Wrapping Our Heads Around the Outbreak
|
|
- John Leonard
- 5 years ago
- Views:
Transcription
1 Wrapping Our Heads Around the Outbreak An Update on the Zika Virus P. Zach White, PharmD PGY1 Pharmacy Resident Mayo Eugenio Litta Children s Hospital Pharmacy Grand Rounds June 7, MFMER slide-1
2 In the news WHO: World Health Organization CDC: Center for Disease Control 2015 MFMER slide-2
3 Objectives Discuss the epidemiology and prevalence of Zika virus (ZKV) Describe the fetal complications of ZKV List the challenges encountered when manufacturing a vaccine for ZKV 2015 MFMER slide-3
4 Zika Virus Timeline Discovered in the Zika Forest of Uganda First human case detected 2007 First outbreak in Micronesia 2013 to 2015 Various outbreaks in French Polynesia and South Pacific May 2015 Feb 2016 Dec 2016 First identification in Brazil WHO declared ZKV a Public Health Emergency of International Concern WHO predicts first vector-borne cases in the United States WHO: World Health Organization ZKV: Zika virus Emerg Infect Dis Sep;15(9): PLoS Negl Trop Dis. 2014;8(1):e2636 Clin Microbiol Infect Oct;20(10):O MFMER slide-4
5 Background Flavivirus - same family as West Nile virus, dengue, tick-borne encephalitis & yellow fever Aedes aegypti mosquito Aggressive in daytime hours Dengue and chikungunya viruses In 2015, Brazil noticed 20-fold increase in microcephaly Higher incidence of Guillain-Barré syndrome reported by Brazil Ministry of Health Ultrasound Obstet Gynecol Jan;47(1):6-7 Center for Disease Control and Prevention 2015 MFMER slide-5
6 Transmission Mosquitos Pregnancy Sexual contact Blood transfusions Saliva? Center for Disease Control and Prevention Oral Dis May MFMER slide-6
7 Active Zika Virus Center for Disease Control and Prevention Accessed 27 May MFMER slide-7
8 Zika Virus in the United States Total cases: States Travel-associated cases: 618 Locally-acquired vector-borne cases: 0 Guillain-Barré syndrome: 1 Pregnant women: 195 Sexually transmitted: 11 Total cases: 1,114 U.S. Territories Travel-associated cases: 4 Locally-acquired vector-borne cases: 1,110 Guillain-Barré syndrome: 8 Pregnant women: 146 Minnesota: 17 Wisconsin: 2 Arizona: 3 Florida: 128 Iowa: 6 Center for Disease Control and Prevention Accessed 5 June MFMER slide-8
9 Zika in the United States We conducted a single-center, retrospective chart review for all VLBW neonates from October 2011-March 2013 and April 2014-October 2015 and compared dexamethasone exposure specifics when prescribed for BPD prevention. The primary outcome was the difference in prescribing rates of dexamethasone for infants still intubated at day of life (DOL) 10. Secondary outcomes looked at mg/kg cumulative dexamethasone use, dexamethasone duration, DOL at time of dexamethasone initiation, and prescriber compliance to the order set. Center for Disease Control and Prevention Accessed 5 June MFMER slide-9
10 Assessment Question All of the continental United States Zika cases have been travel-associated? A) True B) False 2015 MFMER slide-10
11 Maternal Signs and Symptoms 20% of infected patients are symptomatic Underdiagnosed or misdiagnosed as other viral illness Common symptoms include fever, rash, joint pain, conjunctivitis, myalgias, and headache Symptom duration of four to seven days Guillain-Barré symptoms may include bilateral extremity weakness & facial muscle weakness Complications requiring hospitalization are rare Zero fatalities to date Oral Dis May 27 Clin Rev Allergy Immunol May MFMER slide-11
12 Testing Laboratory diagnosis of serum or plasma Virus, viral RNA, viral-specific IgM ZKV present in blood up to 7 days after symptom onset Serum samples > 7 days can be tested for antibodies Viral RNA in urine up to 10 days after onset Identification and confirmation of ZKV-specific antibody is difficult High cross-reactivity with Flavivirus antibody assays IgM: immunoglobulin M N Engl J Med 2016; 374: MFMER slide-12
13 Treatment Prevention Minimize mosquito bites during the first week of infection to prevent spread of the virus Prevent sexual transmission by using condoms for 8 weeks Supportive Get plenty of rest Drink fluids to prevent dehydration Acetaminophen to reduce fever and pain Avoid aspirin and other NSAIDs until dengue is ruled out to reduce bleeding risk NSAIDs: nonsteroidal anti-inflammatory drugs Center for Disease Control and Prevention 2015 MFMER slide-13
14 Mother and Baby Placental transfer of ZKV in all trimesters Major morphological changes occur in 1 st trimester CNS development in all stages Causes fetal microcephaly & severe brain defects Pregnant patients should see their doctor if symptomatic within 14 days of traveling Women should wait 8 weeks after exposure before trying to get pregnant No reports of ZKV transfer through breastmilk Benefits continue to outweigh the risks ZKV: Zika virus World Health Organization DOI: /NEJMoa MFMER slide-14
15 Fetal Complications Center for Disease Control and Prevention, National Center on Birth Defects and Development Disabilities 2015 MFMER slide-15
16 Secondary Complications Seizures Developmental delay Vision problems Hearing loss Movement and balance issues Feeding difficulties 2015 MFMER slide-16
