Publications by Core, Collaborative, BAA, and Ancillary Study* as of 11/5/2013

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1 Publications by Core, Collaborative, BAA, and Ancillary Study* as of 11/5/2013 Study # MS ID Title Reference W1 - CT core analytes on 6% Subsample; quarterly core analytes on QC pools A and B W1, W6 204 Effect of estrogen plus progestin on stroke in JAMA May 28;289(20): postmenopausal women: the Women s Health Initiative: A randomized trial W1, W6 210 Estrogen plus progestin and the risk of coronary heart disease N Engl J Med Aug 7;349(6): W1, W6 222 Estrogen plus progestin and risk of venous thrombosis JAMA Oct 6;292(13): W1 240 Risks and benefits of estrogen plus progestin in healthy JAMA Jul 17;288(3): postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial W1, W6 273 Effects of conjugated equine estrogen in postmenopausal JAMA Apr 14;291(14): women with hysterectomy. The Women s Health Initiative randomized controlled trial W1, W6 345 Conjugated equine estrogens and coronary heart disease: The Arch Intern Med Feb 13;166(3): Women's Health Initiative W1, W6 347 Effects of conjugated equine estrogen on stroke in the Circulation May 23;113(20): Epub 2006 Women's Health Initiative May 15 W1, W6 350 Venous thrombosis and conjugated equine estrogen in Arch Intern Med Apr 10;166(7): women without a uterus W1 447 Low-fat dietary pattern and risk of cardiovascular disease: JAMA Feb 8;295(6): The Women s Health Initiative Randomized Controlled Dietary Modification Trial W1, W Low-fat dietary pattern and risk of invasive breast cancer: JAMA Feb 8;295(6): The Women s Health Initiative Randomized Controlled Dietary Modification Trial R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 1 of 47

2 W1 449 Low-fat dietary pattern and risk of colorectal cancer: the JAMA Feb 8;295(6): Women's Health Initiative randomized controlled dietary modification trial W1 520 The Women's Health Initiative recruitment methods and Ann Epidemiol Oct;13(9 Suppl):S18-77 results W1 521 The Women's Health Initiative postmenopausal hormone Ann Epidemiol Oct;13(9 Suppl):S78-86 trials: Overview and baseline characteristics of participants W1, W2 524 The Women's Health Initiative Observational Study: Ann Epidemiol Oct;13(9 Suppl):S Baseline characteristics of participants and reliability of baseline measures W1, W14, 866 Serum 25-hydroxyvitamin D concentrations in relation to Am J Clin Nutr May 25. [Epub ahead of print] W6 cardiometabolic risk factors and metabolic syndrome in postmenopausal women W2 - OS-measurement precision study (OS-MPS) W2 442 Test-retest reliability of the Women s Health Initiative Med Sci Sports Exerc Mar;41(3): Epub 2009 Physical Activity Questionnaire Feb 6 W1, W2 524 The Women's Health Initiative Observational Study: Ann Epidemiol Oct;13(9 Suppl):S Baseline characteristics of participants and reliability of baseline measures W5 - Correlates of endogenous sex hormone concentrations in WHI W5 20 Relation of demographic factors, menstrual history, Breast Cancer Res Treat Mar;108(2): Epub reproduction and medication use to sex hormones in 2007 May 22 postmenopausal women W5 280 Relation of BMI and physical activity to sex hormones in Obesity (Silver Spring) Sep;14(9): postmenopausal women R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 2 of 47

3 AS110, 1218 Age, body mass, usage of exogenous estrogen, and lifestyle Clin Chem Sep 18. [Epub ahead of print] AS167, factors in relation to circulating sex hormone-binding globulin AS90, concentrations in postmenopausal women BAA21, BAA7, BAA9, W10, W18, W5, W9 W6 - HT CVD Biomarkers: study of CHD, Stroke and VTE - Phase I W1, W6 204 Effect of estrogen plus progestin on stroke in JAMA May 28;289(20): postmenopausal women: the Women s Health Initiative: A randomized trial W1, W6 210 Estrogen plus progestin and the risk of coronary heart disease N Engl J Med Aug 7;349(6): W1, W6 222 Estrogen plus progestin and risk of venous thrombosis JAMA Oct 6;292(13): W1, W6 273 Effects of conjugated equine estrogen in postmenopausal JAMA Apr 14;291(14): women with hysterectomy. The Women s Health Initiative randomized controlled trial W1, W6 345 Conjugated equine estrogens and coronary heart disease: The Arch Intern Med Feb 13;166(3): Women's Health Initiative W1, W6 347 Effects of conjugated equine estrogen on stroke in the Circulation May 23;113(20): Epub 2006 Women's Health Initiative May 15 W1, W6 350 Venous thrombosis and conjugated equine estrogen in Arch Intern Med Apr 10;166(7): women without a uterus W6 429 Can biomarkers identify women at increased stroke risk? PLoS Clin Trials Jun 15;2(6):e28 The Women's Health Initiative Hormone Trials W6 445 Usefulness of baseline lipids and C-reactive protein in Am J Cardiol Jun 1;101(11): Epub 2008 women receiving menopausal hormone therapy as predictors Apr 2 of treatment-related coronary events R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 3 of 47

