Diabetologia 9 Springer-Verlag 1983
|
|
- Randolf Harris
- 5 years ago
- Views:
Transcription
1 Dabetologa (1983) 24: Dabetologa 9 Sprnger-Verlag 1983 Role of Glucose and nsuln n the Dynamc Regulaton of Glucagon Re by the Perfused Rat Pancreas V. Leclercq-Meyer, J. Marchand andw. J. Malasse Laboratory of xpermental Medcne, Free Unversty of Brussels, Brussels, Belgum Summary. The effect of glucose upon the re of glucagon and nsuln from the perfused rat pancreas n vtro was studed by varyng both the concentraton of glucose (from 3.3 to 4.6, 8.5, or 11.1 mmol/1) and the tme of exposure to an elevated concentraton of the sugar (5, 10 or 23 ran). The results suggest that the amount of nsuln red durng the early perod of stmulaton could contrbute to both the speed and extent of the nhbton n glucagon re. The rate of recovery from nhbton n the A cell, however, appeared to be ndependent of nsuln and was related, n a dose-dependent and tme-dependent manner, only to the glucose stmulus. t s suggested that a drect effect of glucose upon the A cell s nvolved n the physologcal regulaton of glucagon secreton. An ndrect effect of glucose, as medated va nsuln re, may contrbute to the rapdty and magntude of nhbton n A cell secretory actvty. Key words. Glucose, rat, glucagon re, nsuln re, perfused rat pancreas. The secretory responsveness of the pancreatc A cell to glucose [1-5] s apparently altered n dabetes melltus, snce both the suppresson of glucagon re by glucose and ts stmulaton n response to hypoglycaema are mpared [1, 2, 6]. Several explanatons have been proposed to account for such anomales, ncludng the lack of nsuln n the perpheral crculaton or wthn the slets [2, 7, 8], a dsrupton of the normal topographcal relatonshp between dfferent cell types n the slets [7, 8], an ntrnsc A cell defect at the level of ether a hypothetcal glucoreceptor [9] or the metabolsm of glucose [10], or autonomc neuropathy [11]. t should be realzed, however, that a delayed secretory response of the A cell to a decrease n extracellular glucose concentraton may also occur n the absence of dabetes, e.g. when the extracellular glucose level n vtro s suddenly lowered after a pror exposure of normal pancreatc tssue to a hgh concentraton of the sugar [4, 12-16] or n vvo towards the end of an oral or ntravenous glucose tolerance test [17-20]. n the present study we have nvestgated whether the magntude and duraton of changes n the extracellular glucose concentraton affect the rapdty and extent of the A cell secretory response. For ths purpose the dynamcs of glucagon re by the normal rat pancreas were examned n vtro n response to changes of varable ampltude and duraton n the glucose concentraton of the perfusate. Materal and Methods Anmals and Technque The technque used to perfuse the rat pancreas has been descrbed prevously [12]. Brefly, fed female albno rats (Wstar or Sprague- Dawley strans; mean _+ SM body weght: 273 _+ 5 g; n = 32) were anaesthetzed wth sodum barbtal (42 mg/kg, P). The entre pancreas was perfused through the coelac and mesenterc arteres va a cannula nserted nto the aorta, all adjacent organs, ncludng the duodenum, beng excluded. MeNo~ The basal medum contaned (n mmol/1) NAC1:118.5, KC1:4.7, KH2PO4:1.2, MgSO4:1.2, CaC2: 2, NaHCO3 : 25 and glucose: 3.3. t was supplemented wth dextran T70, 40g/1 (Pharmaca, Uppsala, Sweden) and bovne albumn fracton V, 5 g/l, (Sgma Chemcals, St. Lous, USA or Armour, astbourne, UK). t was equlbrated aganst a mxture of 02 and CO2 (95: 5), and entered the pancreas wth a ph of 7.4 and a temperature of 37~ The flow rate averaged 1.98_ ml/mn (n = 32) and the pressure amounted to 27.9 _+ 1.0 mmhg ( kpa; n = 32). The glucose pulses were admnstered through sde-arm syrnges workng at a flow rate of ml/mn (Braun nfuson pump, Melsungen, FRG). n a frst seres of experments, glucose was admnstered n hgh concentraton for ether 23 mn, 10 mn or only 5 mn. n the latter case the concentraton of glucose, whch was ntended to be 11.1 mmol/l, only reached that of 8.5 mmol/1 due to the dynamcs of our perfuson system. n a second seres of experments, the concentraton of glucose vared n a narrow range from 3.3 to 4.6 mmol/1, the latter concentraton beng mantaned for 23 ran. Durng the pre- and post-stmulatory perods, the osmolarty of the medum was adjusted to that obtaned n the presence of glucose by the nfuson of an equosmolar amount of NaC.
2 192 no7 A n=4 B n:: V. Leclercq-Meyer C et al.: Glucose, nsuln and Glucagon Re [ --::: 52 T t311 C " t- O 1.5,5 = c- O 1.0 O,5 ~ Tme (ran) _ J L... / L l L Fg. 1. ffects of glucose, admnstered at a hgh (up to 11.1 mmol/1; A and C) or a low concentraton (up to 4.6 mmol/1; B) and for dfferent lengths of tme (23 ran n A and B, 10 mn n C), upon the re of glucagon and nsuln from the perfused rat pancreas. Results are shown as mean _+ SM, together wth the number of ndvdual experments (n) t} o "-. l J, ~ , =' 5 ~ a 4 o 0.4 u 0.2 l '-", t [ Tme (ran) Fg.2. ffects of a short (5 mn) pulse of glucose upon the re of glucagon and nsuln from the perfused rat pancreas (= =, n = 9). Also shown are the results of control experments performed n the presence of 3.3 mmol/1 glucose throughout (o o, n = 7). Same presentaton as n Fg. 1 Samples of the pancreatc effluent were collected, wthout recyclng, at 1 mn ntervals n chlled glass tubes contanng KU aprotnn (Trasylol, Bayer, Brussels, Belgum) and frozen at -25 ~ untl the tme of assay. Glucagon and nsuln levels were estmated usng ndvdual assays for these hormones [21]. n the glucagon assay, the 125-glucagon tracers were obtaned from several sources (Centre Natonal de Transfuson Sangune, Pars, France; New ngland Nuclear, Boston, USA; Novo, Bagsvaerd, Denmark). Porcne glucagon (Novo) was used as the standard and a N- or C-termnal antbody from our laboratory was employed (AGS and 2601, respectvely)9 nsuln was estmated usng 125-nsuln (lnsttut Natonal des Radoelements, Fleurus, Belgum or Radochemcal Centre, Amersham, UK), a gunea-pg ant-nsuln serum (a gft from Dr. P. H. Wrght, ndanapols, USA) and rat nsuln standard R170 (a gft from Dr. J. Sehlchtkrull, Novo). n the case of glucagon, t mght be noted that the basal rates of glucagon re (. e. those observed at 3.3 mmol/1 glucose) were about fve tmes greater n our earler experments (performed n 1979; Fgs 1 and 3) than n the more recent perfusons (performed n 1980M 981 ; Fg. 2). The reasons for such a quanttatve dfference were not found. Glucose was assayed n the pancreatc effluent wth a glucose-oxdase method (GOD-PAP, Boehrnger, Mannhem, FGR) usng an AA- Techncon analyzer. Statstcal Analyss The results are presented as mean_+ SM together wth the number of ndvdual determnatons (n). ntegrated glucagon and nsuln re durng each secretory phase and the amount of glucose whch had perfused the pancreas were computed from the areas under the curves. The separaton between the early and late phases of nsuln re was judged from the lowest secretory rate recorded alter the ntal peak. n each ndvdual experment, the magntude of the nhbtory effect of glucose upon glucagon output was calculated by comparng the last measurement durng the control perod (ran 43) and the mean steady-state value reached durng exposure to the hgher concentraton of glucose. The latter value was computed between mnute 46 and ether mnute 50 (5 ran stmulaton), mnute 54 (10 mn stmulaton) or mnute 67 (23 ran stmulaton) nclusve when the glucose concentraton was rased from 3.3 to 8.5 mmol/1 or more, and between mnutes 50 and 67 when the glucose concentraton was rased for 23 mn from 3.3 to only 4.6 mmol/1. The tme requred to reach a steady-state glucagon output was estmated by graphcal examnaton of each ndvdual experment. Ths method was valdated by the fact that the concentraton of glucagon n the frst sample consdered as representatve of the new equlbrum stage was much lower than that found n the mmedately precedng sample. ndeed, the pared dfference n glucagon output between these two samples averaged % (geometrc mean; n = 24; p < 0.001) of the correspondng mean stcady-state value recorded durng exposure to the hgh concentraton of glucose. Statstcal analyses were conducted usng the two-taled non-pared t-test and the correlaton coeffcent r [22].
