The incidence of esophageal adenocarcinoma is rising in the ENDOSCOPY CORNER
|
|
- Christian Horn
- 5 years ago
- Views:
Transcription
1 CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2010;8: ENDOSCOPY CORNER Acetic Acid Spray Is an Effective Tool for the Endoscopic Detection of Neoplasia in Patients With Barrett s Esophagus GAIUS LONGCROFT WHEATON,* MOSES DUKU,* ROBERT MEAD,* DAVID POLLER, and PRADEEP BHANDARI* *Department of Gastroenterology and Department of Histopathology, Queen Alexandra Hospital, Portsmouth, United Kingdom See related article, Curvers WL et al, on page 1106 in Gastroenterology. BACKGROUND & AIMS: Diagnosis of Barrett s neoplasia requires collection of large numbers of random biopsy samples; the process is time consuming and can miss early-stage cancers. We evaluated the role of acetic acid chromoendoscopy in identifying Barrett s neoplasia. METHODS: Data were collected from patients with Barrett s esophagus examined at a tertiary referral center, between July 2005 and November 2008 using Fujinon gastroscopes and EPX 4400 processor (n 190). All procedures were performed by a single experienced endoscopist. Patients were examined with white light gastroscopy and visible abnormalities were identified. Acetic acid (2.5%) dye spray was used to identify potentially neoplastic areas and biopsy samples were collected from these, followed by quadrantic biopsies at 2 cm intervals of the remaining Barrett s mucosa. The chromoendoscopic diagnosis was compared with the ultimate histological diagnosis to evaluate the sensitivity of acetic acid chromoendoscopy. RESULTS: Acetic acid chromoendoscopy had a sensitivity of 95.5% and specificity of 80% for the detection of neoplasia. There was a correlation between lesions predicted to be neoplasias by acetic acid and those diagnosed by histological analysis (r 0.98). There was a significant improvement in the detection of neoplasia using acetic acid compared with white light endoscopy (P.001). CONCLUSIONS: Analysis of this large series showed that acetic acid-assisted evaluation of Barrett s esophagus detects neoplasia better than white light endoscopy, with sensitivity and specificity equal to that of histological analysis. Keywords: Chromoendoscopy; Dysplasia; Intramucosal Cancer; Endoscopic Mucosal Resection. View this article s video abstract at The incidence of esophageal adenocarcinoma is rising in the western world. It is responsible for 14,500 deaths per year in the United States 1 and 7000 per year in the United Kingdom. 2 Barrett s dysplasia is a well established precursor, which is the basis for endoscopic surveillance of patients with Barrett s esophagus. Standard protocols require the collection of large numbers of biopsies which are conventionally taken in a random quadrantic fashion at 2 cm intervals. Nontargeted multiple biopsies have remained standard practice as most of the dysplastic areas are difficult to see with standard resolution white light endoscopes, and only 13% of early neoplastic lesions appear as macroscopically visible nodules. 3 It has been shown that intensive surveillance biopsies as per the Seattle protocol using jumbo forceps does not improve the detection of intramucosal adenocarcinoma any more reliably than less intensive protocols with standard biopsy forceps. 4 Endoscopic surveillance of Barrett s esophagus makes clinical sense due to its malignant potential, but the poor pick up rate of neoplasia during routine surveillance with white light endoscopy (WLI) and quadrantic biopsy questions the cost effectiveness of this strategy. 5 Recent developments have led to improvements in the optical resolution of endoscopes, and new technologies have been developed which enhance mucosal visualization. Improved methods for identifying in vivo dysplastic areas use either chromoendoscopy, 6 8 of which acetic acid (AA) is 1 method, or narrow band imaging, 9 and spectral imaging techniques like Fujinon intelligent color enhancement. 10 Chromoendoscopy for the detection of Barrett s metaplasia has been available for many years. The 3 dyes commonly used are methylene blue, 11 indigo carmine, 12 and AA. 13 AA dye spray is used routinely for the detection of cervical precancerous lesions, including glandular lesions, at colposcopy. 14 AA was originally used in the esophagus as an aid to detect small segments of residual Barrett s metaplasia after ablation therapy. AA when sprayed on Barrett s mucosa leads to reversible acetylation of nuclear proteins leading to an aceto-white area, causing vascular congestion and improving the visualization of the mucosal surface. 15 This allows the mucosal surface patterns to be assessed, improving the diagnosis of dysplasia or cancer. The reaction only lasts a few minutes, with dysplastic tissue losing the acetowhitening more quickly than background Barrett s epithelium, further highlighting abnormal areas (see Figures 1 and 2). Our contention is that the detection of neoplasia in Barrett s is the main priority and not intestinal metaplasia. The aim of this study is to assess the accuracy of AA dye spray in the detection of Barrett s neoplasia during gastroscopy. Methods This study was approved by a central institutional review board, which allowed a waiver for patient-informed con- Abbreviations used in this paper: AA, acetic acid; EMR, endoscopic mucosal resection; HGD, high grade dysplasia; LGD, low grade dysplasia; WLI, white light endoscopy by the AGA Institute /$36.00 doi: /j.cgh
2 844 LONGCROFT WHEATON ET AL CLINICAL GASTROENTEROLOGY AND HEPATOLOGY Vol. 8, No. 10 Figure 1. HGD in Barrett s pre- (A) and post (B) AA dye spray. sent for data collection. Each patient had signed an informed consent form for the endoscopy procedure. Our department is a specialist center for the assessment and treatment of early gastrointestinal neoplasia, taking referrals from across the South of England for the endoscopic management of dysplasia and intramucosal cancer within Barrett s esophagus. All patients undergoing AA dye spray for evaluation of Barrett s esophagus between 2005 and 2008 were recorded prospectively on a computer database. All procedures were performed by a single experienced endoscopist (PB) with expertise in lesion recognition and endoscopic mucosal resection (EMR). The patient population included Barrett s cases where dysplasia had never been identified (group A) and tertiary referrals for suspected esophageal neoplasia where dysplasia had been found or suspected on random biopsy and post EMR follow-up cases where dysplasia had been treated endoscopically (group B). All patients were endoscoped on a dedicated chromoendoscopy list. Twenty-five percent of the cases were performed under local anesthetic with xylocaine 10 mg spray, with 75% choosing conscious sedation using intravenous midazolam, starting at 2.5 mg and increasing in 1 mg intervals as required to a maximum of 5 mg. Each procedure was allocated minutes. Patients were excluded if they had severe esophagitis, contact bleeding, or acute mucosal trauma. Gastroscopy was performed using Fujinon EG-590zw and EG-590wr gastroscopes with the EPX 4400 processor (Fujinon, Tokyo, Japan). Magnification, if available, was not used for the detection of