4 W11, W6 462 Estrogen receptor polymorphisms and the vascular effects Arterioscler Thromb Vasc Biol Nov 24. [Epub ahead of hormone therapy of print] W6 526 Inflammatory, lipid, thrombotic, and genetic markers of Arch Intern Med Nov 10;168(20): coronary heart disease risk in the Women s Health Initiative trials of hormone therapy AS140, 854 Ambient particulate matter air pollution and venous Environ Health Perspect. 29 Oct [Epub ahead of AS220, thromboembolism in the Women s Health Initiative print] W6 Hormone Therapy Trials W1, W14, 866 Serum 25-hydroxyvitamin D concentrations in relation to Am J Clin Nutr May 25. [Epub ahead of print] W6 cardiometabolic risk factors and metabolic syndrome in postmenopausal women W14, W6 972 Coronary heart disease events in the Women's Health Menopause Oct 25. [Epub ahead of print] Initiative hormone trials: effect modification by metabolic syndrome: A nested case-control study within the Women's Health Initiative randomized clinical trials W7 - Genome-wide scan on breast cancer, CHD, and stroke BAA2, 1104 Pooled versus individual genotyping in a breast cancer Genet Epidemiol Sep;34(6): M3, W7 genome-wide association study W Exploring the interaction between SNP genotype and Genome Med Jul 13;4(7):57. [Epub ahead of print] postmenopausal hormone therapy effects on stroke risk W8 - Nutritional biomarkers study (NBS) W8 464 Use of recovery biomarkers to calibrate nutrient Am J Epidemiol May 15;167(10): Epub consumption self-reports in the Women's Health Initiative 2008 Mar 15 W8 624 Biomarker-calibrated energy and protein consumption and Am J Epidemiol Apr 15;169(8): Epub 2009 increased cancer risk among postmenopausal women Mar 3 W8 646 Biomarker-calibrated energy and protein consumption and Epidemiology Jan 4. [Epub ahead of print] cardiovascular disease risk among postmenopausal women AS179, 831 Protein intake and incident frailty in the Women s Health J Am Geriatr Soc May 7 [Epub ahead of print] W8 Initiative Observational Study R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 4 of 47

5 W8 941 Biomarker-calibrated dietary energy and protein intake Am J Clin Nutr Dec;94(6): Epub 2011 Nov 9 associations with diabetes risk among postmenopausal women from the Women s Health Initiative BAA9, W8 945 Higher biomarker-calibrated protein intake is not associated J Nutr Aug;141(8): Epub 2011 Jun 8. with impaired renal function in postmenopausal women W9 - Biological markers of the effect of HT on risk of fractures in the WHI Clinical Trial W9 433 Baseline serum estradiol and fracture reduction during Osteoporos Int Jan;21(1): Epub 2009 May 13 treatment with hormone therapy: The Women's Health Initiative randomized trial AS110, 1218 Age, body mass, usage of exogenous estrogen, and lifestyle Clin Chem Sep 18. [Epub ahead of print] AS167, factors in relation to circulating sex hormone-binding globulin AS90, concentrations in postmenopausal women BAA21, BAA7, BAA9, W10, W18, W5, W9 W10 - Biological markers of the effect of HT on risk of breast cancer in the WHI Clinical Trial BAA7, W Sex hormone levels and risk of breast cancer with estrogen J Natl Cancer Inst Sep 16. [Epub ahead of print] plus progestin AS110, 1218 Age, body mass, usage of exogenous estrogen, and lifestyle Clin Chem Sep 18. [Epub ahead of print] AS167, factors in relation to circulating sex hormone-binding globulin AS90, concentrations in postmenopausal women BAA21, BAA7, BAA9, W10, W18, W5, W9 R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 5 of 47

6 W11 - CVD biomarkers - Phase II: strokes after Feb 2001 W11, W6 462 Estrogen receptor polymorphisms and the vascular effects Arterioscler Thromb Vasc Biol Nov 24. [Epub ahead of hormone therapy of print] W11, W Tissue factor pathway inhibitor, activated protein C Stroke Feb 23. [Epub ahead of print] resistance, and risk of ischemic stroke due to postmenopausal hormone therapy W14 - CVD biomarkers - Phase I: additional assays W1, W14, 866 Serum 25-hydroxyvitamin D concentrations in relation to Am J Clin Nutr May 25. [Epub ahead of print] W6 cardiometabolic risk factors and metabolic syndrome in postmenopausal women W14, W6 972 Coronary heart disease events in the Women's Health Menopause Oct 25. [Epub ahead of print] Initiative hormone trials: effect modification by metabolic syndrome: A nested case-control study within the Women's Health Initiative randomized clinical trials W11, W Tissue factor pathway inhibitor, activated protein C Stroke Feb 23. [Epub ahead of print] resistance, and risk of ischemic stroke due to postmenopausal hormone therapy W15 - CaD Vitamin D levels in CaD participants with colorectal cancer or fractures W Calcium plus vitamin D supplementation and the risk for N Engl J Med Feb 16;354(7): fractures W Calcium plus vitamin D supplementation and the risk of N Engl J Med Feb 16;354(7): colorectal cancer W Predictors of serum 25-hydroxyvitamin D concentrations Am J Clin Nutr May;91(5): Epub 2010 among postmenopausal women: the Women's Health Mar 10 Initiative Calcium plus Vitamin D Clinical Trial W15, W A prospective study of serum 25-hydroxyvitamin D levels, Am J Epidemiol Jan 1;175(1): Epub 2011 Nov blood pressure, and incident hypertension in 29 postmenopausal women R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 6 of 47

7 AS181, 878 Prospective association of vitamin D concentrations with Am J Clin Nutr Oct 26. [Epub ahead of print] W15, W24 mortality in postmenopausal women: results from the Women's Health Initiative (WHI) AS181, 910 Lack of association between 25(OH)D levels and incident Diabetes Care Mar;34(3): Epub 2011 Feb 2. W15, W24 type 2 diabetes in older women AS103, 1121 Calcium and Vitamin D supplementation and cognitive J Am Geriatr Soc Dec;60(12): doi: AS39, impairment in the Women's Health Initiative /jgs Epub 2012 Nov 23 W15, W24 W18 - HT hormone pretest W The effects of postmenopausal hormone therapy on serum Menopause May-Jun;17(3): Epub 2010 Mar estrogen, progesterone, and sex hormone-binding globulin 3 levels in healthy postmenopausal women AS110, 1218 Age, body mass, usage of exogenous estrogen, and lifestyle Clin Chem Sep 18. [Epub ahead of print] AS167, factors in relation to circulating sex hormone-binding globulin AS90, concentrations in postmenopausal women BAA21, BAA7, BAA9, W10, W18, W5, W9 W19 - WHI HT proteomic pilot Study W19, W Application of serum proteomics to the Women s Health Genome Med Apr 29;1(4):47 Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings W19, W Postmenopausal estrogen and progestin effects on the serum Genome Med Dec 24;1(12):121. [Epub ahead of proteome print] R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 7 of 47