3 V. Leclercq-Meyer et al.: Glucose, nsuln and Glucagon Re 193 Table 1. ffect of glucose upon glucagon and nsuln re by the perfused rat pancreas. Glucose Glucagon re nsuln re Maxmal Length of Total amount Degree of Rapdty of concentraton admnstraton perfused nhbton nhbton (mmol/1) (mn) (mmol) (%) (ran) arly phase (ng) Late phase (ng) Total (early + late phase) (rg) (7) ~ _0.1(9) : _ _ _3 Results expressed as mean +- SM; number of ndvdual experments shown n parentheses 2.OF >20 ' ' l, l l,, r r r ~6._ ~ v U 1.0- = [ Q...,, ~.Or J ~ , 9 : Tme (mn) ,..o,."" o Q; 5 m 0 U Fg,3. Dynamcs of the varatons n the concentraton of glucose (o... o), glucagon (0 0) and nsuln (o o) n the pancreatc effluent durng the early mnutes of the admnstraton of glucose. Mean values refer to 11 (left panel) and 4 (rght panel) ndvdual experments respectvely Results Tme- and Dose-Dependent nhbton of Glucagon Re The rse n the concentraton of glucose resulted n an nhbton of glucagon re n all experments (Fgs. 1 and 2). Such an nhbton was least marked when the output of nsuln durng the early mnutes of the nfuson of glucose was lowest and most marked when the output of nsuln durng the early perod was hghest (Table 1). There was a postve correlaton between the percentage nhbton of glucagon re and ether the peak nsuln concentraton or the amount of nsuln red durng the early perod of stmulaton (Table 2). No correlaton was found wth other varables such as the amount of nsuln red durng the late phase, the total amount of glucose admnstered and the maxmal levels of glucose reached durng the experments. A sgnfcant fall n glucagon output was always observed at mnute 44 ether at the tme when the concentraton of glucose and nsuln n the effluent were frst ncreased or 1 ran later (Fg. 3). The nhbton of glucagon re never preceded the stmulaton of nsuln re. t clearly took less tme to acheve a new steady-state level of glucagon secreton when the concentraton of glucose was ncreased to > 8.3 mmol/1 than n response to a more modest ncrease n glucose concentraton (Table 1, p < 0.001). There were sgnfcant correlatons between the rapdty of the nhbton of glucagon secreton and both the amount of nsuln red durng the early perod of stmulaton and the maxmal levels of glucose reached durng the perfusons (Table 2). Tme- and Dose-Dependent Reversal of the Glucose-nduced nhbton of Glucagon Re The reversal from the glucose-nduced nhbton of glucagon re appeared to be more a tme-dependent than a dose-related phenomenon. Thus, when glucose was admnstered for 23 mn, whether at a hgh or a low concentraton, the glucagon secretory rates recorded 15 mn after restoraton of a low glucose concentraton (mnute 80 at the end of the perfuson) amounted to only % and % respectvely of the secretory rates whch had been recorded mmedately before the onset of nhbton of glucagon secreton (mnute 43). On the other hand, when glucose was admnstered for shorter tmes (such as 10 or 5 ran) these late secretory rates amounted to % and %, respectvely. These late secretory rates of glucagon re were comparable to those seen towards the end of the perfuson n control experments performed throughout n the presence of a fxed 3.3 mmol/1 glucose concentraton (Fg. 2). There was a sgnfcant nverse correlaton between the rate of reversal from the glucose-nduced nhbton of glucagon re and the tme of exposure
4 194 V. Leclercq-Meyer et al.: Glucose, nsuln and Glucagon Re Table2. The correlaton between selected varables n ndvdual experments Part Varables r t p 1 nhbton of glucagon re (%) Versus early phase of nsuln < 0.01 re Versus early peak n nsuln re < 0.01 Versus late phase of nsuln re NS Versus early + late phases of NS nsuln re Versus total amount of glu NS cose admnstered Versus maxmal glucose level NS 2 Rapdty of the nhbton of glucagon re Versus early phase of nsuln < 0.05 re Versus early peak n nsuln re < 0.05 Versus maxmal glucose level < Percent reversal of the nhbton of glucagon re Versus early + late phases of NS nsuln re Versus total amount of glu < 0.05 cose admnstered Versus maxmal glucose level NS Versus tme of exposure to < 0.01 hgh glucose Twenty-four experments were performed n all cases to the glucose stmulus (Table 2). A somewhat lower correlaton was found between the rate of reversal and the total amount of glucose whch had perfused the pancreas (Table 2). The lesser sgnfcance of the latter relatonshp was corroborated by the observaton that an extensve reversal ether occurred (Fg. 1 C) or faled to do so (Fg. 1 B) although the total amount of glucose nfused through the pancreas n ether 10 or 23 mn was the same (0.26 mmol) n these two sets of experments. Dscusson The results of the present experments confrm that the nhbton of glucagon re by glucose may fal to be rapdly reversed n a normal, non-dabetc, expermental preparaton. Thus, a delayed recovery from nhbton n the A cell s not restrcted to pathologcal condtons. The role of nsuln n medatng the response of the pancreatc A cell to changes n the envronmental glucose concentraton has remaned a matter of debate over many years. On the one hand, t has been postulated that the A cells were devod of ntrnsc glucosesensng capacty, and that the effects of glucose were medated ndrectly, through the glucose-nduced changes n nsuln secreton [2, 7, 8]. On the other, there s evdence that glucagon secreton mght not depend solely on nsuln [1, 6]. The results of the present experments are compatble wth the vew that both glucose and nsuln could be nvolved n the regulaton of glucagon re. The relatve mportance of these two regulatory factors may dffer, however, n the suppresson of glucagon re by glucose and stmulaton of glucagon re n response to hypoglycaema, respectvely. The relatonshps found, between both the extent and the rapdty of the nhbton of glucagon re and the amount of nsuln red durng the early perod of exposure to glucose, are compatble wth the vew, but do not demonstrate, that nsuln s nvolved n the nhbton of A cell secretory actvty n response to an ncrease n glucose concentraton. A causal relatonshp between changes n nsuln and glucagon re respectvely s also compatble wth the observaton that the nhbton of glucagon output dd not precede the stmulaton of nsuln re. Ths s not always the case, glucagon re beng reported to precede nsuln re n response to argnne [23]. Alternatvely, t could be postulated that glucose exerts a drect effect upon the secretory actvty of the A cell. Ths vew s supported by the fndng that nhbton of glucagon re occurred even when nsuln was red at a very low rate. When the concentraton of glucose was ncreased to 4.6 retool/1 for 23 mn, the ntegrated output of nsuln dd not exceed 5.8 ng (or 3.2 mu/1). That glucose can nhbt glucagon re n the vrtual absence of nsuln has been documented prevously by other nvestgators (3, 24-28]. The concept of a dual control of glucagon re by both glucose and nsuln cannot be ruled out. n several studes performed n normal pancreatc