Clinical Articles. Peer Reviewed Articles

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1 Clinical Articles Peer Reviewed Articles System Used Acne Scars Evaluation of a Novel Fractional Resurfacing Device for Treatment of Acne Scarring. Walgrave, S., et al. (2009). Lasers in Surgery and Medicine,41(2), Second-Generation 1,550-nm Fractional Photothermolysis for the Treatment of Acne Scars. Chrastil, B., Glaich, A., Goldberg, L., & Friedman, P. (2008). Dermatologic Surgery, 34, Successful Treatment of Acneiform Scarring with CO 2 Fractional Resurfacing. Chapas, A., et al. (2008) Lasers in Surgery and Medicine, 40, Atrophic Scar Revision Using Fractional Photothermolysis. Rahman, Z., Tanner, H., & Jiang, K. (2007). Cosmetic Dermatology, 20(9), The Use Of Fractional Laser Photothermolysis for the Treatment of Atrophic Scars. Alster, T., Tanzi, E., & Lazarus, M. (2007). Dermatologic Surgery, 33, Clinical Trial of a Laser Device Called Fractional Photothermolysis System for Acne Scars. Hasegawa, T., et al (2006). Journal of Dermatology, 33, Fractional Laser Resurfacing for Atrophic and Acne Scarring. Rokhsar, C. (2006). Cosmetic Dermatology, 19(12), Other Scars A Randomized Controlled Trial of Fractional Laser Therapy and Dermabrasion for Scar Resurfacing. Christophel, J., et al. (2012). Dermatol Surg, 1-8. Repigmentation of Hypopigmented Scars Using an Erbium-Doped 1,550-nm Fractionated Laser and Topical Bimatoprost. Massaki A., et al. (2012). Dermatol Surg, 1-7. Fractional Photothermolysis Improves a Depressed Alar Scar Following Mohs Micrographic Surgery. Schulz, K., Walling, H. (2010). Journal of Drugs in Dermatology, 9(1), Successful Treatment of Atrophic Postoperative and Traumatic Scarring with Carbon Dioxide Fractional Resurfacing. Weiss, E., et al. (2010). Archives of Dermatology, 146(2), Fractional Photothermolysis for the Treatment of Surgical Scars. Kunishige, J., et al. (2010). Dermatologic Surgery, 36, 1-4. Fractional Laser Resurfacing for Thermal Burns. Waibel, J., & Beer, K. (2008). Journal of Drugs in Dermatology, 7(1), Fractional Photothermolysis for the Treatment of Striae Distensae In Asian Skin. Kim, B.J., et al. (2008). American Journal of Clinical Dermatology, 9(1), Stevens-Johnson Syndrome-Induced Facial Scar Treated by the Fractional Photothermolysis System. Cho, S.B., et al. (2008). Journal of Cosmetic and Laser Therapy, 10, Atrophic Scar Revision Using Fractional Photothermolysis. Rahman, Z., Tanner, H., & Jiang, K. (2007). Cosmetic Dermatology, 20(9), Fractional Resurfacing for the Treatment of Hypopigmented Scars: A Pilot Study. Glaich, A., et al. (2007). Dermatologic Surgery, 33, Fractional Laser Resurfacing for Atrophic and Acne Scarring. Rokhsar, C. (2006). Cosmetic Dermatology, 19(12), Fractional Photothermolysis for the Treatment Of Surgical Scars: A Case Report. Behroozan, D., et al. (2006). Journal of Cosmetic and Laser Therapy, 8,

