MMBS, MMED (Path),MAACB, MACTM, MACRRM
|
|
|
- Bertram Carr
- 5 years ago
- Views:
Transcription
1 Dr Mere Kende MMBS, MMED (Path),MAACB, MACTM, MACRRM Lecturer- SMSH
2 Brief Overview of Lipids What is dyslipidemia? Classification of hyperlipidemia Primary vs secondary hyperlipidemia Hypercholesterolaemia & Hypertriglyceridemia Diagnosis & Treatment 5mins Video References
3 Constituents of living cells Primary source of energy, precursors for steroid, hormones PGs,& leukotrienes Important structural components of cell membranes Components of bile for digestion
4 Fatty Acids Triacylglycerols (TRIGLYCERIDES) Cholesterols (sterols) Sterol esters Phospholipids Bile acids
5 FAT
6 Mader. Human Biology, 7 th Edition
7
8 Hydrophobic End Hydrophilic End
9 Relative insolubility in water Most lipids except Phospholipids are hydrophobic Has to be packaged as lipoproteins in specific protein complexes (apo-proteins) for transport in plasma FFA (>18Carbon) is transported in albumin
10 Mader. Human Biology, 7 th Edition
11 Mader. Human Biology, 7 th Edition
12 Mader. Human Biology, 7 th Edition
13 Mader. Human Biology, 7 th Edition
14
15 Are apo-protein + packaged lipids Make lipids water soluble for transport in plasma Carry varying amounts of fat to different tissues Apo-proteins are enzyme co-factors, structural proteins & ligands for receptor recognition
16 Chylomicrons (Diet TRIG) VLDL (Liver TRIG) LDL (Liver) IDL (Tissues form VLDL) HDL (liver) Chylomicron remnants (Tissue from chylomicrons) Lipoprotein (a)
17 Harrison s Principle of Internal Medicine 17 th Ed
18 Harper s illustrated Biochemistry 26 th Ed, 2003
19 Triglycerides (triacyl glcerol) Free Cholesterol & Cholesteryl esters Phospholipids FFA (small)
20 A. Despopoulous, S. Silbenagl. Colour Atlas of Physiology, 5 th Edition
21 Chylomicrons (TRIG)- apob48- supplied in DIET VLDL (TRIG)-ApoB100,E,C synthesis : Liver + GIT LDL derived from VLDL in liver, Apo B100 transport CHO to peripheral tissues HDLC Apo A,E & C transport CHO to liver for excretion
22 Harper s Ilustrated Biochemistry 26 th Ed, 2003
23
24 Refers to abnormal metabolism of lipoproteins/lipids Hypolipoproteinemia Hyperlipidemia Tangier s Disease
25 Refers to high cholesterol or high triglycerides Primary/Genetic/Familial Causes Secondary: Diabetes, hypothyroid, nephrotic syndrome Obesity Oral contraceptives steroids Combined cause/polygenic
26 Acute Coronary Syndrome Stroke Peripheral Vessel Disease (claudication)
27 Atlas of clinical Diagnosis, 2 nd Edition
28 ABC of Dermatology, BMJ Pub, 4 th Edition Atlas of clinical Diagnosis, 2 nd Edition
29
30
31
32
33
34
35 Cardiovascular Risk Assessment TOO MANY NOT GOOD Overweight Diabetes Over-weight Diabetes Hypertension Cholesterol HIGHEST RISK Smoking NORMAL RISK
36 Isolated high cholesterol (CHO) Isolated high triglycerides (TRIG) Combined elevation of both CHO & TRIG
37 Inherited Due to various defects in catabolism of lipoprotein include defective transport proteins (apo-proteins), receptors and ligands for receptors (apo E) Early onset of CVD/stroke (<40y old) Acute pancreatitis (+ very high TRIG) Xanthomas (skin, tendons, extensor surfaces, eyelids) Family members with hyperlipidemia/early CVD deaths
38 Type I------V Based on type of lipoprotein elevated Results in elevation of cholesterol or triglycerides or both
39 Familial hyperlipoproteinemia
40 Autosomal dominant Defect in LDL receptors/apo B100 Isolated high CHO- almost due to raised LDL Normal TG CVD Risk 25x >normal after 30 Family history of early death/cvd, Heterozygous >9mmol/L; symptoms at 30-40y; CVD at 50/60y Homozygous >15mmol/L; early CVD; die before 20y
41 Tendon xanthomas (most commonly of the Achilles tendons and the extensor tendons of the knuckles), tuberous xanthomas (softer,painless nodules on the ankles and buttocks), & xanthelasmas (deposits on the eyelids) are common.