neoplasia. Patients Figure 2. A small focus of HGD seen after AA dye spray (circle). Figure 3. Pathway for AA chromoendoscopy. HRE, high-resolution endoscopy. were given 50 ml of a solution containing 5 ml of 10% N-acetyl cysteine and 5 ml of simethicone to drink prior to undertaking the procedure to act as a mucolytic and bubble-bursting agent. Endoscopy was then performed (Figure 3). Patients were first examined with conventional WLI, with any debris thoroughly removed and any visible abnormality suspicious of neoplasia noted (limb A of Figure 3). The length of the Barrett s segment was measured from the top of the gastric fold to the squamocolumnar junction, with islands of Barrett s recorded separately. Twenty ml of AA (2.5%) dye spray was then applied using a spray catheter to identify additional dysplastic foci within the Barrett s segment over and above that which was seen by WLI. (limb B of Figure 3). To help identify dysplasia after AA spray, an assessment of the following features was made: Surface pattern (ridged, villous, nodular, round, irregular); Mucosal vascular pattern (regular or irregular); and Acetowhitening reaction (normal or abnormal). Barrett s mucosa was classified by the endoscopist as nondysplastic if the surface pattern was round, tubular, villous, or ridged, the vascular pattern was normal, and the acetowhitening reaction was normal. 16 Mucosa was defined as dysplastic if the following was observed; irregular surface patterns, increased vascularity, an irregular microvascular pattern or early disappearance of acetowhitening from a focal area of mucosa as compared with the rest of the Barrett s mucosa. 16
3 October 2010 ACETIC ACID IN DETECTION OF NEOPLASIA IN BE 845 Mucosa was defined as invasive cancer if there was a complete loss of surface patterns, increased vascularity, disorganized and dense microvascular pattern, and rapid disappearance of the acetowhitening. In addition depressed areas (Paris type IIc) were regarded as suspicious for malignancy. After AA chromoendoscopy all lesions that became visible were noted and a targeted biopsy was taken and sent in a separate pot to pathology (limb C of Figure 3). This was followed by quadrantic biopsies at every 2 cm of the remaining Barrett s segment. These were sent separately for pathological review (nontargeted histology). If a suspicious lesion was seen on WLI, but appeared normal after AA dye spray it was biopsied as a part of the quadrantic biopsy strategy. In cases where an abnormality was seen on AA targeted biopsy, 4 quadrantic biopsies were not taken from the same quadrant at the same latitude as the targeted biopsy. The final histological diagnosis was achieved by combining the results of the targeted biopsies (limb C) and nontargeted quadrantic biopsies (limb D of Figure 3). All histological slides were reviewed by 2 expert pathologists. Analysis was performed on a per procedure basis, and not on a per lesion basis. Statistics were calculated using Microsoft Excel 2007 and MP associates MathCAD 2001i professional statistical package. Spearman s rank correlation coefficient (r) was calculated to assess the correlation between predicted and true histology. The proximity of r to 1 shows the strength of correlation, with r 1 being a 100% correlation. 2 test was used to assess the statistical significance of the difference between 2 limbs (WLI vs AA). P.05 was considered to be statistically significant. Results We performed 190 procedures on 119 patients with Barrett s metaplasia and neoplasia. Seventy-eight procedures were performed in group A (patients with no prior history of dysplasia) and 112 procedures were performed in group B (tertiary referral group). The median age of the patient cohort was 65 (range: 35 87) with 75% male. The median length of Barrett s segment was 4 cm (range: 2 15). True Neoplasia Histologically confirmed Barrett s neoplasia was found in 46% of the study population (88 out of 190 procedures). There were 21/88 cases of early cancer (T1a and T1b), 51/88 cases of high grade dysplasia (HGD), and 16/88 cases of low grade dysplasia (LGD). Table 2. Correlation Between Targeted Histology and Actual Histology Visible Abnormalities Visible neoplasia was noted by the endoscopist during 43/190 procedures with WLI endoscopy, and during 102/190 following AA dye spray. Use of WLI endoscopy alone, significantly under-diagnosed Barrett s neoplasia. AA dye spray significantly (P.001) improved the Barrett s neoplasia detection rate (2.5-fold) compared with WLI alone as shown in Table 1. Targeted Histology Histology results obtained from AA dye spray targeted biopsies were compared with the final pathological diagnosis (a combination of random and targeted biopsy results). An excellent correlation was identified (r 0.9; see Table 2). AA targeted biopsies diagnosed 63 of the 67 dysplasia cases. All 21 of the 21 cancers were diagnosed by AA targeted biopsies compared with 13 of the 21 with WLI. In some patients more than 1 area of dysplasia was found by targeted biopsy. However, in all cases where dysplasia was found on targeted biopsy there were no additional abnormalities found on random biopsy. Sensitivity and Specificity of AA Targeted Histology Four out of 88 Barrett s neoplasia cases were not identified on targeted histology, giving a false negative rate of 4.5% for all neoplasia. If the LGD population is excluded then the false negative rate falls to 2.7% (2/72). Twenty of 102 nondysplastic Barrett s mucosa, suspected to be neoplastic following AA dye spray because of visible abnormalities, turned out to be inflammation, giving a false positive rate of 19.6%. The overall sensitivity for identification of neoplasia was 95.5% with a specificity of 81%; see Table 3. On subgroup analysis we found a sensitivity of 77% and specificity of 85% for group A and a sensitivity of 98.7% and specificity of 75% for group B. Missed Neoplasia Targeted histology; group C Actual histology (random targeted); group D Dysplasia (HGD LGD) Cancer Correlation r 0.99 There were no missed cancers in either group. There were 4 missed cases of dysplasia; 2 LGD and 2 HGD. Three out of the 4 missed dysplasia were in group A. Two of these cases were classified as LGD and 1 was classified as HGD on the initial multiple quadrantic biopsies but were not identified on AA spray. All these patients have had at least 2 further Table 1. Visible Abnormalities: WLI Versus AA Spray Conventional WLI visible abnormality, limb A AA predicted in vivo histology, limb B B-A (P.001) Normal (1.6-fold) Neoplasia (2.3-fold) Table 3. Sensitivity, Specificity, and Prevalence in the Cohort Sensitivity (%) Specificity (%) Prevalence of neoplasia (%) Whole cohort Group A Group B
