2017 SUNDAY, OCTOBER 15 MONDAY, OCTOBER 16
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1 The Monticello Conference 2017 SUNDAY, OCTOBER pm 5.00 pm Registration/Hospitality in the Tack Room at Boar s Head Inn MONDAY, OCTOBER am 5.30 pm Registration/Hospitality in the Tack Room at Boar s Head Inn 3.15 pm Meet in lobby of Boar s Head Inn 3.30 pm Depart for the Behind the Scenes Tour of Monticello 4.00 pm Behind the Scenes Tour begins 6.00 pm Behind the Scenes Tour concludes, depart for Montalto (this dinner is for conference attendees only, spouses/guests will be returned to Boar s Head Inn) 6.00 pm Meet in lobby of Boar s Head Inn, depart for reception and dinner at Montalto (for conference attendees who did not go on the tour, but are planning to attend the dinner) 6.30 pm 7.30 pm RECEPTION 7.45 pm 9.00 pm DINNER 9.30 pm RETURN TO BOAR S HEAD INN 1
2 The Monticello Conference TUESDAY, OCTOBER am 8.00 am BREAKFAST AT BOAR S HEAD INN Hearth Room 8.00 am MEET IN LOBBY OF BOAR S HEAD INN 8.15 am DEPART FOR MONTALTO 9.00 am am WELCOME AND MEETING OVERVIEW David Weill SESSION I: DEFINING EMPS Moderator: Ann Wylie Rapporteur: Bob Nolan, Alan Rogers, Christy Barlow 9:15 am 9:30 am CHARACTERISTICS OF NATURALLY OCCURRING EMPS Mickey Gunter Elongate Mineral Particles in the Natural and Built Environment 9.30 am 9.40 am Questions 9.40 am 9.55 am EMPS FROM EXCAVATION Bradley Erskine An Example: Calaveras Dam Replacement Project 9.55 am am Questions 2
3 TUESDAY, OCTOBER 17 (CONTINUED) am am MEASURING EMPS IN THE LUNG Victor Roggli What Can Be Measured in the Lung: Asbestiform Minerals and Cleavage Fragments am am Questions am am Coffee Break am am CHARACTERISTICS OF LUNG BURDEN EMPS Fred Pooley Analysis of Respirable Fibrous Particles am am Questions am am BACKGROUND LEVELS OF EMPS Drew Van Orden Identification and Analysis of Ambient EMPs am am Questions am am EMP DEPOSITION AND RETENTION IN THE HUMAN LUNG Bahman Asgharian Dosimetry of Inhaled Elongated Particles in the Respiratory Tract: The Impact of Shape Factor am pm Questions pm pm MEASUREMENT OF EMPS Eric Chatfield What We Should Measure and How Do We Do It? am pm Questions pm pm Lunch 3
4 TUESDAY, OCTOBER 17 (CONTINUED) 1.30 pm 2:30 pm GENERAL DISCUSSION EMP Definitions: What Can and What Should be Known About Them That Would Inform Health-Related Studies SESSION II: EFFECTS AND MECHANISMS Moderator: Roger McClellan Rapporteurs: Eric Chatfield, Victor Roggli, Murray Finkelstein 2.30 pm 2.45 pm EFFECTS AND MECHANISMS Gunter Oberdorster Extrinsic and Intrinsic Physico-Chemical Properties of EMPs: Predictors of Toxicity 2.45 pm pm Questions 2.55 pm pm IN VITRO MODELS AND EXPERIMENTS Brooke Mossman Mechanistic Studies of EMPs: Cell Cultures, Organ Cultures and Beyond? 3.10 pm pm Questions 3.20 pm pm BIOPERSISTENCE AND OTHER OBSERVATIONS FROM EXPERIMENTAL STUDIES David Bernstein Comparative Analysis of Elongated Mineral Particles Using Quantitative Inhalation Toxicology 3.35 pm pm Questions 3.45 pm 4:00 pm Coffee Break 4
5 TUESDAY, OCTOBER 17 (CONTINUED) 4.00 pm pm WHAT CAN WE LEARN FROM NANO PARTICLE STUDIES? Agnes Kane The Asbestos-Carbon Nanotube Analogy: An Update 4.15 pm 4.25 pm Questions 4.25 pm pm BIOLOGICAL RESPONSES TO EMPS Uschi Graham Translocation, Bioprocessing and Tissue Interactions of EMPs following Inhalation Exposure 4.40 pm pm Questions 4.50 pm 5.05 pm TOXICITY PREDICTION Alessandro Gualtieri Towards a General Model to Predict the Toxicity of Mineral Fibers 5.05 pm pm Questions 5.30 pm DEPART MONTALTO 6.00 pm ARRIVE BOAR S HEAD INN 7.00 pm COCKTAILS & DINNER AT BOAR S HEAD INN Hearth Room 5