8 W24 - CaD Vitamin D and breast cancer W Hydroxyvitamin D concentration, vitamin D intake and Maturitas Nov 17. [Epub ahead of print] joint symptoms in postmenopausal women W15, W A prospective study of serum 25-hydroxyvitamin D levels, Am J Epidemiol Jan 1;175(1): Epub 2011 Nov blood pressure, and incident hypertension in 29 postmenopausal women AS181, 878 Prospective association of vitamin D concentrations with Am J Clin Nutr Oct 26. [Epub ahead of print] W15, W24 mortality in postmenopausal women: results from the Women's Health Initiative (WHI) AS181, 910 Lack of association between 25(OH)D levels and incident Diabetes Care Mar;34(3): Epub 2011 Feb 2. W15, W24 type 2 diabetes in older women AS103, 1121 Calcium and Vitamin D supplementation and cognitive J Am Geriatr Soc Dec;60(12): doi: AS39, impairment in the Women's Health Initiative /jgs Epub 2012 Nov 23 W15, W24 W25 - WHI coronary artery calcification study in E-Alone (WHI-CACS) W Oophorectomy, hormone therapy, and subclinical coronary Menopause Jul-Aug;15(4 Pt 1): Epub 2008 artery disease in women with hysterectomy: the Women's May 2 Health Initiative coronary artery calcium study W Estrogen therapy and coronary-artery calcification N Engl J Med Jun 21;356(25): W Calcium/vitamin D supplementation and coronary artery Menopause Jul;17(4): Epub 2010 Jun 14 calcification in the Women's Health Initiative W Association between different measures of blood pressure Hypertension Nov;52(5): Epub 2008 Sep 15 and coronary artery calcium in postmenopausal women W Vasomotor symptoms and coronary artery calcium in Menopause Nov-Dec;17(6): Epub 2010 Jul postmenopausal women 21 W Resting heart rate and coronary artery calcium in J Womens Health (Larchmt) Mar 25. [Epub ahead of postmenopausal women print] R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 8 of 47

9 W27 - Nutrition and physical activity assessment study (AS218) lab work AS218, 1178 Evaluation and comparison of food records, recalls, and Am J Epidemiol Jul 15. [Epub ahead of print] W27 frequencies for energy and protein assessment by using recovery biomarkers AS218, 1385 Physical activity assessment: biomarkers and self-report of Am J Epidemiol Mar 15;177(6): doi: W27 activity-related energy expenditure in the Women s Health /aje/kws269. Epub 2013 Feb 22 Initiative AS218, 1532 Factors relating to eating style, social desirability, body Nutr J May 16;12(1):63. [Epub ahead of print] W27 image and eating meals at home increase the precision of calibration equations correcting self-report measures of diet using recovery biomarkers: findings from the Women's Health Initiative W30 - Dietary assessment study W30 35 Measurement characteristics of the Women's Health Ann Epidemiol Apr;9(3): Initiative food frequency questionnaire W31-4DFR and ovarian cancer W Low-fat dietary pattern and cancer incidence in the Women's J Natl Cancer Inst Oct 17;99(20): Epub Health Initiative Dietary Modification Randomized 2007 Oct 9 Controlled Trial W33-4DFR and DM breast cancer W1, W Low-fat dietary pattern and risk of invasive breast cancer: JAMA Feb 8;295(6): The Women s Health Initiative Randomized Controlled Dietary Modification Trial R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 9 of 47

10 W35 - Full CMS data on all CT/OS participants W Effects of postmenopausal hormone therapy on incident Circ Arrhythm Electrophysiol Nov 20. [Epub ahead atrial fibrillation: The Women's Health Initiative of print] Randomized Controlled Trials W39-27-hydroxycholesterol inhibits cardiovascular effects of estrogen W Relationships of coronary heart disease with 27- Circulation Sep 25;126(13): Epub 2012 Aug hydroxycholesterol, low density lipoprotein cholesterol, and 29 menopausal hormone therapy W40 - Validation of E-alone proteins in W19-HT proteomics W19, W Application of serum proteomics to the Women s Health Genome Med Apr 29;1(4):47 Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings W44 - Biological validation of E+P effects on the serum proteome and comparison of E+P and E-Alone effects (see W18 and W40) W19, W Postmenopausal estrogen and progestin effects on the serum Genome Med Dec 24;1(12):121. [Epub ahead of proteome print] W57 - Extension of CVD Biomarker Study using HT Proteomics Study BAA4, W Novel proteins associated with risk for coronary heart Genome Med Jul 28;2(7):48. [Epub ahead of print] disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling M2 - Anemia and its relationship with sarcopenia, physical function and mortality M2 562 The relationship between incidence of fractures and anemia J Am Geriatr Soc Dec;58(12): in older multiethnic women M2 836 Nutrient intake and anemia risk in the Women's Health J Am Diet Assoc Apr;111(4): Initiative Observational Study R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 10 of 47

