Risk factors of drug-resistant bacterial pneumonia in elderly inpatients in Shandong Province.
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1 Biomedical Research 2017; 28 (13): ISSN X Risk factors of drug-resistant bacterial pneumonia in elderly inpatients in Shandong Province. Hua Feng 1#, Song Yan 2#, Yulin Chen 3, Cuiling Zhu 2, Lanping Wang 4* 1 Sterilization and Supply Room, Affiliated Hospital of Tai Shan Medical College, PR China 2 Department of Burn, Affiliated Hospital of Tai Shan Medical College, PR China 3 Department of Anesthesiology, Affiliated Hospital of Tai Shan Medical College, PR China 4 Operation Room, Affiliated Hospital of Tai Shan Medical College, PR China # These authors contributed equally to this work Abstract Objective: To analyse the risk factors of drug-resistant bacterial pneumonia in elderly inpatients in Shandong Province. Methods: From January 2014 to December 2016, 10 cities and counties were randomly selected in Shandong Province, three medical institutions were also selected in each city or county, 200 cases of elderly patients with bacterial pneumonia were recruited as research objects in each of the medical institutions based on the random principle. They were receiving sputum culture and smear examination, analysis of bacterial pathogens characteristics and drug resistance related risk factors. Results: A total of 6000 subjects were studied. The result of sputum culture and susceptibility test showed that bacterial strains were isolated, among which Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Bowman had the largest number and the most serious drug resistance. Conclusion: Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Acinetobacter baumannii are the main pathogens in elderly patients with bacterial pneumonia in Shandong Province, and the serious drug resistance also needs attention. Keywords: Elderly population, Drug resistance, Bacterial pneumonia, Shandong Province, China. Accepted on May 15, 2017 Introduction Drug-resistant bacterial pneumonia is a big public health issue word widely. It usually happens in patients with stroke (SAP), ventilator-associated pneumonia and Health care-associated pneumonia. Some reports found that, SAP patients with Multiple Drug-Resistant bacterial (MDR) infections are connected with disturbance of consciousness late-onset pneumonia and ICU ward. The prevalence of the MDR bacteria was high in China [1]. For the treatment, yang found that a large dose of ambroxol has significant therapeutic effect in the treatment of multi-drug resistant bacterial pneumonia [2] and a history of bronchiectasis or recent hospitalization is the major indication of starting empirical broad-spectrum antibiotics [3]. In ventilator-associated pneumonia, gramnegative bacteria were the main pathogenic bacteria in VAP, as well most of them were multi-drug resistance [4]. In health care-associated pneumonia, recent hospitalization is the only risk factor for HCAP which is shown to be associated with DRB, which is the similar to SAP [5]. However, few researches were focused on the Shandong Province in China. As a consequence, in order to investigate the clinical data of bacterial pneumonia of elderly inpatients in Shandong Province, during January 2014 to December 2016, the researchers chose three medical institutions in each of 10 counties and cities in Shandong Province based on the random principle. In each medical institution, clinical data of 200 cases of elderly patients with bacterial pneumonia were collected for analyzing the pneumonia pathogens and drug resistance. Some results were achieved and reported below. Materials and Methods General information From January 2014 to December 2016, respectively, three medical institutions were chose in Jinan, Zibo, Qingdao, Zaozhuang, Dongying, Weifang, Jining, Tai'an, Weihai and Rizhao in Shandong Province. In each medical institution, clinical data of 200 cases of elderly patients with bacterial pneumonia were collected for analysis [6-8]. The inclusive criteria for subjects in this study are as follows: (1) age over 55 Biomed Res- India 2017 Volume 28 Issue