4 846 LONGCROFT WHEATON ET AL CLINICAL GASTROENTEROLOGY AND HEPATOLOGY Vol. 8, No. 10 gastroscopies at 6-month intervals with multiple further biopsies and no further evidence of dysplasia has been found. One patient had missed HGD in group B. This patient had received 2 previous EMRs and argon plasma coagulation ablation, and so had multiple islands of neosquamous epithelium. Discussion This is the largest series of AA chromoendoscopy reported, with the largest number of neoplasia cases being detected by this technique. This series shows that AA dye spray significantly improves the detection of neoplasia in Barrett s esophagus. It illustrates that AA targeted biopsies can diagnose dysplasia in the majority of patients, without the need of further multiple nontargeted biopsies. It also illustrates that no cancers are missed by AA targeted biopsies. Only 4 out of 88 patients with neoplasia were missed by AA dye spray; 2 of these were LGD, the other 2 were HGD. These mucosal dysplasias were picked up on conventional quadrantic biopsy. We feel that all of these cases were challenging both for the endoscopist and the pathologist. LGD is a difficult histological diagnosis to make, with an element of subjectivity involved, and at times inflammation can raise a possibility of LGD. We have a policy of repeating endoscopy in patients with LGD after 8 weeks of high dose proton pump inhibitor therapy (omeprazole 40 mg once daily). Both the patients have had 2 further gastroscopies on high dose acid suppression with multiple biopsies but no further LGD has been discovered, suggesting that the initial finding could be inflammation-related. Another patient from group A had HGD diagnosed on 1 of the several biopsies taken as a part of the quadrantic biopsy strategy. He has had 3 further gastroscopies and no further dysplasia has been found. This raises the possibility of microscopic monofocal HGD. The fourth patient with missed dysplasia was from group B and was found to have HGD. This was a challenging case with a history of 2 previous EMRs and argon plasma coagulation ablation resulting in multiple islands of neosquamous epithelium. The remaining 84 cases of Barrett s neoplasia were detected by targeted biopsy. Additional quadrantic biopsies did not alter the overall diagnosis. We believe that this is an important finding and it questions the logic of further quadrantic biopsies in patient groups where neoplasia is already detected by AA dye spray. This finding potentially has significant cost and resource implications for the endoscopist and the pathologist. Our findings are similar to another study quoting a surprisingly high sensitivity of 100% and specificity of 97.7%. 17 However, only 13/100 of the patients in the study had dysplasia, making it difficult to draw any meaningful conclusions from it with respect to dysplasia detection. While patients with excessive inflammation were excluded, a significant factor in the false positive rate of 19.6% was the presence of inflammatory changes appearing like dysplasia. We feel this highlights the importance of treatment with proton pump inhibitors prior to endoscopy. When Barrett s epithelium looks inflamed it is sometimes necessary to arrange further assessment after 8 weeks of a higher dosage of acid suppression, and this intervention should not be overlooked. There was a high prevalence of neoplasia in group A of 16.7%. In a Barrett s surveillance population this would be expected to be much lower. However, it should be noted that this population was not a standard surveillance population. It consisted of Barrett s surveillance cases and symptomatic patients who had no prior diagnosis of dysplasia who had been listed for assessment on a chromoendoscopy list. Therefore it is not surprising that the prevalence of dysplasia in this cohort is higher than a standard asymptomatic surveillance population. Group B is a complex group, consisting of all patients with previously diagnosed dysplasia being assessed for EMR and post EMR follow-up patients to look for metanchronous neoplasia. Endoscopic treatment in this cohort depends on accurate localization of neoplasia, and we were reassured to find that dysplasia could be targeted with a high degree of accuracy in this cohort. Electronic imaging techniques like narrow band imaging, and spectral imaging (Fujinon intelligent color enhancement) have been reported in the evaluation of Barrett s neoplasia. 18,19 However, the studies have been very small and it is not possible to draw any firm conclusions from these studies. A problem with all virtual chromoendoscopy techniques is that they have cost and resource implications as they require commitment to a particular endoscope manufacturer, and need the most recent image processors and endoscopes. Many units (even in the Western world) do not have the latest models of processor and endoscopes, and therefore cannot use this technology. AA dye spray can be performed in any unit and is compatible with all makes and models of endoscope, irrespective of the manufacturer. This is a single-center study, where all endoscopies have been performed by a single experienced endoscopist (P.B.). The results are therefore not generalizable to all endoscopists. It is probable that to achieve similar results formalized training would need to be undertaken in lesion recognition. This is an accepted part of endoscopy, and we believe that if dye spray is to be used widely in the assessment of Barrett s it will be necessary to address this issue. However, we believe that intensive training in a large volume expert center can help achieve the expertise in a relatively short period of time. Some of the patients in group B have had more than 1 procedure performed on them. This is due to our policy to follow up patients post EMR with 3 monthly gastroscopies to look for metanchronous neoplasia. Therefore procedures were evaluated rather than patients. This could be considered a potential limitation but we believe otherwise as these are the most challenging patients to identify dysplastic foci due to the presence of multiple neosquamous islands and distorted anatomy. Patients do develop dysplasia between endoscopies, which is why they are followed up. Therefore previous endoscopy results should not influence the findings of the next procedure. It is important that if we perform a targeted treatment we can safely follow this cohort up, which is reflected in this study. Our study is not a randomized controlled trial, and as such we cannot say how much of the dysplasia would have been found or missed by random biopsies had dye spray not been used. However, our data does show that dysplasia was visible in only 50% of our patients on high resolution WLI. Could protocol-guided quadrantic biopsies every 2 cm be able to pick up the dysplasia in the remaining 50% of patients with invisible (WLI) dysplasia? This is a difficult question to answer from the design of our study but we believe that it would be very difficult to diagnose the dysplasias by quadrantic biopsies alone in this