2 Resurfacing/Photoaging/Photo damage Peer Reviewed Articles Single-Session Combination Treatment with Intense Pulsed Light and Fractional Photothermolysis: A Split-Face Study. Kearney, C. & Brew, D. (2012). Dermatol Surg, 38: ,927-nm Fractional Thulium Fiber Laser for the Treatment of Nonfacial Photodamage: A Pilot Study. Polder, K.D., et al. (2011). Dermatol Surg, 37: System Used Fractional Deep Dermal Ablation Induces Tissue Tightening. Rahman, Z., Zachary, C., et al. (2009). Lasers in Surgery and Medicine, 41, Fractional Photothermolysis for Photoaging of Hands. Jih, M.H., Goldberg, L.H., & Kimyai-Asai, A. (2008). Dermatologic Surgery, 34(1), Fractional Photothermolysis: Treatment of Facial and Nonfacial Cutaneous Photodamage with a 1,550-nm Erbium-Doped Fiber Laser. Wanner, M., Tanzi, E., & Alster, T. (2007). Dermatologic Surgery, 33, Fractional Resurfacing in the Male Patient. Narurkar, V. (2007). Dermatologic Therapy, 20, Prospective Direct Comparison Study of Fractional Resurfacing Using Different Fluences and Densities for Skin Rejuvenation in Asians. Kono, T., et al. (2007). Lasers in Surgery and Medicine, 39, Laser and Cosmetic News: Fractional Laser Resurfacing. Alexiades-Armenakas, M. (2007). Journal of Drugs in Dermatology, 6(7), Rejuvenation of the Aging Face Using Fraxel Laser Treatment. Bass, L. (2005). Aesthetic Surgery Journal, 25, & Melasma Treatment of Melasma Using a Novel 1,927-nm Fractional Thulium Fiber Laser: A Pilot Study. Polder, K.D., Bruce S. (2011). Dermatol Surg, 1-8. Histologic and Ultrastructural Analysis of Melasma After Fractional Resurfacing. Goldberg, D.J., Berlin, A., & Phelps, R. (2008). Lasers in Surgery and Medicine, 40, Fractional Photothermolysis Treatment for Resistant Melasma in Chinese Females. Naito, S.K. (2007). Journal of Cosmetic and Laser Therapy, 9(3), The Treatment of Melasma with Fractional Photothermolysis: A Pilot Study. Rokhsar, C. & Fitzpatrick, R. (2005). Dermatologic Surgery, 31, Utilizing Fractional Resurfacing in The Treatment of Therapy-Resistant Melasma. Tannous, Z. & Astner, S. (2005). Journal of Cosmetic and Laser Therapy, 7, Other Pigmentation Case Report: Resolution of Blue Minocycline Pigmentation of the Face After Fractional Photothermolysis. Izikson, L. & Anderson, R. R. (2008). Lasers in Surgery and Medicine, 40, Fractional Photothermolysis for the Treatment of Telangiectatic Matting: A Case Report. Glaich, A.S., et al. (2007). Journal of Cosmetic and Laser Therapy, 9(2), Fractional Resurfacing: A New Therapeutic Modality for Becker's Nevus. Glaich, A.S., et al. (2007). Archives Dermatology, 143(12), Fractional Photothermolysis for the Treatment of Postinflammatory Erythema Resulting From Acne Vulgaris. Glaich, A.S., et al. (2007). Dermatologic Surgery, 33(7), Pigmentary Disorders in Asian Skin: Treatment with Laser and Intense Pulsed Light Sources. Lin, J.Y., & Chan, H.H. (2006). Skin Therapy Letter, 11(8). Fractional Laser Treatment for Pigmentation and Texture Improvement. Rahman, Z., Alam, M., & Dover, J. (2006). Skin Therapy Letter, 11(9).

3 Managing Superficial Pigmentary Alterations with the Fraxel Laser. Lask, G. (2006). Practical Dermatology, Jan., 58. Fractional Photothermolysis for Treatment of Poikiloderma of Civatte. Behroozan, D., et al. (2006). Dermatologic Surgery, 32,