17 Breaking and Entering Zika Virus AXL Receptors Infection of neural progenitors Neurotropism Microcephaly Cell Stem Cell Volume 18; MFMER slide-17
18 Zika-Induced Microcephaly Preliminary report in Rio De Janeiro 12 of 42 (29%) of ZKV-positive women had fetal abnormalities noticed on ultrasound Abnormalities included fetal death, placental insufficiency, fetal growth restriction and CNS injury Retrospective review of the French Polynesia outbreak in % of the general population was exposed to Zika Baseline prevalence of microcephaly: 2 cases per 10,000 Microcephaly from 1 st trimester exposure: 95 cases per 10,000 The Lancet, Volume 387, Issue 10033, DOI: /NEJMoa MFMER slide-18
19 Data Collection and Reporting There are two objects of medical education: To heal the sick, and to advance the science Charles H. Mayo 2015 MFMER slide-19
20 United States Zika Registry Created by the CDC to better understand ZKV Collaboration with state, tribal, local and territorial health departments Aim is to collect information about pregnancy and infant outcomes Data will be used to: Update recommendations Plan for services Reduce incidence of ZKV during pregnancy CDC: Center for Disease Control ZKV: Zika virus 2015 MFMER slide-20
21 United States Zika Registry Registry inclusion Pregnant women with laboratory evidence of ZKV with or without symptoms Prenatally or perinatally exposed infants born to these women Infants with laboratory evidence of congenital ZKV regardless of symptoms and their mothers Includes positive or inconclusive tests ZKV: Zika virus Center for Disease Control and Prevention Accessed 1 June MFMER slide-21
22 Obstetrics Providers Pediatric Providers Identify suspected pregnancy exposure Identify suspected congenital infant exposure Collect pertinent information Collect pertinent information Note adverse effects (i.e. spontaneous abortion or termination of pregnancy) Note adverse effects (i.e. perinatal or infant deaths, microcephaly, developmental delay) Report to appropriate health department Center for Disease Control and Prevention Accessed 1 June MFMER slide-22
23 Reporting the Data Laboratory-confirmed cases State, tribal, local, or territorial health department Suspected cases Consult the CDC Zika Pregnancy Hotline (770) or CDC will then inform the health department CDC: Center for Disease Control 2015 MFMER slide-23
24 Assessment Question Which of the following statements is true? A) Common symptoms of ZKV include joint pain, conjunctivitis, and myalgia B) Breastfeeding should be discouraged in a mother with confirmed ZKV C) Laboratory-confirmed ZKV cases should be reported directly to the CDC D) Treatment includes antipyretics (i.e. NSAIDs) NSAIDs: nonsteroidal anti-inflammatory drugs 2015 MFMER slide-24
25 Ideal Qualities of Any Vaccine Developed, produced and delivered in large volumes Low processing costs Safe and efficient distribution Short development and delivery times Safe and effective BioPharm Intl. 21 (1) s1 s6 (2008) 2015 MFMER slide-25
26 Bioprocessing Basics Upstream Downstream Cell isolation Clarification of virus Inactivation Concentration Media preparation Preservative stabilizer Formulation Contaminant removal Antigen Growth Sterile filtration Fill and finish Cell harvest Ray et al. BioPharm International Supplements; Oct MFMER slide-26
27 New Vaccine Manufacturing Challenges No history or experience with patient response Promising animal models do not often correlate to effectiveness in humans New, specific biological assay required to validate activity of virus and assure quality control Contaminant removal must be documented Adventitious agents must be removed or inactivated Increased production costs for manufacturers BioPharm Intl. 21 (1) s1 s6 (2008) Nat Biotechnol Nov;24(11): MFMER slide-27
28 Zika Vaccine Challenges Knowledge of the disease is lacking 25 PubMed articles published between PubMed articles published between January May Lack of reliable animal models Lack of reliable biological assays Complex human response to flaviviruses One infection or vaccination against one flavivirus can enhance a secondary severe infection N Engl J Med 2016; 374: MFMER slide-28
29 Zika Vaccine Research Approaches 1) DNA-based vaccine Similar to investigational flavivirus vaccine for West Nile Safe and effective in Phase I trial 2) Genetically engineered vesicular stomatitis virus (VSV) vaccine Same approach used for investigational Ebola vaccine Planning stages 3) Whole-particle, inactivated Zika vaccine Similar approach used for Japanese encephalitis and dengue viruses National Institute of Allergy and Infectious Diseases 2015 MFMER slide-29
30 Approaches, continued 4) Live-attenuated vaccine Promising Phase III trials shown in Brazil for similar dengue virus Advantages Closely mimics natural infection Strong antibody response Lifelong immunity in 1-2 doses Easier to create for viruses Viruses mutate Disadvantages Revert back to virulent form and cause disease Shouldn t administer in immunosuppressed patients Refrigeration to keep potency National Institute of Allergy and Infectious Diseases 2015 MFMER slide-30