11 M3 - NCI Cancer Genetic Markers of Susceptibility (CGEMS) Initiative M3 874 A multistage genome-wide association study in breast cancer Nat Genet May;41(5): Epub 2009 Mar 29 identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1) M3 906 Performance of common genetic variants in breast-cancer N Engl J Med Mar 18;362(11): risk models M3 907 Newly discovered breast cancer susceptibility loci on 3p24 Nat Genet May;41(5): Epub 2009 Mar 29 and 17q23.2 BAA2, 1104 Pooled versus individual genotyping in a breast cancer Genet Epidemiol Sep;34(6): M3, W7 genome-wide association study M4 - Pancreatic Cancer Cohort Consortium (PANSCAN) M4 875 Cigarette smoking and pancreatic cancer: A pooled analysis Am J Epidemiol Aug 15;170(4): Epub 2009 from the Pancreatic Cancer Cohort Consortium (PanScan) Jun 26 AS214, 930 Pancreatic cancer risk and ABO blood group alleles: Results Cancer Res Feb 1;70(3): Epub 2010 Jan 26 M4 from the Pancreatic Cancer Cohort Consortium M4 931 Alcohol intake and pancreatic cancer: a pooled analysis from Cancer Causes Control Apr 7. [Epub ahead of print] the pancreatic cancer cohort consortium (PanScan) M4 932 Anthropometric measures, body mass index and pancreatic Arch Intern Med. 2010;170(9): cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan) M4 933 Family history of cancer and risk of pancreatic cancer: A Int J Cancer Jan 4. [Epub ahead of print] pooled analysis from the pancreatic cancer cohort consortium (PANSCAN) M4 934 Diabetes and risk of pancreatic cancer: A pooled analysis Cancer Causes Control Jan;24(1): Epub 2012 from the Pancreatic Cancer Cohort Consortium Oct 31 AS214, 936 Genome-wide association study identifies variants in the Nat Genet Sep;41(9): Epub 2009 Aug 2 M4 ABO locus associated with susceptibility to pancreatic cancer R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 11 of 47

12 AS214, 1075 A genome-wide association study identifies pancreatic Nat Genet Mar;42(3): Epub 2010 Jan 24. M4 cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33 M Variant ABO blood group alleles, secretor status and risk of Cancer Epidemiol Biomarkers Prev pancreatic cancer: Results from the Pancreatic Cancer Dec;19(12): doi: / EPI Cohort Consortium Epub 2010 Oct 22 M Polymorphisms in genes related to one-carbon metabolism In press, Cancer Causes Control are not related to pancreatic cancer in PanScan and PANC4 M Pathway analysis of genome-wide association study data Carcinogenesis Jul;33(7): doi: highlights pancreatic development genes as susceptibility /carcin/bgs151. Epub 2012 Apr 20 factors for pancreatic cancer M Detectable clonal mosaicism and its relationship to aging and Nat Genet May 6;44(6): doi: /ng.2270 cancer M Genome-wide association study of survival in patients with Gut Nov 24. [Epub ahead of print] pancreatic adenocarcinoma M5 - SHARe (SNP Health Association Resource) GWAS M5 984 Genome-wide meta-analyses of smoking behaviors in Transl Psychiatry May 22;2:e119 African Americans M5 987 Genome-wide association study of age at menarche in Hum Mol Genet Aug 15;22(16): doi: African-American women /hmg/ddt181. Epub 2013 Apr 17. M Gene-environment interactions and obesity traits among Hum Genet Nov 29. [Epub ahead of print] postmenopausal African-American and Hispanic women in the Women s Health Initiative SHARe Study M Genome-wide association study of body height in African- Hum Mol Genet Feb 1;21(3): doi: Americans: the Women s Health Initiative SNP Health /hmg/ddr489. Epub 2011 Oct 21 Association Resource (SHARe) M Replication of breast cancer GWAS susceptibility loci in the Cancer Epidemiol Biomarkers Prev Sep;20(9):1950- Women's Health Initiative African American SHARe study 9. Epub 2011 Jul 27 R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 12 of 47

13 M Association of DXA-derived bone mineral density and fat J Clin Endocrinol Metab Feb 22. [Epub ahead of mass with African ancestry print] M African American race but not genome-wide ancestry is Am Heart J Sep;166(3): e1. doi: negatively associated with atrial fibrillation among /j.ahj Epub 2013 Aug 7. postmenopausal women in the Women's Health Initiative AS264, 1157 The impact of ancestry and common genetic variants on QT Circ Cardiovasc Genet Dec 1;5(6): Epub M5 interval in African Americans 2012 Nov 19 AS264, 1160 Common genetic variation near the connexin-43 gene is Heart Rhythm Nov 24. pii: S (12) M5 associated with resting heart rate in African Americans: A doi: /j.hrthm [Epub ahead of print] genome-wide association study of 13,372 participants M Genome-wide association study of white blood cell count in PLoS Genet Jun;7(6):e Epub 2011 Jun 30 16,388 African Americans: the Continental Origins and Genetic Epidemiology Network (COGENT) AS264, 1199 Novel loci associated with PR interval in a genome-wide Circ Cardiovasc Genet Dec 1;5(6): Epub M5 association study of 10 African American cohorts 2012 Nov 8 M Combined admixture mapping and association analysis Hum Mol Genet Mar 21. [Epub ahead of print] identifies a novel blood pressure genetic locus on 5p13: Contributions from the CARe consortium M Association of genetic variation with systolic and diastolic Hum Mol Genet Apr 1. [Epub ahead of print] blood pressure among African Americans: the Candidate Gene Association Resource (CARe) Study M Estimating kinship in admixed populations. Am J Hum Genet Jul 13;91(1): Epub 2012 Jun 28 M Replication of loci influencing ages at menarche and Hum Mol Genet Mar 15;21(6): doi: menopause in Hispanic women: the Women s Health /hmg/ddr570. Epub 2011 Nov 30 Initiative SHARe study M A meta-analysis and genome-wide association study of PLoS Genetics Mar;8(3):e Epub 2012 Mar 8 platelet count and mean platelet volume in African Americans R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 13 of 47

