REMOVAL OF an eye for treatment

Transcription

1 Intraorbital Implants After Enucleation and Their Complications A 10-Year Review CLINICAL SCIENCES Nancy J. Christmas, MD; Craig D. Gordon; Timothy G. Murray, MD; David Tse, MD; Thomas Johnson, MD; Scott Garonzik; Joan M. O Brien, MD Background: Many different types of orbital implants have been used after enucleation. Associated complications such as infection, exposure, extrusion, and ptosis have been reported. Objective: To describe 342 consecutive patients who underwent enucleation with intraorbital implant placement at the Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Fla, during the past 10.5 years and their complications. Methods: Medical records of orbital implantation after enucleation performed by 3 surgeons (T.G.M., D.T., and T.J.) were reviewed retrospectively. Demographic data, ocular diagnosis, previous ophthalmic surgery, implant characteristics, and postoperative complications were described in all patients, with a minimum of 2 months follow-up, using a standardized format. Results: Eleven complications were observed in 7 patients. Four patients had exposure of the implant, and 1 of these patients developed associated infection. Three patients developed pyogenic granulomas, 1 patient developed ptosis requiring surgical intervention, 1 patient had long-term orbital discomfort, and 1 patient developed an inclusion cyst. Conclusion: Complications after enucleation with orbital implant placement are minimal and are observed with both porous and acrylic orbital implants. Arch Ophthalmol. 1998;116: From Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Fla (Drs Christmas, Murray, Tse, and Johnson and Mr Gordon); SNG Prosthetic Eye Institute, Boca Raton, Fla (Mr Garonzik); and the Department of Ophthalmology, School of Medicine, University of California at San Francisco (Dr O Brien). REMOVAL OF an eye for treatment of ocular disease was first described by Bartisch in The modern form of this operation was introduced in 1841 by Farrell and Bonnet, and in 1885, Mules placed the first orbital implant after evisceration. 2 A year later, Frost described the utility of orbital implant placement after enucleation surgery. In 1941, Ruedemann proposed the use of partially exposed, integrated implants with the attachment of extraocular muscles to allow for better prosthesis movement; he acknowledged the potential risks of extrusion and infection. Use of completely buried integrated implants began in the 1950s, bringing improved cosmesis but relatively poor motility. An ideal orbital implant should offer excellent motility, cosmesis, and few complications. Various orbital implant configurations are available Different materials may be used to create orbital implants, including cartilage, bone, fat, cork, rubber, gold, silver, silk, wool, aluminum, ivory, petroleum jelly, acrylics, silicone, quartz, glass, titanium, and porous materials such as polyethylene and hydroxyapatite (HA) Other buried, quasi-integrated, irregularly shaped implants derived from acrylics have been used. 3,6,9 In these, muscles are passed through tunnels, as in the Allen implant, or through grooves, as in the Iowa and Universal implants. Currently, porous spherical implants are most widely used. Porous polyethylene is made from synthetic, high-density polyethylene powder that is easily molded into shapes. 16 Hydroxyapatite, a porous material derived from reef-building coral of genus Porites, was introduced as a buried orbital implant by Perry in ,20 These porous spherical implants are nontoxic, nonallergenic, and biocompatible, and they become integrated into the host by fibrovascular ingrowth. 16,19,21,22 Fibrovascular ingrowth offers the theoretical advantages of less implant extrusion or mi- This article is also available on our Web site:

2 PATIENTS AND METHODS PATIENTS Institutional Review Board approval from the University of Miami was obtained before chart review. A retrospective chart review was performed for 405 patients who underwent primary enucleation with orbital implant placement (performed by T.G.M., D.T., and T.J.) at Bascom Palmer Eye Institute from January 1, 1987, to June 30, All these cases were analyzed, but data are reported only on 342 patients who had at least 2 months follow-up. Mean patient age at surgery was 49 years (range, years). Mean follow-up was 97.2 weeks (median, 78 weeks; range, weeks). One hundred eighty-seven patients (54.7%) were male and 155 (45.3%) were female. The demographics of this cohort included 228 whites (66.7%), 47 African Americans (13.7%), 48 Hispanics (14.0%), 12 others (3.5%), and 7 unknowns (2.0%). Reasons for primary surgery included diagnoses of uveal melanoma in 104 patients (30.4%), retinoblastoma in 39 (11.4%), ruptured globe in 14 (4.1%), blind painful eye in 162 (47.4%), metastatic cancer in 2 (0.6%), and other various diagnoses in 21 (6.1%) (Table 1). In total, 208 patients had