31 Assessment Question Which of the following are challenges of manufacturing a ZKV vaccine? A) Lack of knowledge about the disease state B) A complex human response to flaviviruses C) Underdiagnosed disease state D) All of the above 2015 MFMER slide-31
32 Sources of Information Center for Disease Control website Bulletin of the World Health Organization Per protocol for public health emergencies of international concern Primary literature not yet approved for publication Unrestricted use, distribution and reproduction Ask Mayo Expert PubMed 2015 MFMER slide-32
33 Conclusion All ZKV cases in the continental U.S. have been travel-associated ZVK has been linked to increase incidence of microcephaly in newborns Expecting mothers should avoid areas with ZKV outbreaks Healthcare providers should utilize the Zika Registry Multiple challenges need to be overcome before a Zika vaccine is made available 2015 MFMER slide-33
34 Questions and Discussion 2015 MFMER slide-34
Zika Virus Update. Partner Webinar 05/12/2016
Zika Virus Update Partner Webinar 05/12/2016 Today s presenters Patricia Quinlisk, MD, MPH, Medical Director /State Epidemiologist Ann Garvey, DVM, MPH, MA, State Public Health Veterinarian/ Deputy State
More informationFY 2017 President s Budget Request Overview for the National Center on Birth Defects and Developmental Disabilities
National Center on Birth Defects and Developmental Disabilities FY 2017 President s Budget Request Overview for the National Center on Birth Defects and Developmental Disabilities Sascha Chaney Associate
More informationPublic Health Image Library. CDC/ Cynthia Goldsmith. Image #
Zika Virus Fredrick M. Abrahamian, D.O., FACEP, FIDSA Clinical Professor of Medicine UCLA School of Medicine Director of Education Department of Emergency Medicine Olive View-UCLA Medical Center Sylmar,
More informationZika Virus and Control Efforts in Arizona
Zika Virus and Control Efforts in Arizona Irene Ruberto, MPH, PhD Epidemiologist Office of Infectious Disease Services Arizona Department of Health Services November 10, 2016 Goal by Humbletree (cc by-nc
More informationWhen infections go viral Zika Virus
When infections go viral Zika Virus John Fangman, MD Associate Professor of Medicine (Infectious Diseases) Senior Medical Director of Ambulatory, Medical College Physicians Medical College of Wisconsin
More informationModule Three About Zika Virus: What is Known and Not Known
Module Three About Zika Virus: What is Known and Not Known HOUSEKEEPING For educational and quality improvement purposes, this TeleECHO Clinic will be recorded By participating in this clinic, you are
More informationZika Virus: The Olympics and Beyond
Zika Virus: The Olympics and Beyond Alice Pong, MD Pediatric Infectious Diseases Rady Children s Hospital-San Diego University of California, San Diego Disclosures I have no disclosures to report 1 Objectives
More informationWhat s Lurking out there??????
What s Lurking out there?????? Dave Warshauer, PhD, D(ABMM) Deputy Director, Communicable Diseases Wisconsin State Laboratory of Hygiene david.warshauer@slh.wisc.edu WISCONSIN STATE LABORATORY OF HYGIENE
More informationZika Virus Guidance for Medical Providers. Denise Smith, PHN, MPA Director of Disease Control Kern County Public Health Services Department
Zika Virus Guidance for Medical Providers Denise Smith, PHN, MPA Director of Disease Control Kern County Public Health Services Department Kern Perinatal Symposium March 3, 2017 CME DISCLOSURE The Planners,
More informationAs suggested by one fellow student, please consider the CDC's "Final Rules for Control of Communicable Diseases: Interstate and Foreign
As suggested by one fellow student, please consider the CDC's "Final Rules for Control of Communicable Diseases: Interstate and Foreign http://www.cdc.gov/quarantine/ aboutlawsregulationsquarantineisolatio
More informationZika Virus. Centers for Disease Control and Prevention
Centers for Disease Control and Prevention Zika Virus Ingrid Rabe Medical Epidemiologist Arboviral Diseases Branch Centers for Disease Control and Prevention February 1, 2016 Zika Virus Single stranded
More informationUpdates in Infectious Diseases. Kelley Struble, DO, MS St. John Physicians Infectious Disease September 30, 2016
Updates in Infectious Diseases Kelley Struble, DO, MS St. John Physicians Infectious Disease September 30, 2016 Disclosures No financial relationships or affiliations to disclose Overview Activity Pre-Test
More informationZIKA VIRUS OUTBREAK. JANET B. EDDY M.D. KU-WICHITA PGY2 OBSTETRICS AND GYNECOLOGY RESIDENCY Dominican Republic 2016
ZIKA VIRUS OUTBREAK JANET B. EDDY M.D. KU-WICHITA PGY2 OBSTETRICS AND GYNECOLOGY RESIDENCY Dominican Republic 2016 Zika time line 1947: 1 st isolated in rhesus monkey in Zika forest of Uganda 1 12/2013:
More informationZika virus: a new global threat for Dr Gina McAllister Clinical Scientist, Virology
Zika virus: a new global threat for 2016 Dr Gina McAllister Clinical Scientist, Virology Moritz U. G. Kraemer and others The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus
More informationEpidemiology and entomology of the Zika virus outbreak
Epidemiology and entomology of the Zika virus outbreak M A T T H E W B A Y L I S I N S T I T U T E O F I N F E C T I O N A N D G L O B A L H E A L T H U N I V E R S I T Y O F L I V E R P O O L Zika in
