Curriculum Vitae. Name: Ryan M. Sheehy, Ph.D. Kansas City University of Medicine and Biosciences: Assistant Professor

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1 Curriculum Vitae Name: Ryan M. Sheehy, Ph.D. Kansas City University of Medicine and Biosciences: Assistant Professor Professional Address: Strickland Education Pavilion Independence Ave. Kansas City, MO Telephone (office): (816) EDUCATION Graceland University, Lamoni, IA Bachelor of Science in Chemistry ( ) Bachelor of Arts in Mathematics ( ) Minor in Spanish ( ) Ph.D., Pharmacology ( ) Advisor: Dr. Raymond Hohl Thesis: Mechanisms of the anti-proliferative actions of the schweinfurthins in cancer cells University of Iowa College of Education, Iowa City, IA Certificate in College Teaching ( ) APPOINTMENTS Lab Assistant ( , ) Science and Math Department Graceland University, Lamoni, IA Graduate Research Assistant ( ) Lab of Dr. Raymond Hohl Department of Pharmacology

2 Page 2 Post Doctoral Fellow ( ) Lab of Dr. Dawn Quelle Project A: Mechanisms of RABL6A signaling in cancer and NET biology Project B: Role of NIAM in B-cell lymphomagenesis using transgenic animal models Department of Pharmacology Assistant Professor of Pharmacology (2017-present) Division of Basic Sciences Kansas City University of Medicine and Biosciences, Kansas City, MO TEACHING 071:120 Drugs: Their Nature, Action, and Use University of Iowa: Lecturer ( ), Course Coordinator ( ) 071:181 Pharmacology for Pharmacy Students University of Iowa College of Pharmacy: Group Tutor ( ), Lecturer ( ) MED Mechanisms of Disease II, Introduction to Antibiotics Kansas City University (2017) STUDENT MENTORING AND TRAINING Taylor Steckler. Undergraduate pharmacy student, University of Iowa ( ) Kelsey Fillman. Undergraduate public health student, University of Iowa ( ) Zoe Bachman. Undergraduate summer intern, Luther College (2014) Chandini Reddi. Post-baccalaureate research assistant, University of Iowa ( ) Angela Schab. Undergraduate biology student, University of Iowa ( ) Blake Letney. Post-baccalaureate research assistant, University of Iowa ( ) Rutu Patel. Undergraduate biology student, University of Iowa (2016) Maureen Lamb. Cellular biology graduate student, University of Iowa (2016) Jordan Kohlmeyer. Cellular biology graduate student, University of Iowa ( ) Mengya Wang. Pharmacology graduate student, University of Iowa (2016) Chandra Maharjan. Pharmacology graduate student, University of Iowa (2017) HONORS AND AWARDS Honor s List, Graceland University ( ) Wallace B. Smith Spectacular Grant ( ) Graceland Sustaining Grant ( ) Dean s List, Graceland University (2007) Yates Leadership Grant ( ) Rodger R. Engel, M.D., Endowed Science Scholarship ( ) President s List, Graceland University ( ) Graceland University Student Life Award (2010) Carmichael Pre-Med Award (2010) CABTRAC Annual Meeting Travel Award (2016)

3 Page 3 PROFESSIONAL AFFILIATIONS American Association of Cancer Research, Associate Member (2013-present) RESEARCH SUPPORT 1. National Institute of Health T32 Training Grant, Postdoctoral Fellowship, , Department of Free Radical and Radiation Biology, PI: Doug Spitz, 2-T32-CA The goal of this project is to investigate the mechanism of RABL6A function in cancer and to explore the impact of RABL6A function on intracellular redox biology. PUBLICATIONS 1. Kuder, C.H., Sheehy, R.M., Neighbors, J.D., Wiemer, D.F. and Hohl, R.J.: Functional evaluation of a fluorescent schweinfurthin: mechanism of cytotoxicity and intracellular quantification. Molecular Pharmacology 82(1):9-16, PMID: Sheehy, R.M., Kuder, C.H., Bachman, Z. and Hohl, R.J.: Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil. Cancer Biology & Therapy 16(8): , PMID: INVITED SEMINARS 1. Sheehy, R.M., and Hohl, R.J.: Investigations into the cellular effects of the schweinfurthins. Waldorf College Sheehy, R.M., and Quelle, D.E.: The role of ARF partners in B-cell malignancies and neuroendocrine tumors. University of Iowa, Department of Free Radical and Radiation Biology Sheehy, R.M., and Quelle, D.E..: RABL6A is required for Akt-mTOR and Myc signaling in pancreatic neuroendocrine tumor cells. University of Iowa Holden Comprehensive Cancer Center 2016 retreat Sheehy, R.M., and Quelle, D.E.: RABL6A-dependent regulation of c-myc expression and activity is essential for cell cycle progression and survival of pancreatic neuroendocrine tumor cell. University of Iowa Holden comprehensive Cancer Center Retreat Cancer Genes and Pathways Sheehy, R.M., and Quelle, D.E.: RABL6A-dependent regulation of c-myc expression and activity is essential for cell cycle progression and survival of pancreatic ABSTRACTS 1. Sheehy, R.M., Pratt, D., Dudakovic, A., Wasko, B. and Hohl, R. The Effects of a Novel Biophosphonate on Isoprenoid Biosynthesis in Breast Cancer Cells. FUTURE in Biomedicine Research Symposium The University of Iowa, Iowa City, IA, July 31, Poster presentation.