5 October 2010 ACETIC ACID IN DETECTION OF NEOPLASIA IN BE 847 group of patients with invisible dysplasia. Even if it does, then it would require a very large number of biopsies with significant resource implications. Alternatively, the endoscopist could elect to use AA spray and that will help better define the dysplasia that is already seen on WLI and also highlight the invisible (WLI) dysplasia as seen in 50% of the dysplastic population. Our data are not enough to completely abandon the strategy of protocol-guided biopsies in all patients with Barrett s but it does justify the role of AA in patients with invisible dysplasia on WLI and also questions the additional gain of multiple nontargeted biopsies after dysplasia has been seen with AA spray. Conclusions Our study demonstrates that AA targeted biopsies are an excellent tool to localize prevalent neoplasia within Barrett s esophagus. It is cheap, quick, universally available, and effective. It questions the relevance of additional nontargeted biopsy in patients where AA has already identified neoplasia. Supplementary Material Note: To access the supplementary material accompanying this article, visit the online version of Clinical Gastroenterology and Hepatology at and at doi: / j.cgh References 1. Jemal A, Siegel R, Ward E, et al. Cancer statistics. CA Cancer J Clin 2009;59: Barr H. The case against oesophageal resection. Ann R Coll Surg Engl 2007;89: Pech O, Gossner L, Manner H, et al. Prospective evaluation of the macroscopic types and location of early Barrett s neoplasia in 380 lesions. Endoscopy 2007;39: Kariv R, Plesec TP, Goldblum JR, et al. The Seattle protocol does not more reliably predict the detection of cancer at the time of esophagectomy than a less-invasive surveillance protocol. Clin Gastroenterol Hepatol 2009;7: Macdonald CE, Wicks AC, Playford RJ. Final results from 10 year cohort of patients undergoing surveillance for Barrett s oesophagus: observational study. BMJ 2000;321: Sharma P, Weston AP, Topalovski M, et al. Magnification chromoendoscopy for the detection of intestinal metaplasia and dysplasia in Barrett s oesophagus. Gut 2003;52: Gossner L, May A, Pech O, et al. Chromoendoscopy for detection of dysplasia or mucosal cancer in Barrett s esophagus. Gastrointestinal Endoscopy 2000;51:A Fortun PJ, Anagnostopoulod GK, Kaye P, et al. Acetic acid-enhanced magnification endoscopy in the diagnosis of specialized intestinal metaplasia, dysplasia and early cancer in Barrett s oesophagus. Aliment Pharmacol Ther 2006;23: Wolfsen HC, Crook JE, Krishna M, et al. Prospective, controlled tandem endoscopy study of narrow band imaging for dysplasia detection in Barrett s esophagus. Gastroenterology 2008;135: Miwako A, Masahiro T, Hideaki A. Magnifying endoscopy in the diagnosis of Barrett s esophagus and Barrett s adenocarcinoma. Esophagus 2007;3: Canto M, Selrakian S, Willis J, et al. Methylene-blue directed biopsies improves detection of intestinal metaplasia and dysplasia in Barrett s oesophagus. Gastrointestinal Endoscopy 2000; 51: Szaloki T. Indigo carmine contrast staining in combination with high resolution electronic endoscopy. Gasztroenterológiai Osztály 2002;143: Hoffman A, Kiesslich R, Bender A, et al. Acetic acid-guided biopsies after magnifying endoscopy compared with random biopsies in the detection of Barrett s esophagus: a prospective randomized trial with crossover design. Gastrointestinal Endoscopy 2006;64: Van Le L, Broekhuizen FF, Janzer-Steele R, et al. Acetic acid visualization of the cervix to detect cervical dysplasia. Obstet Gynecol 1993;81: Lambert R, Rey JF, Sankaranarayanan R. Magnification and chromoscopy with the acetic acid test. Endoscopy 2003;35: Réaud S, Croue A, Boyer J. Diagnostic accuracy of magnifying chromoendoscopy with detection of intestinal metaplasia and dysplasia using acetic acid in Barrett s esophagus. Gastroenterol Clin Biol 2006;30: Vázquez-Iglesias JL, Alonso-Aguirre P, Diz-Lois MT, et al. Acetic acid allows effective selection of areas for obtaining biopsy samples in Barrett s esophagus. Eur J Gastroenterol Hepatol 2007; 19: Sharma P, Bansal A, Marthur S, et al. The utility of a novel narrow band imaging endoscopy system in patients with Barrett s oesophagus. Gastrointestinal Endoscopy 2006;64: Pohl J, May A, Rabenstein T, et al. Comparison of computed virtual chromoendoscopy and conventional chromoendoscopy with acetic acid for detection of neoplasia in Barrett s esophagus. Endoscopy 2007;39: Reprint requests Address requests for reprints to: Dr Pradeep Bhandari, Department of Gastroenterology, Queen Alexandra Hospital, Cosham, Portsmouth PO6 3LY, United Kingdom. deep3570@yahoo.co.uk; fax: (44) Conflicts of interest The authors disclose no conflicts.
Barrett s esophagus. Barrett s neoplasia treatment trends
Options for endoscopic treatment of Barrett s esophagus Patrick S. Yachimski, MD MPH Director of Pancreatobiliary Endoscopy Assistant Professor of Medicine Division of Gastroenterology, Hepatology & Nutrition
More informationNew Developments in the Endoscopic Diagnosis and Management of Barrett s Esophagus
New Developments in the Endoscopic Diagnosis and Management of Barrett s Esophagus Prateek Sharma, MD Key Clinical Management Points: Endoscopic recognition of a columnar lined distal esophagus is crucial
More informationMagnifying Endoscopy and Chromoendoscopy of the Upper Gastrointestinal Tract
Magnifying Endoscopy and Chromoendoscopy of the Upper Gastrointestinal Tract Alina M.Boeriu 1, Daniela E.Dobru 1, Simona Mocan 2 1) Department of Gastroenterology, University of Medicine and Pharmacy;
More informationHow to characterize dysplastic lesions in IBD?
How to characterize dysplastic lesions in IBD? Name: Institution: Helmut Neumann, MD, PhD, FASGE University Medical Center Mainz What do we know? Patients with IBD carry an increased risk of developing
More informationVital staining and Barrett s esophagus
Marcia Irene Canto, MD, MHS Baltimore, Maryland Vital staining or chromoendoscopy refers to staining of endoscopic tissue or topical application of chemical stains or pigments to alter tissue appearances
More informationEditorial: Advanced endoscopic therapeutics in Barrett s neoplasia; where are we now and where are we heading?
Editorial: Advanced endoscopic therapeutics in Barrett s neoplasia; where are we now and where are we heading? Dr. Gaius Longcroft-Wheaton MB,BS, MD, MRCP(UK), MRCP(Gastro) Consultant gastroenterologist
More informationDysplasia 4/19/2017. How do I practice Chromoendoscopy for Surveillance of Colitis? SCENIC: Polypoid Dysplasia in UC. Background
SCENIC: Polypoid in UC Definition How do I practice for Surveillance of Colitis? Themos Dassopoulos, M.D. Director, BSW Center for IBD Themistocles.Dassopoulos@BSWHealth.org Tel: 469-800-7189 Cell: 314-686-2623
More informationBarrett s Esophagus: Old Dog, New Tricks
Barrett s Esophagus: Old Dog, New Tricks Stuart Jon Spechler, M.D. Chief, Division of Gastroenterology, VA North Texas Healthcare System; Co-Director, Esophageal Diseases Center, Professor of Medicine,
More informationChromoendoscopy and Endomicroscopy for detecting colonic dysplasia
Chromoendoscopy and Endomicroscopy for detecting colonic dysplasia Ralf Kiesslich I. Medical Department Johannes Gutenberg University Mainz, Germany Cumulative cancer risk in ulcerative colitis 0.5-1.0%
More informationNovel endoscopic observation in Barrett s oesophagus using high resolution magnification endoscopy and narrow band imaging
Alimentary Pharmacology & Therapeutics Novel endoscopic observation in Barrett s oesophagus using high resolution magnification endoscopy and narrow band imaging G. K. ANAGNOSTOPOULOS*, K. YAO*, P. KAYE,
More informationChanges to the diagnosis and management of Barrett s Oesophagus
Changes to the diagnosis and management of Barrett s Oesophagus A review of the new BSG and NICE guidelines and best practice Anjan Dhar DM, MD, FRCPE, AGAF, MBBS (Hons.), Cert. Med. Ed Senior Lecturer
