High School: New York State Regents Diploma (1989) Brockport Central Schools; Brockport, NY

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1 Jason J. Winnick, Ph.D. Research Assistant Professor Department of Molecular Physiology & Biophysics Vanderbilt University School of Medicine Education: High School: New York State Regents Diploma (1989) Brockport Central Schools; Brockport, NY B.S. Degree: SUNY Brockport (1998) Major: Physical Education (Exercise Physiology) Minor: Biology M.S. Degree: University of South Carolina (2000) Major: Exercise Science Advisor: Dr. Mark Davis Ph.D. Degree: Ohio State University (2006) Major: Exercise Physiology Cognate: Metabolism Advisors: Drs. Mike Sherman and Dara Schuster Post Doctoral: Vanderbilt University ( ) Department of Molecular Physiology and Biophysics Mentor: Dr. Alan Cherrington Current Research Funding: NIH Career Development Award (K01 DK ). Title: The effect of exercise on hepatic glucose metabolism in type 2 diabetes mellitus. The broad aims of the proposal are to determine the effects of aerobic exercise training, weight loss, and their interaction on splanchnic glucose uptake (aim #1) and gluconeogenic / glycogenolytic rates in response to hyperinsulinemia (aim #2) in obese humans with type 2 diabetes mellitus. Role: Principal Investigator. Pending Research Funding: NIH R01. Title: Effect of liver glycogen content on hypoglycemic counterregulation. Revised application sent to NIDDK on 7/5/2015. Role: Principal Investigator.

2 Completed Research Funding: NIH National Research Service Award (F32 DK ). Title: Effect of hepatic glycogen level on hepatic glucose uptake and disposition. Role: Principal Investigator. Title: Pilot Study on the effect of aerobic exercise on peripheral glucose uptake and endogenous glucose production in type 2 diabetes mellitus. This research was funded, in part, by Ohio State University s General Clinical Research Center. PI: Dr. Dara Schuster. Role: Co-Investigator. Honors and Awards: United States Marine Corps: Good Conduct Medal, National Defense Service Medal and Sea Service Deployment Ribbon. Dean s List at SUNY Brockport. Fred and Frieda Thiergartner Scholarship Recipient ( ); Awarded by Ohio State University s College of Education. Molecular Endocrinology Training Program Research Fellow ( ); Vanderbilt University Department of Molecular Physiology and Biophysics (PI: Dr. Richard O Brien). NIH (NIDDK) National Research Service Award Postdoctoral Fellow ( ; Faculty Mentor: Dr. Alan Cherrington) American Diabetes Association Meritorious Travel Award ($1,000). NIH (NIDDK) Career Development Award (8/1/2012-current). Current Position: Research Assistant Professor, Vanderbilt University Department of Molecular Physiology and Biophysics. (2014-current). Relevant Work Experience: United States Marine Corps (active duty; ); Mortarman, Corporal. Chemistry and Exercise Physiology Tutor at SUNY Brockport ( ). Adjunct Lecturer at SUNY Brockport ( ). Graduate Teaching Assistant at the University of South Carolina ( ). Responsibilities: To teach undergraduate exercise science lab classes. Graduate Research Assistant at the University of South Carolina: ( ). Responsibilities: To perform biochemical assays on blood samples collected for research. Adjunct Faculty at Midlands Technical College, Columbia, SC (2000). Responsibilities: Instructed students in the laboratory portion of an introductory biology course.