14 M A gene-centric association scan for Coagulation Factor VII Hum Mol Genet Jun 15. [Epub ahead of print] levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium M Genome-wide association analysis of incident coronary heart PLoS Genet Aug;7(8):e Epub 2011 Aug 4 disease (CHD) in African-Americans: A short report M5, M Genotype imputation of metabochip SNPs using a study- Genet Epidemiol Feb;36(2): specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health Initiative M Smoking and genetic risk variation across populations of Genet Epidemiol May;36(4): European, Asian, and African American ancestry - a metaanalysis of chromosome 15q25 M Identification, replication, and fine-mapping of loci PLoS Genet Oct;7(10):e doi: associated with adult height in individuals of African ancestry /journal.pgen Epub 2011 Oct 6 M A novel variational Bayes multiple locus Z-statistic for Bioinformatics May 4. [Epub ahead of print] genome-wide association studies with Bayesian model averaging M Genome-wide characterization of shared and distinct genetic Am J Hum Genet May 29. pii: S0002- components that influence blood lipid levels in ethnically 9297(13) [Epub ahead of print] diverse human populations M Genome-wide association and population genetic analysis of Am J Hum Genet Sep 7;91(3): doi: C-reactive protein in African American and Hispanic /j.ajhg Epub 2012 Aug 30 American women M A genome-wide association study of breast cancer in women Hum Genet Jan;132(1): doi: /s of African ancestry y. Epub 2012 Aug 25 M A meta-analysis identifies new loci associated with body Nat Genet Apr 14. [Epub ahead of print] mass index in individuals of African ancestry M Generalization of adiposity genetic loci to US Hispanic Nutr Diabetes Aug 26;3:e85. women R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 14 of 47

15 M6 - Population Architecture of Genes and Environment (PAGE) M Associations between incident ischemic stroke events and Circ Cardiovasc Genet Mar 8. [Epub ahead of print] stroke and cardiovascular disease-related GWAS SNPs in the Population Architecture Using Genomics and Epidemiology (PAGE) Study M Association of genetic variants and incident coronary heart Circ Cardiovasc Genet Dec 1;4(6): Epub disease in multiethnic cohorts: The PAGE Study 2011 Oct 31 M The next PAGE in understanding complex traits: Design for Am J Epidemiol Aug 11. [Epub ahead of print] the analysis of population architecture using genetics and epidemiology (PAGE) study M Genetic determinants of lipid traits in diverse populations PLoS Genet Jun;7(6):e Epub 2011 Jun 30 from the Population Architecture using Genomics and Epidemiology (PAGE) Study M Evaluation of the metabochip genotyping array in African PLoS One. 2012;7(4):e Epub 2012 Apr 23. Americans and implications for fine mapping of GWASidentified loci: the PAGE study M Consistent directions of effect for established type 2 Diabetes Jun;61(6): Epub 2012 Apr 3 diabetes risk variants across populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium M Fine-mapping and initial characterization of QT interval loci PLoS Genet. 2012;8(8):e doi: in African Americans /journal.pgen Epub 2012 Aug 9 M HNF1B and endometrial cancer risk: Results from the PLoS ONE Jan 27;7(1):e30390 PAGE study M Boosting for detection of gene-environment interactions Stat Med Jul 5. [Epub ahead of print] M Genetic risk factors for body mass index and obesity in an Obesity (Silver Spring) Jun 22. [Epub ahead of ethnically diverse population: results from the Population print] Architecture using Genomics and Epidemiology (PAGE) Study R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 15 of 47

16 M5, M Genotype imputation of metabochip SNPs using a study- Genet Epidemiol Feb;36(2): specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health Initiative M Genetic variation and reproductive timing: African American PLoS ONE 8(2): e Feb. women from the Population Architecture Using Genomics and Epidemiology (PAGE) Study M Investigation of gene-by-sex interactions for lipid traits in BMC Genet May 1;14:33. doi: / diverse populations from the population architecture using genomics and epidemiology study AS224, 1689 Pleiotropic effects of genetic risk variants for other cancers Gut Aug 9. doi: /gutjnl [Epub M6 on colorectal cancer risk: PAGE, GECCO and CCFR ahead of print] consortia. Gut Aug 9. doi: /gutjnl [Epub ahead of print] M Genetic variants associated with fasting glucose and insulin BMC Med Genet Sep 25;14(1):98. [Epub ahead of concentrations in an ethnically diverse population: results print] from the Population Architecture using Genomics and Epidemiology (PAGE) Study M Replication of genetic loci for ages at menarche and Hum Reprod March 18. [E-pub ahead of print] menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study M Post-Genome-Wide Association Study challenges for lipid Ann Hum Genet Jun 28. [Epub ahead of print] traits: describing age as a modifier of gene-lipid associations in the Population Architecture Using Genomics and Epidemiology (PAGE) Study R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 16 of 47

17 M13 - GWAS of hormone treatment and CVD and metabolic outcomes in the WHI (GARNET) M A genome-wide association meta-analysis of circulating sex PLoS Genet. 2012;8(7):e Epub 2012 Jul 19. hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. M24 - Large-scale DNA sequencing and molecular profiling of well-phenotyped NHLBI cohorts M Evolution and functional impact of rare coding variation Science Jul 6;337(6090):64-9. Epub 2012 May 17 from deep sequencing of human exomes M Imputation of exome sequence variants into population- Am J Hum Genet Nov 2;91(5): doi: based samples and blood-cell-trait-associated loci in African /j.ajhg Epub 2012 Oct 25 Americans: NHLBI GO Exome Sequencing Project. M Analysis of 6,515 exomes reveals a very recent origin of Nature Jan 10;493(7431): doi: most human /nature Epub 2012 Nov 28 protein-coding variants BAA1 - Ancestry association analyses of WHI traits AS153, 964 Stronger bone correlates with African admixture in African J Bone Miner Res May 16. doi: /jbmr.430. BAA1 American women [Epub ahead of print] BAA Relationship between adiposity and admixture in African- Int J Obes (Lond) Apr 12. [Epub ahead of print] American and Hispanic-American women BAA Relationship between hypertension and admixture in post- J Hum Hypertens May 26. [Epub ahead of print] menopausal African American and Hispanic American Women BAA Relationship between diabetes risk and admixture in Diabetologia Feb 10. [Epub ahead of print] postmenopausal African American and Hispanic American women BAA Relationship between gallbladder surgery and ethnic Am J Gastroenterol Jun;107(6): doi: admixture in African American and Hispanic American /ajg Epub 2012 Mar 13. women R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 17 of 47