42
43 Yellow, creamy & elevated papule
44 Large subcutaneous tumor adherent to the Achilles Tendon.
45
46 Phenotype I (AR) IIa (AD) IIb LP high chylo LDL LDL & VLDL III (AD) Chylo remnants & IDL IV (AD) VLDL V (AR) Chylo & VLDL TRIG >9++ < >9++ CHO <6 > / Plasma milky clear clear turbid turbid milky xanthomas Eruptive, buttocks Knee/ elbow none Palmar, tendon none pancreatitis yes no no no no yes IHD no Yes ++ Yes++ Yes++ -/+ -+ PVD no yes yes yes -/+ -/+ Gene defect LPL, apocii LDL R/ B100? Apo E2/E2 Apo A- V? yes Apo A- V?
47 Diabetes Mellitus (high TRIG+/- CHO) Nephrotic syndrome (high CHO) Severe Hypothyroidism (high CHO) Cushing s Syndrome (TRIG) Obesity (TRIG) OCP (TRIG) Cholestasis/Obstructive Jaundice (high CHO)
48 High CHO and LDLC No identifiable mode of inheritance?environmental & poorly understood genetics Diet alone can control CHO in some patients
49 Total cholesterol LDL cholesterol (LDLC) HDL cholesterol (HDL) Ratio of LDL:HDLC Triglycerides Apo-lipoproteins A & B Lipoprotein (a)
50 Measured after an overnight fast. Creamy layer in tube non-fasting/defect in chylomicron metabolism Plasma is usually clear when TG levels are <4.5 mmol/l (<400 mg/dl) & cloudy when levels are higher
51 Clinical- early CVD, very high CHO, xanthomas Many diagnosed incidentally Laboratory Total cholesterol Triglycerides LDLC & HDLC Ratio LDLC:HDLC Others: Small dense LDLC Apo A and B Lipoprotein (a) & lipoprotein electrophoresis
52 Normal TRIG level > 2.3 mmol/l (> 200 mg/dl). Normal Total cholesterol <5.5mmol/L HDL Cholesterol Good cholesterol <1mmol/L ---Bad LDLC Bad cholesterol >2.5mmol/L Bad
53 Over-weight /Obesity Hypertension Diabetes Mellitus Heart Disease
54 Lifestyle changes (Weight Loss /diet/exercise) Medication Lower Cholesterol & Triglycerides Treat secondary problems
55 Lifestyle Changes (smoking/alcohol/drug) Weight loss BMI= wt (kg)/ht x ht (m) IBW= [ 25 x ht x ht] (m) Acceptable IBW= IBW + 10% of IBW Low fat Diet Exercise (3omins /day) Manage existing Risk factors (DM)
56 Fish, canola oil & flaxseeds (Omega 3) Olive oil Nuts (unsaturated Fatty Acids) Peanuts, walnuts, almonds, hazelnuts High Fibre (oat meal, oat bran, kidney beans, apples, pears) Green Leafy Vegetables
57 Adapted from Lullman Color Atlas of Pharmacology 2000
58 HMG co-enzyme reductase (statins)-block Cholesterol synthesis) Simvastatin, pravastatin, atorvastatains, lovastains Cholesterol absorption inhibitors (enhances excretion) ezitimibe Bile acid sequestrant (Increase LDLC excretion) Cholestyramine, cholestipol & cholesvelem Nicotinic acid (increases LDLC & TRIG excretion) Clofibrates (Increase LDLC excretion & Increase HDLC) Gemfibrozil & fenofibrozil Fish Oil (Omega 3)---decreases TRIG
59 What Does Diabetes Do.mp4
60 ESC Koay & N Walmsley: A primer of Chemical Pathology 1996 Harrisons Principle of Internal Medicine 17 th Edition PJ. Gallagher, GA Tanner. Medical Physiology, 2 nd edition A. Despopoulous, S. Silbenagl. Colour Atlas of Physiology, 5 th Edition
Hyperlipidemia. Prepared by : Muhannad Mohammed Supervisor professor : Dr. Ahmed Yahya Dallalbashi
Hyperlipidemia Prepared by : Muhannad Mohammed Supervisor professor : Dr. Ahmed Yahya Dallalbashi Outline The story of lipids Definition of hyperlipidemia Classification of hyperlipidemia Causes of hyperlipidemia
THE CLINICAL BIOCHEMISTRY OF LIPID DISORDERS
THE CLINICAL BIOCHEMISTRY OF LIPID DISORDERS Hormonal regulation INSULIN lipid synthesis, lipolysis CORTISOL lipolysis GLUCAGON lipolysis GROWTH HORMONE lipolysis CATECHOLAMINES lipolysis LEPTIN catabolism
Dyslipidemia. Team Members: Laila Mathkour, Khalid Aleedan, Bayan Al-Mugheerha, Fatima AlTassan