More informationZika Virus in the Primary Care Setting
Zika Virus in the Primary Care Setting Monica McArthur, MD PhD Assistant Professor of Pediatrics Center for Vaccine Development University of Maryland School of Medicine Maryland Chapter ACP Meeting 17
More informationZika Virus. Robert Wittler, MD
Zika Virus Robert Wittler, MD Disclosure I have no relevant financial relationships with the manufacturers(s) of any commercial products(s) and/or provider of commercial services discussed in this CME
More informationZika Virus. Disclosure. Zika Virus 8/26/2016
Zika Virus Robert Wittler, MD Disclosure I have no relevant financial relationships with the manufacturers(s) of any commercial products(s) and/or provider of commercial services discussed in this CME
More informationGuidance for Investigation and Management of Zika Virus Infection
Guidance for Investigation and Management of Zika Virus Infection Update: February 11, 2016 Public Health Agency of Canada has issued recommendations from the Committee to Advise on Tropical Medicine and
More informationEverything you ever wanted to know about Zika Virus Disease
Everything you ever wanted to know about Zika Virus Disease (in 14 slides) Jon Temte, MD/PhD University of Wisconsin School of Medicine and Public Health 28 January 2016 Zika Virus mosquito-borne flavivirus
More informationCenters for Disease Control and Prevention Zika Virus in Pregnancy What Midwives Need To Know
Centers for Disease Control and Prevention Zika Virus in Pregnancy What Midwives Need To Know Margaret A. Lampe, RN, MPH Pregnancy and Birth Defects Surveillance Team Zika Virus Emergency Response U.S.
More informationZika Virus What Every Woman Needs to Know
Zika Virus What Every Woman Needs to Know Carrie L. Byington, MD The Jean and Thomas McMullin Professor and Dean of Medicine Senior Vice President Health Science Center Vice Chancellor for Health Services
More informationCarol M. Smith, M.D., M.P.H. Commissioner of Health and Mental Health Ulster County Department of Health and Mental Health May 20, 2016
Carol M. Smith, M.D., M.P.H. Commissioner of Health and Mental Health Ulster County Department of Health and Mental Health May 20, 2016 Michael Hein County Executive Zika virus was first discovered in
More informationZIKA VIRUS. John J. Russell MD May 27, 2016
John J. Russell MD May 27, 2016 HISTORY Discovered 1947 Zika Forest of Uganda in rhesus monkeys, thus the name Found in humans in Africa in 1952 Not considered a public health threat until outbreak in
More informationZIKA VIRUS. Causes, Symptoms, Treatment and Prevention
ZIKA VIRUS Causes, Symptoms, Treatment and Prevention Introduction Zika virus is spread to people through mosquito bites. The most common symptoms of Zika virus disease are fever, rash, joint pain, and
More informationEuropean Centre for Disease Prevention and Control. Zika virus disease
European Centre for Disease Prevention and Control Zika virus disease Stockholm, 19 February 2016 Background information Zika virus is a member of the Flaviviridae family and transmitted by mosquitoes
More informationZika Virus. Maternal & Fetal Effects. John P. Elliott, MD Medical Director, Valley Perinatal Services Phoenix, Arizona
Zika Virus Maternal & Fetal Effects John P. Elliott, MD Medical Director, Valley Perinatal Services Phoenix, Arizona Objective of Presentation Sneeka Peeka at Zika Disclosure I have nothing to disclose
More informationZika Virus Identifying an Emerging Threat. Florida Department of Health in Miami-Dade County Epidemiology, Disease Control, & Immunization Services
Zika Virus Identifying an Emerging Threat Florida Department of Health in Miami-Dade County Epidemiology, Disease Control, & Immunization Services What is Zika Virus? Zika virus is a vector-borne disease
More informationSPECIALIZED FAMILY CARE Provider Training
SPECIALIZED FAMILY CARE Provider Training Category: Health Issue Title: Zika Virus Materials: Centers for Disease Control Fact Sheet on Zika Virus Goal: Specialized Family Care Provider to learn the risks,
More informationTHE ZIKA VIRUS. August 3, Sonia G. Pandit, MPH MBA Chief Executive Officer The Pandit Group
THE ZIKA VIRUS August 3, 2016 Sonia G. Pandit, MPH MBA Chief Executive Officer The Pandit Group sonia@thepanditgroup.com 443-990-1372 www.thepanditgroup.com What Makes Zika Unique? Viral disease (Flavi
More informationZika Virus. Frequently Asked Questions: Zika Virus and Pregnancy Version
Zika Virus Frequently Asked Questions: Zika Virus and Pregnancy Version What is Zika? Zika is a viral infection that usually causes a mild illness that typically lasts between 2 and 7 days. 80% of people
More informationZIKA Jordan H. Perlow MD Banner University Medical Center Division of Maternal Fetal Medicine Phoenix Perinatal Asoociates
ZIKA Jordan H. Perlow MD Banner University Medical Center Division of Maternal Fetal Medicine Phoenix Perinatal Asoociates Disclosures I have no relevant financial relationships to disclose or conflicts
More informationThis memo is intended to provide information to NC clinicians and laboratories regarding diagnosis, management and reporting of Zika virus infection.
