Environmental Contaminant Standards

Transcription

1 ENVIRONMENTAL CONTAMINANT STANDARDS Environmental Contaminant Standards 2012 Dioxin Mixes PCBs, Mixes, and Metabolites Flame Retardants Chlorinated Paraffins PCNs and PCN Mixes PAHs and Substituted PAHs PAH Metabolites PAH Mixes Phenolic Mixes Pharmaceutical and Personal Care Products (PPCPs) Halogenated Aromatics Standards in Solvents Compatible with Polar Matrices Phthalates Pesticides and Pesticide Mixes Industrial Chemicals

2 2012 Cambridge Isotope Laboratories introduces several firsts in this New Product Guide. In the past year, CIL has synthesized the first isotope-labeled standard for chlorinated paraffin analysis, a group of compounds that are being evaluated for inclusion in the Stockholm Treaty. We also have a new suite of hydroxy-pah mixes available, including a calibration set, labeled spiking solution, and native Precision and Recovery standard, as well as the individual standards that were used to formulate the mixes. A suite of standards to study phenolic compounds is now offered, as is a new suite of standards for the study of polychlorinated naphthalenes. New dioxin and PCB mixtures, flame retardants, pollutant, and pesticide standards round off the list of new standards. Part number Description Size Dioxin Mixes EDF-5493 Dioxin/Furan Native Mix (unlabeled) 2378 isomers+1368-tcdd/f+1379-tcdd 1/2/5 µg/ml in nonane This new mix of native analytes includes all seventeen 2,3,7,8-containing dioxin and furan native congeners, as well as the first eluting dioxin and furan congeners (1,3,6,8-TCDD and 1,3,6,8-TCDF) and 1,3,7,9-TCDD. EDF ML Method 1613 Internal Standard Stock Solution ( 13 C 12 ) 200 ng/ml in nonane 2.5 ml EDF ML Method 1613 Labeled Compound Stock Solution ( 13 C 12 ) 100/200 ng/ml in nonane 5 ml Laboratories analyzing many samples by US EPA Method 1613 will appreciate the value of our new, larger sizes for the Internal Standard Stock and Labeled Compound Stock solutions. The volumes of these two spiking solutions are matched to enable analysis of the same number of samples. PCBs, Mixes and Metabolites PCB-182-CS 2,2,3,4,4,5,6 -HeptaCB (unlabeled certified standard) 100 µg/ml in isooctane PCB-182 is useful as a sampling/syringe standard. CIL now offers the unlabeled Certified Standard version of this PCB congener. EC-5375 Marker-7 PCB Mixture (w/pcb-118) ( 13 C 12 ) 1000 ng/ml in nonane EC-5495 Marker-7 PCB Mixture (w/pcb-118) (unlabeled) 1000 ng/ml in isooctane PCB-118 is considered both a Dioxin-like PCB (one of the 12 toxic PCBs given Toxic Equivalence Factors (TEFs) by the World Health Organization (WHO)), and a Marker PCB (one of the 7 most commonly found PCBs in technical PCB mixtures). Many laboratories will analyze both Dioxin-like and Marker PCBs, so to avoid duplication the older Marker PCB mixtures did not include PCB-118. For labs that analyze just the Marker PCBs, CIL now offers both labeled and unlabeled mixtures of Marker-7 PCBs. EC-5492 CDC PCB Recovery Standard Check Solution (unlabeled) 200 ng/ml in toluene 1 ml This mixture contains the unlabeled analogs of the Recovery Standard for OH-PAHs (ES-5474). EC-4935-B WHO Coplanar & Mono-Ortho PCBs (unlabeled) 5000 ng/ml in isooctane The WHO Coplanar (IUPAC# 77, 81,126, and 169) & Mono-Ortho (105,114,118,123,156,157,167,189) PCB mixture contains all 12 of the dioxin like PCBs at 5000 ng/ml. This represents a 5x higher concentration than previously offered; especially useful for high volume testing laboratories, or those requiring a higher concentration for mixing purposes. MEOCB Methoxy-2,3,3,4,5-PentaCB ( 13 C 12 ) 50 µg/ml in toluene MEOCB Methoxy-2,2,3,4,5,5 -HexaCB ( 13 C 12 ) 50 µg/ml in toluene These PCB metabolites (at first appearance, metabolites of PCB-107 and -146, but actually rearrangements of the more predominant PCB-105,-118 and -153) are part of the new suite of standards for analysis of phenolic compounds. The Methoxy PCBs are derivatized versions of the Hydroxy- metabolites commonly found in human samples.

