KATHLEEN P. HOWARD. Swarthmore College, Swarthmore, PA Associate Professor, Department of Chemistry, 2003 present

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1 KATHLEEN P. HOWARD Department of Chemistry phone: (610) Swarthmore College fax: (610) College Avenue Swarthmore, PA PROFESSIONAL EXPERIENCE Swarthmore College, Swarthmore, PA Associate Professor, Department of Chemistry, 2003 present Assistant Professor, Department of Chemistry, University of Pennsylvania, Philadelphia PA Adjunct Associate Professor of Biochemistry and Biophysics, July 2003 present Visiting Faculty, Department of Biochemistry and Biophysics, Fall 2000 Fall 2001 University of Pennsylvania, Philadelphia, PA Postdoctoral fellow in the Department of Chemistry (9/95-9/97) Recipient of Arthritis Foundation Postdoctoral Fellowship Advisor: Dr. Stanley J. Opella Project: Development of Nuclear Magnetic Resonance Techniques for Determining the Structures of Membrane-Bound Molecules. Reconstituted membrane molecules into phospholipid bilayers that spontaneously oriented in a magnetic field. Implemented oriented sample NMR experiments on home-built solid state NMR spectrometers. EDUCATION Yale University, New Haven, CT Ph.D. in Chemistry (1995) Advisor: Dr. James H. Prestegard Dissertation: NMR Studies of the Structure and Dynamics of Membrane-Bound Diacylglycerol Glycolipids. Fellowships and Awards: National Research Service Award, Samuel K. Bushnell Fellowship, Yale Department of Chemistry Excellence in Teaching Award Princeton University, Princeton, NJ B.A. in chemistry, cum laude (1990) Senior Thesis Advisor: Dr. Jannette Carey Independent Research Thesis: Glutaraldehyde Crosslinking Reveals Tetramer Formation by Tryptophan Repressor

2 SWARTHMORE COURSES TAUGHT Chemistry 1 - Chemistry in the Human Environment Chemistry 10H Honors General Chemistry Chemistry 45A Intermediate Physical Chemistry Chemistry 45C - Biophysical Chemistry Chemistry 50 - Modern Instrumental Methods in Chemistry and Biochemistry Chemistry 94 - Research Project Chemistry 96 - Research Thesis Chemistry Theory and Applications of Spectroscopy Chemistry Advanced Topics in Biophysical Chemistry Chemistry 110/ Physics 139 Physical Basis of Biomolecular Structure and Function RESEARCH STUDENTS SUPERVISED Danielle Wall 98 Seth Garber 99 Valencia King 99 Margaret Parker 00 Karen Lloyd 00 Akira Irie '03 Diana Aronson '05 Krisna Duong-Ly '05 Garrett Ash '05 Emily Ullman '06 Jessica Wong '06 PUBLICATIONS (undergraduate co-authors) Duong-Ly, K., Nanda, V., DeGrado, W., and Howard K.P. (2005) The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment. Protein Science, in press. Howard, K.P., Liu, W., Crocker, E., Nanda, V., Lear, J., DeGrado, W.F., and Smith, S.O. (2005) Rotational orientation of monomers within a designed homo-oligomer transmembrane helical bundle. Protein Science, in press. Howard, K.P., Lear, J.D., and DeGrado, W.F. (2002) Sequence determinants of the energetics of folding of a transmembrane four-helix bundle protein. Proceedings of the National Academy of Sciences, 99(13), Parker, M., King, V. and Howard, K.P. (2001) NMR study of doxorubicin binding to cardiolipin containing magnetically oriented phospholipid bilayers. Biochimica Biophysica Acta Biomembranes, 1514(2), Mangels, M., Harper, A., Smirnov, A.I., Howard, K.P. and Lorigan, G.A. (2001) Investigating Magnetically Aligned Phospholipid Bilayers with EPR Spectroscopy at 94 GHz, Journal of Magnetic Resonance, 151, Cardon, T.B., Tiburu, E., Padmanabhan, A., Howard, K.P. and Lorigan, G.A. (2001) Magnetically Aligned Phospholipid Bilayers at the Parallel and Perpendicular Orientations for X-Band Spin- Label EPR Studies, Journal of the American Chemical Society; 123(12),