3 Graduate Teaching Assistant at Ohio State University ( ). Responsibilities: Taught undergraduate activity courses in racquetball, diet and exercise, and golf. Graduate Research Assistant at Ohio State University ( ). Responsibilities: To implement and oversee the training of humans with type 2 diabetes as they participated in a study examining the effects of exercise on glucose metabolism and risk factors associated with type 2 diabetes in African- and Caucasian-Americans. (P.I. Dr. Dara Schuster). Graduate Teaching Assistant at Ohio State University ( ). Responsibilities: Taught undergraduate laboratory courses for introductory exercise physiology classes, as well as the laboratory sections for a course focusing on adult fitness testing and exercise prescription. Graduate Administrative Assistant at Ohio State University ( ). Responsibilities: To assist the Vice-Provost (Dr. Mike Sherman) with administrative responsibilities as related to the mission of the university. Editorial Assistant: The International Journal of Sports Medicine ( ). Responsibilities: To coordinate the review process of submitted manuscripts, and the interaction between authors and the Co-editor in chief (Dr. Mike Sherman). Postdoctoral Research Fellow: Vanderbilt University Department of Molecular Physiology and Biophysics (Alan D. Cherrington lab; ). Research Instructor: Vanderbilt University Department of Molecular Physiology and Biophysics. ( ). Research Involvement: University of South Carolina (M.S. degree): Thesis Title: Effect of carbohydrate feeding on peripheral and central nervous system function during intermittent high intensity exercise. For this study, we examined the effects of ingesting a 6% CHO-electrolyte drink on objective and subjective measures of peripheral and central nervous system function during exercise designed to mimic team sports such as basketball, soccer, and tennis. Funding Source: Gatorade Sports Science Institute; (PI: Dr. Mark Davis). This project resulted in one first author publication. Ohio State University (Ph.D. degree): Worked as a graduate research assistant on a study where I was responsible for the baseline assessment, orientation, exercise prescription and participation and monitoring of subjects. This study was designed to examine the effects of different modes of exercise (resistance and aerobic training) on glucose metabolism and measures of risk factors in African- and Caucasian-American subjects with type 2 diabetes mellitus. Funding Source: NIDDK (KO8 DK05263; PI: Dr. Dara Schuster). This project resulted in one first author publication.

4 Dissertation Title: Effect of aerobic exercise on peripheral glucose uptake and endogenous glucose production in type 2 diabetes mellitus (Co-Advisors: Drs. Mike Sherman and Dara Schuster). For this study, we examined the effect of 7- days of aerobic exercise training on peripheral and hepatic insulin sensitivity in men and women with type 2 diabetes mellitus during isoglycemic/ hyperinsulinemic clamp conditions. Funding Sources: Ohio State University s General Clinical Research Center NIH (MO1 RR00034; PI: Dr. William Malarkey), and The International Journal of Sports Medicine. This project resulted in one first author publication. Vanderbilt University (Postdoctoral and current faculty position): Title: Effect of hepatic glycogen level on hepatic glucose uptake and disposition. These studies were designed to determine whether an acute, physiological increase in the hepatic glycogen content would affect the ability of the liver to take up glucose and/ or alter the disposition of glucose after it has been taken up by the liver. Funding source: NIDDK (RO1 DK43706; PI: Dr. Alan Cherrington) and (F32 DK080606; PI: Dr. Jason Winnick). This project resulted in three first author publications. Title: Characterization of Hepato-Selective Insulin Analogues. These studies were designed to characterize the effects of a hepatoselective insulin analog on hepatic glucose production and muscle glucose uptake during euglycemic/ hyperinsulinemic clamp conditions. Funding Source: Novo Nordisk (PI: Dr. Alan Cherrington). This project has resulted in one third author paper and is expected to result in another second author publication. Title: The effect of chronic 11β-HSD1 inhibition on basal glucose and lipid metabolism and the metabolic response to elevated stress hormones. Funding Source: Abbott Laboratories (PI: Dr. Alan Cherrington). This project resulted in one first author publication. Current Investigation: We are now focusing on how increased liver glycogen content improves both hepatic and hormonal counterregulatory responses to hypoglycemia. This project is expected to result in multiple first author publications (one of which is currently in revision in the Journal of Clinical Investigation). Current Investigation: The effect of exercise on hepatic glucose metabolism in type 2 diabetes mellitus. The broad aims of the proposal are to determine the effects of aerobic exercise training, weight loss, and their interaction on splanchnic glucose uptake (aim #1) and gluconeogenic / glycogenolytic rates in response to hyperinsulinemia (aim #2) in obese humans with type 2 diabetes mellitus. Funding source: NIDDK (K-01 DK093799; PI: Dr. Jason Winnick). This project will result in multiple senior author publications.