2 Feng/Yan/Chen/Zhu/Wang years; (2) pathogens are bacteria; (3) without any immunosuppressive agents and glucocorticoid treatment before this study; (4) without any serious liver and kidney dysfunction and any blood disorders; (5) without any severe trauma, or empyrosis; (6) without any special antibody treatment within 1 month prior to this study; (7) all subjects were informed this study and volunteered to participate in this study. Research method All patients were asked to collect sputum samples after admission, and store the samples properly for drug susceptibility and sputum bacterial culture test in the test laboratory (Nanjing Jiancheng Bio, China). All the medical institutions involved in the study have the consistency of the good test level, all the inspectors in the study have received the relevant training and assessment before the study, all of them are qualified; test equipment and reagents are recognized by the researchers to ensure that the determination has good consistency [9-12]. In the process of collecting sputum samples, the relevant medical personnel should perform strict implementation of aseptic procedures to reduce the risk of iatrogenic infection, or interference to the test results; sputum specimens should be collected in the early morning, because sputum at this time has large amount and contains a large number of bacteria. Before sample collection, patients should be asked to rinse mouth with water for several times to remove oral bacteria. Then patients forced the sputum from deep in the trachea spit and spit into the prepared sterile containers in advance to avoid saliva and other secretions mixed into the sputum. If the patient has difficulty to sputum, or cannot expectorate, throat swab will be used to replace sputum specimens; specimens of sputum or throat swab should be sent to inspection laboratory timely [13-17]. Results Distribution and constitution of pathogens In this study, strains of pathogens were isolated, and the specific distribution and composition ratio were shown in Table 1. Table 1. Distribution of pathogens of all patients. Pathogens Number of strains (n) Composition ratio Klebsiella pneumoniae Baumanii Pseudomonas aeruginosa Escherichia coli Haemophilus influenzae Stenotrophomonas maltophilia Staphylococcus aureus Streptococcus pneumoniae Staphylococcus haemolyticus Burkholderia cepacia Drug susceptibility test In this study, drug susceptibility test results of pneumonia pathogens including Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Acinetobacter baumannii are listed in Tables 2 and 3. Statistical analysis The data of this study were analysed by SPSS18.0 software, and the statistical data were presented as the constituent ratio, which were mainly described by statistical aspects. Table 2. Drug susceptibility test results of Pseudomonas aeruginosa and Acinetobacter baumannii results. Types antimicrobials of Pseudomonas aeruginosa Acinetobacter baumannii MDR (-) strain MDR (+) strain MDR (-) strain MDR (+) strain Constituent ratio Constituent ratio PRL CTX CFP CAZ IMP SAM TZP Biomed Res- India 2017 Volume 28 Issue 13
3 Risk factors of drug-resistant bacterial pneumonia in elderly inpatients in Shandong Province ATM CN TOB LEV CIP MH SXT FEP MEM TE AK SCP FEP Table 3. Drug susceptibility test results of Escherichia coli and Klebsiella pneumoniae. Types antimicrobials of Escherichia coli Klebsiella pneumoniae ESBLs (-) strain ESBLs (+) strain ESBLs (-) strain ESBLs (+) strain PRL AMP KZ CAZ CXM CTX FEP FOX SAM AMC TZP ATM AK CN NET TOB LEV CIP SXT Biomed Res- India 2017 Volume 28 Issue
4 Feng/Yan/Chen/Zhu/Wang Discussion Bacterial pneumonia is one of the most important factors leading to the death of the elderly population, which is the fifth death cause in non-cancer patients according to the literature and closely related to the physiological characteristics of the elderly [18-20]. Another Medical study has confirmed that the mortality rate of the elderly patients with pneumonia reached 5-13%, while the mortality rate even more than 15.4% in the 80 y old population. Besides, the risk of pneumonia in older groups increased by about 10 times than the young people [21-24]. In recent years, more and more novel types of antibiotics have been used in clinical, which not only effectively improve the symptoms and signs of pneumonia, survival also received a corresponding extension, but drug resistance becomes the obvious disadvantage [25]. Not only in bacterial pneumonia in the elderly group, is drug resistance in other infectious diseases also faced with serious situation. It should be noted that the elderly group with bacterial pneumonia have strong drug resistance and high risk of multiple organ failure, so effective and reliable testing and other related diagnostic techniques are in need for guiding the clinical treatment next. Because the antibiotic choice dependence on the clinical experience of doctors has a certain risk, investigation of the source of the patient's epidemiological pathology and drug resistance have indicated a good clinical significance. A total of 6000 subjects in this study were recruited from 300 medical institutions of 10 cities and counties in Shandong Province. The inspectors in the study accepted training before the study and followed strict implementation of aseptic procedures to ensure consistency of test results. 