3 Flame Retardants DLM Tributyl phosphate (D 27 ) 1 mg/ml in acetonitrile ULM Tributyl phosphate (unlabeled) 1 mg/ml in acetonitrile DLM Triethyl phosphate (D 15 ) 1 mg/ml in acetonitrile ULM Triethyl phosphate (unlabeled) 1 mg/ml in acetonitrile With brominated diphenyl ether (BDE) flame retardants being phased out or banned altogether, industry is turning to other flame retardant options. Consequently, Alkyl phosphate flame retardants are coming under increased scrutiny for health and environmental concerns as their use increases. CIL has begun to develop high purity standards for select alkyl phosphate compounds, and will continue to develop more in the future. CLM-8569-T-1.2 Dechlorane Plus syn (bis-cyclopentene- 13 C 10 ULM-7886-T-1.2 Dechlorane Plus syn (unlabeled CLM-8588-T-1.2 Dechlorane Plus anti (bis-cyclopentene- 13 C 10 ULM-7887-T-1.2 Dechlorane Plus anti (unlabeled Although Dechlorane Plus has been in use for over 40 years, it is only recently that it has become a compound of environmental interest. CIL is pleased to announce DP standards now in toluene as well as the nonane solutions we have produced for several years.toluene is more miscible with certain solvents and can be used in a variety of applications to complement the more traditional methods utilizing nonane standards. Chlorinated Paraffins CLM ,5,5,6,6,10-Hexachlorodecane ( 13 C 10 ) 100 µg/ml in nonane ULM ,5,5,6,6,10-Hexachlorodecane (unlabeled) 95%+ CP 100 µg/ml in nonane Chlorinated Paraffins, or chloroalkanes, are industrial chemicals that have been used extensively for many years as coolants and lubricants, plasticizers, and flame retardants, among other uses. Short-chain (C10-C13) chlorinated paraffins (SCCP) have come under increased scrutiny in recent years because of concern for long-range transport, persistence in the environment, bioaccumulation, and potentially toxic endpoints. CIL has been working diligently to synthesize a single-component SCCP standard to assist researchers in what is an extremely difficult analytical process. We are pleased to announce our first offering of labeled and unlabeled 10-carbon alkane standards containing six-chlorines. Look to CIL for future developments of Chlorinated Paraffin standards. PCNs and PCN Mixes ECN-5261-A 1,2,3,5,6,7-HexaCN ( 13 C 10 ) 10 µg/ml in isooctane ECN-5270-A 1,2,3,4,5,6,7-HeptaCN ( 13 C 10 ) 10 µg/ml in isooctane CIL has undertaken a new synthesis and formulation project for our polychlorinated naphthalene product line. These two labeled PCNs previously contained small but detectable levels of native impurities. A fresh synthesis has yielded labeled standards without interfering amounts of native analytes. ECN-5489 PCN Calibration Solutions (CS1 - CS7) in isooctane 7 x 0.5 ml ECN-5490 PCN Cleanup Solution ( 13 C 10 ) 0.5 ng/ml in methanol:isooctane 5 ml ECN-5497 PCN Native PAR Solution (unlabeled) 1000 ng/ml in isooctane Polychlorinated Naphthalenes (PCNs) are a group of 75 compounds structurally similar to PCBs. Until the 1970s, PCNs were high volume chemicals commercially produced as mixtures of several congeners, distributed under trade names such as Halowax. Owing to the harmful POP properties and risks related to continuing production, use and releases of PCNs to the environment, the committee members of the Stockholm Convention have listed PCNs as chemicals they are considering for inclusion in a future revision of the treaty. In a move to help researchers develop methods to clearly identify these compounds in various sample matrices, CIL has developed new calibration and spiking standards for analysis of many of the most important PCN congeners. PAHs and Substituted PAHs CLM Chlorobenz[a]anthracene ( 13 C 6 ULM Chlorobenz[a]anthracene (unlabeled ULM-2416-I-1.2 Benzo[b]fluoranthene (unlabeled) 200 µg/ml in isooctane ULM-2417-I-1.2 Benzo[k]fluoranthene (unlabeled) 200 µg/ml in isooctane ULM-2426-I-1.2 Indeno[1,2,3-cd]pyrene (unlabeled) 200 µg/ml in isooctane CIL has developed a new pair of labeled and unlabeled chlorinated Benz[a]anthracene standards. Several native PAH standards are now available in isooctane solvent, replacing existing solutions in methylene chloride.