5 Current Investigation: In collaboration with Dr Naji Abumrad, we are focusing the mechanisms by which Roux-en-Y gastric bypass surgery increases insulin secretion in obese humans with type 2 diabetes. Professional Organization Memberships: American Diabetes Association European Association for the Study of Diabetes Invited Referee: International Journal of Sports Medicine American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) Diabetes Research and Clinical Practice Medicine and Science in Sports and Exercise Metabolism Journal of Applied Physiology Cell Biochemistry & Function Diabetes Peer-Reviewed Publications: Winnick, Jason J., Davis, J.M., Welsh, R.S., Carmichael, M.D., Murphy, E.A., and Blackmon. J.A. (2005). Carbohydrate feedings during team sport exercise preserve physical and CNS function. Medicine and Science in Sports and Exercise. 37(2): Winnick, Jason J., Sherman, W.M., Habash, D.L., Stout, M.B., Failla, M.L., Belury, M.A., and Schuster, D.P. (2008). Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. Journal of Clinical Endocrinology and Metabolism. 93: Winnick, Jason J., Gaillard, T. and Schuster, D.P. (2008). Resistance training differentially affects weight loss and glucose metabolism of Caucasian- and African-Americans with type 2 diabetes mellitus. Ethnicity and Disease. 18(2): An, Z., Moore, M.C., Winnick, Jason J., Farmer, B., Neal, D.W., Lautz, M., Smith, M., Rodewald, T., and Cherrington, A.D. (2009). Portal infusion of escitalopram enhances hepatic glucose disposal in conscious dogs. European Journal of Pharmacology. 607(1-3):

6 Winnick, Jason J., An, Z., Moore, M.C., Ramnanan, C.J., Farmer, B., Shiota, M., and Cherrington, A.D. (2009). A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin. American Journal of Physiology. 297(2): E358-E366. An, Z., Winnick, Jason J., Farmer, B., Neal, D., Lautz, M., Irimia, J.M., Roach, P.J., and Cherrington, A.D. (2010). A soluble guanylate cyclase dependent mechanism is involved in the regulation of net hepatic glucose uptake by nitric oxide in vivo. Diabetes. 59(12): Winnick, Jason J., An, Z., Ramnanan, C.J., Smith, M., Irimia, J., Neal, D.W., Moore, M.C., Roach, P.J., and Cherrington, A.D. (2010). Hepatic glycogen supercompensation activates AMPK, impairs insulin signaling and reduces glycogen deposition in the liver. Diabetes. 60: Moore, M.C., Coate, K.C., Winnick, Jason J., An, Z. and Cherrington, A.D. (2012). Regulation of Hepatic Glucose Uptake and Storage In Vivo. Advances in Nutrition. 3(3): An, Z., Winnick, Jason J., Moore, M.C., Farmer, B., Smith, M., Irimia, J.M., Roach, P.J. and Cherrington, A.D. (2012). A Cyclic Guanosine Monophosphate- Dependent Pathway Can Regulate Net Hepatic Glucose Uptake in Vivo. Diabetes. 61(10): Winnick, Jason J., An, Z., Kraft, G., Ramnanan, C.J., Irimia, J.M., Smith, M., Lautz, M., Roach, P.J. and Cherrington, A.D. (2013). Liver Glycogen Loading Dampens Glycogen Synthesis Seen in Response to Either Hyperinsulinemia or Intraportal Glucose Infusion. Diabetes. 62(1): Winnick, Jason J., Ramnanan, C.J., Viswanathan, S., Roop, J., Scott, M., Jacobson, P., Jung, P., Basu, R., Cherrington, A.D. and Edgerton, D.S. (2013). Effects of 11β-hydroxysteroid dehydrogenase-1 Inhibition on Hepatic Glycogenolysis and Gluconeogenesis. American Journal of Physiology. 304: E747-E756. Edgerton DS, Moore MC, Winnick, Jason J., Scott, M., Farmer, B., Naver, H., Jeppesen, C.B., Madsen, P., Kjeldsen, T.B., Nishimura, E., Brand, C.L., and Cherrington, A.D. (2014). Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog. Diabetes. 63 (11): Gregory, J., Kraft, G., Scott, M., Neal, D., Farmer, B., Smith, M., Hastings, J., Allen, E., Donahue, E., Rivera, N., Winnick, Jason J., Edgerton, D., Fledelious, C., Nishimura, E., Brand, C., and Cherrington, A.D. (2015). Insulin Delivery into the Peripheral Circulation: a Key Contributor to Hypoglycemia in Type 1 Diabetes. Diabetes. Jun 17.