3 Mangels, M., Cardon, T., Harper, A. Howard, K.P. and Lorigan, G.A. (2000) Spectroscopic Characterization of Spin Labeled Magnetically Oriented Phospholipid Bilayers by EPR Spectroscopy, Journal of the American Chemical Society, 122(29), Howard, K.P. (2000) Thermodynamics of DNA Duplex Formation. Journal of Chemical Education, 77(11) King, V., Parker, M. and Howard, K.P (2000) Pegylation of Magnetically Oriented Lipid Bilayers. Journal of Magnetic Resonance, 142 (1), Garber, S.M., Lorigan, G.A., and Howard K.P. (1999) Magnetically Oriented Phospholipid Bilayers for Spin Label EPR Studies. Journal of the American Chemical Society, 121, Howard, K.P. & Opella, S.J. (1996) High Resolution Solid State NMR of Integral Membrane Proteins Reconstituted into Magnetically Oriented Phospholipid Bilayers. Journal of Magnetic Resonance, 112, Howard, K.P. & Prestegard, J.H. (1996) Conformation of Sulfoquinovosyl Diacylglycerol at the Surface of Magnetically-Oriented Phospholipid Bilayers. Biophysical Journal, 71, Howard, K.P. & Prestegard, J.H. (1996) Conformation and Dynamics of Digalactosyl Diacylglycerol. Journal of the American Chemical Society, 118, Howard, K.P. & Prestegard, J.H. (1995) Conformation of Monogalactosyl Diacylglycerol at the Surface of Magnetically-Oriented Phospholipid Bilayers. Journal of the American Chemical Society, 117, Martin, K.S., Royer, C.A., Howard, K.P., Carey, J., Liu, Y., Matthews, K., Heyduk, E., Lee, J.C. (1994) Electrostatic Forces Contribute to Interactions Between trp repressor Dimers. Biophysical Journal, 66, Metz, G., Howard, K.P., van Liemt, W.B.S., Prestegard, J.H., Lugtenburg, J., & Smith, S.O. (1994) NMR studies of ubiquinone location in oriented model membranes: Evidence for a single motionally-averaged population. Journal of the American Chemical Society, 117, Sanders, C.R., Hare, B., Howard, K.P., & Prestegard, J.H. (1993) Magnetically-Oriented Phospholipid Micelles as a Tool for the Study of Membrane-Associated Molecules. Progress in NMR Spectroscopy, 26(5), Hare, B.J., Howard, K.P., & Prestegard, J.H. (1993) Torsion Angle Analysis of Glycolipid Order at Membrane Surfaces. Biophysical Journal, 64, Chung, J., Tolman, J.R., Howard, K.P., & Prestegard, J.H. (1993) Three Dimensional 13 C- 13 C Correlated Experiments on Oligosaccharides. Journal of Magnetic Resonance B, 102, Gosser, Y., Howard, K.P., & Prestegard, J.H. (1993) Three Dimensional 1 H-Detected 13 C- 13 C Correlation Experiments for Carbon Backbone Assignments of Enriched Natural Products. Journal of Magnetic Resonance B, 101, Ram P., Kim E., Thomson D., Howard, K.P., & Prestegard J.H. (1992) Computer Modeling of Glycolipids at Membrane Surfaces. Biophysical Journal, 63,