11,352 strains of pathogens were isolated from the sputum or throat swab specimens of 6,000 elderly patients with bacterial pneumonia. Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli are the most four strains of sputum culture. Their resistance is also serious and by drug susceptibility test, which need clinical focus. For pseudomonas aeruginosa, more than 50% percent of CTX, SXT, TE were being resistant. For acinetobacter baumannii, it was resistant to nearly all drugs. For Escherichia coli, almost it was resistant to all drugs except FOX, TZP, AK, NET and TOP. For Klebsiella pneumoniae, it is also resistant to half of parts of anti-drugs. In conclusion, resistant bacterial pneumonia in elderly inpatients in Shandong province in China is serious. References 1. Ji FB, Zhuo C. Risk factors and etiology of stroke associated pneumonia in elderly patients with multiple drug-resistant bacterial infections. Chinese J Antibiotics 2012; 37: Ma HM. Development and validation of a clinical risk score for predicting drug-resistant bacterial pneumonia in older Chinese patients. Respirology 2014; 19: Yang WX. Experience for the treatment of large dose of ambroxol applied in multi-drug resistant bacterial pneumonia. J Clin Pulm Med Zhang WD, Li BL. The analysis of multi-drug resistance and risk factors of ventilator-associated pneumonia caused by Gram-negative bacteria. Prog Mod Biomed Chen YJ. The clinical study of Ulinastatin and Xuebijing on elderly patients with severe pneumonia. Lingnan J Emerg Med Ty Z, Ly J, M Z. Clinical study of elderly patients with pneumonia of positive bacterial. Lingnan J Emerg Med 2010; 15: Dk L, H CQ, Wl F. Distribution characteristics and drug resistance of pathogens in elderly bacterial pneumonia. Int J Lab Med 2013; 34: Hz Y. Pathological analysis of endemic bacterial pneumonia and clinical study on drug resistance. Medical Info 2014; 27: Xq F. Exploration of the distribution characteristics and drug resistance of pathogens in senile bacterial pneumonia. Continuing Medical Education China 2015; 7: Kroll H, Kiefel V, Santoso S. Clinical aspects and typing of platelloantigens. Vox Sanguinis 1998; 74: Yy D. Distribution characteristics and drug resistance of pathogens in elderly bacterial pneumonia. Medical Info 2014; Mona B. Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD. Chest 2011; 139: Y L. Distribution, drug resistance and homology analysis of bacterial pneumonia in Xinxiang area W L. Clinical application of serum PCT in acquired bacterial pneumonia in elderly community. Chinese J Microecol 2015; 27: Metcalfe P. Nomenclature of human platelet antigens. Vox Sanguinis 2003; 85: Hadhri S. Gene frequencies of the HPA-1 to -6 and -15 human platelet antigens in Tunisian blood donors. Tissue Antigens 2010; 76: Hye KJ. Usefulness of plasma procalcitonin to predict severity in elderly patients with community-acquired pneumonia. Tubercul Resp Dis 2013; 74: Klugman K. Clinical impact of antibiotic resistance in respiratory tract infections. Med Et Maladies Infectieuses 2007; 29: Xj D, Qn C, Wy Z. Analysis of fungal infection and related factors in lower respiratory tract of hospital in Zhoushan island area. Chinese J Infect Dis 2013; 31: p Livermore DM, Brown DFJ. Detection of β-lactamasemediated resistance. J Antimicrob Chemother 2001; 48: Cunha BA. Pneumonia in the elderly. Clin Microbiol Infect 2001; 85: Ty Z. Clinical study of elderly patients with sputum bacterial culture positive pneumonia Biomed Res- India 2017 Volume 28 Issue 13
5 Risk factors of drug-resistant bacterial pneumonia in elderly inpatients in Shandong Province 23. Shehata N. Mass-scale high-throughput multiplex polymerase chain reaction for human platelet antigen single-nucleotide polymorphisms screening of apheresis platelet donors. Transfusion 2011; 51: Gupta V. AmpC β-lactamases in nosocomial isolates of Klebsiella pneumoniae from India. Ind J Med Res 2012; 136: Yamasaki K. Laboratory surveillance for prospective plasmid-mediated AmpC beta-lactamases in the Kinki region of Japan. J Clin Microbiol 2010; 48: * Correspondence to Lanping Wang Operation Room Affiliated Hospital of Tai Shan Medical College PR China Biomed Res- India 2017 Volume 28 Issue
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