undergone treatment before enucleation, with 6 patients undergoing plaque radiotherapy, 5 undergoing external beam radiation therapy, 9 undergoing ruptured globe repair, and 188 undergoing a spectrum of other ophthalmic surgeries. Final histopathologic diagnoses included atrophi bulbi, phthisis bulbi, rupture secondary to trauma or corneal ulceration, neovascular glaucoma secondary to central retinal vein occlusion or Coats disease, proliferative vitreoretinopathy, retinal detachment, malignant melanoma, medulloepithelioma, endophthalmitis, persistent hyperplastic primary vitreous, microphthalmos, and squamous cell carcinoma with intraocular extension. Acrylic implants used in this series included the sphere (8 patients), Iowa (29 patients), and Universal (1 patient) types (Table 2). Microporous implants were limited to HA (275 patients) and porous polyethylene (Medpor) (22 patients). Implants made of silicone (6 patients) and glass (1 patient) were also used. In 288 patients (84.2%), the implant was wrapped in a donor scleral shell. The mean implant size was 20 mm (median, 20 mm; range, mm). Drilling for peg placement was performed on 5 HA implants. SURGICAL TECHNIQUE This technique has been reported previously. 39 Briefly, enucleation was performed by opening the conjunctiva and the Tenon capsule for 360 around the corneal limbus with Wescott scissors. Hemostasis was achieved with wet field cautery. The 4 quadrants were opened using Stevens scissors. Each of the 4 rectus muscles was isolated on a muscle hook and cleaned of surrounding Tenon attachments; secured on a double-armed 5-0 polyglactin suture, with locking bites at each end; and then disinserted from the globe. The superior and inferior oblique muscles were dissected from the globe. The optic nerve was cut deep within the orbit with the Foster enucleation snare or with long Metzenbaum scissors. The globe was removed from the socket and was sent to the pathology laboratory for evaluation in all cases. If the implant was covered in donor sclera, windows were made. The implant was placed into the orbit. The 4 rectus muscles were sutured securely into the scleral windows. The Tenon capsule was closed in a doublelayered fashion using interrupted 5-0 polyglactin sutures. The conjunctiva was closed with running 7-0 polyglactin suture. An antibiotic ophthalmic ointment was applied to the wound, and a conformer was inserted. A pressure patch was then applied. The socket was evaluated at each postoperative visit. Socket motility was determined subjectively by assessing the patient s ocular motility in cardinal positions of gaze. The cosmetic appearance was determined subjectively by evaluation of eyelid contour and symmetry with the fellow eye. Complications throughout the postoperative period were recorded. gration and less secondary infection, and permits drilling of a tunnel into the implant and insertion of a peg. Coupling of the peg to the prosthesis enhances motility, a feature other implants lack. Although the literature includes many successful reports of intraorbital implant use, 3,6-9,16,23-28 several reports can be found regarding associated complications, such as exposure, infection, and peg extrusion. 6,13,19,23,29-38 We describe 342 patients who underwent intraorbital implant placement at Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Fla, during the past 10.5 years and their complications. RESULTS Postoperative follow-up was recorded for an average of 97.2 weeks (median, 78 weeks; range, weeks). During this period, no instance of orbital hemorrhage or implant migration was noted. Complications occurred in 7 patients (Table 3). These complications were noted 7 days to 25 months after placement of the intraorbital implant. These patients ranged in age from 4 to 89 years (mean, 56.3 years) and included 3 males and 4 females. Six patients had received treatment or surgery before enucleation. Final histopathologic diagnoses included retinoblastoma, traumatic rupture, perforated corneal ulcer, endophthalmitis, and phthisis bulbi. Four cases of exposure of the implant were noted, 1 related to a recurrent infection and 2 related to conjunc- Table 1. Indications for Enucleation Indication No. (%) of Patients Reviewed No. of Patients With Complications Uveal melanoma 104 (30.4) 0 Retinoblastoma 39 (11.4) 1 Ruptured globe 14 (4.1) 2 Blind painful eye 162 (47.4) 3 Metastatic cancer 2 (0.6) 0 Other 21 (6.1)