4 PRESENTATIONS (undergraduate co-authors) Duong-Ly, K. Nanda, V., DeGrado, W. and Howard, K.P. (February 2005) " EPR Spectroscopy of Spin-Labeled M2TM in Lipid Bilayers" Presented at the Biophysical Society meeting, Annaheim Long Beach, CA. Duong-Ly, K. Nanda, V., DeGrado, W. and Howard, K.P. (November 2004) " EPR Spectroscopy of a Transmembrane Peptide Oligomer in Lipid Bilayers" Presented at the Haverford College Undergraduate Science Research Symposium. Haverford, PA. Howard, K.P., Liu, W., Lear, J., DeGrado, W. and Smith, S.O. (October 2004) Determination of the Rotational Orientation of Monomers within a Designed Transmembrane Helical Bundle using 2 H NMR Spectroscopy, poster presented at the International Society for Magnetic Resonance Conference, Ponte Verda, FL. Duong-Ly, K. Nanda, V., DeGrado, W. and Howard, K.P. (October 2004) The conformation of the pore region of M2 proton channel depends on lipid bilayer environment poster presented at the International Society for Magnetic Resonance Conference, Ponte Verda, FL. Howard, K. (June 2004) Rotational Orientation of Monomers within a Designed Transmembrane Helical Bundle. Seminar presented for Judy Voet s retirement symposium 25 years of Biochemistry at Swarthmore, Swarthmore, PA. Duong-Ly, K. and Howard, K.P. (June 2004), "Probing Transmembrane Peptide Oligomer Formation Using EPR Spectroscopy", poster presented at the University of Pennsylvania s Department of Biophysics and Biochemistry 2004 Department Retreat. Howard, K.P., Liu, W., Lear, J. DeGrado, W., Smith, S.O. (June 2004) Rotational Orientation of Monomers within Designed Transmembrane Homooligomer by 2H NMR, poster presented at the University of Pennsylvania s Department of Biophysics and Biochemistry 2004 Department Retreat. Duong-Ly, K. and Howard, K.P. (May 2004), "Probing Transmembrane Peptide Oligomer Formation Using EPR Spectroscopy", Chemistry Department Poster Session, Swarthmore College, Swarthmore PA. Duong-Ly, K. and Howard, K.P. (June 2003), "Probing Transmembrane Peptide Oligomer Formation Using EPR Spectroscopy", poster presented at the University of Pennsylvania s Department of Biophysics and Biochemistry 2003 Department Retreat. Duong-Ly, K. and Howard, K.P. (May 2003), "Probing Transmembrane Peptide Oligomer Formation Using EPR Spectroscopy", Chemistry Department Poster Session, Swarthmore College, Swarthmore PA. Howard, K.P., Lear, J. and DeGrado, W. (June 2002) Transmembrane Interface of the M2 Protein from Influenza Virus poster presented at the University of Pennsylvania s Department of Biophysics and Biochemistry Annual Department Retreat. Howard, K.P., Lear, J. and DeGrado, W. (February 2002) Transmembrane Interface of the M2 Protein from Influenza Virus poster presented at the Biophysical Society Meeting, SanFrancisco, CA.