6 WEDNESDAY, OCTOBER am 8.00 am BREAKFAST AT BOAR S HEAD INN Hearth Room 8.00 am MEET IN LOBBY OF BOAR S HEAD INN 8.15 am DEPART FOR MONTALTO 9.00 am am GENERAL DISCUSSION Toxicology, Mechanisms and Experimental Issues am am Coffee Break SESSION III: HUMAN EXPOSURE, EFFECTS AND RISKS Moderator: Graham Gibbs Rapporteurs Wayne Berman, Morton Lippmann, Philip Hibbs am am RELATIONSHIPS BETWEEN QUALITATIVE ASPECTS OF EXPOSURE AND DISEASE FROM LUNG TISSUE STUDIES Bruce Case Does Qualitative Examination of EMP Recovered from Human and Animal Lungs Provide Reliable Information on their Carcinogenic and other Effects? am am Questions am am THE EPIDEMIOLOGIC EVIDENCE FOR EMP-RELATED HUMAN HEALTH EFFECTS Paola Boffetta Carcinogenic Risk of Elongated Particles: The Contribution of Epidemiology am am Questions 6
7 WEDNESDAY, OCTOBER 18 (CONTINUED) am am pm pm pm pm PARTICLE DIMENSIONS AND MESOTHELIOMA Ed Ilgren and Yosara Andrea Mejia The Role of Fiber Width in Mesothelioma - Bolivian Crocidolite, Finnish Anthophyllite and Fiber Width am pm Questions ARE CANCER RISKS IN TACONITE MINING CAUSED BY ASBESTIFORM OR NON-ASBESTIFORM EMPS? Jeff Mandel The Taconite Story pm am Questions NON-CANCER ENDPOINT RISKS WE MIGHT ANTICIPATE FROM NON-ASBESTIFORM EMPS Mark Utell Refractory Ceramic Fibers as an EMP: Fibre Characteristics, Potential Health Effects and Clinical Observations pm am Questions pm 1.50 pm Lunch 1.50 pm 2.05 pm OTHER FACTORS TO CONSIDER; SURFACE PROPERTIES 2.15 pm 2.30 pm Art Langer and Robert Nolan Surface Chemistry and Structure: Factors Controlling the Biological Potential of Inorganic Particulate 2.05 pm pm Questions FIBER POTENCY VS EMP POTENCY IN HUMANS David Garabrant Fiber Potency Analyses for Mesothelioma and Lung Cancer 2.30 pm pm Questions 7
8 WEDNESDAY, OCTOBER 18 (CONTINUED) 2.40 pm pm DOSE RESPONSE Tony Cox Biomathematical Mechanisms of Non-Linear Dose-Response for Respirable Elongated Mineral Particles 2.55 pm pm Questions 3.05 pm 3.20 pm RISK FROM NON-OCCUPATIONAL EMP EXPOSURES Bian Liu Environmental Mesothelioma Risk 3.20 pm 3.30 pm Questions 3.30 pm 3.45 pm Coffee Break 3.45 pm 4.00 pm MESOTHELIOMA AND TALC Gary Marsh and Christy Barlow The Mineralogy and Epidemiology of Cosmetic Talc 4.00 pm 4.10 pm 4.10 pm pm RISK ESTIMATES FOR EMPS Annie Jarabek What a Difference the Dose Makes: Dosimetry Approaches to Aid Experimental Design, Inform Inferences, and Support Evidence Integration for Risk Assessment Applications 4.25 pm 4.35 pm Questions 4.45 pm DEPART MONTALTO 5.15 pm ARRIVE BOAR S HEAD INN 6.00 pm MEET IN LOBBY OF BOAR S HEAD INN 6.15 pm DEPART FOR FARMINGTON COUNTRY CLUB 6.30 pm 7:30 pm RECEPTION LOWER PATIO 7.45 pm 9:30 pm DINNER MAIN DINING ROOM 9.45 pm RETURN TO BOAR S HEAD INN 8
9 THURSDAY, OCTOBER am 8.00 am BREAKFAST AT BOAR S HEAD INN Hearth Room 8.00 am MEET IN LOBBY OF BOAR S HEAD INN 8.15 am DEPART FOR MONTALTO 9.00 am am OTHER FACTORS TO CONSIDER: GENETICS AND THE ENVIRONMENT Michele Carbone Gene-Environment Interaction in Asbestos Carcinogenesis and Mesothelioma am am Questions am am Coffee Break am pm GENERAL DISCUSSION Is there human evidence that non-asbestiform EMPS cause health effects? If so, under what circumstances? What are the levels of risk from EMPS? pm 1.00 pm Lunch SESSION IV: RAPPORTEURS REPORTS AND GENERAL DISCUSSION 1.00 pm 4.00 pm Moderator: John Hoskins Rapporteurs: Brooke Mossman, Gunter Oberdorster, Robert Glenn 9
10 THURSDAY, OCTOBER 19 (CONTINUED) SESSION V: FUTURE RESEARCH Moderator: David Weill Rapporteurs: Gunter Oberdorster, Brooke Mossman, Robert Glenn 4.00 pm 4.15 pm STATE OF KNOWLEDGE IN FRANCE Erell Leocat State of Knowledge in France Pertaining to Legislation and to the ANSES Report 4:25 pm 5:30 pm 4.15 pm pm Questions GENERAL DISCUSSION WHAT WE DO NOT KNOW AND WHAT IS NEEDED TO FILL THE GAPS 5.30 pm DEPART MONTALTO 6.00 pm ARRIVE AT ROTUNDA 6.15 pm 7:15 pm RECEPTION UPPER WEST OVAL ROOM 7.45 pm DINNER DOME ROOM 9.00 pm KEYNOTE SPEAKER: ANDREW O SHAUGHNESSY The Illimitable Freedom of the Human Mind Thomas Jefferson s Idea of a University CLOSING REMARKS pm RETURN TO BOAR S HEAD INN FRIDAY, OCTOBER am 8.30 am BREAKFAST AT BOAR S HEAD INN Hearth Room 10
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