Dyslipidemia Objectives: Not given. Team Members: Laila Mathkour, Khalid Aleedan, Bayan Al-Mugheerha, Fatima AlTassan Team Leader: Amal Alshaibi Revised By: Yara Aldigi and Basel almeflh Resources: 435
Dyslipidemia. (Med-341)
Dyslipidemia (Med-341) Anwar A Jammah, MD, FRCPC, FACP, CCD, ECNU. Associate Professor of Medicine Consultant Medicine, Endocrinology, Thyroid Oncology Department of Medicine, King Saud University The
ATP III (Adult Treatment Panel III) CLASSIFICATION C IN ADULTS
LABORATORY AND RISK FACTORS OF ATHEROSCLEROSIS S R. Mohammadi Biochemist (Ph.D.) Faculty member of Medical Faculty RISK FACTORS FOR CHD Clinical Risk Factors Laboratory Risk Factors MAJOR CLINICAL RISK
Hypertriglyceridemia. Ara Metjian, M.D. Resident s Report 20 December 2002
Hypertriglyceridemia Ara Metjian, M.D. Resident s Report 20 December 2002 Review of Lipids Chylomicrons (CM): Dietary lipids absorbed through the GI tract are assembled intracellularly into CM. Very Low
STRUCTURE AND METABOLISM Of LIPIDS AND LIPOPROTEINS. R. Mohammadi Biochemist (Ph.D.) Faculty member of Medical Faculty
STRUCTURE AND METABOLISM Of LIPIDS AND LIPOPROTEINS R. Mohammadi Biochemist (Ph.D.) Faculty member of Medical Faculty STRUCTURE OF LIPIDS AND LIPOPROTEINS DEFINTITION: Compounds Insoluble in water But
Pathophysiology of Lipid Disorders
Pathophysiology of Lipid Disorders Henry Ginsberg, M.D. Division of Preventive Medicine and Nutrition CHD in the United States CHD is the single largest killer of men and women 12 million have history
Antihyperlipidemic Drugs
Antihyperlipidemic Drugs Lipid disorders: Disorders of lipid metabolism are manifest by elevation of the plasma concentrations of the various lipid and lipoprotein fractions (total and LDL cholesterol,
1Why lipids cannot be transported in blood alone? 2How we transport Fatty acids and steroid hormones?
1Why lipids cannot be transported in blood alone? 2How we transport Fatty acids and steroid hormones? 3How are dietary lipids transported? 4How lipids synthesized in the liver are transported? 5 Lipoprotien
Unit IV Problem 3 Biochemistry: Cholesterol Metabolism and Lipoproteins
Unit IV Problem 3 Biochemistry: Cholesterol Metabolism and Lipoproteins - Cholesterol: It is a sterol which is found in all eukaryotic cells and contains an oxygen (as a hydroxyl group OH) on Carbon number
Chapter (5) Etiology of Low HDL- Cholesterol
Chapter (5) Etiology of Low HDL- Cholesterol The aim of this chapter is to summarize the different etiological factors mainly the role of life-style and different disease conditions contributing to the
Cholesterol metabolism. Function Biosynthesis Transport in the organism Hypercholesterolemia
Cholesterol metabolism Function Biosynthesis Transport in the organism Hypercholesterolemia - component of all cell membranes - precursor of bile acids steroid hormones vitamin D Cholesterol Sources: dietary
Southern Derbyshire Shared Care Pathology Guidelines. Dyslipidaemia
Southern Derbyshire Shared Care Pathology Guidelines Dyslipidaemia This guideline applies to patients with significantly abnormal lipid profiles, which may be primary (genetic), secondary to other diseases
Lipids, lipoproteins and cardiovascular disease
Lipids, lipoproteins and cardiovascular disease Presented by Dr. Mohammad Saadeh The requirements for the Clinical Chemistry Philadelphia University Faculty of pharmacy Cardiovascular disease Plasma enzymes
ANTIHYPERLIPIDEMIA. Darmawan,dr.,M.Kes,Sp.PD
ANTIHYPERLIPIDEMIA Darmawan,dr.,M.Kes,Sp.PD Plasma lipids consist mostly of lipoproteins Spherical complexes of lipids and specific proteins (apolipoproteins). The clinically important lipoproteins, listed
Maintain Cholesterol