5 Howard, K. (November 2001) "Transmembrane Interace of the M2 Protein from Influenza A Virus", invited seminar at the National High Magnetic Field Laboratory, Tallahassee, FL. Howard K. (April 2001) Development and Application of Magnetically Orienting Bilayers for the Study of Membrane-Bound Molecules, invited seminar given at Villanova University, Department of Chemistry. Parker, M., Lloyd, K. and Howard K. (February 2001) Design and Application of Magnetically Orienting Bilayers for the Study of Membrane-Bound Molecules poster presented at the Biophysical Society Meeting, Boston, MA. Howard K. (December 2000) Development and Application of Magnetically Orienting Bilayers for the Study of Membrane-Bound Molecules, invited seminar given at Drexel University, Department of Chemistry. Howard K. (September 2000) Development and Application of Magnetically Orienting Bilayers for the Study of Membrane-Bound Molecules, invited seminar given at Haverford College, Department of Chemistry. Parker, M., King, V. Garber, S., and Lloyd, K. and Howard K. (July 2000) Design and Application of Magnetically Orienting Bilayers For the Study of Membrane-Bound Molecules poster presented at the University of Pennsylvania s Department of Biophysics and Biochemistry Annual Department Retreat. Howard, K. (March 2000) NMR Studies of Membrane-Bound Molecules Using Magnetically Oriented Phospholipid Bilayers invited seminar given at Georgetown University, Department of Chemistry. Lloyd, K. and Howard, K. (February 2000) Studying Transmembrane Helical Peptides in Magnetically Oriented Phospholipid Bilayers poster presented at Biophysical Society Meeting, New Orleans, Louisiana. Parker, M. and Howard, K. (February 2000) Doxorubicin Binding to Cardiolipin Containing Magnetically Oriented Phospholipid Bilayers poster presented at Biophysical Society Meeting, New Orleans, Louisiana. King, V. Garber, S., Parker, M., and Howard K. (July 1999) Design and Application of Magnetically Orienting Bilayers for the Study of Membrane-Bound Molecules poster presented at the 14 th International Meeting on NMR Spectroscopy, Edinburgh, Scotland. Garber, S., King, V. and Howard K. (February 1999) Design and Application of Magnetically Orienting Bilayers for the Study of Membrane-Bound Molecules poster presented at the Biophysical Society Meeting, Baltimore, Maryland. Howard, K. (December 1997) NMR Studies of Membrane-Bound Molecules Using Magnetically Oriented Phospholipid Bilayers invited seminar given at Bryn Mawr College, Department of Chemistry. Howard, K. (November 1997) NMR Studies of Membrane-Bound Molecules Using Magnetically Oriented Phospholipid Bilayers presentation for the Howard Hughes Medical Institute Interdisciplinary Research Seminar Series at Swarthmore College.

6 Howard, K. (September 1997) Design of Magnetically Orienting Bilayers for the Study of Membrane-Bound Molecules seminar presented at the Tri-College Life Science Symposium, Bryn Mawr College. Howard, K. and Opella, S.J. (June 1997) NMR Studies of Membrane Proteins Reconstituted into Magnetically Oriented Phospholipid Bilayers poster presented at the Gordon Research Conference on Magnetic Resonance, Henniker, NH. Howard, K. (June 1997) Preparation of Membrane Protein Containing Bicelles talk presented at the Biological Solid State NMR Workshop, University of Pennsylvania. Howard, K. (December 1996) NMR Studies of Membrane-Bound Molecules Using Magnetically Oriented Phospholipid Bilayers invited seminar presented at the University of Pittsburgh, Department of Chemistry. Howard, K. (December 1996) NMR Studies of Membrane-Bound Molecules Using Magnetically Oriented Phospholipid Bilayers invited seminar presented at the University of California-Davis, Department of Chemistry. Howard, K. (December 1996) NMR Studies of Membrane-Bound Molecules Using Magnetically Oriented Phospholipid Bilayers invited seminar presented at American University, Washington DC, Department of Chemistry. Howard, K. (December 1996) NMR Studies of Membrane-Bound Molecules Using Magnetically Oriented Phospholipid Bilayers invited seminar presented at the Rutgers University-Camden, Department of Chemistry. Howard, K. (December 1996) NMR Studies of Membrane-Bound Molecules Using Magnetically Oriented Phospholipid Bilayers invited seminar presented at the University of Illinois-Urbana, Department of Biochemistry. Howard, K. and Opella, S.J. (November 1996) NMR Studies of Membrane Proteins Reconstituted into Magnetically Oriented Phospholipid Bilayers poster presented at the Eastern Analytical Society Meeting, Somerset, NJ. Howard, K. and Opella, S.J. (July 1996 ) Solid State NMR Structural Studies of Membrane Proteins Reconstituted into Magnetically Oriented Phospholipid Bilayers poster presented at the FASEB Meeting - Molecular Biophysics of Cellular Membranes, Saxtons River, VT. Howard, K. and Opella, S.J. (March 1996 ) Solid State NMR Studies of Membrane Proteins Reconstituted into Magnetically Oriented Phospholipid Bilayers. poster presented at the Experimental NMR Conference, Monterey, CA. Howard, K. and Prestegard, J.H. (March 1994) NMR Studies of Diacylglyerol Glycolipids Bound to Magnetically Oriented Phospholipid Bilayers poster presented at the Experimental NMR Conference, Monterey, CA. Howard, K. and Prestegard (February 1993) NMR Studies of Diacylglyerol Glycolipids Bound to Magnetically Oriented Phospholipid Bilayers poster presented at the Biophysical Society Meeting, Washington DC. PROFESSIONAL ACTIVITIES

