EXERCISE AND FIBROMYALGIA: THE AL- ÁNDALUS PROJECT

Transcription

1 EXERCISE AND FIBROMYALGIA: THE AL- ÁNDALUS PROJECT Fernando Estévez- López (project manager) & Manuel Delgado- Fernández (principal invesrgator) On behalf of the al- Ándalus project members Department of Physical Educa6on and Sport, Faculty of Sport Sciences, University of Granada, Granada (Spain)

2 Contents ² Fibromyalgia diagnosis ² Phenotype characteriza6on (fa6gue) ² Variables associated with fa6gue ² Design of the al- Ándalus project ² Collabora6ons ² Funding

3 Diagnosis Pain Symptoms n=579 FM and 294 HC Segura- Jiménez et al. Rheumatology, 2014

4 Diagnosis Usefulness of the thresholds n=489 FM and 250 HC Aparicio et al. Med Sci Sports Exerc, 2015

5 Phenotype characterizaron Valida6on of ques6onnaires: The Mul6dimensional Fa6gue Inventory (MFI) Munguía- Izquierdo et al. Clin Exp Rheumatol, 2012 The Posi6ve and Nega6ve Affect Schedule (PANAS) Estévez- López et al. PeerJ, 2016 The Ra6ng Perceived Exer6on (RPE) Soriano- Maldonado et al. J Sports Sci, 2015 Physical ac6vity and sedentary 6me ques6onnaires Munguía- Izquierdo et al. Arch Phys Med Rehabil, 2011; Munguía- Izquierdo et al. Clin Exp Rheumatol, 2013 Segura- Jiménez et al. Arch Phys Med Rehabil, 2014

6 Phenotype characterizaron Reliability and feasibility of physical fitness tests Carbonell- Baeza et al. Int J Sports Med Norma6ve data of physical fitness tests Álvarez- Gallardo et al. Scand J Med Sci Sports, In press

7 Phenotype characterizaron Fa6gue in fibromyalgia and healthy par6cipants Segura- Jiménez et al. Semin Arthri6s Rheum, 2015

8 Phenotype characterizaron Fa6gue among fibromyalgia women and men Segura- Jiménez et al. Pain Res Manag, 2016

9 FaRgue in fibromyalgia 20 FaRgue (MFI, 4-20) General fargue Physical fargue Reduced acrvity Reduced morvaron Mental fargue n=442 Segura- Jiménez et al. Semin Arthri6s Rheum, 2015

10 Phenotype characterizaron 74.7% 25.3% Figure. Prevalence of severe fa6gue (SF- 36 vitality < 36) in fibromyalgia n=442 Unpublished data

11 AssociaRons with fargue Physical variables (e.g., physical fitness) Segura- Jiménez et al. J Sports Sci, In press Segura- Jiménez et al. Scand J Med Sci Sports, 2017 Segura- Jiménez et al. Eur J Pain, 2016 Gavilán- Carrera et al. Submi-ed Psychological variables (e.g., level of depression) Soriano- Maldonado et al. Qual Life Res, 2015 Estévez- López et al. Submi-ed

12 Exercise and fibromyalgia: the al- Ándalus project Cross- secronal study 2012 n=600 FM n=300 HC Phenotype

13 Exercise and fibromyalgia: the al- Ándalus project Cross- secronal study years follow up study 5- years follow up 2014 study 2017 n=600 FM n=300 HC Phenotype n=300 FM n=150 HC Phenotype & Genotype n=300 FM n=150 HC Phenotype & Genotype

14 Exercise and fibromyalgia: the al- Ándalus project RCT- I 2012 Phenotype & Genotype Land- based exercise Water- based (32ºC) exercise Usual care (control group) n=60 FM n=60 FM n=60 FM Phenotype & Genotype RCT- II Hydrotherapy (34ºC) Hydrotherapy + exercise n=50 FM n=50 FM

15 Exercise and fibromyalgia: the al- Ándalus project Phenotype (self- reports) ² Beck Depression Inventory- II ² Current pain (VAS) ² FIQR ² SF- 36 ² Trait Meta- Mood Scale ² Posi6ve and Nega6ve Affect Schedule ² Pilsburgh Sleep Quality Index ² Mul6dimensional Fa6gue Inventory ² Chronic Pain Self- Efficacy Scale ² Pain Catastrohizing Scale Clinical observarons ² Tender points ² Neuropsychological tests (memory) ² Mini Mental State Examina6on ² Body composi6on (bioimpedance) ² Physical fitness tests ² Physical ac6vity (accelerometry) ² 64 SNP Genotype

16 CollaboraRons

17 Funding v Spanish Ministry of Economy and CompeRRveness: 1.1. Proyecto I+D+I (DEP ); Proyecto I+D+i Retos de la Sociedad (DEP R); PhD fellowship (FPI; BES ); PhD fellowship (FPI; BES ); v Junta de Andalucía (southern Spain government): 2.1. Consejería de Turismo, Comercio y Deporte (CTCD TRA); Consejería de Salud (PI ); v Spanish Ministry of EducaRon: 3.1. PhD fellowship (AP ); PhD fellowship (FPU12/00963); PhD fellowship (FPU13/01088); PhD fellowship (FPU14/02518); PhD fellowship (FPU15/00002); v University of Granada: 4.1. Proyecto de excelencia BioTic 4.2. Becas de Iniciación a la Inves6gación. v European University of Madrid: 5.1. Ayudas a la inves6gación Cátedra Real Madrid (2010/04RM); Estimated funding: >1,000,000

18 PHYSICAL EXERCISE AND FIBROMYALGIA: THE AL- ÁNDALUS PROJECT Fernando Estévez- López (project manager) & Manuel Delgado- Fernández (principal invesrgator) Website of the Project: