Il Patient Blood Management in Italia. Dr. Giancarlo Maria Liumbruno Direttore Generale, Centro Nazionale Sangue Istituto Superiore di Sanità, Roma
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1 Il Patient Blood Management in Italia Dr. Giancarlo Maria Liumbruno Direttore Generale, Centro Nazionale Sangue Istituto Superiore di Sanità, Roma Aggiornamenti in Medicina Trasfusionale - Enna, 4 ottobre 2017
2 Disclosure I do declare that I have no relevant financial or nonfinancial relationships within the products or services described, reviewed, evaluated or compared in this presentation.
3 This resolution of the World Health Assembly urges all 189 member states of the United Nations to implement various transfusion related strategies including Patient Blood Management with its three pillar approach.
4 Padilla A, WHO 2010
5 According to the Health Ministry Decree of 4 th September 2012 regarding the national self-sufficiency plan of blood and blood components the concept of PBM was first introduced as a tool to pursue the objective of achieving the national self-sufficiency. To achieve this goal the Decree established that it was necessary to define and implement innovative and more effective methods and tools to ensure the appropriate clinical and organizational management of blood.
6
7 Multidisciplinary recommendations on PBM in elective major orthopaedic surgery - July scientific societies January 2016 Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) Italian Society of Italian Society of Orthopaedics and Traumatology (SIOT) Italian Society of Anaesthesia, Analgesia, Resuscitation and Intensive Therapy (SIAARTI) Italian Society for the Study of Haemostasis and Thrombosis (SISET) The National Association of Hospital Medical Directors (ANMDO)
8 Provisions on quality and safety of blood and blood components Art. 25 Transfusion safety 5. For the prevention of avoidable transfusions and with particular reference to the preparation of the patient who will undergo pre-scheduled surgical treatments, specific programmes are defined and implemented nationwide (Patient Blood Management) on the basis of guidelines to be issued by the National Blood Centre within six months after entryinto force of the present Decree.
9 The 2016 self-sufficiency national plan states that the aforementioned regulatory guidelines shall be based on the scientific guidelines on PBM recently published in Blood Transfusion. PBM implementation will foresee the active participation also of transfusion medicine specialists.
10 Meta-analisi sull associazione tra anemia pre-operatoria e mortalità post-chirurgica pazienti anemici (39,1%) Mortalità, danno renale, infezioni, stroke La dimostrazione che l anemia pre-operatoria è associata con outcome negativi dopo interventi chirurgici costituisce lo strumento ideale per creare il senso dell urgente necessità di implementare il PBM L anemia pre-operatoria è associata ad outcome negativi dopo interventi chirurgici; Fowler AJ, BJS 2015
11 Blood Transfus 2017, in press
12 Blood Transfus 2017, in press
13 Recommendation N. 4: pre- intra- and post-operative period In clinically stable inpatients needing (allogeneic or autologous) RBC transfusions a single unit blood transfusion policy shall be adopted. Further RBC units shall be transfused after a thorough clinical reassessment of the patient.
14
15 Leahy MF, Transfusion 2014
16
17 Time needed to get significant results Leahy MF, Transfusion 2014
18 Heyes J, QJM: An International Journal of Medicine 2017
19 Blood Transfus 2017
20 Autologous blood - Italy: Recommendation N. 6: Predeposit autologous blood donation programmes shall be carried out pursuant to the pertinent law in force ( At the moment, predeposit autologous donation is indicated for: i) patients with rare erythrocyte phenotype or with complex alloimmunisations for whom it is difficult to obtain compatible homologous blood components; ii) donors of bone marrow haematopoietic stem cells; iii) children who are to undergo scoliosis surgery.) donated units transfused units , Italian National Blood Centre
21 Blood Transfus 2017
22 Anemizzazione da prelievo Sangue prelevato (ml/die) Il prelievo ematico per esami di laboratorio è associato indipendentemente all insorgenza di anemia acquisita durante il ricovero ospedaliero (Salisbury AC, Arch Intern Med 2011) 12,4 33,5 73, Reparto (n = 50) Ter. intensiva senza catet. art. Ter. intens. con catet. arter. (n = 31) Smoller BR, N Engl J Med 1986
23 Blood Transfus 2017
24 1. Iron status can be easily evaluated and normal ferritin concentrations exclude iron deficiency 2. Non-anaemic iron deficiency does not require any intervention 3. Oral iron is "always" efficacious if patientstolerate highdailydoses 4. The use of intravenous iron should be restricted to severe cases of anaemia 5. There is no need for reassessment after iron repletion with intravenous iron 6. All intravenous iron formulations are alike 7. Intravenous iron is associated with a high risk of anaphylaxis 8. Premedication reduces infusion reactions during intravenous iron administration 9. Intravenous iron may increase the risks of infection and oxidative stress 10. No adjuvant iron is needed with erythropoiesis stimulating agent treatment if the ferritin level is normal Blood Transfus 2017
25 Vaglio S, Blood Transfus 2017
26 Blood Transfus 2017
27 Il Ministero della Salute ha recentemente inviato le Linee Guida sul PBM alle Regioni e Province autonome invitandole ad assicurarne la applicazione da parte delle Aziende sanitarie, ai fini dell'erogazione di prestazioni terapeutiche efficaci, del contenimento del fabbisogno trasfusionale, del miglioramento dell assistenza sanitaria dei pazienti e della riduzione dei costi. Il CNS sarà impegnato nel monitoraggio dell'applicazione delle Linee Guida mediante indicatori all uopo sviluppati. Blood Transfus 2017
28
29 Frequenza della terapia trasfusionale nei pazienti ricoverati Pazienti trasfusi durante il ricovero: 1 su 10
30 Activity-based costs of blood transfusions in surgical patients at four hospitals
31 Transfusion
32 Trentino KM, Transfusion 2015
33 Grazie per l attenzione!
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