7 Manuscripts Under Revision or In Preparation: Abstracts: Winnick, Jason J., Kraft, G., Gregory, J., Edgerton, D.S., Williams, P., Smith, M., Farmer, B., Scott, M., Neal, D., Donahue, P., Allen, E. and A.D. Cherrington. Liver glycogen loading augments the counterregulatory response to insulininduced hypoglycemia. This manuscript is under revision for publication in the Journal of Clinical Investigation. Abumrad, NN, Bosompem, A, Gregory, JM, Sidani, RM, Tamboli, RA and Jason J Winnick. A novel mechanism by which Roux-en-Y gastric bypass surgery increases insulin responsiveness in obese humans with type 2 diabetes. I will be the senior author on this paper and expect to submit it to the Journal of Clinical Investigation this coming fall. Winnick, Jason J., Duvuuri, V., Gaillard, T., Osei, K., Habash, D.L., and Schuster, D.P. (2002). Impact of exercise on body composition and glucose metabolism in African-Americans and Caucasians with type 2 diabetes mellitus. Diabetes. 51(S2): A539. Schuster, D.P., Winnick, Jason J., Gaillard, T., and Osei, K. (2003). Racial differences in the impact of exercise on body composition in African-Americans and Caucasian-Americans with type 2 diabetes mellitus. Diabetes. 52(S1): A506. Schuster, D.P., Winnick, Jason J., Osei, K., and Gaillard, T. (2004). Racial differences in body composition in response to resistive exercise in African- Americans and Caucasian-Americans with type 2 diabetes. Diabetes. 53(S2): A533. Winnick, Jason J., and Schuster, D.P. (2004). The comparison of multiple body composition assessment modalities in obese patients with type 2 diabetes mellitus. Diabetes. 53(S2): A533. Winnick, Jason J., and Schuster D.P. (2005). African Americans demonstrate a preferential response to resistive training versus aerobic training in body composition and glucose metabolism. Diabetes. 54(S1): A598. Winnick, Jason J., Sherman, W.M., Stout, M.B., and Schuster, D.P. (2007). Short-Term Aerobic Exercise Training Differentially Affects Muscle and Hepatic Insulin Sensitivity in Humans with Type 2 Diabetes Mellitus. Diabetes. 56(S1): A278.

8 An, Z., Moore, M.C., Winnick, Jason J., Lautz, M., Farmer, B., Neal, D., and Cherrington, A.D. (2007). Portal infusion of the selective serotonin reuptake inhibitor Escitalopram enhances hepatic glucose disposal in vivo. Diabetes. 56(S1): A394. Winnick, Jason J., An, Z., Moore, M.C., Neal, D.W., Farmer, B., and Cherrington, A.D. (2008). Hepatic Glycogen Content Does Not Alter the Uptake of Glucose by the Liver In Vivo. Diabetes. 57(S1): A420. An, Z., Winnick, Jason J., Moore, M.C., Neal, D., Farmer, B., Rodewald, T., Snead, W., and Cherrington, A.D. (2008). A NO/sGC/cGMP Dependent Mechanism Is Involved in the Regulation of Net Hepatic Glucose Uptake by Hepatic Nitric Oxide In Vivo. Diabetologia. 51(S1): S268. Winnick, Jason J, An, Z., Ramnanan, C. J, Smith, M., Irimia-Dominguez, J., Neal, D.W, Roach, P.J, and Cherrington A.D. (2009). Increasing the hepatic glycogen content impairs insulin signaling and glycogen synthesis. Diabetes. 58(S1): A386. An, Z., Winnick, Jason J., Moore, M.C., Farmer, B., Neal, D.W., Snead, W., Vaughan, S., and Cherrington, A.D. (2009). A sgc/cgmp dependent mechanism is involved in the regulation of net hepatic glucose uptake in conscious dogs. Diabetes. 58(S1): A20. An, Z., Winnick, Jason J., Farmer, B., Lautz, M., Neal, D.W., Snead, W., and Cherrington, A.D. (2010). The cgmp pathway plays a role in the regulation of net hepatic glucose uptake (NHGU) in conscious dogs. Diabetes. 59(S1): A412. Winnick, Jason J., An, Z., Smith, M., Snead, W., and Cherrington, A.D. (2010). Hepatic glycogen supercompensation reduces glycogen synthesis without altering net hepatic glucose uptake in dogs. Diabetologia. 53(S1): S251. Winnick, Jason J., Roop, J., Scott, M., Jacobson, P., Jung, P., Basu, R., Rizza, R., Cherrington, A. and Edgerton, D. (2011). The effect of chronic 11βhydroxysteroid dehydrogenase-1 inhibition on glucose metabolism in response to stress hormones. Diabetes. 60(S1): A272. Winnick, Jason J., Kraft, G., Farmer, B., Lautz, M., Allen, E. and Cherrington, A..D. (2012). Liver glycogen loading amplifies counterregulatory hormone release and the hepatic response to hypoglycemia. Diabetes 61(S1): A453. Winnick, Jason J., Kraft, G., Snead, W., Farmer, B. and Cherrington, A.D. (2012). Liver glycogen loading augments the counterregulatory response to hypoglycemia. Diabetologia 55(S1): S99.