18 BAA Relationship between hysterectomy and admixture in Am J Obstet Gynecol Jan 17. pii: S0002- African American women 9378(13) doi: /j.ajog [Epub ahead of print] BAA2 - High-dimensional genotype in relation to breast cancer and WHI clinical trial interventions BAA2 846 Variation in the FGFR2 gene and the effects of Cancer Epidemiol Biomarkers Prev postmenopausal hormone therapy on invasive breast cancer Nov;18(11): Epub 2009 Oct 27 BAA Variation in the FGFR2 gene and the effect of a low-fat Cancer Epidemiol Biomarkers Prev Jan;19(1):74-9. dietary pattern on invasive breast cancer BAA Assessment of clinical validity of a breast cancer risk model J Natl Cancer Inst Oct 18. [Epub ahead of print] combining genetic and clinical information BAA Genetic variants in the MRPS30 region and postmenopausal Genome Med Jun 24;3(6):42. [Epub ahead of print] breast cancer risk BAA2, 1104 Pooled versus individual genotyping in a breast cancer Genet Epidemiol Sep;34(6): M3, W7 genome-wide association study BAA4 - Proteomics and the health effects of postmenopausal hormone therapy BAA4, W Novel proteins associated with risk for coronary heart Genome Med Jul 28;2(7):48. [Epub ahead of print] disease or stroke among postmenopausal women identified by in-depth plasma proteome profiling BAA5 - Identification and validation of circulating biomarkers for the early detection of breast cancer in pre-clinical specimens BAA Detection of elevated plasma levels of epidermal growth Cancer Res Nov 1;70(21): Epub 2010 Oct factor receptor before breast cancer diagnosis among 19. hormone therapy users AS316, 1782 Discovery and preliminary confirmation of novel early Breast Cancer Res Treat Sep;135(2): doi: BAA5 detection biomarkers for triple-negative breast cancer using /s Epub 2012 Aug 19 preclinical plasma samples from the Women's Health Initiative observational study R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 18 of 47

19 BAA Autoantibody signatures involving glycolysis and Cancer Res Mar 1;73(5): Epub 2012 Dec 26 splicesome proteins precede a diagnosis of breast cancer among postmenopausal women BAA7 - Endogenous estradiol and the effects of estrogen therapy on major outcomes of WHI BAA7, W Sex hormone levels and risk of breast cancer with estrogen J Natl Cancer Inst Sep 16. [Epub ahead of print] plus progestin AS110, 1218 Age, body mass, usage of exogenous estrogen, and lifestyle Clin Chem Sep 18. [Epub ahead of print] AS167, factors in relation to circulating sex hormone-binding globulin AS90, concentrations in postmenopausal women BAA21, BAA7, BAA9, W10, W18, W5, W9 BAA8 - Predictive value of nutrient biomarkers for CHD death BAA Dietary patterns are associated with disease risk among J Nutr Feb;142(2): Epub 2011 Dec 21 participants in the Women s Health Initiative Observational Study BAA9 - Biochemical antecedents of fracture in minority women BAA9 841 Serum 25 hydroxyvitamin (OH)D and clinical fracture risk in J Bone Miner Res Jun 27. doi: /jbmr.449. a multiethnic cohort of women: The Women's Health [Epub ahead of print] Initiative (WHI) BAA9 863 Renal function and nonvertebral fracture risk in multiethnic Osteoporos Int May 28. [Epub ahead of print] women: the Women's Health Initiative (WHI) BAA9, W8 945 Higher biomarker-calibrated protein intake is not associated J Nutr Aug;141(8): Epub 2011 Jun 8. with impaired renal function in postmenopausal women R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 19 of 47

20 AS110, 1218 Age, body mass, usage of exogenous estrogen, and lifestyle Clin Chem Sep 18. [Epub ahead of print] AS167, factors in relation to circulating sex hormone-binding globulin AS90, concentrations in postmenopausal women BAA21, BAA7, BAA9, W10, W18, W5, W9 BAA10 - Adipokines and risk of obesity-related diseases BAA Resistin, but not adiponectin and leptin, is associated with Stroke May 5. [Epub ahead of print] the risk of ischemic stroke among postmenopausal women BAA Hepatocyte growth factor and the risk of ischemic stroke Stroke May;41(5): Epub 2010 Mar 4 developing among postmenopausal women. Results from the Women's Health Initiative BAA Adipokines linking obesity with colorectal cancer risk in Cancer Res Jun 15;72(12): Epub 2012 Apr postmenopausal women 17 BAA A prospective study of inflammation markers and Cancer Epidemiol Biomarkers Prev Mar 17. [Epub endometrial cancer risk in postmenopausal hormone non- ahead of print] users BAA Hepatocyte growth factor and clinical diabetes in Diabetes Care June 2. [Epub ahead of print] postmenopausal women AS152, 1507 The aromatase gene (CYP19A1) variants and circulating PLoS One. 2012;7(7):e Epub 2012 Jul 25 AS192, hepatocyte growth factor in postmenopausal women BAA10 BAA11 - Physical activity, obesity, inflammation and CHD in a multi-ethnic cohort of women BAA Physical activity and inflammation in a multiethnic cohort of Med Sci Sports Exerc Jun;44(6): doi: women /MSS.0b013e318242b11a R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 20 of 47