May 18, 2016 (replaces version dated March 31, 2016) To: From: North Carolina Health Care Providers and Laboratories Megan Davies, MD, State Epidemiologist Scott Zimmerman, DrPH, MPH, HCLD (ABB), State
More informationZika Virus Update for Emergency Care Providers
Zika Virus Update for Emergency Care Providers What is this Zika Virus? Jeff Doerr Epidemiologist Southeastern Idaho Public Health Zika Virus Single stranded RNA virus Genus Flavivirus, Family Flaviviridae
More informationTown of Wolfeboro New Hampshire Health Notice Wolfeboro Public Health Officer Information Sheet Zika Virus
Aedes Zika Virus Information Sheet Town of Wolfeboro New Hampshire Health Notice Wolfeboro Public Health Officer Information Sheet Zika Virus The Zika Virus is a mosquito borne illness spread by the Aedes
More informationWhat is Zika virus (Zika)?
Zika Virus Basics What is Zika virus (Zika)? Viral infection caused by the bite of an infected mosquito Linked to serious birth defects and other poor pregnancy outcomes in babies of mothers who were infected
More informationZika Virus. ZIKA VIRUS & PREGNANCY Stephen Champlin, M.D. FLAVIVIRIDAE VIRUS SPECTRUM. Virus family Flaviviridae
ZIKA VIRUS & PREGNANCY Stephen Champlin, M.D. Zika Virus Virus family Flaviviridae Positive sense, single-stranded RNA virus FLAVIVIRIDAE VIRUS SPECTRUM Arbovirus - spread by arthropods to mammals Flaviviridae
More informationGeneral Description. Significance
General Description The Zika virus is a member of the Flavivirus family, and is a small, enveloped virus (easy to kill with a hospital disinfectant). Zika virus is an emerging mosquito-borne virus that
More informationFact Sheet for Health Care Providers: Interpreting Results from the Aptima Zika Virus assay. September 7, 2016
Dear Health Care Provider: Fact Sheet for Health Care Providers: Interpreting Results from the Aptima Zika Virus assay September 7, 2016 The U.S. Food and Drug Administration (FDA) has issued an Emergency
More informationObjectives. Dengue, Chikungunya and Zika Virus Infection: Answers to Common Questions. Case 1. Dengue Introduction 10/15/2018
Dengue, Chikungunya and Zika Virus Infection: Answers to Common Questions Wayne Ghesquiere MD FRCPC Infectious Diseases Consultant Clinical Assistant Prof, UBC Victoria, BC Objectives Discuss common Arbovirus
More informationZika virus infection Interim clinical guidance for Primary Care
Zika virus infection Interim clinical guidance for Primary Care Zika virus infection is a notifiable disease in Ireland under the Infectious Diseases (Amendment) Regulations 2016 (S.I.. 276 of 2016). All
More informationPresentation Overview
Presentation Overview Characteristics of Zika virus Characteristics of Zika virus infection Epidemiology and outbreaks Vector and transmission Clinical symptoms Diagnosis and testing Treatment and prevention
More information3/24/2017. CDC S Response to Zika ZIKA 101. Updated February 2, 2017 INTRODUCTION
CDC S Response to Zika ZIKA 101 Updated February 2, 2017 INTRODUCTION 1 What is Zika? Zika virus is spread to people primarily through the bite of an infected Aedes species mosquito (Ae. aegypti and Ae.
More informationZIKA UPDATE NOVEMBER Ministry of Health, Barbados
ZIKA UPDATE NOVEMBER 2016 Ministry of Health, Barbados Zika Virus Disease Objectives By the end of this presentation you should be able: To recount the track of the current global Zika virus epidemic To
More informationZIKA COLLABORATION MEETING: CLINICAL PERSPECTIVE. Julius L. Tonzel Vector-borne Diseases Epidemiologist Louisiana Office of Public Health
ZIKA COLLABORATION MEETING: CLINICAL PERSPECTIVE Julius L. Tonzel Vector-borne Diseases Epidemiologist Louisiana Office of Public Health DISCLOSURE STATEMENT The speakers, the speakers spouses, and the
More informationZika Preparedness: Lessons for the U.S. Public Health System
Zika Preparedness: Lessons for the U.S. Public Health System Jeffrey Duchin, MD Health Officer, Public Health - Seattle & King County Professor in Medicine, Division of Infectious Diseases Adjunct Professor,
More informationMercer MRC A Newsletter for and about our volunteers
Mercer MRC A Newsletter for and about our volunteers May 2017 Volume 1, Issue 5 Brian Hughes, County Executive Marygrace Billek, Director, Dept. of Human Services Lyme Disease Awareness Month May is Lyme
More informationA RELOOK AT ZIKA VIRAL INFECTION AND ITS LATEST OUTBREAK IN INDIA
24 th December 2018 A RELOOK AT ZIKA VIRAL INFECTION AND ITS LATEST OUTBREAK IN INDIA BACKGROUND Zika virus infection, which erupted on a large scale in 2015-2016, has infected more than 1.5 million people.