tssue, no drect effect of exogenous nsuln upon glucagon re could be observed [24, 28-31]. However, n the presence of glucose, exogenous nsuln was found to decrease glucagon output n pancreatc tssue removed from streptozotocn-treated gunea pgs and rats [31-33]. Recent studes suggest that the transport of glucose [34] and 3-O-methyl-glucose [35] n non-b slet cells occur more slowly than n B cells. Hence, the transport of glucose could represent a rate-lmtng factor for ts metabolsm n the A cell and nsuln could concevably affect glucagon re by facltatng glucose transport. A prolonged nhbton of glucagon re was noted upon the arrest of glucose nfuson n hgh concentraton and for a prolonged perod of tme. Ths confrms prevous work performed wth the perfused rat pancreas [4, 12-14, 16]. The same phenomenon was observed when glucose was admnstered for the same length of tme but n a much lower concentraton. Only when glucose was admnstered for a shorter tme (5-10 mn) dd the glueagon secretory rate return rapdly to levels close to those seen before the glucose nfuson. The more or less rapd reversblty of glucagon re was apparently ndependent of nsuln re and related only to the envronmental glucose concentraton and, even more, to the length of exposure to the sugar. Once agan the relatonshp between the rate of recovery n glucagon output and the magntude and duraton of the prevous glucose admnstraton could concevably depend on the amount of glucose accumulated
5 V. Leclercq-Meyer et al.: Glucose, nsuln and Glucagon Re n the A cell durng ths pror treatment. f so, a greater than twofold ncrease n the length of exposure to glucose (from 10 to 23 mn) would seem to cause a greater accumulaton of glucose than an equal ncrease n the concentraton of the sugar (from 4.6 to 11.1 mmol/1). Ths s not an unrealstc postulate snce the relatonshp between glucose concentraton and glucose transport affects a hyperbolc pattern (tendng to saturaton at hgh glucose concentratons) n those tssues n whch glucose transport s ndeed rate-lmtng, e.g. n muscle. n concluson, the present fndngs emphasze the vew that glucose per se apparently plays a crtcal role n the control of glucagon re whereas the possble ndrect effect of glucose, as medated va nsuln re, appears to play, at the most, a modest modulatng effect on the magntude and rapdty of the nhbtory acton of the sugar. Acknowledgements. Ths work was supported n part by grants and from the Belgan Foundaton for Scentfc Medcal Research. References 1. Gerch J, Charles MA, Grodsky GM (1976) Regulaton of pancreatc nsuln and glucagon secreton. Ann Rev Physol 38: Unger RH, Dobbs R, Orc L (1978) nsuln, glucagon and somatostatn secreton n the regulaton of metabolsm. Ann Rev Physol 40: Gefch J, Charles MA, Grodsky GM (1974) Characterzaton of the effects of argnne and glucose on glucagon and nsuln re from the perfused rat pancreas. J Cln nvest 54: Paglara AS, Stllngs SN, Hover B, Martn D, Matschnsky FM (1974) Glucose modulaton of amno-acd nduced glucagon and nsuln re from the solated perfused rat pancreas. J Cln nvest 54: Wer GC, Knowlton SD, Martn DB (1974) Glucagon secreton from the perfused rat pancreas. Studes wth glucose and catecholamnes. J Cln nvest 54: Reach G, Assan R (1979) Glucagon and dabetes melltus. Dab Mrtab 5: Unger RH, Raskn P, Srkant CB, Orc L (1977) Glucagon and the A cells. Rec Progr Horm Res 33: Unger RH, Orc L (1981) Glucagon and the A-cell. New ngl J Med 304: Gerch J, Langlos M, Noacco C, Karam JH, Forsham PH (1973) Lack of glucagon response to hypoglycema n dabetes: evdence for an ntrnsc alpha cell defect. Scence 182: Day JL, Anderson J (1973) Abnormaltes of glucagon metabolsm n dabetes melltus. Cln ndocr 2: Campbell LV, Kraegen W, Lazarus L (1977) Defectve blood glucose counter-regulaton n dabetcs s a selectve form of autonomc neuropathy. Br Med J 2: Leclercq-Meyer V, Marchand J, Leclercq R, Malasse WJ (1976) Glucagon and nsuln re by the n vtro perfused rat pancreas. nfluence of the collod composton of the perfusate. Dab Mrtab 2: Leclercq-Meyer V, Marchand J, Leclercq R, Malasse WJ (1979) nteractons of a-ketosocaproate, glucose and argnne n the secreton of glucagon and nsuln from the perfused rat pancreas. Dabetologa 17: Wer GC, Clore T, Zmachnsk C J, Bonner-Wer S (1981) slet secreton n a new expermental model for non nsuln-dependent dabetes. Dabetes 30: Coller S, Mandel T, Hoffman L, Caruso G (1981) Organ culture of fetal mouse pancreas. The effect of culture condtons on nsuln and glucagon secreton. Dabetes 30: Frankel B J, Gerch J, Hagura R, Fanska R, Gerrtsen GC, Orodsky GM (1974) Abnormal secreton of nsuln and glucagon by the n vtro perfused pancreas of the genetcally dabetc hamster. J Cln nvest 53: Hedng LG (1971) Radommunologcal determnaton of pancreatc and gut glucagon n plasma. Dabetologa 7: De Fronzo RA, Hendler R, Chrstensen N (1980) Stmulaton of counterregulatory hormonal responses n dabetc man by a fall n glucose concentraton. Dabetes 29: Yamamoto T, Raskn P, Aydn, Unger RH (1979) ffects of nsuln on the response of mmunoreactve glucagon to an ntravenous glucose load n human dabetes. Metabolsm 28: Blackard WJ, Nelson C, Andrews SS (1974) Portal and perpheral ven mmunoreactve glucagon concentratons after argnne or glucose nfusons. Dabetes 23 : Leclercq-Meyer V, Marchand J, Rebolledo O, Malasse WJ, Leclercq R (1975) A combned radommunoassay for glucagon and nsuln. Dabetologa 11 : Snedecor AW, Cochran WG (1967) Statstcal methods, 6th edn. owa Unversty Press, Ames 23. Pek S, Ta TY, Crowther R, Fajans SS (1976) Glucagon re precedes nsuln re n response to common secretagogues. Dabetes 25: Matschnsky FM, Paglara AS, Hover BA, Pace CS, Ferrendell JA, Wllams A (1976) Hormone secreton and glucose metabolsm n slets of Langerhans of the solated perfused pancreas from normal and streptozotocn dabetc rats. J BN Chem 251: Paglara AS, Stllngs SN, Zawalch WS, Wllams AD, Matschnsky FM (1977) Glucose and 3-O-methylglucose protecton aganst alloxan posonng of pancreatc alpha and beta cells. Dabetes 26: Matschnsky FM, Rujanavech C, Paglara AS, Norfleet WT (1980) Adaptatons of a2- and/3-cells of rat and mouse pancreatc slets to starvaton, to refeedng after starvaton and to obesty. J Cln nvest 65: Hermansen K (1981) Pancreatc D-cell recognton of D-glucose. Studes wth D-glucose, D-glyceraldehyde, dhydroxyacetone, D- mannoheptulose, D-fructose, D-galactose and D-rbose. Dabetes 30: Goto Y, Berelowtz M, Frohman LA (1981) Acute effects of alloxan- and streptozotocn-nduced nsuln defcency on somatostatn and glucagon secreton. Dabetologa 20: Paglara AS, Stllngs SN, Haymond MW, Hover BA, Matschnsky FM (1975) nsuln and glucose as modulators of the amno acd-nduced glucagon re n the solated pancreas of alloxan and streptozotocn dabetc rats. J Cln nvest 55 : Hermansen K, Orskov H, Chrstensen S (1979) Streptozotocn dabetes: a glucoreceptor dysfuncton affectng D cells as well as B and A cells. Dabetologa 17: Ostenson C-G (1979) Regulaton of glucagon re: effects of nsuln on the pancreatc Az-cell of the gunea pg. Dabetologa 17: Ostenson C-G, Andersson A, Broln S, Petersson B, Hellerstrrm C (1977) ffects of nsuln on the glucagon re, glucose utlzaton and ATP content of the pancreatc A cells of the gunea pg. n: Fog PP, Bajaj JS, Fol NL (eds) Glucagon: ts role n physology and clncal medcne, Sprnger, New York, Hedelberg, Berln, pp Wer CG, Knowlton SD, Atkns RF, Mc Kennan KX, Martn DB (1976) Glucagon secreton from the perfused pancreas of streptozotocn-treated rats. Dabetes 25 : dahl L-A (1981) Glucose content n the A-cell slets of pgeon pancreas. Dabetologa 21 : (Abstract) 35. Malasse WJ, Gorus FK, Ppeleers DG (1982) Alloxan uptake by pancreatc B and non-b slet cells. Bol Cell 45: 282 (Abstract) Receved: 8 June 1982 and n revsed form: 19 October 1982 Dr. V. Leclercq-Meyer Laboratory of xpermental Medcne Unverst6 Lbre de Bruxelles 115, Boulevard de Waterloo B Brussels, Belgum 195