Maintain Cholesterol What is Cholesterol? Cholesterol is a Lipid Molecule that has a waxy appearance and is found in every cell of the body and has some important natural functions. It is manufactured
Lipoproteins Metabolism Reference: Campbell Biochemistry and Lippincott s Biochemistry
Lipoproteins Metabolism Reference: Campbell Biochemistry and Lippincott s Biochemistry Learning Objectives 1. Define lipoproteins and explain the rationale of their formation in blood. 2. List different
determination of Triglyceride in Serum Amal Alamri
determination of Triglyceride in Serum Amal Alamri Triglyceride are fatty acid esters of glycerol,and are the main lipids in the diet. They broken down(by lipase) in the small intestine to a mixture of
Plasma lipoproteins & atherosclerosis by. Prof.Dr. Maha M. Sallam
Biochemistry Department Plasma lipoproteins & atherosclerosis by Prof.Dr. Maha M. Sallam 1 1. Recognize structures,types and role of lipoproteins in blood (Chylomicrons, VLDL, LDL and HDL). 2. Explain
13/09/2012. Dietary fatty acids. Triglyceride. Phospholipids:
CARDIOVASCULAR DISEASES (CVD) and NUTRITION Major cause of morbidity & mortality in Canada & other developed countries e.g., majority of approved health claims on food labels relate to lowering CVD Relation
Dyslipidaemia. Dr NM Oosthuizen Dept of Chemical Pathology SA
Dyslipidaemia Dr NM Oosthuizen Dept of Chemical Pathology SA13 2014 Endogenous and exogenous pathways Endogenous Exogenous Reverse cholesterol transport Dyslipidaemias Causes can be primary or secondary
Lipids Types, Food Sources, Functions
Lipids Types, Food Sources, Functions What Are Lipids? Lipids Diverse group of molecules that are insoluble in water Fats The lipid content of diets and foods 1 Lipids in Body Cells and Tissues Types of
Antihyperlipidemic drugs
Antihyperlipidemic drugs The clinically important lipoproteins are LDL low density lipoprotein, VLDL very low density lipoprotein, HDL high density lipoprotein. Hyperlipidemia may caused 1. by individual
Lipids, pt. 1. Feb. 3, Bio 28: Nutrition Instructor: Paul Nagami Laney College
Lipids, pt. 1 Feb. 3, 2014 Bio 28: Nutrition Instructor: Paul Nagami Laney College Today s Agenda Reminders + Administrative Details What Are Lipids? Chemistry and Types of Lipids Fatty Acids Saturated
Familial hypercholesterolaemia
Familial hypercholesterolaemia Jaimini Cegla MRCP FRCPath PhD Consultant in Chemical Pathology and Metabolic Medicine Hammersmith Hospital Lipid Clinic 20 April 2017 An unrecognised, potentially fatal,
2.5% of all deaths globally each year. 7th leading cause of death by % of people with diabetes live in low and middle income countries
Lipid Disorders in Diabetes (Diabetic Dyslipidemia) Khosrow Adeli PhD, FCACB, DABCC Head and Professor, Clinical Biochemistry, The Hospital for Sick Children, University it of Toronto Diabetes A Global
Fats and Other Lipids
Fats and Other Lipids Chapter 6 Chapter 6: Fats and other Lipids 1 6.1 Understanding Lipids Lipids include: 1. Fatty acids 2. Triglycerides 3. Phospholipids 4. Cholesterol Oil and Water Don t Mix Because
Hypertriglyceridemia: Why, When, and How to Treat. Gregory Cohn, MD, FNLA, FASPC
Hypertriglyceridemia: Why, When, and How to Treat Gregory Cohn, MD, FNLA, FASPC DISCLOSURES Consultant to Akcea Therapeutics (in the past 12 months). OUTLINE I. Lipoproteins II. Non-HDL-C III. Causes and
Podcast (Video Recorded Lecture Series): Lipoprotein Metabolism and Lipid Therapy for the USMLE Step One Exam
Podcast (Video Recorded Lecture Series): Lipoprotein Metabolism and Lipid Therapy for the USMLE Step One Exam Howard J. Sachs, MD www.12daysinmarch.com Email: Howard@12daysinmarch.com Podcast (Video Recorded
Learning Objectives. Cholesterol and Lipids in Kids: It s a Matter of the Heart. Is Atherosclerosis a Pediatric Disease?
