44 year-old male. Follicular Hyperkeratosis 3/4/2019. Clinical: Erythematous scaling papules symmetrically on the forearms, abdomen and lower back
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1 DISCLOSURE OF RELATIONSHIPS WITH INDUSTRY Dermatopathology Case Challenge: Recognizing Mimics and Masqueraders Tammie Ferringer, MD Section Head and Fellowship Director of Dermatopathology Depts of Dermatology and Pathology Danville, PA Tammie Ferringer, MD F131 Dermatopathology Case Challenge: Recognizing Mimics and Masqueraders DISCLOSURES I do not have any relevant relationships with industry. I have no relevant relationships with industry year-old male Clinical: Erythematous scaling papules symmetrically on the forearms, abdomen and lower back DDX: Allergic contact dermatitis vs drug rash vs irritant dermatitis vs scabies vs pigmented purpuric dermatitis 3 4 Follicular Hyperkeratosis Discoid lupus Pityriasis rubra pilaris Lichen sclerosus Keratosis pilaris 5 6 1
2 Vacuolar Interface Dermatitis
3 Follicular Hyperkeratosis Discoid lupus Pityriasis rubra pilaris Lichen sclerosus Keratosis pilaris Vacuolar Interface Skin, left volar forearm: Interface dermatitis with follicular plugging (see comment) Comment: The microscopic differential diagnosis includes drug or viral eruption, connective tissue disease (including Wong type dermatomyositis), pigmented purpuric dermatoses, and pityriasis lichenoides. Additional History ROS positive for weakness and dysphagia 2 weeks prior PCP noted enlarge lymph nodes in the neck Metastatic tonsillar squamous cell carcinoma Wong-type dermatomyositis Variant of DM with erythematous hyperkeratotic follicular papules similar to PRP Reported in children and adults Myositis occurs at similar rate of classic DM In Wong s original report 52% developed malignancy Subsequent reports have shown no increased rate of malignancy Palmoplantar keratoderma is sometimes present 1. DF Mutasim, A Egesi, KE Spicknall. Wong-type dermatomyositis: a mimic of many dermatoses. J Cutan Pathol : R Haro, JM Revelles, MC Farina, et al. Wong s dermatomyositis: a new case and review of the literature
4 Matsumoto A, Wang R, Carlson JA Take Home Columnar dyskeratosis/pseudo -coronoid lamella Vacuolar Interface Wong Type DM year old G2P1 female at 8 weeks gestation
5 CD3+. CD56-, CD4-, ISH for EBV- CD8 Mib Subcutaneous Panniculitislike T-cell Lymphoma Β-F1 (αβ) positive GM1 (γδ) negative Am J Surg Pathol 2016;40: ) Mib-1 CD8 Chen SJT, Tse JY, Harms PW, Hristov AC, Chan MP. Utility of CD123 immunohistochemistry in differentiating lupus erythematosus from cutaneous T-cell lymphoma. Histopathology Dec 31. doi: /his [Epub ahead of print]
6 CD123 LEP SPTCL Ki-67 Beta F1 CD123 SPTCL Xinyu W, Subtil A, Craiglow B, Watsky K, Marks, A, Ko C. JAAD Case Rep Feb 4;4(2): LEP S/p high dose prednisone Healthy baby girl All was well, until After delivery developed rapid progression of new lesions despite treatment with increased prednisone, methotrexate and romidepsin Fever Leukopenia, anemia, hyperferritinemia, and increased LFTs Ultrasound suggested cholecystitis Admitted Fatal HPS due to SPLTCL
7 Hemophagocytic Syndrome Life-threatening syndrome of excessive immune activation Histiocytes activated and secrete excess cytokines Cytotoxic T lymphocytes and NK cells are unable to eliminate activated macrophages Familial Hemophagocytic Lymphohistiocytosis Mutations in genes involved in perforin-dependent cytotoxicity PRF1, UNC13D, STX11, STXBP2 Most frequently presents in first year of life Jordan MB, et al. How I treat hemophagocytic lymphohistiocytosis. Blood Oct 13;118(15): Reactive Hemophagocytic Syndrome Viral illness Autoimmune disease (Macrophage activation syndrome) Lymphoma Immunodeficiency Jordan MB, et al. How I treat hemophagocytic lymphohistiocytosis. Blood Oct 13;118(15): Hemophagocytosis Presence of fragments or intact RBC, platelets, or WBCs within the cytoplasm of macrophages Kerl K, et al. Hemophagocytosis in Cutaneous Autoimmune Disease. Am J Dermatopathol Jul
8 Courtesy Travis Vandergriff What s The Skin Got To Do With It? Cutaneous findings in 10 to 65% Manifestation of the trigger or underlying disease Viral exanthem Lupus, Dermatomyositis, Still s Disease Cutaneous lymphoma (SPLTCL) Manifestation of the associated liver dysfunction and coagulation problems HPS at Geisinger Age Underlying Disease Cutaneous Findings Dermatology Consult 33 SPLTCL SPLTCL + DOD 70 Adult Onset Still Disease AOSD + DOD 49? 1 st visit: none 2 nd consult: HSV 25 Paramyxovirus Generalized erythematous papules 7 Juvenile idiopathic arthritis + DOD - Alive rash - Alive 26 EBV/JRA None - Alive 56 HIV/DLBCL/Aspergillus pneumonia None - DOD Outcome yo male with intermittent fevers, joint pain, and persistent plaques Adult Onset Stills Disease Eventually developed acute mental status changes and massive GI bleed resulting in his death 8
9 Adult Onset Stills Disease Spiking fever >=39 C Arthralgia/arthritis Evanescent rash (77-100%)-asymptomatic salmon pink macules/papules with fever on trunk, extremities and areas of pressure Persistent papules and plaques Increased WBC with 80% neutrophils 12-15% RHS Take Home Histologic features of SPTCL and lupus panniculitis show marked overlap and may require prolonged follow-up Atypical CD8+/Ki-67+ lymphocytes rimming adipocytes suggest SPTCL Take Home Non-specific morbilliform, purpuric or triggerspecific eruptions with fever, hepatosplenomegaly, neurologic symptoms, cytopenias, increased ferritin levels, liver function impairment or coagulation problems think about Hemophagocytic Syndrome Persistent plaques of AOSD have apoptotic keratinocytes 32 year-old female DDx:? Scarring alopecia
10 year-old female Clinical: Erythematous scalp with hair loss, scaling. Fungal culture was negative. Has Crohn s. Patient on Remicaide. DDx:? Scarring alopecia. 5 months of scaling and hair loss Failed dandruff shampoo, econazole, and betamethasone TNF-Inhibitor Induced Alopecia 3/2016: started remicade 10/2017: c/o scaling and hair loss Am J Dermatopathology 2011;33:
11 TNF-Inhibitor Induced Alopecia TNF-Inhibitor Induced Alopecia Psoriasis + Alopecia Areata + Mixed Infiltrate Doyle LA, et al. Am J Dermatopathology 2011;33:161. Am J Dermatopathology 2011;33: Take Home TNF Inhibitor delayed reactions Psoriasiform dermatitis Often with interface, spongiosis and mixed infiltrate Alopecia AA histology with psoriasis, mixed infiltrate and atrophic sebaceous glands 65 11
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