Interactions of a-ketoisocaproate, Glucose and Arginine in the Secretion of Giucagon and Insulin from the Perfused Rat Pancreas
Dabetologa 17, 121-126 (1979) Dabetologa 9 by Sprnger-Verlag 1979 Interactons of a-ketosocaproate, Glucose and Argnne n the Secreton of Gucagon and Insuln from the Perfused Rat Pancreas V. Leclercq-Meyer,
More informationAiloxan-Induced Alteration of Insulin Release, Rubidium Efflux and Glucose Metabolism in Rat Islets Stimulated by Various Secretagogues
Dabetologa 16, 253-260 (1979) Dabetologa 9 by Sprnger-Verlag 1979 Aloxan-Induced Alteraton of Insuln Release, Rubdum fflux and Glucose Metabolsm n Rat Islets Stmulated by Varous Secretagogues J. C. Henqun,
More information(From the Gastroenterology Division, Cornell University Medical College, New York 10021)
ROLE OF HEPATIC ANION-BINDING PROTEIN IN BROMSULPHTHALEIN CONJUGATION* BY N. KAPLOWITZ, I. W. PERC -ROBB,~ ANn N. B. JAVITT (From the Gastroenterology Dvson, Cornell Unversty Medcal College, New York 10021)
More informationDiabetologia 9 Springcr-Verlag 1988
Dabetologa (1988) 31 : 435-442 Dabetologa 9 Sprngcr-Verlag 1988 Tme-dependent potentaton of nsuln release nduced by alpha-ketosocaproate and leucne n rats: possble nvolvement of phosphonostde hydrolyss
More informationDiabetologia. Review Articles. Secretion of Somatostatin from the Normal and Diabetic Pancreas. Diabetologia 19, (1980)
Dabetologa 19, 492-504 (1980) Dabetologa 9 by Sprnger-Verlag 1980 Revew Artcles Secreton of Somatostatn from the Normal and Dabetc Pancreas Studes In Vtro K. Hermansen Second Unversty Clnc of Internal
More informationRENAL FUNCTION AND ACE INHIBITORS IN RENAL ARTERY STENOSISA/adbon et al. 651
Downloaded from http://ahajournals.org by on January, 209 RENAL FUNCTION AND INHIBITORS IN RENAL ARTERY STENOSISA/adbon et al. 65 Downloaded from http://ahajournals.org by on January, 209 Patents and Methods
More informationBiology 30 Take Home Quiz
Bology 30 Take Home Quz 1) Glucose levels n the blood are rased by the hormone and lowered by the hormone. a) nsuln glucagon b) glucagon nsuln c) nsuln calctonn d) calctonn nsuln 2) A fat soluble hormone
More informationPotential role of the CD38/cADPR signaling pathway as an underlying mechanism of the effects of medetomidine on insulin and glucose homeostasis
Veternary Anaesthesa and Analgesa, 2013, 40, 512 516 do:10.1111/vaa.12039 SHORT COMMUNICATION Potental role of the CD38/cADPR sgnalng pathway as an underlyng mechansm of the effects of medetomdne on nsuln
More informationGlutamate acting on NMDA receptors stimulates neurite outgrowth from'cerebellar granule cells
Volume 223, number 1, 143-147 FEB 05216 October 1987 Glutamate actng on NMDA receptors stmulates neurte outgrowth from'cerebellar granule cells Ian A. Pearce, Martn A. Cambray-Deakn and Robert D. Burgoyne
More informationGASTROINTESTINAL MOTILITY AND GASTRIC ph AND EMPTYING FOLLOWING INGESTION OF DIAZEPAM
Br. J. Anaesth. (1988), 61, 712-719 GASTROINTESTINAL MOTILITY AND GASTRIC ph AND EMPTYING FOLLOWING INGESTION OF DIAZEPAM B. A. SCHURIZEK, K. KRAGLUND, F. ANDREASEN, L. V. JENSEN AND B. JUHL Premedcaton
More informationA review of glucose transport in the lens
A revew of glucose transport n the lens John W. Patterson T The transport of glucose nto the lens s revewed aganst a background of data on glucose transport n muscle and the red blood cell. In muscle,
More informationMetabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-coa effects
Metabolc control of mtochondral propertes by adenne nucleotde translocator determnes palmtoyl-coa effects Implcatons for a mechansm lnkng obesty and type 2 dabetes Jolta Capate 1,5, Stephan J. L. Bakker
More informationInfluence of Sodium ~-Hydroxybutyrate on Glucose and Free Fatty Acid Metabolism in Normal Dogs*
Dabetologa 3, 488-493 (1967) nfluence of Sodum ~-Hydroxybutyrate on Glucose and Free Fatty Acd Metabolsm n Normal Dogs* E. BALASSE, E. COUTURER and J. R.M. F~ANCKSON Departments of Expermental Medcne and
More informationTHE NATURAL HISTORY AND THE EFFECT OF PIVMECILLINAM IN LOWER URINARY TRACT INFECTION.
MET9401 SE 10May 2000 Page 13 of 154 2 SYNOPSS MET9401 SE THE NATURAL HSTORY AND THE EFFECT OF PVMECLLNAM N LOWER URNARY TRACT NFECTON. L A study of the natural hstory and the treatment effect wth pvmecllnam
More informationTIME RESPONSE OF JEJUNAL SUCRASE AND MALTASE ACTIVITY TO A HIGH SUCROSE DIET IN NORMAL MAN
GASTROEKTEROLOGY Copyrght 1969 by The Wllams & Wlkns Co. Vol. 56, No.3 Prnted n U.S.A. TIME RESPONSE OF JEJUNAL SUCRASE AND MALTASE ACTIVITY TO A HIGH SUCROSE DIET IN NORMAL MAN NORTON S. RoSENSWEIG, M.D.,
More informationEffectiveness of the Intestinal Polypeptides, IRP, GIP, VIP and Motilin on Insulin Release in the Rat
]:)abetologa 10, 459--463 (1974) 9 by Srnger-Verlag 1974 Effectveness of the Intestnal Polyetdes, IRP, GIP, VIP and Motln on Insuln Release n the Rat D.S. Turner, LaurMne Etherdge, V. Marks, J.C. Brown
More informationModeling Multi Layer Feed-forward Neural. Network Model on the Influence of Hypertension. and Diabetes Mellitus on Family History of
Appled Mathematcal Scences, Vol. 7, 2013, no. 41, 2047-2053 HIKARI Ltd, www.m-hkar.com Modelng Mult Layer Feed-forward Neural Network Model on the Influence of Hypertenson and Dabetes Melltus on Famly
More informationA SIMULATION STUDY OF MECHANISM OF POSTFLIGHT ORTHOSTATIC INTOLERANCE
Proceedngs 3rd Annual Conference IEEE/EMBS Oct.5-8, 001, Istanbul, TURKEY A SIMULATION STUDY OF MECHANISM OF POSTFLIGHT ORTHOSTATIC INTOLERANCE W. Y HAO 1, J. BAI 1, W. Y. ZHANG, X. Y. WU 3 L. F. ZHANG
More informationConcentration of teicoplanin in the serum of adults with end stage chronic renal failure undergoing treatment for infection
Journal of Antmcrobal Chemotherapy (1996) 37, 117-121 Concentraton of tecoplann n the serum of adults wth end stage chronc renal falure undergong treatment for nfecton A. MercateUo'*, K. Jaber*, D. Hfflare-Buys*,
More informationHYPEIIGLTCAEMIA AS A MENDELIAN P~ECESSIVE CHAI~ACTEP~ IN MICE.