4 Peer Reviewed Articles System Used Ethnic skin Fractional Photothermolysis for the Treatment of Striae Distensae In Asian Skin. Kim, B.J., et al. (2008). American Journal of Clinical Dermatology, 9 (1), Fractional Photothermolysis Treatment for Resistant Melasma in Chinese Females. Naito, S.K. (2007). Journal of Cosmetic and Laser Therapy, 9(3), Prospective Direct Comparison Study of Fractional Resurfacing Using Different Fluences and Densities for Skin Rejuvenation in Asians. Kono, T., et al. (2007). Lasers in Surgery and Medicine, 39, The Prevalence and Risk Factors of Post-Inflammatory Hyperpigmentation After Fractional Resurfacing in Asians. Chan, H.H. (2007). Lasers in Surgery and Medicine, 39(5), Clinical Trial of a Laser Device Called Fractional Photothermolysis System for Acne Scars. Hasegawa, T., et al. (2006). Journal of Dermatology, 33, Pigmentary Disorders in Asian Skin: Treatment with Laser and Intense Pulsed Light Sources. Lin, J.Y. & Chan, H.H. (2006). Skin Therapy Letter, 11:8. Effective and Safe Use of Lasers, Light Sources, and Radiofrequency Devices in the Clinical Management of Asian Patients with Selected Dermatoses. Chan, H. (2005). Lasers in Surgery and Medicine, 37, Other Clinical Applications 1927-nm Fractional Resurfacing of Facial Actinic Keratoses: A Promising New Therapeutic Option. Weiss, E.T., et al. (2013). Journal of the American Academy of Dermatology. 68(1), Treatment of Macular Seborrheic Keratosis Using a Novel 1,927-nm Fractional Thulium Fiber Laser. Polder, K.D., et al. (2012). Dermatol Surg, 38: Calcium Hydroxylapatite Nodule Resolution After Fractional Carbon Dioxide Laser Therapy. Reddy K.K., et al. (2012). Arch Dermatol, Vol. 148 (No. 5), Reduction of Thickened Flap Using Fractional Carbon Dioxide Laser. Brightman, L.A., et al. (2011). Lasers in Surgery and Medicine, 43: Treatment of Actinic Cheilitis Using a 1,927-nm Thulium Fractional Laser. Ghasri, P., et al. (2011). Dermatol Surg, 38: New Technique Using Combined Pulsed Dye Laser and Fractional Resurfacing for Treating Facial Angiofibromas in Tuberous Sclerosis. Weiss, E.T. & Geronumus, R.G. (2010). Lasers in Surgery and Medicine, 42: Fractional Photothermolysis of Residual Hemangioma. Blankenship, C.M. & Alster, T.S. (2008). Dermatologic Surgery, 34, The Safety and Efficacy of Fractional Photothermolysis for the Correction of Striae Distensae. Stotland, M.C., et al. (2008). Journal of Drugs in Dermatology, Sept., 7(9), Side Effects and Complications of Fractional Laser Photothermolysis: Experience with 961 Treatments. Graber, E.M., Tanzi, E.L. & Alster, T.S. (2008). Dermatologic Surgery, 34(3), Clinical Experience with the Fraxel SR Laser: 202 Treatments in 59 Consecutive Patients. Cohen, S.R., et al. (2008). Plastic and Reconstructive Surgery, 297e-304e. Enhanced Efficacy of Photodynamic Therapy After Fractional Resurfacing: Fractional Photodynamic Rejuvenation. Ruiz-Rodriguez, R., et al. (2007). Journal of Drugs in Dermatology, Aug., Fractional Photothermolysis for the Treatment of Adult Colloid Milium. Marra, D.E., et al. (2007). Archives of Dermatology, 143, The Prevalence and Risk Factors of Post-Inflammatory Hyperpigmentation After Fractional Resurfacing in Asians. Chan, H.H. (2007). Lasers in Surgery and Medicine, 39(5), Fractional Photothermolysis: A Novel Treatment for Disseminated Superficial Actinic Porokeratosis. Chrastil, B., et al. (2007). Archives of Dermatology, 143,

5 Systemic Toxicity from Topically Applied Lidocaine in Conjunction with Fractional Photothermolysis. Marra, D.E., et al. (2006). Archives of Dermatology, 142 (8),