7 Reviewer for Journal of the American Chemical Society, Biochemistry, Journal of Magnetic Resonance, Journal of Physical Chemistry, Langmuir, Concepts in Magnetic Resonance, Analytical Biochemistry and Journal of Chemical Education, Grant reviewer for National Science Foundation, ACS-PRF Grant program Education Committee, Biophysical Society ( ) Edited the Society's pamphlet titled "Careers in Biophysics" for high school and college students contemplating a scientific career. Testified as a Witness for a Congressional Hearing: "Meeting the Demands of the Knowledge Based Economy: Strengthening Undergraduate Science, Mathematics and Engineering Education" Committee on Science, US House of Representatives, Washington, DC. (March 2002) Member of Biophysical Society, Protein Society, American Chemical Society, American Association for the Advancement of Science, and Sigma Xi. EXTERNAL GRANT SUPPORT Spectroscopy of Peptides/Lipids in Magnetically Oriented Membranes National Science Foundation CAREER Award, CHE Research grant used to support supplies, equipment and summer research stipends for students. Proposal involves the development of novel EPR and NMR methods and the application of these methods to study membrane protein structure and dynamics Development of X-ray Diffraction Projects Camille and Henry Dreyfus Foundation Special Grant in the Chemical Sciences. This grant, along with Swarthmore College matching funds, was used for the purchase of a new Rigaku x-ray diffractometer for use in Physical Chemistry and Instrumental Methods teaching labs Peptide/Lipid Studies in Field Oriented Membranes National Institutes of Health 1 R15 GM Research grant used to support supplies, equipment and summer research stipends for students. Proposal involves the development of both EPR and NMR methods for determining the structures and dynamics of both lipid and peptide components of membrane bilayers. June 1998 Scholarship from International Center for Diffraction Data Money received for tuition and supply fee to attend week long clinic on x-ray diffraction techniques. Clinic attended in preparation for initiating new teaching of x-ray methods at Swarthmore SWARTHMORE COLLEGE COMMITTEES Hewlitt Committee examining the retention of women and minorities in Science Division, Howard Hughes Medical Institute Committee, Summer

8 Chemistry Department Colloquium Organizer, Fall Spring 2003 Faculty Advisory Committee to Admissions and Financial Aid, Fall Spring 2003 Search Committee for Associate Provost of Information Technology, Fall Chemistry Department Honors Program Coordinator Foreign Studies Committee, New Science Building Environmental Concerns Committee, Fall Spring 2000 Search Committee for Academic Computing Coordinator for Natural Sciences, Spring 1999 Search Committee for the Head of Cornell Science Library, Spring 1999 Health Sciences Advisory Committee, Chemistry Department Library Representative, Chemistry Departmental Representative to Sigma Xi, Spring 1998

Kaylah Lalonde, Ph.D. 555 N. 30 th Street Omaha, NE (531)

Kaylah Lalonde, Ph.D. 555 N. 30 th Street Omaha, NE (531) Kaylah Lalonde, Ph.D. kaylah.lalonde@boystown.org 555 N. 30 th Street Omaha, NE 68131 (531)-355-5631 EDUCATION 2014 Ph.D., Speech and Hearing Sciences Indiana University minor: Psychological and Brain