More informationBarrett s Esophagus. Abdul Sami Khan, M.D. Gastroenterologist Aurora Healthcare Burlington, Elkhorn, Lake Geneva, WI
Barrett s Esophagus Abdul Sami Khan, M.D. Gastroenterologist Aurora Healthcare Burlington, Elkhorn, Lake Geneva, WI A 58 year-old, obese white man has had heartburn for more than 20 years. He read a magazine
More informationAGA SECTION. Gastroenterology 2016;150:
Gastroenterology 2016;150:1026 1030 April 2016 AGA Section 1027 Procedural intervention (3) Upper endoscopy indications 3 6 Non-response of symptoms to a 4 8 week empiric trial of twice-daily PPI Troublesome
More informationAdvances in Endoscopic Imaging
Advances in Endoscopic Imaging SGNA meeting February 20, 2010 Amar R. Deshpande, MD Asst Professor of Medicine Division of Gastroenterology University of Miami Miller School of Medicine Objectives To recognize
More informationIn 1998, the American College of Gastroenterology issued ALIMENTARY TRACT
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2012;10:1232 1236 ALIMENTARY TRACT Effects of Dropping the Requirement for Goblet Cells From the Diagnosis of Barrett s Esophagus MARIA WESTERHOFF,* LINDSEY HOVAN,
More informationHistopathology of Endoscopic Resection Specimens from Barrett's Esophagus
Histopathology of Endoscopic Resection Specimens from Barrett's Esophagus Br J Surg 38 oct. 1950 Definition of Barrett's esophagus A change in the esophageal epithelium of any length that can be recognized
More informationChromoendoscopy as an Adjunct to Colonoscopy
Chromoendoscopy as an Adjunct to Colonoscopy Policy Number: 2.01.84 Last Review: 1/2018 Origination: 7/2017 Next Review: 7/2018 Policy Blue Cross and Blue Shield of Kansas City (Blue KC) will not provide
More informationPhilip Chiu Associate Professor Department of Surgery, Prince of Wales Hospital The Chinese University of Hong Kong
Application of Chromoendoscopy, NBI and AFI in Esophagus why, who, and how? Philip Chiu Associate Professor Department of Surgery, Prince of Wales Hospital The Chinese University of Hong Kong Cancer of
More informationPage 1. Is the Risk This High? Dysplasia in the IBD Patient. Dysplasia in the Non IBD Patient. Increased Risk of CRC in Ulcerative Colitis
Screening for Colorectal Neoplasia in Inflammatory Bowel Disease Francis A. Farraye MD, MSc Clinical Director, Section of Gastroenterology Co-Director, Center for Digestive Disorders Boston Medical Center
More informationORIGINAL ARTICLE: Clinical Endoscopy
ORIGINAL ARTICLE: Clinical Endoscopy Diagnostic yield of methylene blue chromoendoscopy for detecting specialized intestinal metaplasia and dysplasia in Barrett s esophagus: a meta-analysis Saowanee Ngamruengphong,
More informationVolumetric laser endomicroscopy can target neoplasia not detected by conventional endoscopic measures in long segment Barrett s esophagus
E318 Volumetric laser endomicroscopy can target neoplasia not detected by conventional endoscopic measures in long segment esophagus Authors Institution Arvind J. Trindade, Benley J. George, Joshua Berkowitz,
More informationACG Clinical Guideline: Diagnosis and Management of Barrett s Esophagus
ACG Clinical Guideline: Diagnosis and Management of Barrett s Esophagus Nicholas J. Shaheen, MD, MPH, FACG 1, Gary W. Falk, MD, MS, FACG 2, Prasad G. Iyer, MD, MSc, FACG 3 and Lauren Gerson, MD, MSc, FACG
More informationMANAGEMENT OF BARRETT S RELATED NEOPLASIA IN 2018
MANAGEMENT OF BARRETT S RELATED NEOPLASIA IN 2018 Sachin Wani Medical Director Esophageal and Gastric Center Division of Gastroenterology and Hepatology University of Colorado Anschutz Medical Campus DISCLOSURES
More informationHistory. Prevalence at Endoscopy. Prevalence and Reflux Sx. Prevalence at Endoscopy. Barrett s Esophagus: Controversy and Management
Barrett s Esophagus: Controversy and Management History Norman Barrett (1950) Chronic Peptic Ulcer of the Oesophagus and Oesophagitis Allison and Johnstone (1953) The Oesophagus Lined with Gastric Mucous
More informationThe Harvard community has made this article openly available. Please share how this access benefits you. Your story matters.
Real-Time Increased Detection of Neoplastic Tissue in Barrett s Esophagus with Probe-Based Confocal Laser Endomicroscopy: Final Results of an International Multicenter, Prospective, Randomized, Controlled
More informationJoel A. Ricci, MD SUNY Downstate Medical Center Department of Surgery
Joel A. Ricci, MD SUNY Downstate Medical Center Department of Surgery Norman Barrett (1950) described the esophagus as: that part of the foregut, distal to the cricopharyngeal sphincter, which is lined
More informationManagement of Barrett s: From Imaging to Resection
Management of Barrett s: From Imaging to Resection Michael Wallace, MD, MPH, FACG Professor of Medicine Mayo Clinic Florida Goals of Endoscopic Evaluation in Barrett s Detect Barrett s and dysplasia Reduce/eliminate
More informationBENEFIT APPLICATION BLUE CARD/NATIONAL ACCOUNT ISSUES
Medical Policy BCBSA Ref. Policy: 2.01.84 Last Review: 11/15/2018 Effective Date: 11/15/2018 Section: Medicine Related Policies 2.01.87 Confocal Laser Endomicroscopy 6.01.32 Virtual Colonoscopy/Computed
More informationPresent Day Management of Barrett s Esophagus
Slide 1 Present Day Management of Barrett s Esophagus Kinnari R. Kher, M.D. Slide 2 Goals Risk factors for development of Barrett s esophagus Risks for progression to Esophageal Adenocarcinoma Current
More informationAblation for Barrett s Esophagus: Burn or Freeze
Ablation for Barrett s Esophagus: Burn or Freeze John R. Saltzman MD Director of Endoscopy Brigham and Women s Hospital Professor of Medicine Harvard Medical School Disclosures No relevant disclosures
More informationBarrett Esophagus - RadioFrequency Ablation (BE-RFA) - Project manual + FAQ
Barrett Esophagus - RadioFrequency Ablation (BE-RFA) - Project manual + FAQ Table of contents 1 General project information...3 1.1 Inclusion criteria...3 1.2 Registration time points...3 1.3 Project variable
More informationLearning Objectives:
Crescent City GI Update 2018 Ochsner Clinic, NOLA Optimizing Endoscopic Evaluation of Barrett s Esophagus What Should I Do in My Practice? Gregory G. Ginsberg, M.D. Professor of Medicine University of
More informationChromoendoscopy or Narrow Band Imaging with Targeted biopsies Should be the Cancer Surveillance Endoscopy Procedure of Choice in Ulcerative Colitis
Chromoendoscopy or Narrow Band Imaging with Targeted biopsies Should be the Cancer Surveillance Endoscopy Procedure of Choice in Ulcerative Colitis Bret A. Lashner, M.D. Professor of Medicine Director,
More informationCurrent Management: Role of Radiofrequency Ablation
Esophageal Adenocarcinoma And Barrett s Esophagus: Current Management: Role of Radiofrequency Ablation Ketan Kulkarni, MD Regional Gastroenterology Associates of Lancaster INTRODUCTION The prognosis of
More informationCryospray ablation using pressurized CO 2 for ablation of Barrett s esophagus with early neoplasia: early termination of a prospective series
E17 Cryospray ablation using pressurized CO 2 for ablation of Barrett s esophagus with early neoplasia: early termination of a prospective series Authors Romy E. Verbeek 1, Frank P. Vleggaar 1, Fiebo J.