Scott J. Soifer, MD Professor and Vice Chair Department of Pediatrics University of California, San Francisco UCSF Benioff Children s Hospital Cholesterol and Lipids in Kids: It s a Matter of the Heart
CLINICAL IMPORTANCE OF LIPOPROTEINS
25 Hyperlipidemias CLINICAL IMPORTANCE OF LIPOPROTEINS Raised levels of low-density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are independent risk factor
Zuhier Awan, MD, PhD, FRCPC
Metabolism, Atherogenic Properties and Agents to Reduce Triglyceride-Rich Lipoproteins (TRL) The Fifth IAS-OSLA Course on Lipid Metabolism and Cardiovascular Risk Muscat, Oman, February 8-11, 2019 Zuhier
Lipoproteins Metabolism
Lipoproteins Metabolism LEARNING OBJECTIVES By the end of this Lecture, the student should be able to describe: What are Lipoproteins? Describe Lipoprotein Particles. Composition of Lipoproteins. The chemical
Classification. Etiology
Dyslipidemia Dyslipidemia is the elevation of plasma cholesterol, triglycerides (TGs), or both, or a low high-density lipoprotein level that contributes to the development of atherosclerosis. Causes may
Introduction Hyperlipidemia hyperlipoproteinemia Primary hyperlipidemia (Familial) Secondary hyperlipidemia (Acquired)
Introduction Hyperlipidemia, or hyperlipoproteinemia, is the condition of abnormally elevated levels of any or all lipids and/or lipoproteins in the blood. Hyperlipidemias are divided in primary and secondary
Antihyperlipidemic Drugs
Antihyperlipidemic Drugs Hyperlipidemias. Hyperlipoproteinemias. Hyperlipemia. Hypercholestrolemia. Direct relationship with acute pancreatitis and atherosclerosis Structure Lipoprotein Particles Types
Lipid/Lipoprotein Structure and Metabolism (Overview)
Lipid/Lipoprotein Structure and Metabolism (Overview) Philip Barter President, International Atherosclerosis Society Centre for Vascular Research University of New South Wales Sydney, Australia Disclosures
BIOCHEMISTRY BLOOD - SERUM Result Range Units
BIOCHEMISTRY BLOOD - SERUM Result Range Units LIPIDS CHOLESTEROL 3.9 0.0-5.5 mmol/l TRIGLYCERIDES 0.7 < 1.5 mmol/l LIPID STUDIES HDL(Protective) 1.5 > 1.2 mmol/l LDL(Atherogenic) 2.1 0.5-3.5 mmol/l Cholesterol/HDL
Lipids digestion and absorption, Biochemistry II
Lipids digestion and absorption, blood plasma lipids, lipoproteins Biochemistry II Lecture 1 2008 (J.S.) Triacylglycerols (as well as free fatty acids and both free and esterified cholesterol) are very
Lipoprotein Pathophysiology. Lipoprotein Pathophysiology
Lipoprotein Pathophysiology Genetic Dyslipidemia Thomas A. Hughes, M.D. Professor of Medicine Division of Endocrinology, Metabolism, and Diabetes University of Tennessee Health Science Center GW is a 47
Topic 11. Coronary Artery Disease
Topic 11 Coronary Artery Disease Lipid metabolism http://news.bbc.co.uk/2/hi/health/7372495.stm Sterol Metabolism and Coronary Artery Disease Big Picture: Exogenous Cholesterol and Fat Metabolism Fats-Triglycerides
Behind LDL: The Metabolism of ApoB, the Essential Apolipoprotein in LDL and VLDL
Behind LDL: The Metabolism of ApoB, the Essential Apolipoprotein in LDL and VLDL Sung-Joon Lee, PhD Division of Food Science Institute of Biomedical Science and Safety Korea University Composition of Lipoproteins:
Lipids Board Review. Ira Goldberg, MD New York University School of Medicine. Which of the following is the best initial therapy choice?
Lipids Board Review Ira Goldberg, MD New York University School of Medicine 1. A 22 year old male college student is referred for severe hypertriglyceridemia ( 1500 mg/dl [ 17.0 mmol/l]). He has a history
PIEDMONT ACCESS TO HEALTH SERVICES, INC. Guidelines for Screening and Management of Dyslipidemia
PIEDMONT ACCESS TO HEALTH SERVICES, INC. Policy Number: 01-09-021 SUBJECT: Guidelines for Screening and Management of Dyslipidemia EFFECTIVE DATE: 04/2008 REVIEWED/REVISED: 04/12/10, 03/17/2011, 4/10/2012,
Anti Hyperlipidemic Drugs. Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia
Anti Hyperlipidemic Drugs Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia Lipoproteins Macromolecular complexes in the blood that transport lipids Apolipoproteins
Drug regulation of serum lipids
Drug regulation of serum lipids Foundations of Biomedical Science MEDS90001 Dr Michelle Hansen Pharmacology & Therapeutics mjhansen@unimelb.edu.au References Katzung, Basic & Clinical Pharmacology Ch 35
BIOB111_CHBIO - Tutorial activity for Session 12
BIOB111_CHBIO - Tutorial activity for Session 12 General topic for week 6 Session 12 Lipids Useful Links: 1. Animations on Cholesterol (its synthesis, lifestyle factors, LDL) http://www.wiley.com/college/boyer/0470003790/animations/cholesterol/cholesterol.htm
Chapter VIII: Dr. Sameh Sarray Hlaoui
Chapter VIII: Dr. Sameh Sarray Hlaoui Lipoproteins a Lipids are insoluble in plasma. In order to be transported they are combined with specific proteins to form lipoproteins: Clusters of proteins and lipids.
