , , , NAACCR North American Combined 1. 3,499, ,008, , , , , Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the combined. Statistics exclude data for AL, LA, MS and TX from July 2005 through December See Introduction. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

133

134 NAACCR U.S. Combined Pediatric Cancer Incidence Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES Pediatric Cancer III-106