HYPEGLTCAEMA AS A MENDELAN P~ECESSVE CHA~ACTEP~ N MCE. BY P. J. CAM~CDGE, M.D. (LEND.), 32 Nottngham Place, Ma~'y~ebone, London, W, 1, AND H. A. H. {OWAZD, B.So. (Lol, m.). h'~ the course of an nvestgaton
More informationThallium Redistribution in Dogs with Severe Coronary Artery Stenosis of Fixed Caliber
Thallum Redstrbuton n Dogs wth Severe Coronary Artery Stenoss of Fxed Calber 439 GERALD M. POHOST, ROBERT D. OKADA, DENNIS D. O'KEEFE, HENRY GEWIRTZ, GEORGE BELLER, H. WILLIAM STRAUSS, JOHN S. CHAFFIN,
More informationEFFECT OF TOPICAL LIGNOCAINE ON THE SYMPATHODRENAL RESPONSES TO TRACHEAL INTUBATION
Br. J. Anaesth. (1987), 59, 300-304 EFFECT OF TOPICAL LIGNOCAINE ON THE SYMPATHODRENAL RESPONSES TO TRACHEAL INTUBATION D. R. DERBYSHIRE, G. SMITH AND K. J. ACHOLA Hypertenson and tachycarda assocated
More informationPhysical Model for the Evolution of the Genetic Code
Physcal Model for the Evoluton of the Genetc Code Tatsuro Yamashta Osamu Narkyo Department of Physcs, Kyushu Unversty, Fukuoka 8-856, Japan Abstract We propose a physcal model to descrbe the mechansms
More informationFigure S1. 1g tumors (weeks) ikras. Lean Obese. Lean Obese 25 KPC
Fgure S 5 Tme to develop g tumors (weeks) 5 5 Tme to develop g tumors (weeks) 5 5 KRS KPC Fgure S. Effect of obesty on tumor ntaton. Tme to develop tumors of about g n KPC and KRS mce fed low or hgh-fat
More informationRECENT STUDIES in this department
Preventon of Coronary Atheroscleross by -Androgen Admnstraton n the Cholesterol-Fed Chck By JEREMAH STAMLER, M.D., RUTH PCK, M.D., AND LOUS X. KATZ, M.D. s are hghly effectve both prophylacteally and therapeutcally
More informationMyocardial Mural Thickness During the Cardiac Cycle
Myocardal Mural Thckness Durng the Cardac Cycle By Erc O. Fegl, M.D., and Donald L. Fry, M.D. An understandng of the relatonshp between forces and veloctes of contracton n muscle fbers to the pressures
More informationDiabetologia 9 Springer-Verlag1996
Dabetologa (1996) 39:758-765 Dabetologa 9 Sprnger-Verlag1996 Orgnals Long-term and rapd regulaton of ob mrna levels n adpose tssue from normal (Sprague Dawley rats) and obese (db/db mce, fa/fa rats) rodents
More informationUsing the Perpendicular Distance to the Nearest Fracture as a Proxy for Conventional Fracture Spacing Measures
Usng the Perpendcular Dstance to the Nearest Fracture as a Proxy for Conventonal Fracture Spacng Measures Erc B. Nven and Clayton V. Deutsch Dscrete fracture network smulaton ams to reproduce dstrbutons
More informationARTICLE IN PRESS Neuropsychologia xxx (2010) xxx xxx
Neuropsychologa xxx (200) xxx xxx Contents lsts avalable at ScenceDrect Neuropsychologa journal homepage: www.elsever.com/locate/neuropsychologa Storage and bndng of object features n vsual workng memory
More informationEngineered commensal microbes for dietmediated colorectal-cancer chemoprevention
SUPPLEMENTARY NFORMATON Artcles https://do.org/10.1038/s41551-017-0181-y n the format provded by the authors and unedted. Engneered commensal mcrobes for detmedated colorectal-cancer chemopreventon Chun
More informationComp. Biochem. PhysioL Vol. 83B, No. 1, pp , /86 $ LIPOLYSIS POST MORTEM IN NORTH ATLANTIC KRILL
Comp. Bochem. PhysoL Vol. 83B, No. 1, pp. 51-55, 1986 35-491/86 $3.+. Prnted n Great Brtan 1986 Pergamon Press Ltd LIPOLYSIS POST MORTEM IN NORTH ATLANTIC KRILL OLAV SAETHER, 1 TROND E. ELLINGSEN 2 and
More informationDetection of Organ Dysfunction in Type II Diabetic Patients
211 Amercan Control Conference on O'Farrell Street, San Francsco, CA, USA June 29 - Jul 1, 211 Detecton of Organ Dsfuncton n Tpe II Dabetc Patents O. Vahd, R. B. Gopalun, and K.E. Ko Abstract Tpe II dabetes
More informationA Mathematical Model of the Cerebellar-Olivary System II: Motor Adaptation Through Systematic Disruption of Climbing Fiber Equilibrium
Journal of Computatonal Neuroscence 5, 71 90 (1998) c 1998 Kluwer Academc Publshers. Manufactured n The Netherlands. A Mathematcal Model of the Cerebellar-Olvary System II: Motor Adaptaton Through Systematc
More information310 Int'l Conf. Par. and Dist. Proc. Tech. and Appl. PDPTA'16
310 Int'l Conf. Par. and Dst. Proc. Tech. and Appl. PDPTA'16 Akra Sasatan and Hrosh Ish Graduate School of Informaton and Telecommuncaton Engneerng, Toka Unversty, Mnato, Tokyo, Japan Abstract The end-to-end
More informationJames A. Talbot$ and Robert S. Hodges
THE JOURNAL OF BOLOGCAL CHEMSTRY Val. 256, No. 23. ssue of December O, pp. 12374-12378. 1981 Prnted n U S.A (Receved for publcaton, May 13, 1981) James A. Talbot$ and Robert S. Hodges From the Department
More informationEffect on Left Ventricular Performance of Stimulation of an Afferent Nerve from Muscle
Effect on Left Ventrcular Performance of Stmulaton of an Afferent Nerve from Muscle By Jere H. Mtchell, M.D., Donald S. Menwak, M.D., Kern Wldenthal, M.D., Wllam D. Wlls, Jr., M.D., Ph.D., and Alvn M.