4 PAH Metabolites CLM Hydroxyfluorene ( 13 C 6 ULM Hydroxyfluorene (unlabeled CLM Hydroxypyrene ( 13 C 6 ULM Hydroxypyrene (unlabeled CLM-8463-T Hydroxyphenanthrene ( 13 C 6 ULM-8464-T Hydroxyphenanthrene (unlabeled CLM-4859-T Hydroxyphenanthrene ( 13 C 6 ) 50 µg/ml in toluene 96% CP CLM Hydroxyphenanthrene ( 13 C 4 ULM Hydroxyphenanthrene (unlabeled CLM Hydroxyphenanthrene ( 13 C 4 ULM Hydroxyphenanthrene (unlabeled CLM Hydroxynaphthalene ( 13 C 6 ULM Hydroxynaphthalene (unlabeled CLM Hydroxynaphthalene ( 13 C 6 ULM Hydroxynaphthalene (unlabeled CLM Hydroxyfluorene ( 13 C 6 ULM Hydroxyfluorene (unlabeled CLM Hydroxyfluorene ( 13 C 6 ULM Hydroxyfluorene (unlabeled ULM Methyl-1-naphthol (unlabeled ES-5472 CDC OH-PAH Calibration Standards (CS1-CS10) in toluene 10 x 0.5 ml ES-5473-A CDC OH-PAH Spiking Standard ( 13 C) 25/100 ng/ml in acetonitrile 1.5 ml ES-5474 CDC PCB Recovery Standard for OH-PAHs ( 13 C 12 ) 200 ng/ml in toluene 1.0 ml ES-5484 CDC OH-PAH Native PAR Standard (unlabeled) 1000/4000 ng/ml in toluene CIL introduces a suite of new individual standards and standard mixtures for the study of Hydroxylated Polyaromatic Hydrocarbons (OH- PAHs). These PAH metabolites have been of interest for many years as biomarkers for asphalt production, coal smoke, and aerosols, as well as other uses. The presence of these compounds in human urine is an indication of exposure to PAHs from industrial sources. The Centers for Disease Control and Prevention, as well as other health laboratories around the world, have been studying these compounds to determine human exposure to PAHs from combustion for many years. CIL has offered many of these over the years, but this is the first time they have all been available at the same time. The individual standards were formulated in toluene to improve stability; the labeled spike diluted in acetonitrile for miscibility in polar matrices. PAH Mixes ES-5481 PAH Mixture (D) 2500 µg/ml in toluene 5 ml ES PAH Surrogates Standard Mixture (D) 200 µg/ml in 90% toluene:10% isooctane ES-5481 is a new mixture containing six deuterated PAH compounds at very high concentration. In addition, a new size of our popular ES-5164 PAH mixture has been added for the convenience of those researchers whose needs do not require 10 ml volumes Phenolic Mixes ES-5482 Phenolic Calibration Standards (CS1 - CS6) in nonane 6 x 0.5 ml ES-5483 Phenolic Spiking Standard ( 13 C) 10/25 ng/ml in methanol 10 ml ES-5496 Phenolic Native PAR standard (unlabeled) 5000 ng/ml in nonane CIL has produced a number of individual standards to quantify levels of PCB metabolites found in the human body. PCBs are hydroxylated in the liver s attempt to metabolize aromatic chemical contaminants. Other compounds, such as Triclosan (5-Chloro-2-(2,4- dichlorophenoxy) phenol or 2,4,4 -Trichloro-2-hydroxydiphenyl ether) and PCP (Pentachlorophenol) are structurally Phenolic ubiquitous exposure biomarkers from various sources. The analytes in the calibration solutions are the derivatized analogues of the target analytes- 4-Methoxy-2,3,3,4,5-pentachlorobiphenyl for 4-Hydroxy-2,3,3,4,5-pentachlorobiphenyl, 5-Chloro-2-(2,4-dichlorophenoxy)anisole for Triclosan, Pentabromoanisole for Pentabromophenol, etc. The spiking solution consists of the parent (underivatized) Hydroxy compounds, so the isotope dilution incorporates the derivatization process. The unusual concentration levels in the calibration solutions result from the correction of the molecular weights of the derivatized analytes. Pharmaceutical and Personal Care Products (PPCPs) DLM Diclofenac (phenyl-d 4 ) (CP 96%) 100 µg/ml in methylene chloride ULM Diclofenac (unlabeled) 100 µg/ml in methylene chloride DLM Progesterone (2,2,4,6,6,17A,21,21,21-D 9 ) 100 µg/ml in p-dioxane CIL introduces labeled and unlabeled standards for Diclofenac, a non-steroidal anti-inflammatory drug (NSAID). CIL has also developed a new Progesterone standard (D 9, 98%) replacing our previous standard (D 8, 96%). Although having greater isotopic enrichment (98% vs 96%) and higher mass (D 9 vs D 8 ) the price remains the same!