3 tival dehiscence or to paucity of conjunctiva covering the implant. Two of these patients had a small area of exposure, with 1 healing spontaneously and 1 undergoing drilling with peg placement in the area of exposure. The other 2 patients had larger areas of exposure resulting in partial extrusion of the implant; both patients underwent implant removal, with 1 undergoing implant exchange. Excessive orbital pain was noted in 1 patient who had long-term discomfort for more than 3 years. In this patient, the Iowa implant was replaced with a sphere. One patient had significant ptosis after enucleation and placement of the orbital implant. The ptosis was greater than 2 mm, and surgical repair was recommended. Three patients developed pyogenic granulomas within the socket. In all 3 patients these granulomas were excised, but in 1 patient multiple recurrences of inflammation were observed. One inclusion cyst of the socket was observed without treatment. None of the patients with complications had undergone drilling or peg placement before the complication. Patients were typically fitted with a prosthesis approximately 6 to 8 weeks after surgery. All patients had good socket motility and good cosmesis. COMMENT Table 2. Types of Implants Type No. of Patients Reviewed No. (%) of Patients With Complications Acrylic Sphere 8 2 (0.25) Iowa 29 1 (3.4) Universal 1 0 (0) Microporous Hydroxyapatite (1.5) Medpor 22 0 (0) Solid Silicone 6 0 (0) Glass 1 0 (0) An ideal orbital implant should yield excellent motility and cosmesis with few complications. Many authors 2,4,7,18,20 have suggested that an implant that is completely buried will minimize migration and extrusion. Attachment of the extraocular rectus muscles to the implant results in improved motility and cosmesis. The microporous HA implant fulfills these criteria and, therefore, has come into popular use, as demonstrated by this series. Other implants, such as the porous polyethylene sphere (Medpor) and acrylics, including the sphere and the older quasiintegrated Iowa and Universal implants, were also used after primary enucleation in this series. Simple spheres composed of silicone and glass were used less frequently. Complications in our series were minimal, with a rate of 3%. Five implants underwent drilling for prosthetic integration. This small number did not allow for significant evaluation of complications related to this procedure. The final cosmetic appearance and socket or prosthesis motility were judged by the surgeon to be good in all 342 patients, and this was true even without placement of a peg in most cases of HA implantation. This observation was, however, based on a subjective grading and is, therefore, less reliable than if gauged by a standardized objective rating based on photographs and measurements. In our series, different types of implants were used, but it is difficult to determine the best type of implant based on statistical analysis with the small number of complications. Also, our review of the indications for enucleation shows no correlation of complications based on histopathologic diagnosis. Several studies explore the use of porous implants and their complications (Table 4). Karesh and Dresner 16 reported no extrusions, infections, or exposures of porous polyethylene implants in 21 patients after a mean follow-up of 19 months. Reported exposure rates of HA implants range from 0% to 22%. 5,23-26,29,34,37 Nunery and colleagues 36 showed that the exposure rate of HA implants (11.1%) was higher than that of silicone spheres (0%). They also noted increased incidence of postoperative inflammation with HA implants. 36 Buettner and Bartley 29 proposed that exposure of HA implants is related to the inflammatory reaction incited by the implant or by delayed fibrous ingrowth. Remulla and coworkers 19 emphasized the advantage of wrapping the implant for better protection from extrusion; these authors were unable to correlate preoperative diagnosis or treatment with exposure rates. Kim and colleagues 35 demonstrated that, with HA implants, small areas of exposure ( 3 mm) may close spontaneously but that larger defects require surgical treatment. Goldberg and coworkers 31 suggested that Table 3. Clinical Data of 7 Patients With Complications of Orbital Implants Patient No. Type of Implant* Wrapping Complications Timing, d Management 1 HA Sclera Inclusion cyst 14 Observation Exposure, 5 mm 180 Antibiotics, healed Pyogenic granuloma 750 Excision 2 HA Sclera Ptosis, 2 mm 21 Recommended surgical repair 3 HA Sclera Exposure, 1 mm 7 Drill hole at site 4 HA Sclera Infection 14 Antibiotics Pyogenic granuloma 240 Excision Exposure, extrusion 420 Implant exchange 5 Acrylic None Pyogenic granuloma 14 Excision (recurrent) 6 Acrylic None Exposure, 5 mm 14 Implant removal 7 Iowa None Pain, chronic severe 14 Implant exchange *HA indicates hydroxyapatite. 1201