6 Peer Reviewed Articles System Used Other Clinical Applications Skin Responses to Fractional Photothermolysis. Laubach, H., et al. (2005). Lasers in Surgery and Medicine, 1-8. Short-Term Side Effects of Fractional Photothermolysis. Fisher, G. & Geronemus R. (2005). Dermatologic Surgery, 31, Concurrent Use of a Handheld Forced Cold Air Device Minimizes Patient Discomfort During Fractional Photothermolysis. Fisher, G., et al. (2005). Dermatologic Surgery, 31, Basic Science Immunohistochemical Evaluation of the Heat Shock Response to Fractional Resurfacing. Hantash, B.M., et al. (2010). Journal of Biomedical Optics, 15(6). Histological Comparison of Two Different Fractional Photothermolysis Devices Emitting at nm. Thongsima, S., Zurakowski, D., & Manstein, D. (2010). Lasers in Surgery and Medicine, 42, Effects of Skin Temperature on Lesion Size in Fractional Photothermolysis. Laubach, H., et al. (2007). Lasers in Surgery and Medicine, 39, In Vivo Histological Evaluation of a Novel Fractional Resurfacing Device. Hantash, B., et al. (2007). Lasers in Surgery and Medicine, Ex Vivo Histological Evaluation of a Novel Fractional Resurfacing Device. Hantash, B., et al. (2007). Lasers in Surgery and Medicine, 39, The Effects of Pulse Energy Variations on the Dimensions of Microscopic Thermal Treatment Zones in Fractional Resurfacing. Bedi, V., et al. (2007). Lasers in Surgery and Medicine, 39, Laser-Induced Transepidermal Elimination of Dermal Content by Fractional Photothermolysis. Hantash, B., et al. (2006). Journal of Biomedical Optics, 11(4), Intradermally Focused Infrared Laser Pulses: Thermal Effects at Defined Tissue Depths. Khan, M., et al. (2005). Lasers in Surgery and Medicine, , Fractional Photothermolysis: A New Concept for Cutaneous Remodeling Using Microscopic Patterns of Thermal Injury. Manstein, D., et al. (2004). Lasers in Surgery and Medicine, 34, Review Articles Fractional Resurfacing for Total Body Rejuvenation. Narurkar, V.A. (2008). Journal of Drugs in Dermatology,7(4), Successful Treatment of Acneiform Scarring with CO 2 Fractional Resurfacing. Chapas, A.M., et al. (2008). Lasers in Surgery and Medicine, 40, Fractional Photothermolysis: A Novel Aesthetic Laser Surgery Modality. Hantash, B.M. & Mahmood, M.B. (2007). Dermatologic Surgery, 33, Fractionated Photothermolysis: The Fraxel -nm Glass Fiber Laser Treatment. Chiu, R.J. & Kridel, R. (2007). Facial Plastic Surgery Clinics of North America, 15, Fractional Resurfacing. Tannous, Z. (2007). Clinics in Dermatology, 25, Fractional Photothermolysis: Current and Future Applications. Geronemus, R. (2006). Lasers in Surgery and Medicine, 38, Effective and Safe Use of Lasers, Light Sources, and Radiofrequency Devices in the Clinical Management of Asian Patients with Selected Dermatoses. Chan, H. (2005). Lasers in Surgery and Medicine, 37, Publications in Foreign languages German: Fractional Photothermolysis. Laubach, H. J. & Manstein, D (2007). Hautarzt, 58,

7 French: Fractional Photo-Thermolysis by Laser Fraxel as an Adjuvant for Facial Surgical Rejuvenation. Buis, J., & Mazer, J. (2007). Ann Chir Plast Esthet, 52(3),

8 Abstracts System Used Prospective Split-Face Trial of a Fixed Spacing Array Computer Scanned Fractional C0 2 Laser vs. Hand Scanned nm Fractional For Rhytids. Weiss, R., Weiss, M., & Beasley, K. (2008). American Society for Laser Medicine and Surgery Abstracts. Retrospective Analysis of 877 Cases of Fractional Resurfacing with a Second Generation Erbium Doped nm Laser. Narurkar, V.A. (2008). American Society for Laser Medicine and Surgery Abstracts. Quantitative Assessment of Skin Improvement Post and Fractional Resurfacing: A Primos and Visia Imaging Study. Stumpp, O.F., et al. (2008). American Society for Laser Medicine and Surgery Abstracts. Fractional Resurfacing: Evaluation of Different Exposure Parameters in a Pig Model. Wanner, M. & Manstein, D. (2008). American Society for Laser Medicine and Surgery Abstracts. White Papers System Used Initial Clinical Results with the New 1927 nm Wavelength: A New Addition to the Fraxel re:store Platform. Solta Clinical Affairs. (2009) August. The Sequential Combination of Thermage and Fraxel Treatments Results in Synergistic Improvements. Weiss, R. (2009). Fractional Deep Dermal Ablation (FDDA) Treatment: Combining the Efficacy of a Deeply CO 2 Laser Device with the Safety of a Fractional Treatment Modality. Stumpp, O., et al. (2007). April. Fractional Deep Dermal Ablation (FDDA) Treatment of Photodamage and Tissue Laxity. Adrian, R. (2007). April. Ablarive Fraxel Laser Treatment: Clinical Perspectives. Adrian, R. (2007). Janaury. Fraxel Laser Treatment of Actinic Keratosis. Herron, S., et al. (2007). January. Histochemical Analysis of a Split Region Treatment of the Fraxel SR1500 Laser and the Palomar Lux 1540 Laser. Narurkar, V., et al. (2007). January.

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