Imbalances in lipid components
Drugs for Dyslipidemia Vivien Gam, Pharm.D. 1 Dyslipidemia Imbalances in lipid components High total cholesterol High LDL cholesterol Low HDL cholesterol High triglycerides Significant risk factor for
PLASMA LIPOPROTEINS AND LIPIDS DETERMINATION OF PLASMA CHOLESTEROL AND TRIGLICERIDE LEVEL
PLASMA LIPOPROTEINS AND LIPIDS DETERMINATION OF PLASMA CHOLESTEROL AND TRIGLICERIDE LEVEL Lipids are characterized by low polarity and limited solubility in water. Their plasma concentration is about 500-600
A N A C P S P E C I A L R E P O R T. Understanding and Managing Your. Triglycerides
A N A C P S P E C I A L R E P O R T Understanding and Managing Your Triglycerides What are Triglycerides? Triglycerides are one of several types of fat in your body, and the most common of them all. Along
Lipoprotein Formation, Structure and Metabolism: Cholesterol Balance and the Regulation of Plasma Lipid Levels
Lipoprotein Formation, Structure and Metabolism: Balance and the Regulation of Plasma Lipid Levels David E. Cohen, MD, PhD Director of Hepatology, Gastroenterology Division, Brigham and Women s Hospital
Lipid & Fat: Overview
Lipid & Fat: Overview What is a lipid? Triglycerides, Phospholipids and Sterols Triglycerides = Fat Saturated & unsaturated Essential fatty acids ü Omega 3 & Omega 6 Trans fat Why do you need fat? How
Management of Post-transplant hyperlipidemia
Management of Post-transplant hyperlipidemia B. Gisella Carranza Leon, MD Assistant Professor of Medicine Lipid Clinic - Vanderbilt Heart and Vascular Institute Division of Diabetes, Endocrinology and
DYSLIPIDEMIA PHARMACOLOGY. University of Hawai i Hilo Pre- Nursing Program NURS 203 General Pharmacology Danita Narciso Pharm D
DYSLIPIDEMIA PHARMACOLOGY University of Hawai i Hilo Pre- Nursing Program NURS 203 General Pharmacology Danita Narciso Pharm D 1 LEARNING OBJECTIVES Know normal cholesterol levels Understand what the role
Joslin Diabetes Center Advances in Diabetes and Thyroid Disease 2013 Consensus and Controversy in Diabetic Dyslipidemia
Consensus and Controversy in Diabetes and Dyslipidemia Om P. Ganda MD Director, Lipid Clinic Joslin diabetes Center Boston, MA, USA CVD Outcomes in DM vs non- DM 102 Prospective studies; 698, 782 people,
Cholesterol, Heart Attack and Stroke. Dr Tai E Shyong Consultant Department of Endocrinology Singapore General Hospital
Cholesterol, Heart Attack and Stroke Dr Tai E Shyong Consultant Department of Endocrinology Singapore General Hospital Outline Why are we interested in cholesterol What is a heart attack and how does it
MOLINA HEALTHCARE OF CALIFORNIA
MOLINA HEALTHCARE OF CALIFORNIA HIGH BLOOD CHOLESTEROL IN ADULTS GUIDELINE Molina Healthcare of California has adopted the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel
Nutrition, Food, and Fitness. Chapter 6 Fats: A Concentrated Energy Source
Nutrition, Food, and Fitness Chapter 6 Fats: A Concentrated Energy Source Tools: Printer (color optional) 4 sheets of 8.5 x 11 paper Scissors Directions: 1. Print 2. Fold paper in half vertically 3. Cut
OM s Health Corner Cholesterol & Heart Disease!!
Cholesterol & Heart Disease!! We may associate cholesterol with fatty foods, but most of the waxy substance is made by our own bodies. The liver produces 75% of the cholesterol that circulates in our blood.
Focus on FH (Familial Hypercholesterolemia) Joshua W. Knowles, MD PhD for PCNA May, 2013
Focus on FH (Familial Hypercholesterolemia) Joshua W. Knowles, MD PhD for PCNA May, 2013 Conflicts CMO for The FH Foundation Pre-talk quiz What is cascade screening? 1. screening all family members 2.