4 Table 4. Studies of Complications Associated With Intraorbital Implants Source, y Total No. of Patients No. (%) of Complications Type of Implant* No. of Patients/Complication Spivey et al, (19) Iowa 8/ptosis, 6/shallow cul-de-sac, 4/ectropion, 3/severe pain, 14/extrusion, 3/excessive motility, 19/discharge, 9/prosthesis falls out, 6/edema, 5/dehiscence, 3/discomfort Tyers and Collin, (59) Baseball 4/extrusion, 2/exposure, 9/ptosis, 5/shallow fornices, 1/implant migration, 3/conjunctival cysts Helms et al, Case report Glass Posterior intracranial migration Dutton, (6) HA 1/poor peg placement, 2/buried peg Buettner and Bartley, (22) HA Exposure Goldberg et al, (100) HA Exposure Shields et al, (15) HA 6/excessive pain, 1/excessive discharge, 2/excessive edema, 1/erosion, 2/buried peg (1/extrusion), 3/audible click Nunery et al, (10) HA Exposure 78 1 (1) Silicone Exposure Shields et al, (6) HA 8/conjunctival thinning, 4/erosion, 1/orbital infection, 2/peg extrusion, 3/audible click DePotter et al, (12) HA 2/erosion, 5/conjunctival thinning Karesh and Dresner, (0) Medpor None Kim et al, (100) HA Exposure Leatherbarrow et al, (23) Baseball 2/conjunctival dehiscence, 1/severe pain, 4/ptosis, 3/implant migration, 2/exposure el-shahed et al, Case report HA Exposure Fan and Robertson, (3) Allen 2/exposure, 4/tissue breakdown McNab, (15) HA 7/implant too large, 3/scleral exposure, 2/coral exposure, 3/shallowing inferior fornix Remulla et al, (11) Porous Exposure Ashworth et al, (17) HA 4/exposure, 1/conjunctival cyst, 1/orbital cellulitis, 1/socket infection, 3/eccentric implants Jordan et al, (100) HA Abscess Kaltreider and Newman, (28) HA 21/exposure, 4/infection, 1/malposition, 7/conjunctival lesions, 2/peg extrusions, 2/peg malpositions, 3/conjunctival overgrowth, 1/prosthetic fitting, 2/shifting of surface Oestreicher et al, (3) HA Exposure Present study (3) See Table 3 See Table 3 *HA indicates hydroxyapatite. use of HA implants, even with exposure, was less likely to lead to extrusion or infection compared with exposure with silicone or acrylic implants. Ashworth and colleagues 23 reported 60 cases of HA implantation: 3 patients (11%) in the primary implant group had exposure and 1 patient (4%) developed orbital cellulitis. In their secondary implant group, there was 1 patient with exposure, 1 patient with conjunctival cyst, 1 patient with socket infection, and 3 patients with eccentric implants. Shields and colleagues 26 described 100 cases of HA implants, among which they reported 6 patients with excessive postoperative orbital pain, 2 patients with wound edema, and 1 patient with erosion. As in the present series, Shields et al had excellent cosmesis in 98% and excellent motility in 99% of nondrilled patients. In their subsequent report of 250 patients with HA implants, Shields et al 28 described 8 patients with conjunctival thinning, 4 patients with erosions, and 1 patient with orbital infection. Jordan and coworkers 33 described 2 patients with abscesses found within HA implants. The most common complication observed with the Iowa implant is late exposure of the mounds and possible extrusion of the implant. Spivey and colleagues 9 also described ptosis and pain occurring with these implants. The Universal implant was designed to shorten the protracted implantation procedure and to reduce the rate of extrusion associated with the Iowa implant while still offering good motility, as demonstrated by Anderson and coworkers. 3 Contraindications for the use of these quasi-integrated implants include congenital nystagmus and severe scarring. The Allen implant has been shown by Fan and Robertson 6 to have a low long-term incidence of superficial tissue breakdown (2.2%) and exposure (1.1%), with satisfactory motility. Several techniques may be used to minimize complications after enucleation with placement of orbital implants. These techniques include choosing an appropriately sized implant, positioning the implant deeply in the orbit, wrapping the implant with donor sclera, meticulously closing the anterior Tenon capsule over the implant, securing the conjunctiva over the implant without tension, and using a posterior vault on the prosthesis to minimize wear. Orbital implants have been used for more than a century. Serious complications can occur, but they do so infrequently, as demonstrated by this series. Long-term benefits and risks of different implant types require ongoing evaluation. Accepted for publication June 9, WeappreciatetheeditorialeffortsofSharonWheeler, MA. 1202

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Philadelphia, Pa: JB Lippincott; 1992: Announcement The ARCHIVES is available by request to nonfederal physicians in the United States (50 states and Washington, DC) whose official American Medical Association masterfile record shows a primary specialty of ophthalmology in an office- or hospitalbased practice as a staff physician, resident in training beyond the first year, or clinical fellow. If you meet the above qualification criteria and are not currently receiving the ARCHIVES and would like to receive it each month, you must complete a free subscription request card. To receive a request card, please write, Kathryn Osten, American Medical Association, Circulation Processing Department, 515 N State St, Chicago, IL (FAX ). A subscription request card will be sent to you in response. If you are a resident or fellow, please include verification of your training program and a complete mailing address. 1203