5 Halogenated Aromatics CLM ,5-Dichlorophenol ( 13 C 6 ) 100 µg/ml in methanol ULM Tetrachloro-m-xylene (unlabeled) 100 µg/ml in isooctane 2,5-Dichlorophenol is a metabolite of 1,4-Dichlorobenzene, an industrial chemical with many uses. Due to recent interest at the US Centers for Disease control (please see their recent Biomonitoring Summary) CIL is formulating this standard for release in the summer of This is an emerging contaminant expected to be targeted by more regulatory groups. Tetrachloro-m-xylene is commonly used as an internal standard. CLM Pentabromoanisole ( 13 C 6 ULM Pentabromoanisole (unlabeled Pentabromoanisole is a metabolite of pentabromophenol, a common flame retardant. It is part of the new suite of standards now available for analysis of phenolic compounds. Standards in Solvents Compatible with Polar Matrices ULM Vinyl chloride (unlabeled) 50 µg/ml in methanol ULM Methyl-1-naphthol (unlabeled ULM NNK (unlabeled) 100 µg/ml in nonane:ethanol (9:1) ULM-6935-MT-1.2 2,4,4 -Trichloro-2-hydroxydiphenyl ether (Triclosan)(unlabeled) 100 µg/ml in MTBE CIL is expanding many of our standards into polar solvents, more suited to liquid chromatography and related analytical procedures. Our goal is to remove the laborious solvent exchange procedures needed to transition from GC-able solvents like nonane and isooctane into the preferred polar solvents. Phthalates CLM-6847-MT-1.2 Mono(3-carboxypropyl) phthalate (ring-1,2-13 C 2, dicarboxyl- 13 C 2 )100 µg/ml in MTBE ULM-6848-MT-1.2 Mono(3-carboxypropyl) phthalate (unlabeled) 100 µg/ml in MTBE ULM di-n-butyl phthalate (unlabeled) 100 µg/ml in nonane ULM Benzyl butyl phthalate (unlabeled) 100 µg/ml in nonane Due to stability concerns in some of our phthalate mono-ester standards, CIL has started a program to develop standards in less aggressive solvents. One such compound, MCPP, has been reformulated in MTBE, switching from the previous offering in acetonitrile. CIL continues to expand our line of phthalate standards with the addition of new native standards for di-n-butyl Phthalate and Benzyl Butyl Phthalate. Pesticides and Pesticide Mixes CLM ,5,6-Trichloro-2-pyridinol (4,5,6-13 C 3 ) CP 97% Please inquire CLM [(Dimethoxyphosphorothioyl)sulfanyl]succinic acid ( 13 C 7 ) CP 97% Please inquire ULM Endrin Aldehyde (unlabeled) 50 µg ULM Endrin Ketone (unlabeled) 50 µg ES-5475 Unlabeled Pesticide Stock Solution 1 (unlabeled) 5 µg/ml in nonane ES-5476 Unlabeled Pesticide Stock Solution 2 (unlabeled) 5 µg/ml in nonane ES C-Pesticide Stock Solution 1 ( 13 C) 5 µg/ml in nonane 0.5 ml EC-5477 Chlorinated Internal Standard Stock Solution 1 (unlabeled) 25 µg/ml in nonane CIL has produced labeled 3,5,6-Trichloro-2-pyridinol (TCPy) and 2-[(Dimethoxyphosphorothioyl)sulfanyl]succinic acid, metabolites of chlorpyrifos and malathion. While CIL has offered 13 C- labeled versions of Endrin Aldehyde and Endrin Ketone as dried down standards for years, we now offer the complementary native versions in the same form. Another project has generated several new pesticide mixtures, both labeled and unlabeled. Visit to see full descriptions of these new mixtures or contact us at CIL. Additional mixtures will be added later in Industrial Chemicals DLM Butoxyethanol (1,1,2,2-D 4 ) 1000 µg/ml in water ULM Butoxyethanol (unlabeled) 1000 µg/ml in water 2-Butoxyethanol is used in lacquers, varnishes, soaps, cosmetics, and other household cleaners. Along with additives such as Ethylene glycol, it has come under increasing scrutiny as one of the chemicals used in the process of fractional distillation ( fracking ) of natural gas and the potential for groundwater contamination.