Structure of Plasma membrane

Transcription

1 Structure of Plasma membrane

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3 Lipids in Plasma membrane

4 Lipid Functions in Plasma membrane

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6 Movements of lipid molecules

7 Movements of lipid molecules

8 Cholesterol in plasma membranes

9 Cholesterol in plasma membranes Increase firmness and integrity of cell membrane (50% of Cell membrane structure) cholesterol helps to separate phospholipids, so the fatty acid chains can't come together and crystallize Helps preventing extremes and maintaining consistency of membrane

10 Functional Phospholipids in plasma membranes

11 Proteins in plasma membranes

12 Proteins in plasma membranes

13 Protein functions in plasma membranes

14 Protein functions in plasma membranes

15 Channels

16 Channels

17 Chemical gated Channels

18 Carriers Channels (Transporters)

19 Carriers (Transporters) C

20 ATP dependent Carriers

21 Receptors

22 Receptors & G proteins

23 Receptors & G proteins

24 Enzymes

25 Receptors & Enzymes

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27

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29 Receptors & Channels

30 Receptors & G proteins

31 Cell Identity Markers

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33 Cell Identity Markers

34 Linkers

35 Tight Junction

36 Gap Junction

37 Desmosome (Adhering Junction)

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39 Transport across Plasma Membranes

40 Transport through plasma membranes Passive transport modalities -Simple diffusion: transport through lipid bilayer, transport through channels, Ficks law of diffusion. -Facilitated diffusion: by carriers Differences in diffusion Kinetics between the previous modalities Equivalent Concentration of particles.

41 Transport through plasma membranes Passive transport modalities -Osmosis: concept of osmotic pressure (Van t Hoff s law), Oncotic (Colloid-osmotic) pressure. Osmolarity, Osmolality Hydrostatic pressure and filtration

42 Transport through plasma membranes Active transport modalities - Primary active transport (ATP-ase carriers or Pumps) (functions of pumps: Na+/K+ pump, Ca++ pump, H+ pump, H+/K+ pump). - Secondary active transport (Na+ dependent carriers) examples

43 Transport through plasma membranes Active transport modalities - Vesicular transport: endocytosis, phagocytosis, transcytosis, pinocytosis and exocytosis and its control in secretory cells.-

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45 Active Transport Mechanisms Primary active transport Secondary active transport Vesicular transport

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47 Types of Pumps Na+/K+ pump H+ pump H+/K+ pump Ca++ pump

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50 Phosphorylation & dephosphorylation

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52 Types of Pumps Na+/K+ pump H+ pump H+/K+ pump Ca++ pump

53 The importance of pumps for cell functions

54 Secondary Active Transport

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56 Secondary Active Transport -Co-transport -Counter transport

57 Vesicular Transport

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59 Fig

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61 Formation of vesicles at ER

62 Endocytosis

63 Phagocytosis

64 Receptor mediated endocytosis

65 Exocytosis

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67 Transcytosis

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69 Control of Transport and activity of Enzymes

70 Receptors & Enzymes

71 Receptors & Channels

72 Receptors & G proteins

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74

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76 Control of Exocytosis

77 Summary of Lectures -Homeostasis -Control of body functions by feed-back mechanisms to keep homeostasis -Functions of Cell organells (ER, Golgi complex, Mitochondria, Lisosomes) -Cytoskeletal structures and Functions:

78 Plasma membrane - Membrane structure and function of lipids of plasma membrane including phospholipids, cholesterol and PIP2) -Functions of Protein structures of plasma membranes (Channels, Carriers, Receptors, Pumps, enzymes, cell markers, G proteins, adhesion molecules) -Activation of chemical gated channels

79 Transport through plasma membranes Passive transport modalities -Simple diffusion: transport through lipid bilayer, transport through channels, Ficks law of diffusion. -Facilitated diffusion: by carriers Differences in diffusion Kinetics between the previous modalities Equivalent Concentration of particles.

80 Transport through plasma membranes Passive transport modalities -Osmosis: concept of osmotic pressure (Van t Hoff s law), Oncotic (Colloid-osmotic) pressure.osmolarity, osmolality Hydrostatic pressure

81 Transport through plasma membranes Active transport modalities - Primary active transport (ATP-ase carriers or Pumps) (functions of pumps: Na+/K+ pump, Ca++ pump, H+ pump, H+/K+ pump). - Secondary active transport (Na+ dependent carriers) examples

82 Transport through plasma membranes Active transport modalities - Vesicular transport: endocytosis, phagocytosis, transcytosis, pinocytosis and exocytosis and its control in secretory cells.-