21 BAA12 - Hormone therapy, estrogen metabolism and risk of breast cancer or hip fracture in the WHI hormone trial BAA Hormone therapy, estrogen metabolism, and risk of breast Cancer Epidemiol Biomarkers Prev Aug 29. [Epub cancer in the Women s Health Initiative Hormone Therapy ahead of print] Trial BAA13 - Markers of B-cell stimulation as potential predictors of Non-Hodgkins lymphoma BAA Investigation of Epstein-Barr virus as a potential cause of B- Cancer Epidemiol Biomarkers Prev Jul 24. [Epub cell non-hodgkin lymphoma in a prospective cohort ahead of print] BAA Markers of b-cell activation in relation to risk of non- Cancer Res Sep 15;72(18): Epub 2012 Jul 30 Hodgkin lymphoma BAA14 - Inflammation and thrombosis gene pathways and cardiovascular disease BAA Loci influencing blood pressure identified using a Hum Mol Genet Apr 15;22(8): doi: cardiovascular gene-centric array /hmg/dds555. Epub 2013 Jan 8 BAA The interleukin-6 receptor as a target for prevention of Lancet Mar 13. [Epub ahead of print] coronary heart disease: a mendelian randomisation analysis BAA Gene-centric meta-analyses of 108,912 individuals confirm Hum Mol Genet Jan 1;22(1): Epub 2012 known body mass index loci and reveal three novel signals Sep 21 BAA18 - Follow-up studies of genetically determined risk factors BAA OPG and srankl serum levels and incident hip fracture in Bone Jun 2. pii: S (13) [Epub postmenopausal Caucasian women in the Women's Health ahead of print] Initiative Observational Study BAA19 - Omega-3 fatty acid biomarkers and cognitive decline in WHIMS AS103, 1259 Omega-3 fatty acids and domain-specific cognitive aging: Neurology Sep 25. [Epub ahead of print] BAA19 Secondary analyses of data from WHISCA AS39, 1558 Correcting the effects of -20 C storage and aliquot size on Lipids Sep;47(9): Epub 2012 Jul 11 BAA19 erythrocyte fatty acid content in the Women's Health Initiative R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 21 of 47

22 BAA20 - Evaluation of specific markers of rheumatoid arthritis, inflammation, thrombogenesis and risk of cardiovascular disease and total BAA Predictive value of autoantibody testing for validating self- Am J Epidemiol Mar 13. [Epub ahead of print] reported diagnoses of rheumatoid arthritis in the Women s Health Initiative BAA21 - Understanding the role of sex hormones in colorectal cancer AS129, 1173 Quantifying mediating effects of endogenous estrogen and Cancer Epidemiol Biomarkers Prev May 7. [Epub AS167, insulin in the relation between obesity, alcohol consumption ahead of print] BAA21 and breast cancer AS110, 1218 Age, body mass, usage of exogenous estrogen, and lifestyle Clin Chem Sep 18. [Epub ahead of print] AS167, factors in relation to circulating sex hormone-binding globulin AS90, concentrations in postmenopausal women BAA21, BAA7, BAA9, W10, W18, W5, W9 BAA22 - Predictive modeling for CVD in a multiethnic cohort in women BAA Comparison of the Framingham and Reynolds Risk Scores 2012 Apr 10;125(14): , S1-11. Epub 2012 Mar 7 for global cardiovascular risk prediction in the multiethnic Women s Health Initiative BAA Clinical utility of lipoprotein-associated phospholipase A2 Clin Chem Aug 2. [Epub ahead of print] for cardiovascular disease prediction in a multiethnic cohort of women BAA Concordant release of glycolysis proteins into the plasma Cancer Res Feb 24. [Epub ahead of print] preceding a diagnosis of ER+ breast cancer R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 22 of 47

23 AS9 - Oral bone loss AS9 72 Postmenopausal bone loss and its relationship to oral bone Periodontol. 2000; June23(1): loss AS11 - Validation and exploration of sleep and mood predictors AS11 43 Sleep complaints of postmenopausal women Clin J Womens Health. 2001;1(5): AS Ethnicity, sleep, mood, and illumination in postmenopausal BMC Psychiatry Apr 7;4:8 women AS Mortality related to actigraphic long and short sleep Sleep Med Sep 24. [Epub ahead of print] AS Relationships among dietary nutrients and subjective sleep, Sleep Med Feb;11(2): Epub 2009 Dec 14 objective sleep, and napping in women AS Light exposure is related to social and emotional functioning Psychiatry Res Jun 30;143(1): Epub 2006 and to quality of life in older women May 24 AS Circadian sleep, illumination, and activity patterns in Physiol Behav Jan;68(3): women: influences of aging and time reference AS Short version of the CES-D (Burnam screen) for depression Psychiatry Res Sep 20;103(2-3): in reference to the structured psychiatric interview AS Evening light exposure: implications for sleep and depression J Am Geriatr Soc Apr;50(4):738-9 AS Association of morning illumination and window covering Sleep and Biological Rhythms. 2004;2: with mood and sleep among postmenopausal women AS Self-reported sleep latency in postmenopausal women J Korean Med Sci 2007;22: AS15 - The relationship between osteopenia and periodontitis AS Association of dopamine genotypes with physical activity Medicine & Science in Sports & Exercise 39(5 Suppl):S376 and body habitus in post-menopausal women (2007) AS Intraindividual variation in plasma 25-hydroxyvitamin D Cancer Epidemiol Biomarkers Prev Apr 20. [Epub measures 5 years apart among postmenopausal women ahead of print] R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 23 of 47

24 AS Associations between smoking and tooth loss according to J Am Dent Assoc Mar;144(3): the reason for tooth loss: the Buffalo OsteoPerio Study AS36 - HRT and changes in mammographic density AS Estrogen-plus-progestin use and mammographic density in J Natl Cancer Inst Sep 21;97(18): postmenopausal women: Women's Health Initiative randomized trial AS Conjugated equine estrogen influence on mammographic J Clin Oncol Dec 20;27(36): Epub 2009 density in postmenopausal women in a substudy of the Nov 9 Women s Health Initiative Randomized Trial AS Dietary vitamin D and calcium intake and mammographic Menopause Jul 7. [Epub ahead of print] density in postmenopausal women AS Breast tenderness after initiation of conjugated equine Breast Cancer Res Treat Feb;131(3): Epub estrogens and mammographic density change 2011 Oct 7 AS39 - Women's Health Initiative Memory Study (WHIMS) AS39 60 The Women's Health Initiative Memory Study (WHIMS): Control Clin Trials Dec;19(6): A trial of the effect of estrogen therapy in preventing and slowing the progression of dementia AS Baseline experience with Modified Mini Mental State Exam: Aging Ment Health May;7(3): The Women's Health Initiative Memory Study (WHIMS) AS the effect of hypertension and baseline blood pressure on J Am Geriatr Soc Aug;56(8): Epub 2008 Jul cognitive decline and dementia in postmenopausal women: 15 The Women's Health Initiative Memory Study AS Estrogen plus progestin and the incidence of dementia and JAMA May 28;289(20): mild cognitive impairment in postmenopausal women: the Women s Health Initiative Memory Study: A randomized controlled trial R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 24 of 47