More informationGastrointestinal Imaging
Endoscopic Imaging of Gastroesophageal Reflux Disease Kerry B Dunbar, MD Assistant Professor of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine Abstract
More informationEndoscopic Radiofrequency Ablation or Cryoablation for Barrett s Esophagus
Endoscopic Radiofrequency Ablation or Cryoablation for Barrett s Esophagus Policy Number: 2.01.80 Last Review: 6/2018 Origination: 6/2012 Next Review: 6/2019 Policy Blue Cross and Blue Shield of Kansas
More informationQuality ID #249 (NQF 1854): Barrett s Esophagus National Quality Strategy Domain: Effective Clinical Care
Quality ID #249 (NQF 1854): Barrett s Esophagus National Quality Strategy Domain: Effective Clinical Care 2018 OPTIONS FOR INDIVIDUAL MEASURES: REGISTRY ONLY MEASURE TYPE: Process DESCRIPTION: Percentage
More informationQuality ID #249 (NQF 1854): Barrett s Esophagus National Quality Strategy Domain: Effective Clinical Care
Quality ID #249 (NQF 1854): Barrett s Esophagus National Quality Strategy Domain: Effective Clinical Care 2018 OPTIONS FOR INDIVIDUAL MEASURES: CLAIMS ONLY MEASURE TYPE: Process DESCRIPTION: Percentage
More informationChromoendoscopy - Should It Be Standard of Care in IBD?
Chromoendoscopy - Should It Be Standard of Care in IBD? John F. Valentine, MD, FACG Professor of Medicine Division of Gastroenterology, Hepatology and Nutrition University of Utah What is the point of
More informationBarrett s Esophagus: Review of Diagnostic Issues and Pre- Neoplastic Lesions
Barrett s Esophagus: Review of Diagnostic Issues and Pre- Neoplastic Lesions Robert Odze, MD, FRCPC Chief, Gastrointestinal Pathology Associate Professor of Pathology Brigham and Women s Hospital Harvard
More informationUniversity Mainz. Early Gastric Cancer. Ralf Kiesslich. Johannes Gutenberg University Mainz, Germany. Early Gastric Cancer 15.6.
Ralf Kiesslich Johannes Gutenberg University Mainz, Germany DIAGNOSIS Unmask lesions - Chromoendoscopy -NBI Red flag technology - Autofluorescence Surface and detail analysis - Magnifying endoscopy - High
More informationCurrent Management of Low-Grade Dysplasia in Barrett Esophagus
Current Management of Low-Grade Dysplasia in Barrett Esophagus Gary W. Falk, MD, MS Dr Falk is a professor of medicine in the Division of Gastroenterology at the University of Pennsylvania Perelman School
More informationOesophagus and Stomach update dysplasia and early cancer
Oesophagus and Stomach update dysplasia and early cancer Dr Tim Bracey STR teaching 13/4/16 Please check pathkids.com for previous talks One of the biggest units in the country (100 major resections per
More informationCitation for published version (APA): Phoa, K. Y. N. (2014). Endoscopic management of Barrett s esophagus with dysplasia
UvA-DARE (Digital Academic Repository) Endoscopic management of Barrett s esophagus with dysplasia Phoa, Nadine Link to publication Citation for published version (APA): Phoa, K. Y. N. (2014). Endoscopic
More informationCorporate Medical Policy
Corporate Medical Policy Chromoendoscopy as an Adjunct to Colonoscopy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: chromoendoscopy_as_an_adjunct_to_colonoscopy 7/2012 11/2017
More informationManagement of Barrett s Esophagus. Case Presentation
Management of Barrett s Esophagus Lauren B. Gerson MD, MSc Associate Clinical Professor, UCSF Director of Clinical Research Gastroenterology Fellowship Program California Pacific Medical Center San Francisco,
More informationEvaluating Treatments of Barrett s Esophagus That Shows High-Grade Dysplasia
...PRESENTATIONS... Evaluating Treatments of Barrett s Esophagus That Shows High-Grade Dysplasia Based on a presentation by Bergein F. Overholt, MD Presentation Summary Thermal ablation and surgery are
More informationRecurrent intestinal metaplasia at the gastroesophageal junction following endoscopic eradication of dysplastic Barrett s esophagus may not be benign
THIEME E849 Recurrent intestinal metaplasia at the gastroesophageal junction following endoscopic eradication of dysplastic Barrett s esophagus may not be benign Authors Georgina R. Cameron 1, 3, Paul
More informationEndoscopic Management of Barrett s Esophagus
Endoscopic Management of Barrett s Esophagus Sammy Ho, MD Director of Pancreaticobiliary Services and Endoscopic Ultrasound Montefiore Medical Center Barrett s Esophagus Consequence of chronic GERD Mean
More informationHelicobacter pylori Improved Detection of Helicobacter pylori
DOI:http://dx.doi.org/10.7314/APJCP.2016.17.4.2099 RESEARCH ARTICLE Improved Detection of Helicobacter pylori Infection and Premalignant Gastric Mucosa Using Conventional White Light Source Gastroscopy
More informationRelative risk of dysplasia for patients with intestinal metaplasia in the distal oesophagus and in the gastric cardia
Gut 2000;46:9 13 9 PAPERS Division of Gastroenterology, University of Kansas, VA Medical Center, Kansas City, Missouri, USA P Sharma A P Weston Department of Pathology, VA Medical Center, Kansas M Topalovski
More informationAmerican Journal of Gastroenterology. Volumetric Laser Endomicroscopy Detects Subsquamous Barrett s Adenocarcinoma
Volumetric Laser Endomicroscopy Detects Subsquamous Barrett s Adenocarcinoma Journal: Manuscript ID: AJG-13-1412.R1 Manuscript Type: Letter to the Editor Keywords: Barrett-s esophagus, Esophagus, Endoscopy
More informationIs Radiofrequency Ablation Effective In Treating Barrett s Esophagus Patients with High-Grade Dysplasia?