9 Winnick, Jason J., Kraft, G., Gregory, J., Farmer, B., Scott, M., Neal, D., Allen, E. and Cherrington, A.D. (2013). Hepatic glycogen loading increases the counterregulatory response to hypoglycemia by a liver-brain neural connection. Diabetologia. 56(S1): S50. Invited Presentations: Title: Liver glycogen loading augments the counterregulatory response to hypoglycemia. Location: Berlin, Germany (EASD conference). October 5, Title: The Effect of Liver Glycogen Loading On Hepatic Responses to Metabolic Stress. Location: The University of Iowa s Department of Health and Human Physiology. January 17, Title: The Effect of Liver Glycogen Loading On Hepatic Responses to Metabolic Stress. Location: Ohio State University s Department of Human Nutrition. April 12, Title: The Effect of Liver Glycogen Loading On Hepatic Responses to Metabolic Stress. Location: Case Western Reserve University s Department of Medicine. May 22, Title: Hepatic glycogen loading increases the counter-regulatory response to hypoglycemia by a liver-brain neural connection. Location: Barcelona, Spain (EASD conference). September 23, Title: Liver glycogen loading: A weapon against negative outcomes associated with type 1 diabetes or a double-edged sword? Location: SUNY Buffalo Department of Exercise and Nutrition Sciences. November 19, Title: Liver glycogen loading: A weapon against negative outcomes associated with type 1 diabetes or a double-edged sword? Location: Vanderbilt University Children s Hospital Department of Pediatrics. February 21, Title: Liver glycogen loading: A weapon against negative outcomes associated with type 1 diabetes or a double-edged sword? Location: University of Ottawa Department of Cellular and Molecular Medicine. March 11, Title: Liver glycogen loading: A weapon against negative outcomes associated with type 1 diabetes or a double-edged sword? Location: Ohio University Department of Biomedical Sciences. March 13, 2015.

10 References: 1. Alan D. Cherrington, Ph.D. Professor, Department of Molecular Physiology and Biophysics. Vanderbilt University, Nashville, TN (615) or ***Dr. Cherrington was my postdoctoral mentor ( ) and I am currently a Research Assistant Professor in his lab. He is also my K-01 grant co-mentor. 2. Naji Abumrad, M.D. Professor and Chair, Department of Surgery. Vanderbilt University, Nashville, TN (615) or naji.abumrad@vanderbilt.edu ***Dr. Abumrad is my K-01 grant co-mentor. 3. W. Michael (Mike) Sherman, Ph.D. Provost, University of Akron; Akron, OH. (330) or Provost@uakron.edu ***Dr. Sherman was my Ph.D. advisor at Ohio State, and has since moved to Akron to assume the indicated position.