More informationZika: Deet, There It Is. Anna Powell, MD Reproductive Infectious Disease Fellow THEGOS
Zika: Deet, There It Is Anna Powell, MD Reproductive Infectious Disease Fellow THEGOS Disclosure I have no financial disclosures or conflicts of interest Lessons from Rubella At peak of rubella epidemic
More informationZika Virus. Lee Green Vector-Borne Epidemiologist Indiana State Department of Health. April 13, 2016
Zika Virus Lee Green Vector-Borne Epidemiologist Indiana State Department of Health April 13, 2016 What Is It? Flavivirus WNV Dengue St. Louis Encephalitis Yellow Fever Tick Borne Encephalitis Single stranded
More informationZika and Emerging Infectious Diseases. Clifford T. Mauriello, MD, FAAP Assistant Clinical Professor May 31, 2016
Zika and Emerging Infectious Diseases Clifford T. Mauriello, MD, FAAP Assistant Clinical Professor May 31, 2016 Famous Last Words The time has come to close the book on infectious diseases. We have basically
More informationZika Virus Outbreak An Update and Overview of the New York State Response
Zika Virus Outbreak An Update and Overview of the New York State Response Elizabeth Dufort, MD, FAAP Medical Director Division of Epidemiology New York State Department of Health Zika Virus- The Basics
More informationCDC Responds to ZIKA Zika 101
CDC Responds to ZIKA Zika 101 Updated April 29, 2016 What is Zika virus disease (Zika)? Disease spread primarily through the bite of an Aedes species mosquito infected with Zika virus. Many people infected
More informationOutbreaks of Zika Virus: What Do We Know? Presented by Dr Jonathan Darbro Mosquito Control Lab, QIMR Berhgofer 15 September 2016
Outbreaks of Zika Virus: What Do We Know? Presented by Dr Jonathan Darbro Mosquito Control Lab, QIMR Berhgofer 15 September 2016 Overview History Distribution Modes of Transmission Symptoms Some Causal
More informationZika Virus Dr Conor Doherty
Zika Virus Dr Conor Doherty Zika Virus Single stranded RNA enveloped icosahedral virus Flavivirus (e.g. dengue, yellow feve er) First described in Zika forest in Uganda in 1947 Initial enzootic monkey
More informationRelevant Communicable Diseases in HCT/Ps
Relevant Communicable Diseases in HCT/Ps Phyllis I. Warkentin, MD Professor of Pathology and Pediatrics University of Nebraska Medical Center FACT Chief Medical Officer Relevant Communicable Diseases in
More informationWhat You Need to Know ZIKA VIRUS
What You Need to Know ZIKA VIRUS What is Zika Virus? Zika virus is a flavivirus related to dengue, West Nile, yellow fever and Japanese encephalitis Zika virus first identified in 1947 and named for the
More informationZika Update. PSSNY 2016 Annual Convention June 25, Suzanna Gim, PharmD, MPH
Zika Update PSSNY 2016 Annual Convention June 25, 2016 Suzanna Gim, PharmD, MPH Email: suzannagim@gmail.com Learning Objectives Describe the epidemiology and prevalence of Zika virus disease Identify the
More informationGeographic distribution ZIKV
Shelley M. Wood, RN, BSN, CEN March 16, 2016 Geographic distribution ZIKV 1947 2007 http://www.ncbi.nlm.nih.gov/pmc/articles/pmc2819875/ 1 Current Active Zika transmission WHO declared global health threat
More informationZika in Texas. How to Prevent the Spread of the Zika Virus
Zika in Texas How to Prevent the Spread of the Zika Virus 1 Introduction 2 Zika in Texas 3 Overview of Zika Zika spreads primarily through the bite of an infected Aedes species mosquito. Can be spread
More informationZika virus: clinical and epidemiological features
Zika virus: clinical and epidemiological features Dominic Dwyer Medical Virologist, Westmead Hospital Director, ICPMR and Pathology West NSW Health Pathology dominic.dwyer@sydney.edu.au, Zika virus Flavivirus
More informationQuestions and Answers for Pediatric Healthcare Providers: Infants and Zika Virus Infection
1 of 5 01/02/2016 20:39 Questions and Answers for Pediatric Healthcare Providers: Infants and Zika Virus Infection Summary CDC has developed interim guidelines for healthcare providers in the United States
More informationZika Pregnancy and Birth Defects Surveillance
Zika Pregnancy and Birth Defects Surveillance Sowmya Adibhatla, MPH Zika Surveillance and Response Coordinator Overview History/Background Zika cases update Zika virus infection Testing guidance Recommendations
More informationZika Virus: What We Know and Don t Know Meg Fisher, MD Medical Director. Disclosures. Objectives
Zika Virus: What We Know and Don t Know Meg Fisher, MD Medical Director Disclosures I have no financial disclosures. I do not plan to discuss off label uses of medications. Objectives Discuss the epidemiology
More informationZika Outbreak: What Pharmacists Need to Know
Zika Outbreak: What Pharmacists Need to Know Timothy Gauthier, PharmD, BCPS-AQ ID Miami Veterans Affairs Healthcare System Timothypgauthier@gmail.com, Social media: @IDstewardship Meghan Jeffres, PharmD
More informationZika: Updates and Lessons Learned for Primary Care Clinicians
Zika: Updates and Lessons Learned for Primary Care Clinicians Kirsten Salmeen, MD Assistant Professor UCSF Obstetrics, Gynecology & Reproductive Sciences Maternal-Fetal Medicine I have no financial disclosures.