Advances in Lipid Management
Advances in Lipid Management Kavita Sharma, MD Assistant Professor of Medicine, Division of Cardiology Clinical Director of the Lipid Management Clinics, The Ohio State University Wexner Medical Center
An educational booklet for patients with familial hypercholesterolemia DR. LEIV OSE
An educational booklet for patients with familial hypercholesterolemia DR. LEIV OSE CONTENTS WHAT WILL YOU LEARN FROM THIS BOOKLET? You will learn about Familial Hypercholesterolemia, its cause, and the
Walter B. Bayubay CLS (ASCP), AMT, MA Ed, CPI
Walter B. Bayubay CLS (ASCP), AMT, MA Ed, CPI Biochemical Analysis (Lipid Panel) Analyte Total Cholesterol Reference Range Patient A < 200 241 LDL-C /= 40 38 Triglycerides
CHOLESTEROL CONTENT CREATED BY. Learn more at
CHOLESTEROL CONTENT CREATED BY Learn more at www.health.harvard.edu TALK WITH YOUR DOCTOR Table of Contents what is cholesterol? 4 Whether this is your first visit or a follow-up, asking your doctor these
Case Discussions: Treatment Strategies for High Risk Populations. Most Common Reasons for Referral to the Baylor Lipid Clinic
Case Discussions: Treatment Strategies for High Risk Populations Peter H. Jones MD, FNLA Associate Professor Methodist DeBakey Heart and Vascular Center Baylor College of Medicine Most Common Reasons for
BCH 447. Triglyceride Determination in Serum
BCH 447 Triglyceride Determination in Serum Introduction: Triglycerides are esters of fatty acids and are hydrolyzed by lipase to glycerol and free fatty acids. Triglyceride determinations when performed
ATP IV: Predicting Guideline Updates
Disclosures ATP IV: Predicting Guideline Updates Daniel M. Riche, Pharm.D., BCPS, CDE Speaker s Bureau Merck Janssen Boehringer-Ingelheim Learning Objectives Describe at least two evidence-based recommendations
Glossary For TheFatNurse s For All Ages Series Apolipoprotein B (APOB or ApoB) are the primary apolipoproteins of chylomicrons and low-density lipoproteins (LDL - known commonly by the misnomer "bad cholesterol"
Nutrition & Wellness for Life 2012 Chapter 6: Fats: A Concentrated Energy Source
Tools: Printer 8.5 x 11 paper Scissors Directions: 1. Print 2. Fold paper in half vertically 3. Cut along dashed lines Copyright Goodheart-Willcox Co., Inc. All rights reserved. Tissue in which the body
History. Aron first proposed that fat may be essential for normal growth Tested on animals-vitamins A,D,E added. Fat deficiency severely affected
Chapter 5 LIPIDS History 1918 Aron first proposed that fat may be essential for normal growth Tested on animals-vitamins A,D,E added Fat deficiency severely affected Bone growth Reproduction Called Vitamin
Lipids do not like water! (aka: hydrophobic) Generally insoluble
Lipids Lipids Lipids do not like water! (aka: hydrophobic) Generally insoluble Lipids They act like this because of their molecular structure (non-polar) Lipids are made mostly of C and H atoms, with O
Lipid & Fat: Overview
Lipid & Fat: Overview What is a lipid? Triglycerides, Phospholipids and Sterols Triglycerides = Fat Saturated & unsaturated Essential fatty acids ü Omega 3 & Omega 6 Trans fat Why do you need fat? How
STATIN UTILIZATION MANAGEMENT CRITERIA
STATIN UTILIZATION MANAGEMENT CRITERIA DRUG CLASS: HMG Co-A Reductase Inhibitors & Combinations Agents which require prior review: Advicor (niacin extended-release/lovastatin) Crestor (rosuvastatin)(5mg,10mg,
Pediatric Dyslipidemia: Angela Gooden MSN, RN, CPNP- AC/PC, Texas Children s Hospital, Pediatric Cardiology
Pediatric Dyslipidemia: Angela Gooden MSN, RN, CPNPAC/PC, Texas Children s Hospital, Pediatric Cardiology Objectives Define pediatric dyslipidemia Describe the association between pediatric dyslipidemia
Death is inevitable but premature death is not. Sir Richard Doll
Welcome to the Diabetes Care for You webinar Please log onto the conference call so you can hear our presenter From any SCFT Cisco phone dial 800800 From a mobile phone or any other phone dial 01273 242
Cholesterol Levels -- What They Mean, Diet and Treatment
Cholesterol Levels -- What They Mean, Diet and Treatment What Is Cholesterol? We may associate cholesterol with fatty foods, but most of the waxy substance is made by our own bodies. The liver produces
Your cholesterol levels. Questions or concerns
Because you have high cholesterol you should: Know your cholesterol levels Take the medicine to lower cholesterol that your doctor has told you to take Follow your doctor s treatment plan Keep your appointments
There are many ways to lower triglycerides in humans: Which are the most relevant for pancreatitis and for CV risk?