More informationSerum Concentrations of Allergen-specific IgG Antibodies in Inhalant Allergy: Effect of Specific Immunotherapy
Serum Concentratons of Allergen-specfc IgG Antbodes n Inhalant Allergy: Effect of Specfc Immunotherapy MAJID ALI, M.D., M. P. RAMANARAYANAN, PH.D., DONALD J. NALEBUFF, M.D., RICHARD G. FADAL, M.D., AND
More informationEconomic crisis and follow-up of the conditions that define metabolic syndrome in a cohort of Catalonia,
Economc crss and follow-up of the condtons that defne metabolc syndrome n a cohort of Catalona, 2005-2012 Laa Maynou 1,2,3, Joan Gl 4, Gabrel Coll-de-Tuero 5,2, Ton Mora 6, Carme Saurna 1,2, Anton Scras
More informationPERIPHERAL vascular collapse occurring
Evaluaton of Plasma, Metaramnol, and Hydrocortsone n Expermental Endotoxm Shock Downloaded from http://ahajournals.org by on January, 0 By WESLEY W. SPINK, M.D., AND JAMES VICK, M.S. PERIPHERAL vascular
More informationMonte Carlo Analysis of a Subcutaneous Absorption Insulin Glargine Model: Variability in Plasma Insulin Concentrations
2012 2nd Internatonal Conference on Bomedcal Engneerng and Technology IPCBEE vol. 34 (2012) (2012) IACSIT Press, Sngapore Monte Carlo Analyss of a Subcutaneous Absorpton Insuln Glargne Model: Varablty
More informationTHE ASSOCIATION OF PNEUMOCOCCI, HEMOPHILUS INFLUENZAE, AND STREPTOCOCCUS HEMOLYTICUS WITH CORYZA, PHARYNGITIS, AND SINUSITIS
THE ASSOCIATION OF PNEUMOCOCCI, HEMOPHILUS INFLUENZAE, AND STREPTOCOCCUS HEMOLYTICUS WITH CORYZA, PHARYNGITIS, AND SINUSITIS IN MAN B~ L. T. WEBSTER, M.D., AND A. D. CLOW (From the Laboratores of The Rockefeller
More informationLeukemia in Polycythemia Vera. Relationship to Splenic Myeloid Metaplasia and Therapeutic Radiation Dose
Leukema n Polycythema Vera Relatonshp to Splenc Myelod Metaplasa and Therapeutc Radaton Dose JOHN H. LAWRENCE, M.D., D.SC, F.A.C.P., H. S. WINCHELL, M.D., PH.D., F.A.CP., and W. G. DONALD, M.D., F.A.C.P.
More informationIncorrect Beliefs. Overconfidence. Types of Overconfidence. Outline. Overprecision 4/22/2015. Econ 1820: Behavioral Economics Mark Dean Spring 2015
Incorrect Belefs Overconfdence Econ 1820: Behavoral Economcs Mark Dean Sprng 2015 In objectve EU we assumed that everyone agreed on what the probabltes of dfferent events were In subjectve expected utlty
More informationContinuous Determination of Beat-to-Beat Stroke Volume from Aortic Pressure Pulses in the Dog
15 Contnuous Determnaton of Beat-to-Beat Stroke Volume from Aortc Pressure Pulses n the Dog MAURICE J. BOURGEOIS, M.D., BARRY K. GILBERT, PH.D., GOETZ VON BERNUTH, M.D., AND EARL H. WOOD, M.D., PH.D. SUMMARY
More informationImportance of Atrial Compliance in Cardiac Performance
Importance of Atral Complance n Cardac Performance By Hroyuk Suga ABSTRACT Effects of changes n atral complance on cardac performance were analyzed usng a crculatory analog model. The atrum was assumed
More informationProject title: Mathematical Models of Fish Populations in Marine Reserves
Applcaton for Fundng (Malaspna Research Fund) Date: November 0, 2005 Project ttle: Mathematcal Models of Fsh Populatons n Marne Reserves Dr. Lev V. Idels Unversty College Professor Mathematcs Department
More informationJoint Modelling Approaches in diabetes research. Francisco Gude Clinical Epidemiology Unit, Hospital Clínico Universitario de Santiago
Jont Modellng Approaches n dabetes research Clncal Epdemology Unt, Hosptal Clínco Unverstaro de Santago Outlne 1 Dabetes 2 Our research 3 Some applcatons Dabetes melltus Is a serous lfe-long health condton
More informationThe Relation between Protein Synthesis and Lipide Accumulation in L Strain Cells and Ehrlich Ascites Cells*
Publshed Onlne: 1 May, 1959 Supp nfo: http://do.org/10.1083/jcb.5.3.421 Downloaded from jcb.rupress.org on December 19, 2018 The Relaton between Proten Synthess and Lpde Accumulaton n L Stran Cells and
More informationSTUDIES ON FAZADINIUM BROMIDE (AH 8165): A NEW NON-DEPOLARIZING NEUROMUSCULAR BLOCKING AGENT
STUDIES ON FAZADINIUM BROMIDE (AH 8165): A NEW NON-DEPOLARIZING NEUROMUSCULAR BLOCKING AGENT R. HUCHES, J.P. PAYNE, AND N. SUGAI INTRODUCTION PRELIMINARY REPORTS on the neuromuscular blockng acton of fazadnum
More informationReduction of the Oxygen Utilization of the Heart by Left Heart Bypass
Reducton of the Oxygen Utlzaton of the Heart by Left Heart Bypass By Clarence Denns, M.D., Ph.D., Davd P. Hall, M.D., Juan R. Moreno, M.D., and Ake Sennng, M.D. Downloaded from http://ahajournals.org by
More informationStudies In Blood Preservation
Howard Unversty Dgtal Howard @ Howard Unversty Faculty Reprnts 12-1-1939 Studes In Blood Preservaton Charles R. Drew Follow ths and addtonal works at: http://dh.howard.edu/reprnts Part of the Medcne and
More informationAn Angiocardiographic Method for Directly Determining Left Ventricular Stroke Volume in Man
An Angocardographc Method for Drectly Determnng Left Ventrcular Stroke Volume n Man By Harold T. Dodge, M.D., Robert E. Hay, M.D., and Harold Sander, M.D. n prevous studes from ths and other laboratores,
More informationDiabetologia 9 Springer-Verlag 1982
Dabetoloa (1982) 22:258-263 Dabetoloa 9 Sprner-Verla 1982 Glucaon Immunoreactvty n Plasma from Normal and Dystrophc Mce B. Ahr6n and I. Lundqust Department of Pharmacoloy, Unversty of Lund, Lund, Sweden
More informationRelease of antidiuretic hormone during mass-induced elevation of intracranial pressure
Release of antduretc hormone durng mass-nduced elevaton of ntracranal pressure LYNN GAUFIN, M.D., W. RONALD SKOWSKY, M.D., AND STANLEY J. GOODMAN, M.D. Department of Surgery, Dvson of Neurosurgery, Unversty
More informationAppendix for. Institutions and Behavior: Experimental Evidence on the Effects of Democracy
Appendx for Insttutons and Behavor: Expermental Evdence on the Effects of Democrac 1. Instructons 1.1 Orgnal sessons Welcome You are about to partcpate n a stud on decson-makng, and ou wll be pad for our
More informationElevated Glucose Levels Increase Retinal Glycolysis and Sorbitol Pathway Metabolism
Elevated Glucose Levels Increase Retnal Glycolyss and Sorbtol Pathway Metabolsm Implcatons for Dabetc Retnopathy Mara K. Van den Enden,* Jens R. Nyengaard,^ Eva Ostrow,% Judth H. Burgan,X and Joseph R.