More information3/29/2017. Zika in Northeast Ohio. Cuyahoga County Board of Health (CCBH)
Joe Lynch, RS, MPH Program Manager Environmental Public Health Cuyahoga County Board of Health Zika in Northeast Ohio Cuyahoga County Board of Health (CCBH) Take care of public health matters for over
More informationZika 101 for Occupational Safety and Health Professionals
CDC Responds to ZIKA Zika 101 for Occupational Safety and Health Professionals CDR Jill M. Shugart, MSPH, REHS CDC/National Institute for Occupational Safety and Health Emergency Preparedness and Response
More informationZIKA VIRUS. Annanya Gangopadhyay*, Shubhrajit Mantry, Abhinay Chhetri, Sudip das
ZIKA VIRUS Annanya Gangopadhyay*, Shubhrajit Mantry, Abhinay Chhetri, Sudip das, Himalayan Pharmacy Institute, Majhitar, Rangpo, E. Sikkim 737136, INDIA ARTICLE INFO: Article history: Received: 02 December
More informationZIKA PRESENTED BY DENNIS QUERTERMOUS, DIANNA HUNTER, MERCEDES RUTLEDGE, AND DRE'ANDRIA THOMPSON
ZIKA PRESENTED BY DENNIS QUERTERMOUS, DIANNA HUNTER, MERCEDES RUTLEDGE, AND DRE'ANDRIA THOMPSON ZIKA OVERVIEW Family: Flaviviridae Genus: Flavivirus Enveloped, single-stranded RNA virus First identified
More information*This response is constantly evolving and recommendations in this presentation may change over time, please call your district epidemiologist or a
*This response is constantly evolving and recommendations in this presentation may change over time, please call your district epidemiologist or a GDPH epidemiologist 404-657-2588, 8-5 pm M-F for current
More informationZika virus: Interim guidance information for LMCs (midwives), GPs and other health professionals dealing with Zika virus in pregnancy 5 February 2016
Zika virus: Interim guidance information for LMCs (midwives), GPs and other health professionals dealing with Zika virus in pregnancy 5 February 2016 This interim guidance is the result of consultation
More informationZika Virus. It may be devastating, But we might just get one step ahead of it. Learning in Retirement Winter 2017 Daniel Burnside. photo: Newsweek.
Zika Virus It may be devastating, But we might just get one step ahead of it Learning in Retirement Winter 2017 Daniel Burnside photo: Newsweek.com INTRODUCTION TO VIRUSES STRUCTURE GENOME LIFE CYCLE
More informationZIKA VIRUS. Facts & Figures
ZIKA VIRUS Facts & Figures ISSUED FEBRUARY 20, 2017 Over the past year, Zika Virus has become a signifi cant point of concern in our communities. As with any emergent illness or disease, it is important
More informationNorth Carolina Department of Health and Human Services Division of Public Health
North Carolina Department of Health and Human Services Division of Public Health Pat McCrory Governor February 8, 2016 (replaces version dated January 28, 2016) Richard O. Brajer Secretary Daniel Staley
More informationWelcome All. Western Australia Oncology Menopause Endometriosis New Mothers
Welcome All Western Australia ZIKA VIRUS What s the latest? Dr Clay Golledge COUNTRIES WITH ONGOING ZIKA CIRCULATION American Samoa Curacao Guyana Nicaragua Tonga Barbados Dominican Republic Haiti Panama
More informationAn Introduction to Dengue, Zika and Chikungunya Viruses
An Introduction to Dengue, Zika and Chikungunya Viruses Natalie Marzec, MD, MPH Zoonoses Epidemiologist 2017 Global Health and Disasters Course Objectives Arbovirus Overview Public Health Activities Clinical
More informationFIRST CONFIRMED CASE OF IMPORTED ZIKA VIRUS IN HOUSTON, TEXAS. Preventing Transmission
FIRST CONFIRMED CASE OF IMPORTED ZIKA VIRUS IN HOUSTON, TEXAS Preventing Transmission Objectives Discuss the epidemiology of Zika virus Describe the Zika case investigation of the first confirmed case
More informationWhat is Zika virus? What are the symptoms and complications of Zika virus infection? Are cases expected in Canada?