Philadelphia College of Osteopathic Medicine DigitalCommons@PCOM PCOM Physician Assistant Studies Student Scholarship Student Dissertations, Theses and Papers 12-2016 Is Radiofrequency Ablation Effective
More informationRadiofrequency Ablation: Stepwise circumferential and focal RFA of Barrett s s esophagus using the HALO System
Radiofrequency Ablation: Stepwise circumferential and focal RFA of Barrett s s esophagus using the HALO System Used abbreviations BE: Barrett s esophagus EC: Early cancer ER: Endoscopic resection HGD:
More informationHow to remove BE cancer: EMR or ESD? Expected outcome
How to remove BE cancer: EMR or ESD? Expected outcome Presented by Horst Neuhaus Institution Dpt. of Gastroenterology Evangelisches Krankenhaus Düsseldorf, Germany Indications for endoscopic resection
More informationSixteen-year follow-up of Barrett s esophagus, endoscopically treated with argon plasma coagulation
Original Article Sixteen-year of Barrett s esophagus, endoscopically treated with argon plasma coagulation United European Gastroenterology Journal 2014, Vol. 2(5) 367 373! Author(s) 2014 Reprints and
More informationBarrett s Esophagus. Radiofrequency Ablation with the HALO Technology A Reference Book
Radiofrequency Ablation with the HALO Technology A Reference Book 540 Oakmead Parkway, Sunnyvale, CA 94085 What is Barrett s esophagus? Barrett s esophagus is a change that occurs within the cellular lining
More informationMedicare Advantage Medical Policy
Medicare Advantage Medical Policy Current Policy Effective Date: 1/1/18 Title: Endoscopic Radiofrequency Ablation or Cryoablation for Barrett Esophagus Description/Background Barrett Esophagus and the
More informationFrozen Section Analysis of Esophageal Endoscopic Mucosal Resection Specimens in the Real-Time Management of Barrett s Esophagus
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2006;4:173 178 Frozen Section Analysis of Esophageal Endoscopic Mucosal Resection Specimens in the Real-Time Management of Barrett s Esophagus GANAPATHY A. PRASAD,*
More informationEndoscopic Radiofrequency Ablation or Cryoablation for Barrett Esophagus
Endoscopic Radiofrequency Ablation or Cryoablation for Barrett Esophagus Policy Number: Original Effective Date: MM.02.005 09/01/2010 Line(s) of Business: Current Effective Date: PPO; HMO; QUEST Integration
More informationDuring the past 30 years, the incidence of esophageal ORIGINAL ARTICLES
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2006;4:38 43 ORIGINAL ARTICLES Optical Coherence Tomography to Identify Intramucosal Carcinoma and High-Grade Dysplasia in Barrett s Esophagus JOHN A. EVANS,* JOHN
More informationMagnification endoscopy, high resolution endoscopy, and chromoscopy; towards a better optical diagnosis
iv7 PAPER Magnification endoscopy, high resolution endoscopy, and chromoscopy; towards a better optical diagnosis M J Bruno... In the past few years, optical magnification endoscopy and chromoscopy have
More informationConfocal Laser Endomicroscopy
Confocal Laser Endomicroscopy Policy Number: 2.01.87 Last Review: 3/2018 Origination: 3/2013 Next Review: 9/2018 Policy Blue Cross and Blue Shield of Kansas City (Blue KC) will not provide coverage for
More information2019 COLLECTION TYPE: MIPS CLINICAL QUALITY MEASURES (CQMS) MEASURE TYPE: Process
Quality ID #249 (NQF 1854): Barrett s Esophagus National Quality Strategy Domain: Effective Clinical Care Meaningful Measure Area: Transfer of Health Information and Interoperability 2019 COLLECTION TYPE:
More informationGregory G. Ginsberg, M.D.
Radiofrequency Ablation for Barrett s Esophagus with HGD Gregory G. Ginsberg, M.D. Professor of Medicine University of Pennsylvania School of Medicine Abramson Cancer Center Gastroenterology Division Executive
More informationBarrett s Esophagus. lining of the lower esophagus that bears his name (i.e., Barrett's esophagus). We now
Shamika Johnson Anatomy & Physiology 206 April 20, 2010 Barrett s Esophagus What is Barrett s Esophagus? Norman Barrett was a pathologist. In 1950, he described an abnormality in the lining of the lower
More informationDefinition of GERD American College of Gastroenterology
Definition of GERD American College of Gastroenterology GERD is defined as chronic symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus DeVault et al. Am J
More informationBarrett s Esophagus: What to Do for No Dysplasia, LGD, and HGD?
Barrett s Esophagus: What to Do for No Dysplasia, LGD, and HGD? Nicholas Shaheen, MD, MPH Center for Esophageal Diseases and Swallowing University of North Carolina 1 Outline What are the risks of progression
More informationSAM PROVIDER TOOLKIT
THE AMERICAN BOARD OF PATHOLOGY Maintenance of Certification (MOC) Program SAM PROVIDER TOOLKIT Developing Self-Assessment Modules (SAMs) www.abpath.org The American Board of Pathology (ABP) approves educational
More informationRFA and Cyrotherapy for Esophageal Disease
RFA and Cyrotherapy for Esophageal Disease Daniel L. Miller MD Chief, General Thoracic Surgery WellStar Healthcare System/ Mayo Clinic Care Network Clinical Professor of Surgery Medical College of Georgia/
More informationTHE AMERICAN JOURNAL OF GASTROENTEROLOGY Vol. 97, No. 1, by Am. Coll. of Gastroenterology ISSN /02/$22.00
THE AMERICAN JOURNAL OF GASTROENTEROLOGY Vol. 97, No. 1, 2002 2002 by Am. Coll. of Gastroenterology ISSN 0002-9270/02/$22.00 Published by Elsevier Science Inc. PII S0002-9270(01)03982-X ORIGINAL CONTRIBUTIONS
More informationASGE and AGA Issue Consensus Statement on Surveillance and Management of Dysplasia in Patients With Inflammatory Bowel Disease
ASGE and AGA Issue Consensus Statement on Surveillance and Management of Dysplasia in Patients With Inflammatory Bowel Disease DOWNERS GROVE, Ill., (March 5, 2015) The American Society for Gastrointestinal
More informationCASE DISCUSSION: The Patient with Dysplasia: Surgery or Active Surveillance? Noa Krugliak Cleveland, MD David T. Rubin, MD
CASE DISCUSSION: The Patient with Dysplasia: Surgery or Active Surveillance? Noa Krugliak Cleveland, MD David T. Rubin, MD Disclosure Statement NKC: No relevant conflicts to disclose. DTR: No relevant
More informationNewly developed magnifying endoscopic classification of the Japan Esophageal Society to identify superficial Barrett s esophagus related neoplasms
https://doi.org/10.1007/s10388-018-0623-y SPECIAL ARTICLE Newly developed magnifying endoscopic classification of the Japan Esophageal Society to identify superficial Barrett s esophagus related neoplasms
More informationParis classification (2003) 삼성의료원내과이준행
Paris classification (2003) 삼성의료원내과이준행 JGCA classification - Japanese Gastric Cancer Association - Type 0 superficial polypoid, flat/depressed, or excavated tumors Type 1 polypoid carcinomas, usually attached
More informationIdentification of gastric atrophic changes: from histopathology to endoscopy