More informationParameter Estimates of a Random Regression Test Day Model for First Three Lactation Somatic Cell Scores
Parameter Estmates of a Random Regresson Test Day Model for Frst Three actaton Somatc Cell Scores Z. u, F. Renhardt and R. Reents Unted Datasystems for Anmal Producton (VIT), Hedeweg 1, D-27280 Verden,
More informationThe Influence of the Isomerization Reactions on the Soybean Oil Hydrogenation Process
Unversty of Belgrade From the SelectedWorks of Zeljko D Cupc 2000 The Influence of the Isomerzaton Reactons on the Soybean Ol Hydrogenaton Process Zeljko D Cupc, Insttute of Chemstry, Technology and Metallurgy
More information. 1B ii. Downloaded from ijem.sbmu.ac.ir at 15: on Sunday November 11th
( ) 3 1 ( (1 : (3 e-mal: r.alzadeh@lam.ac.r : :. ( ) / ± / ( ) / ± /. ( ) / ± /... / :. P< / (P= / ) (P= / ) (P= / ) :. (P= / ). : 97/3/0 : 97/3/7 : 97/1/0 : 4... 1B. 1. 3. - Peroxsome Prolferator-Actvated
More informationProtein-Lipid Relationships in Normal Dog Plasma
Proten-Lpd Relatonshps n Normal Dog Plasma pplcaton of Cohn Method 0 By ELL M. EUSS ND JULIE RYMUNT lthough Cohn's merofmetonaton method number 0 was specfcally devsed to meet the condtons of proten concentraton
More informationEncoding processes, in memory scanning tasks
vlemory & Cognton 1976,4 (5), 501 506 Encodng processes, n memory scannng tasks JEFFREY O. MILLER and ROBERT G. PACHELLA Unversty of Mchgan, Ann Arbor, Mchgan 48101, Three experments are presented that
More information(Accepted 28 May 1981) SUMMARY
J. gen. Vrol. (1981), 56, 259-265. Prnted n Great Brtan 259 Key words: acyclovr/bromovnyldeoxyurdne/herpes smplex vrus~latent Effects of Oral Treatment wth Acyclovr and Bromovnyldeoxyurdne on the Establshment
More informationArterial Hypertension Is Associated with Hypalgesia in Humans SERGIO GHIONE, CATERINA ROSA, LORENA MEZZASALMA, AND ELISABETTA PANATTONI
rteral Hypertenson Is ssocated wth Hypalgesa n Humans SERGIO GHIONE, CTERIN ROS, LOREN MEZZSLM, ND ELISBETT PNTTONI SUMMRY n assocaton between ncreased blood pressure and hypalgesa has been reported n
More informationTHE PHYSIOLOGY OF EXCITABLE CELLS
THE PHYSIOLOGY OF EXCITABLE CELLS Evelyn Morn Department of Electrcal & Computer Engneerng Queen s Unversty, Kngston, Ont. In all cells a potental exsts across the cell membrane due to dfferences n the
More informationInternational Journal of Emerging Technologies in Computational and Applied Sciences (IJETCAS)
Internatonal Assocaton of Scentfc Innovaton and Research (IASIR (An Assocaton Unfyng the Scences, Engneerng, and Appled Research Internatonal Journal of Emergng Technologes n Computatonal and Appled Scences
More informationNormal variation in the length of the luteal phase of the menstrual cycle: identification of the short luteal phase
Brtsh Journal of Obstetrcs and Gvnaecologjl July 1984, Vol. 9 1, pp. 685-689 Normal varaton n the length of the luteal phase of the menstrual cycle: dentfcaton of the short luteal phase ELIZABETH A. LENTON,
More informationStatistical Analysis on Infectious Diseases in Dubai, UAE
Internatonal Journal of Preventve Medcne Research Vol. 1, No. 4, 015, pp. 60-66 http://www.ascence.org/journal/jpmr Statstcal Analyss on Infectous Dseases 1995-013 n Duba, UAE Khams F. G. 1, Hussan H.
More informationTime-Dependent Changes in Cerebral Choline and Acetylcholine Induced by Transient Global Ischemia in Rats
643 Tme-Dependent Changes n Cerebral Cholne and Acetylcholne Induced by Transent Global Ischema n Rats Oscar U. Scremn, MD, PhD, and Donald J. Jenden, MD, PhD We occluded the carotd and vertebral arteres
More informationImplications of Intraindividual Variability in Bioavailability Studies of Furosemide
Eur J Cln Pharmacol (1984) 27:595-602 European Journal of Clncal Pharmacology Sprnger-Verlag 1984 Implcatons of Intrandvdual Varablty n Boavalablty Studes of Furosemde A. Grahnrn 1, M. Hammaflund 2, and
More informationKOUJI KAJINAMI, MD,*t HIROYASU SEKI, MD,t NOBORU TAKEKOSHI, MD,t HIROSHI MABUCHI, MD* Kanazawa, Japan
JACC Vol. 26, No. 5 209 November I, 995:209-2 Nonnvasve Predcton of Coronary Atheroscleross by Quantfcaton of Coronary Artery Calcfcaton Usng Electron Beam Computed Tomography: Comparson Wth Electrocardographc
More informationEVALUATION OF BULK MODULUS AND RING DIAMETER OF SOME TELLURITE GLASS SYSTEMS
Chalcogende Letters Vol. 12, No. 2, February 2015, p. 67-74 EVALUATION OF BULK MODULUS AND RING DIAMETER OF SOME TELLURITE GLASS SYSTEMS R. EL-MALLAWANY a*, M.S. GAAFAR b, N. VEERAIAH c a Physcs Dept.,
More informationAn Analysis of Excessive Running in the Development of Activity Anorexia
Pergamon 31-9384(95)83-6 Physology & Behavor, Vol. 58, No. 3, pp. 451-457, 1995 Copyrght 1995 Elsever Scence Ltd Prnted n the USA. All rghts reserved 31-9384/95 $9.5 +. An Analyss of Excessve Runnng n
More informationHEPATIC TAURINE CONCENTRATION AND DIETARY TAURINE AS REGULATORS OF BILE ACID CONJUGATION WITH TAURINE
16-585/78/751-71$2./ GASTROENTEROLOGY 75:71-75, 1978 Copyrght 1978 by the Amercan Gastroenterologcal Assocaton Vol. 75, No.1 Prnted n U.S.A. HEPATIC TAURINE CONCENTRATION AND DIETARY TAURINE AS REGULATORS
More informationGLUCOSE REGULATION IN TYPE 1 DIABETIC PATIENTS BY A MULTI-DOSES REGIMEN
GLUCOSE REGULATION IN TYPE 1 DIABETIC PATIENTS BY A MULTI-DOSES REGIMEN Campos-Delgado D.U. Hernández-Ordoñez M. Femat R. Facultad de Cencas, Av. Salvador Nava s/n, Zona Unverstara, C.P. 78290, UASLP,
More informationWhat Determines Attitude Improvements? Does Religiosity Help?