25 AS Effect of estrogen plus progestin on global cognitive function JAMA May 28;289(20): in postmenopausal women: the Women's Health Initiative Memory Study: A randomized controlled trial AS Association between reported alcohol intake and cognition: Am J Epidemiol Feb 1;161(3): Results from the Women's Health Initiative Memory Study AS Conjugated equine estrogens and global cognitive function in JAMA Jun 23;291(24): postmenopausal women: Women's Health Initiative Memory Study AS Conjugated equine estrogens and incidence of probable JAMA Jun 23;291(24): dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study AS Interaction between body mass index and central adiposity J Am Geriatr Soc Jan;59(1): and risk of incident cognitive impairment and dementia: Results from the Women's Health Initiative Memory Study AS Benchmarks for designing two-stage studies using modified Clin Trials. 2006;3(2): mini-mental state examinations: Experience from the Women s Health Initiative Memory Study AS Identifying risk factors for cognitive change in the Women's In: Hogervorst E, Henderson VW, Gibbs RB, Brinton RD, Health Initiative Memory Study: a neural networks eds. Hormones, Cognition and Dementia. New York, NY: approach Cambridge University Press, 2009:11-24 AS Subtypes of mild cognitive impairment in older Alzheimer Dis Assoc Disord May 13. [Epub ahead postmenopausal women: The Women's Health Initiative of print] Memory Study AS The relationship between cognitive function and physical J Gerontol A Biol Sci Med Sci Mar;65(3): performance in older women: Results from the Women's Epub 2009 Sep 29. Health Initiative Memory Study AS Psychiatric disorders and cognitive dysfunction among older, Am J Geriatr Psychiatry Feb;18(2): postmenopausal women: Results from the Women's Health Initiative Memory Study R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 25 of 47

26 AS Ascertaining dementia-related outcomes for deceased or Int J Geriatr Psychiatry Mar 18. [Epub ahead of proxy-dependent participants: an overview of the Women's print] Health Initiative Memory Study supplemental case ascertainment protocol AS183, 727 Women s Health Initiative Memory Study (WHIMS) In: Hogervorst E, Henderson VW, Gibbs RB, Brinton RD, AS39 Program: Emerging findings eds. Hormones, Cognition and Dementia. New York, NY: Cambridge University Press, 2009:1-10 AS Women's cognitive health: Postmenopausal dementia and the Womens Health Issues May-Jun;14(3):71-4 Women's Health Initiative Memory Study AS183, 883 Postmenopausal hormone therapy and cognitive outcomes: J Steroid Biochem Mol Biol Feb 28;118(4-5):304- AS39 the Women s Health Initiative Memory Study 310. Epub 2009 Nov 22 AS Depressive symptoms and incidence of mild cognitive J Am Geriatr Soc Jan;59(1):57-66 impairment and probable dementia in elderly women: The Women s Health Initiative Memory Study AS103, 1121 Calcium and Vitamin D supplementation and cognitive J Am Geriatr Soc Dec;60(12): doi: AS39, impairment in the Women's Health Initiative /jgs Epub 2012 Nov 23 W15, W24 AS183, 1150 Cognitive function and retinal and ischemic brain changes: Neurology Mar 14. [Epub ahead of print] AS39, AS62 The Women s Health Initiative AS Depressive symptoms, antidepressant use, and future Int Psychogeriatr Feb 3:1-13. [Epub ahead of print] cognitive health in postmenopausal women: the Women's Health Initiative Memory Study AS39, 1558 Correcting the effects of -20 C storage and aliquot size on Lipids Sep;47(9): Epub 2012 Jul 11 BAA19 erythrocyte fatty acid content in the Women's Health Initiative AS62 - Prevention of age-related maculopathy in the WHI HRT CT: WHI-SE AS Hormone therapy and age-related macular degeneration: The Arch Ophthalmol Jul;124(7): Women's Health Initiative Sight Exam Study R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 26 of 47

27 AS Cardiovascular disease, its risk factors and treatment, and Am J Ophthalmol Mar;143(3): Epub 2007 age-related macular degeneration: Women's Health Initiative Jan 10 Sight Exam ancillary study AS183, 1150 Cognitive function and retinal and ischemic brain changes: Neurology Mar 14. [Epub ahead of print] AS39, AS62 The Women s Health Initiative AS70 - The prevalence and prognostic importance of myocardial ischemia during daily life, and its relationship to migraine status: WHI AS Prevalence and correlates of panic attacks in Arch Intern Med Sep 22;163(17): postmenopausal women: Results from an ancillary study to the Women s Health Initiative AS Panic attacks, daily life ischemia, and chest pain in Psychosom Med Nov-Dec;68(6): Epub 2006 postmenopausal women Nov 13 AS75 - Adherence to dietary modification in the WHI AS Influences on older women's adherence to a low-fat diet in Psychosom Med May-Jun;64(3):450-7 the Women's Health Initiative AS83 - Thrombotic, inflammatory and genetic markers for coronary heart disease in postmenopausal women: a WHI umbrella study AS Inflammatory biomarkers, hormone replacement therapy, JAMA Aug 28;288(8):980-7 and incident coronary heart disease: Prospective analysis from the Women's Health Initiative observational study AS Tissue plasminogen activator antigen and D-dimer as Circulation Jul 20;110(3): Epub 2004 Jul 6 markers for atherothrombotic risk among healthy postmenopausal women AS84 - Estrogen, vitamin E and cognitive change in women AS Serum alpha-tocopherol, concurrent and past vitamin E Neurology Feb 27;68(9):670-6 intake, and mild cognitive impairment R:\Committees\P&P\PROGRESS\2013\2013 Reports Page 27 of 47