There are many ways to lower triglycerides in humans: Which are the most relevant for pancreatitis and for CV risk? Michael Davidson M.D. FACC, Diplomate of the American Board of Lipidology Professor,
A Review: Atherosclerosis & its treatment
73 Review Article A Review: Atherosclerosis & its treatment Yogesh K. Patil* Department of Pharmacology, Shree Mahavir Institute of Pharmacy, Nashik, Maharashtra, India *yogesh_kpatil85@yahoo.co.in ABSTRACT
B. Patient has not reached the percentage reduction goal with statin therapy
Managing Cardiovascular Risk: The Importance of Lowering LDL Cholesterol and Reaching Treatment Goals for LDL Cholesterol The Role of the Pharmacist Learning Objectives 1. Review the role of lipid levels
Lipid Metabolism in Familial Hypercholesterolemia
Lipid Metabolism in Familial Hypercholesterolemia Khalid Al-Rasadi, BSc, MD, FRCPC Head of Biochemistry Department, SQU Head of Lipid and LDL-Apheresis Unit, SQUH President of Oman society of Lipid & Atherosclerosis
10/1/2008. Therapy? Disclosure Statement
What s New in Lipid Therapy? Brooke Hudspeth, PharmD Diabetes Care Kroger Pharmacy Disclosure Statement In accordance with policies set forth by the Accreditation Council for Continuing Medical Education
Lipid Management: A Case-Based Approach. Overview. Simple Lipid Therapy Approach. Patients have lipid disorders of:
Lipid Management: A Case-Based Approach Patrick E. McBride, M.D., M.P.H. Professor of Medicine, Cardiovascular Medicine Associate Director, Preventive Cardiology Program UW School of Medicine and Public
Lipid Metabolism Prof. Dr. rer physiol. Dr.h.c. Ulrike Beisiegel
Lipid Metabolism Department of Biochemistry and Molecular Biology II Medical Center Hamburg-ppendorf 1 Lipids. visceral fat. nutritional lipids 0 1.5 3 4.5 9 h. serum lipids. lipid accumulation in the
LIPID METABOLISM. Sri Widia A Jusman Department of Biochemistry & Molecular Biology FMUI
LIPID METABOLISM Sri Widia A Jusman Department of Biochemistry & Molecular Biology FMUI Lipid metabolism is concerned mainly with fatty acids cholesterol Source of fatty acids from dietary fat de novo
Lipids. PBHL 211 Darine Hachem, MS, LD
Lipids PBHL 211 Darine Hachem, MS, LD Outline Functions of lipids in our body Types of lipids Sources of lipids Recommendation of fat intake Fat association with heart diseases Provide energy (9Kcal/g
Financial Disclosures
1 Lipids in Type 2 Diabetes July 20, 2013 Abhimanyu Garg, M.D. Professor of Internal Medicine Chief, Division of Nutrition and Metabolic Diseases Distinguished Chair in Human Nutrition Research UT Southwestern
North Americans consume 100 g of fat per day on
PRACTICE AT THE BEDSIDE Common problems in the management of hypertriglyceridemia Michelle A. Fung, Jiri J. Frohlich Case A 41-year-old man presents for assessment of severe hypertriglyceridemia. He has
CHAPTER 28 LIPIDS SOLUTIONS TO REVIEW QUESTIONS
28 09/16/2013 17:44:40 Page 415 APTER 28 LIPIDS SLUTINS T REVIEW QUESTINS 1. The lipids, which are dissimilar substances, are arbitrarily classified as a group on the basis of their solubility in fat solvents
Definition: Water insoluble No common structure (though generally large R groups)
Lipids Definition Definition: Water insoluble No common structure (though generally large R groups) Water Solubility (Hydrophilic) What makes molecules water soluble (hydrophilic)? Like dissolves like
Plasma fibrinogen level, BMI and lipid profile in type 2 diabetes mellitus with hypertension
World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original
Approach to Dyslipidemia among diabetic patients
Approach to Dyslipidemia among diabetic patients Farzad Hadaegh, MD, Professor of Internal Medicine & Endocrinology Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences
Comprehensive Treatment for Dyslipidemias. Eric L. Pacini, MD Oregon Cardiology 2012 Cardiovascular Symposium
Comprehensive Treatment for Dyslipidemias Eric L. Pacini, MD Oregon Cardiology 2012 Cardiovascular Symposium Primary Prevention 41 y/o healthy male No Medications Normal BP, Glucose and BMI Social History:
High density lipoprotein metabolism
High density lipoprotein metabolism Lipoprotein classes and atherosclerosis Chylomicrons, VLDL, and their catabolic remnants Pro-atherogenic LDL HDL Anti-atherogenic Plasma lipid transport Liver VLDL FC
Management of dyslipidaemia in HIV infected children: rationale for treatment algorithm
Management of dyslipidaemia in HIV infected children: rationale for treatment algorithm Authors: Julie Lanigan, Lisa Cooke and Clare Stradling Date of Preparation: September 2010 Date reviewed: October
Familial Hypercholesterolemia
Understanding (FH) Familial Hypercholesterolemia For more information, visit Understanding Familial Hypercholesterolemia (FH) Your doctor may have told you that too much of the bad type of cholesterol
Metabolism, Atherogenic Properties and Agents to reduce Triglyceride-Rich Lipoproteins Manfredi Rizzo, MD, PhD
Metabolism, Atherogenic Properties and Agents to reduce Triglyceride-Rich Lipoproteins Manfredi Rizzo, MD, PhD Associate Professor of Internal Medicine Faculty of Medicine, University of Palermo, Italy
Lipids What s new (and what s not)
Lipids What s new (and what s not) Overview Background evidence Obesity Guidelines Treatment options Pragmatic lipidology Side effects Familial Hypercholesterolaemia Cases Summary Background evidence CHD