Comment les cellules osseuses communiquent entre elles. Gérard Friedlander Journées UPA 2011
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1 Comment les cellules osseuses communiquent entre elles Gérard Friedlander Journées UPA 2011
2 Structure de l os
3 Osteocyte
4 Ostéoclaste
5 Remodelage osseux
6 RANKL RANK NF-kB pathway Stem cell progenitor precursor Osteoblast M-CSF Osteoprotegerin
7 RANKL RANK NF-kB pathway Stem cell progenitor precursor Osteoblast M-CSF Osteoprotegerin
8 RANKL RANK NF-kB pathway Stem cell progenitor precursor Osteoblast M-CSF Osteoprotegerin
9 RANKL RANK NF-kB pathway Stem cell progenitor precursor Osteoblast M-CSF Osteoprotegerin
10 Human osteopetrosis due to RANKL mutations: the osteoclast is not guilty
11 progenitor precursor
12 NF-kB pathway RANK progenitor precursor
13 RANKL Osteoblast NF-kB pathway RANK progenitor precursor
14 RANKL Osteoblast NF-kB pathway RANK progenitor precursor
15 RANKL Osteoblast NF-kB pathway RANK progenitor precursor
16 Nuclear factor-kb inhibits osteoblastic bone formation
17 RANK RANKL NF-kB OPG Osteoblast
18 RANK RANKL NF-kB NF-kB OPG Osteoblast
19 RANK RANKL NF-kB NF-kB Fra-1 OPG Osteoblast
20 Suppression of NF-kB increases bone formation and ameliorates osteopenia in ovariectomized mice
21 I B IKK- I B P NF- B
22 I B NF- B IKK- I B P NF- B
23 I B NF- B IKK- I B P proteasome NF- B NF- B
24 I B IKK- proteasome Marrow stromal cell NF- B NF- B I B P precursor - NF- B + Osteoblast
25 I B IKK- proteasome Marrow stromal cell NF- B NF- B I B P precursor - NF- B + NF- B inhibitors Osteoblast
26 Bidirectional ephrin signalling controls bone homeostasis
27 ephrinb2 Monocytes s Pre-osteoblasts Osteoblasts Osteocytes
28 ephrinb2 EphB4 Monocytes s Pre-osteoblasts Osteoblasts Osteocytes
29 ephrinb2 EphB4 Monocytes + s Pre-osteoblasts Osteoblasts Osteocytes
30 EphB4 Monocytes s Pre-osteoblasts Osteoblasts Osteocytes
31 ephrinb2 EphB4 Monocytes s Pre-osteoblasts Osteoblasts Osteocytes
32 ephrinb2 EphB4 - Monocytes s Pre-osteoblasts Osteoblasts Osteocytes
33 ephrinb2 EphB4 - + Monocytes s Pre-osteoblasts Osteoblasts Osteocytes
34 PTH and PTHrP stimulate bone formation through EphrinB2
35 Action de la PTH
36 ephrinb2 EphB4 - + Monocytes s Pre-osteoblastsOsteoblasts Osteocytes
37 ephrinb2 EphB4 PTH PTHrP - + Monocytes s Pre-osteoblastsOsteoblasts Osteocytes
38 ephrinb2 EphB4 PTH PTHrP - + Monocytes s Pre-osteoblastsOsteoblasts Osteocytes
39 ephrinb2 EphB4 PTH PTHrP - + Monocytes s Pre-osteoblastsOsteoblasts Osteocytes
40 Intermittent PTH requires osteoclasts and c-fos to enhance bone formation
41 Osteoblast PTH
42 Osteoblast PTH
43 PTH Osteoblast
44 PTH C-fos Osteoblast
45 Osteocalcin: a skeleton key to metabolism
46
47 Osteoblast
48 Osteoblast Ocn
49 Osteoblast Ocn OST-PTP Gla Ocn
50 Osteoblast Pancreas beta cell Ocn OST-PTP Gla Ocn Adipocyte
51 Osteoblast Pancreas beta cell Insulin Ocn OST-PTP Gla Ocn Adipocyte
52 Osteoblast Pancreas beta cell Insulin Ocn OST-PTP Adiponectin Gla Ocn Adipocyte
53 Osteoblast Pancreas beta cell Insulin Ocn Improve Glucose handling Lower fat mass OST-PTP Adiponectin Gla Ocn Adipocyte
54 Jagged1 Promotes Breast Cancer Bone Metastasis
55 Jagged1 Bone tumor cell
56 Bone tumor cell Bone tumor cell proliferation Jagged1 Il-6 secreted Notch Hey1 Il-6 Osteoblast
57 Bone tumor cell Bone tumor cell proliferation Jagged1 Il-6 secreted Notch Notch Hey1 Il-6 Osteoblast Pre-osteoclast Cell differentiation osteoclast Bones osteolysis
58 Bone tumor cell Bone tumor cell proliferation Jagged1 Il-6 secreted Notch Notch Hey1 Il-6 Osteoblast Pre-osteoclast Cell differentiation osteoclast Bones osteolysis TGF
59 Bone tumor cell Bone tumor cell proliferation Jagged1 Il-6 secreted -secretase Notch inhibitor Notch Hey1 Il-6 Osteoblast Pre-osteoclast Cell differentiation osteoclast Bones osteolysis TGF
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