Internatonal Journal of Busness and Socal Scence Vol. 4 No. 9; August 2013 What Determnes Atttude Improvements? Does Relgosty Help? Madhu S. Mohanty Calforna State Unversty-Los Angeles Los Angeles, 5151
More informationRole of Hepatocytes in Direct Clearance of Lipopolysaccharide in Rats
GASTROENTEROLOGY 1995;19:1969-1976 Role of Hepatocytes n Drect Clearance of Lpopolysaccharde n Rats YOSHHIRO MIMURA, SHOTARO SAKISAKA, MASARU HARADA, MICHIO SATA, and KYUICHI TANIKAWA Second Department
More informationExposure to Free Fatty Acid Increases the Transfer of Albumin across Cultured Endothelial Monolayers
Exposure to Free Fatty Acd Increases the Transfer of Albumn across Cultured Endothelal Monolayers Bernhard Henng, D. Mchael Shasby, Alce B. Fulton, and Arthur A. Spector An ntal exposure to hgh concentratons
More informationPrediction of Total Pressure Drop in Stenotic Coronary Arteries with Their Geometric Parameters
Tenth Internatonal Conference on Computatonal Flud Dynamcs (ICCFD10), Barcelona, Span, July 9-13, 2018 ICCFD10-227 Predcton of Total Pressure Drop n Stenotc Coronary Arteres wth Ther Geometrc Parameters
More informationIn the present study, we have isolated native EGF receptor monomers and dimers from A431 cell membranes, and we
Proc. Natl. Acad. Sc. USA Vol. 84, pp. 7832-7836, November 1987 Bochemstry Mechansm of epdermal growth factor receptor autophosphorylaton and hgh-affnty bndng (receptor-tyrosne knases/lgand-nduced receptor
More informationModeling the Survival of Retrospective Clinical Data from Prostate Cancer Patients in Komfo Anokye Teaching Hospital, Ghana
Internatonal Journal of Appled Scence and Technology Vol. 5, No. 6; December 2015 Modelng the Survval of Retrospectve Clncal Data from Prostate Cancer Patents n Komfo Anokye Teachng Hosptal, Ghana Asedu-Addo,
More informationKinetics of Corneal Epithelium Turnover In Vivo
Investgatve Ophthalmology & Vsual Scence, Vol. 3, No. 0, October 990 Copyrght Assocaton for Research n Vson and Ophthalmology Knetcs of Corneal Epthelum Turnover In Vvo Studes of Lovasrarn Rchard J. Cenedella
More informationTAKESHI UTSUNOMIYA and JAY S. ROTH
STUDIES ON THE FUNCTION OF INTRACELLULAR RIBONUCLEASES V. Rbonuclease Actvty n Rbosomes and Polysomes Prepared from Rat Lver and Hepatomas TAKESHI UTSUNOMIYA and JAY S. ROTH From the Insttute of Cellular
More informationEFFECTS OF STORAGE TIMES AND TEMPERATURES ON T3, T4, LH, PROLACTIN, INSULIN, CORTISOL AND PROGESTERONE CONCENTRATIONS IN BLOOD SAMPLES FROM COWS l
EFFECTS OF STORAGE TMES AND TEMPERATURES ON T3, T4, LH, PROLACTN, NSULN, CORTSOL AND PROGESTERONE CONCENTRATONS N BLOOD SAMPLES FROM COWS l T. J. Remers 2, J. P. McCann and R. G. Cowan Cornell Unversty
More informationDiabetologia 9 Springer-Verlag 1988 "
Dabetologa (188) 31: 214-220 Dabetologa Sprnger-Verlag 188 " Dabetc neuropathy n the upper lmb and the effect of twelve months sorbnl treatment R. J. C. Guy 1, S. G. Glbey 1, M. Sheehy 2, P. Asselman 2
More informationPrice linkages in value chains: methodology
Prce lnkages n value chans: methodology Prof. Trond Bjorndal, CEMARE. Unversty of Portsmouth, UK. and Prof. José Fernández-Polanco Unversty of Cantabra, Span. FAO INFOSAMAK Tangers, Morocco 14 March 2012
More informationCirculation. report good agreement between blood pressures. determined by the direct intra-arterial and the
Crculaton A Journal of the Amercan -Heart Assocaton OCTOBER 1954 VOL. X NO. 4 Downloaded from http://ahajournals.org by on November 27, 2018 Comparson of Indrect and Drect Methods of Measurng Arteral Blood
More informationVolume 30, Issue 1. International Capital Mobility in African Countries: Do the legal origins matter?
Volume 30, Issue 1 Internatonal Captal Moblty n Afrcan Countres: Do the legal orgns matter? Chrysost Bangaké LEO, Unversty of Orléans (France) Jude Eggoh LEO, Unversty of Orléans (France) Abstract Ths
More informationCopy Number Variation Methods and Data
Copy Number Varaton Methods and Data Copy number varaton (CNV) Reference Sequence ACCTGCAATGAT TAAGCCCGGG TTGCAACGTTAGGCA Populaton ACCTGCAATGAT TAAGCCCGGG TTGCAACGTTAGGCA ACCTGCAATGAT TTGCAACGTTAGGCA
More informationLaboratory of Experimental Medicine, Brussels Free University, B-1070 Brussels', Belgium and Novo Nordisk A/S, DK-2880 Bagsvaerd, Denmark
Vol. 43, No. 2, October 1997 Pages 233-240 CATONC AND SECRETORY EFFECTS OF 6-O-ACETYL-D-GLUCOSE N RAT PANCREATC SLETS Hassan JJAKL, Ole KRK and Willy J. MALASSE Laboratory of Experimental Medicine, Brussels
More informationAnalysis of the QRS Complex for Apnea-Bradycardia Characterization in Preterm Infants
Author manuscrpt, publshed n "Conference proceedngs : Annual Internatonal Conference of the IEEE Engneerng n Medcne and Bology Socety. 2009;:946-9" DOI : 0.09/IEMBS.2009.533353 Analyss of the QRS Complex
More informationST Segment Tracking for Rapid Determination of Patency of the Infarct-Related Artery in Acute Myocardial Infarction
JACC Vol. 26, No. 3 675 ST Segment Trackng for Rapd Determnaton of Patency of the nfarct-related Artery n Acute Myocardal nfarcton ALAND R. FERNANDEZ, MD, RAFAEL F. SEQUERA, MD, FRCP, FACC, SMON CHAKKO,
More information~~~~~~~~~~~~~~~~2- ~~~~~~~~~~~~~~~~~10. go 3 NAFM
2528 orrectons Proc. Natl. Acad. Sc. USA 73 (1976) orrecton. In the artcle "A 15-hydroxyprostaglandn dehydrogenase specfc for prostaglandn A n rabbt kdney" by H. G. Oen, E. A. Ham, M. E. Zanett, E. H.
More informationPHYSIOLOGICAL MODELLING OF HEMODYNAMIC EFFECTS OF SIMULTANEOUS ADMINISTRATION OF NORADRENALINE AND DOBUTAMINE TO SEPTIC PATIENTS IN CICU
PHYSIOLOGICAL MODELLING OF HEMODYNAMIC EFFECTS OF SIMULTANEOUS ADMINISTRATION OF NORADRENALINE AND DOBUTAMINE TO SEPTIC PATIENTS IN CICU M. Mahfouf 1 M.A. Denaï 1 J.J. Ross 2 1 Dept of Automatc Control
More informationEssential Fatty Acid Requirements for Term and Preterm Infants
Lpds n Modern Nutrton, edted by M. Horsberger and U. Bracco. Nestld Nutrton, Vevey/Raven Press, New York 987. Essental Fatty Acd Requrements for Term and Preterm Infants Zv Fredman Department of Pedatrcs,
More informationLateral Transfer Data Report. Principal Investigator: Andrea Baptiste, MA, OT, CIE Co-Investigator: Kay Steadman, MA, OTR, CHSP. Executive Summary:
Samar tmed c ali ndus t r esi nc 55Fl em ngdr ve, Un t#9 Cambr dge, ON. N1T2A9 T el. 18886582206 Ema l. nf o@s amar t r ol l boar d. c om www. s amar t r ol l boar d. c om Lateral Transfer Data Report
More informationA POROUS MEDIA APPROACH TOWARDS A DYNAMIC MECHANISTIC MODEL OF DRUG ELIMINATION BY THE LIVER. A Thesis Submitted to the
A POROUS MEDIA APPROAH TOWARDS A DYNAMI MEHANISTI MODEL OF DRUG ELIMINATION BY THE LIVER A Thess Submtted to the ollege of Graduate Studes and Research n Partal Fulfllment of the Requrements for the Degree
More informationII. Key stimuli in avoidance learning
Anmal Learnng & Behavor 1986, 14 (/), 101-109 Ethologcal analyss of predator avodance by the paradse fsh (Macropodus operculars L.): II. Key stmul n avodance learnng V. CSANYI L. Eotvos Unversty of Budapest.
More informationInteraction of Phospholipase A2 from Naja melanoleuca Snake Venom with Monomeric Substrate Analogs
bur. J Bochem. 132, 183-188 (1983) ( FEBS 1983 Interacton of Phospholpase A2 from Naja melanoleuca Snake Venom wth Monomerc Substrate Analogs Actvaton of the Enzyme by Proten-Proten or Lpd-Proten Interactons?
More information