The Digital Clinic: Unlock the Power of Diabetes Data Eran Atlas - CEO Copyright DreaMed Diabetes, Ltd. 2017, All Rights Reserved

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1 The Digital Clinic: Unlock the Power of Diabetes Data Eran Atlas - CEO

2 Basic Copyright Notice & Disclaimer Basic Copyright Notice & Disclaimer 2017 This presentation is copyright protected. All rights reserved. You may download or print out a hard copy for your private or internal use. You are not permitted to create any modifications or derivatives of this presentation without the prior written permission of the copyright owner. This presentation is for information purposes only and contains non-binding indications. Any opinions or views expressed are of the author and do not necessarily represent those of Swiss Re. Swiss Re makes no warranties or representations as to the accuracy, comprehensiveness, timeliness or suitability of this presentation for a particular purpose. Anyone shall at its own risk interpret and employ this presentation without relying on it in isolation. In no event will Swiss Re be liable for any loss or damages of any kind, including any direct, indirect or consequential damages, arising out of or in connection with the use of this presentation.

3 New Era in Diabetes Treatment

4 Managing Diabetes Is Complex

5 Technology to Rescue Starting From Type 1 and Moving to Type 2 Diabetes

6 More Data = Potential Improvement in Quality of Care

7 Continuous Glucose Monitoring Used for New Quality Measures

8 Continuous Glucose Monitoring Used for New Quality Measures Editorial: Periodically, a new idea, method, or tool leads to a turning point in the Management of diabetes. We believe such a moment is now upon us, brought by development of reliable devices for continuous glucose monitoring (CGM).

9 Yet, Patients Are Far From Targets

10 The Downside of More Data

11 Why Patients Are Out of Control? Patients Poor accessibility to expert physician to optimize the insulin treatment profile (both in developed and developing countries) Lack of knowledge / NO treatment tools for diabetes self management and optimizing insulin treatment profile between clinic visits Healthcare Providers Need expertise to deduce from the data (the patient s glucose levels, insulin injections, meals, physical activity and more) how to optimize the insulin treatment profile Optimize Insulin treatment is Time Consuming. Healthcare Market Trends Worldwide rapid decrease in number of specialist in Endocrinology Full capacity in Diabetes Centers of Excellence (e.g. the Diabetes Institute at Schneider) Geographic distance makes periodic visits to Diabetes Centers much more complex

12 DreaMed Advisor The Near Future Digital Clinic

13 MD-Logic Concept Prof Moshe Phillip Schneider Children s MC, Israel Diabetes Institute Director Dr Revital Nimri Schneider Children s MC, Israel Diabetes Institute Senior Diabetologist Prof Thomas Danne Auf Der Bult, Hannover, Germany Diabetes Institute Chief Physician Prof Olga Kordonouri Auf Der Bult, Hannover, Germany Head of Diabetology Prof Tadej Battelino University Children Center, Ljubljana, Slovenia Diabetes Institute - Director Dr Natasa Bratina University Children Center, Ljubljana, Slovenia Diabetes Institute Senior Diabetologist

14 How Similar Is The Algorithm Recommendations to What Experts Would Recommend?

15 The Expert Survey Study In collaboration with Dr. Eyal Dassau, Harvard University

16 Similar Level of Agreement Between Experts and Advisor

17 Just Another Team Member!!! Advisor is just another Expert member of the care team, equivalent to knocking on the door of a colleague in search of a helpful tip for managing a patient

18 How Do We Know That The Algorithm Is As Good As Expert HCPs?

19 Pilot Study

20 Advisor Performed As Good As Experts Endos

21 Advisor Group Showed Larger Decrease in Hypoglycemia

22 NextDREAM consortium: Multicenter study to evaluate DreaMed Advisor

23 Next Step: DreaMed Advisor for Real-Time Support On Insulin Dosing IT STARTS WITH INFORMATION PERSONALIZED Guidance

24 Take Home Message Decision support systems represent a new evolution in the treatment of patients with diabetes and are HERE TO STAY. turns pure information into specific and personalized actionable recommendations Pilot clinical studies results show that is in agreement with expert physicians in similar way to their agreement with each other Pilot clinical studies results show that is as good as expert Diabetologists in controlling glucose levels

25 Acknowledgement

26 Thank You for Your Attention Eran Atlas DreaMed Diabetes CEO

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