What is Zika virus? Zika Virus Update for Healthcare Professionals Updated June 22, 2016; italicized text indicates clarification of wording contained in previous versions. Zika virus is a Flavivirus transmitted
More informationZika Virus A Public Health Emergency of Olympic Proportions
Zika Virus A Public Health Emergency of Olympic Proportions Carrie L. Byington M.D.** HA and Edna Benning Presidential Professor Division of Pediatric Infectious Diseases ** With Thanks to Andrew Pavia,
More informationZika: Frequently Asked Questions
4824-16 NJ Zika Facts Flier 0216 Version 021616 ENGLISH STATE COPY Stock ID: Reading Level: 5.9 excluding company name, proper nouns, phone numbers, website urls, sources and terms microcephaly, insect
More informationSexual & Reproductive Health in the Context of Zika Virus
Contents 1 The Zika Epidemic & its Impact on Health 2 Transmission, Pregnancy & Human Rights 3 GTR s Program & Public Policy Recommendations 4 GTR's Recommendations for Health Care Providers 5 GTR's Sexual
More informationZika Virus Communication Media Talking Points
Zika Virus Communication Media Talking Points Benjamin Haynes Senior Press Officer, News Media Branch, CDC Department of Health and Human Services Centers for Disease Control and Prevention Media Talking
More informationZika Virus Update. Florida Department of Health (DOH) Mark Lander. June 16, Florida Department of Health in Columbia County
Zika Virus Update Florida Department of Health (DOH) Mark Lander June 16, 2016 Florida Department of Health in Columbia County 1 Zika Virus Originally identified in Africa and Southeast Asia First identified
More informationZika Outbreak Discussion
Zika Outbreak Discussion May 10, 2016 2016 Zurich Healthcare Customer Symposium Speakers Krishna Lynch Senior Healthcare Risk Consultant Zurich Clayton Shoup Business Director, Workers Compensation Zurich
More informationClinical Policy: Diagnostic Testing for Zika Virus Reference Number: CP.MP.111 Effective Date: 06/16
Clinical Policy: Diagnostic Testing for Zika Virus Reference Number: CP.MP.111 Effective Date: 06/16 Last Review Date: 05/16 Revision Log See Important Reminder at the end of this policy for important
More informationWaiting in the Wings: Emergence, Impact and Control of Mosquito-Borne Viruses
International Center for Enterprise Preparedness (InterCEP) Waiting in the Wings: Emergence, Impact and Control of Mosquito-Borne Viruses Web Forum On April 14, 2016, Kathryn A. Hanley, Professor in the
More informationZIKA VIRUS. Epic and aspects of management
ZIKA VIRUS Epic and aspects of management Classification - Belong to the family Flaviviridae which are mosquitoes borne viruses such as Dengue virus ( DEN V ), West Nile virus ( WN V ), Yellow fever Virus
More informationZIKA VIRUS TESTING GUIDANCE, UPDATED 7/20/2016
Section 1: Which patients should be offered testing? SUMMARY OF CATEGORIES OF PATIENTS WHO SHOULD BE TESTED FOR ZIKA 1) Pregnant women who traveled to a Zika-affected area (see link to current list in
More informationZika Virus. Public Information Update/phone script. Date: March 28, 2016 Time: 11:00 a.m.
Zika Virus Public Information Update/phone script Date: March 28, 2016 Time: 11:00 a.m. ** Highlighted text indicates new, revised or updated information Note to operators: When people call asking questions
More informationZIKA VIRUS: INFORMATION FOR CLINICIANS
CDC S Response to Zika ZIKA VIRUS: INFORMATION FOR CLINICIANS Updated July 27, 2017 These slides provide clinicians with information about Zika virus epidemiology Diagnoses and testing Case reporting Zika
More information2017 SCAAP Summer Conference. Lilian Peake, MD, MPH
2017 SCAAP Summer Conference Lilian Peake, MD, MPH 1. Mosquito-borne Diseases 2. Challenges to Preventing and Controlling Mosquito-borne Diseases 3. Effects of Zika Virus on Child Health None Accelerating
More informationJan Byrne, M.D. Cortesia Maisa Wanderley
Jan Byrne, M.D. University of Utah Maternal-Fetal Medicine Clinical Genetics National Birth Defects Prevention Network Utah Fetal Center at Primary Children s Cortesia Maisa Wanderley Dr. Byrne has no
More informationDisease spread primarily through the bite of an infected Aedes aegypti or Ae. albopictus mosquito.
What is Zika virus disease (Zika)? Disease spread primarily through the bite of an infected Aedes aegypti or Ae. albopictus mosquito. Manypeople infected with Zika virus won t have symptoms or will only
More informationZika Virus Basics. Flaviviridae Flavivirus Disease Vector Vaccine *Dengue (serotypes 1-4) Zika Virus Basics. Zika Virus Transmission Cycle
Zika: Infection,, and Protection Roxanne P. Liles, Ph.D., MLS(ASCP) CM Assistant Professor of Biology Louisiana State University at Alexandria 318-473-6518 rliles@lsua.edu Zika Virus Basics Virion: Enveloped
More informationCDC An Overview for State and Territorial Leaders
Centers for Disease Control and Prevention CDC An Overview for State and Territorial Leaders Matthew Penn, JD, MLIS Director, Public Health Law Program Office for State, Tribal, Local and Territorial Support
More informationFact Sheet. Zika Virus
Fact Sheet Zika Virus The following provides information on the use and containment of Zika virus (ZIKV). Investigators should use these guidelines as part of their risk assessment when planning experiments
More informationZika Virus and Prevention in Mississippi
Mississippi State Department of Health Mississippi Morbidity Report Volume 32, Number 1 July 2016 Background: Zika Virus and Prevention in Mississippi Key Messages: Zika virus infection during pregnancy
More informationMosquito Threats in Burbank West Nile virus and Zika Update. Presented by Kelly Middleton, Director of Community Affairs
Mosquito Threats in Burbank West Nile virus and Zika Update Presented by Kelly Middleton, Director of Community Affairs The District at a Glance An independent special district formed under authority of
More informationMosquito Threats in LA County West Nile virus & Zika
Mosquito Threats in LA County West Nile virus & Zika The District at a Glance An independent special district formed under authority of the CA State Health and Safety Code Formed in 1952 and governed by
More information