Evidence in perspective 533 Identification of gastric atrophic changes: from histopathology to endoscopy Authors Mário Dinis-Ribeiro 1,2, Ernst J. Kuipers 3 Institutions Bibliography DOI http://dx.doi.org/
More informationThe Pathologist s Role in the Diagnosis and Management of Neoplasia in Barrett s Oesophagus Cian Muldoon, St. James s Hospital, Dublin
The Pathologist s Role in the Diagnosis and Management of Neoplasia in Barrett s Oesophagus Cian Muldoon, St. James s Hospital, Dublin 24.06.15 Norman Barrett Smiles [A brief digression - Chair becoming
More informationEndoscopic Radiofrequency Ablation or Cryoablation for Barrett`s Esophagus. Original Policy Date
MP 2.01.52 Endoscopic Radiofrequency Ablation or Cryoablation for Barrett`s Esophagus Medical Policy Section Medicine Issue 12:2013 Original Policy Date 12:2013 Last Review Status/Date Reviewed with literature
More informationGastric Polyps. Bible class
Gastric Polyps Bible class 29.08.2018 Starting my training in gastroenterology, some decades ago, my first chief always told me that colonoscopy may seem technically more challenging but gastroscopy has
More informationTreat Barrett s, Remove the Risk. HALO System
Treat Barrett s, Remove the Risk HALO System The HALO 360 System Advanced Ablation Technology for Barrett s Esophagus The HALO 360 System is designed to remove the Barrett s epithelium in a short, well-tolerated
More informationBarrett esophagus. Bible class Inselspital
Barrett esophagus Bible class Inselspital 2015.08.10 Guidelines Definition? BSG: ACG: Definition? BSG: ACG: What are the arguments for and against IM as prerequisite for the Dg? What are the arguments
More informationOriginal article INTRODUCTION
Diseases of the Esophagus (2014), DOI: 10.1111/dote.12166 Original article A Barrett s esophagus registry of over 1000 patients from a specialist center highlights greater risk of progression than population-based
More informationFEP Medical Policy Manual
FEP Medical Policy Manual Effective Date: April 15, 2018 Related Policies: 2.01.87 Confocal Laser Endomicroscopy 6.01.32 Virtual Colonoscopy/CT Colonography Chromoendoscopy as an Adjunct to Colonoscopy
More informationThis medical position statement considers a series of
GASTROENTEROLOGY 2011;140:1084 1091 American Gastroenterological Association Medical Position Statement on the Management of Barrett s Esophagus The Institute Medical Position Panel consisted of the authors
More informationBarrett s Esophagus: Ablate Everyone?
Nicholas J. Shaheen, MD, MPH, FACG Barrett s Esophagus: Ablate Everyone? Nicholas J. Shaheen, MD, MPH, FACG Center for Esophageal Diseases and Swallowing University of North Carolina Greetings from UNC,
More informationPathology in Slovenian CRC screening programme:
Pathology in Slovenian CRC screening programme: Findings, organisation and quality assurance Snježana Frković Grazio University Medical Center Ljubljana, Slovenia Slovenia s population: 2 million Incidence
More informationCLINICAL GUIDELINE FOR THE MANAGEMENT OF BARRETT S OESOPHAGUS Summary.
CLINICAL GUIDELINE FOR THE MANAGEMENT OF BARRETT S OESOPHAGUS Summary. Page 1 of 12 Recurrent LGD at any point- discuss at MDT And consider RFA Patients with LGD should have a repeat endoscopy in 6 months.
More informationEndoscopic Corner CASE 1. Kimtrakool S Aniwan S Linlawan S Muangpaisarn P Sallapant S Rerknimitr R
170 Endoscopic Corner Kimtrakool S Aniwan S Linlawan S Muangpaisarn P Sallapant S Rerknimitr R CASE 1 A 54-year-old woman underwent a colorectal cancer screening. Her fecal immunochemical test was positive.
More informationCorrelation between Gastric Mucosal Morphologic Patterns and Histopathological Severity of
Hindawi Publishing Corporation BioMed Research International Volume 2015, Article ID 808505, 7 pages http://dx.doi.org/10.1155/2015/808505 Research Article Correlation between Gastric Mucosal Morphologic
More informationBarrett s Oesophagus Information Leaflet THE DIGESTIVE SYSTEM. gutscharity.org.
THE DIGESTIVE SYSTEM http://healthfavo.com/digestive-system-for-kids.html This factsheet is about Barrett s Oesophagus Barrett s Oesophagus is the term used for a pre-cancerous condition where the normal
More informationPatterns of recurrent and persistent intestinal metaplasia after successful radiofrequency ablation of Barrett s esophagus
Patterns of recurrent and persistent intestinal metaplasia after successful radiofrequency ablation of Barrett s esophagus Robert J. Korst, MD, a,b Sobeida Santana-Joseph, MSN, a,b John R. Rutledge, MAS,
More informationEMR, ESD and Beyond. Peter Draganov MD. Professor of Medicine Division of Gastroenterology, Hepatology and Nutrition University of Florida
EMR, ESD and Beyond Peter Draganov MD Professor of Medicine Division of Gastroenterology, Hepatology and Nutrition University of Florida Gastrointestinal Cancer Lesion that Can be Treated by Endoscopy
More informationBarrett s esophagus (BE) is a precancerous state
CLINICAL ALIMENTARY TRACT Gastroenterology 2017;153:681 688 Late Recurrence of Barrett s Esophagus After Complete Eradication of Intestinal Metaplasia is Rare: Final Report From Ablation in Intestinal
More informationEmerging Interventions in Endoscopy. Margaret Vance Nurse Consultant in Gastroenterology St Mark s Hospital
Emerging Interventions in Endoscopy Margaret Vance Nurse Consultant in Gastroenterology St Mark s Hospital Colon Cancer Colon cancer is common. 1 in 20 people in the UK will develop the disease 19 000
More informationPathology in Slovenian CRC screening programme: Organisation and quality assurance. Snježana Frković Grazio and Matej Bračko
Pathology in Slovenian CRC screening programme: Organisation and quality assurance Snježana Frković Grazio and Matej Bračko June 2009 to December 2013 (first three rounds) 33 969 colonoscopies were performed
More informationDiagnostic value of autofluorescence imaging combined with narrow band imaging in intraepithelial neoplasia of Barrett s esophagus
JBUON 2015; 20(2): 399-405 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE Diagnostic value of autofluorescence imaging combined with narrow band
More informationDescription. Section: Medicine Effective Date: July 15, Subsection: Original Policy Date: September 13, 2012 Subject: Page: 1 of 17
Page: 1 of 17 Last Review Status/Date: June 2016 Description Chromoendoscopy refers to the application of dyes or stains during endoscopy to enhance tissue differentiation or characterization. When used
More informationEndoscopic therapy of Barrett s esophagus Oliver Pech and Christian Ell
Endoscopic therapy of Barrett s esophagus Oliver Pech and Christian Ell Department of Internal Medicine 2, HSK Wiesbaden, Wiesbaden, Germany Correspondence to Oliver Pech, MD, PhD, Department of Gastroenterology,
More information