4 Page 4 2. Sheehy, R.M., Bachman, Z., and Hohl, R. Schweinfurthin activity enhanced by verapamil. AACR annual meeting. San Diego, CA, April 5-9, Poster presentation. 3. Sheehy, R.M., Bachman, Z., and Hohl, R. Schweinfurthin activity enhanced by verapamil. University of Iowa Health Sciences Research Week. The University of Iowa, Iowa City, IA, April 22, Poster presentation. 4. Sheehy, R.M., Bachman, Z., and Hohl, R. Schweinfurthin activity enhanced by verapamil. Pharmacology Research Retreat. The University of Iowa, Iowa City, IA, May 8, Poster presentation. 5. Sheehy, R.M., Reddi, C., Schab, A.M., Reilly, J.E., Nteeba, J., Jing, X., Meyerholz, D.K., Janz, S. and Quelle, D.E. The Role of a Novel Tumor Suppressor, NIAM, in Myc-driven B-cell Malignancies. Health Sciences Research Week. The University of Iowa, Iowa City, IA, April 13, Poster presentation. 6. Sheehy, R.M., Schab, A.M., Hagen, J., Salma, U.S., Darboro, B.W., and Quelle, D.E. RABL6A is Required for Akt-mTOR and Myc Signaling in Pancreatic Neuroendocrine Tumors. Pharmacology Research Retreat. The University of Iowa, Iowa City, IA, June 1, Poster presentation. 7. Sheehy, R.M., Schab, A.M., Hagen, J., Salma, U.S., Darboro, B.W., and Quelle, D.E. RABL6A is Required for Akt-mTOR and Myc Signaling in Pancreatic Neuroendocrine Tumors. University of Iowa Holden Comprehensive Cancer Center 2016 retreat. June 22, Poster presentation. 8. Sheehy, R.M., Schab, A.M., Reddi, C., Reilly, J.E., Nteeba, J., Lamb, M.C., Jing, X., Meyerholz, D.K., Janz, S., and Quelle, D.E. The Role of a Novel Tumor Suppressor, NIAM, in Myc-driven B-cell Malignancies. University of Iowa Holden Comprehensive Cancer Center 2016 retreat. June 22, Poster presentation. 9. Sheehy, R.M., Schab, A.M., Hagen, J., Salma, U.S., Darboro, B.W., Bellizzi, A.M., and Quelle, D.E. RABL6A is Required for Akt-mTOR and Myc Signaling in Pancreatic Neuroendocrine Tumors. NANETS 2016 annual meeting. Oct. 1, Poster presentation. 10. Sheehy, R.M., Schab, A.M., Hagen, J., Salma, U.S., Darboro, B.W., Bellizzi, A.M., and Quelle, D.E. RABL6A is Required for Akt-mTOR and Myc Signaling in Pancreatic Neuroendocrine Tumors. CABTRAC 2016 annual meeting. Nov. 5, Poster presentation. 11. Sheehy, R.M., Schab, A.M., Salma, U.S., Hagen, J., Keck, K.J., O Dorisio, T., Howe, J.R., Darbro, B.W., Bellizzi, A.M., Quelle, D.E. RABL6A-dependent regulation of c-myc expression and activity is essential for cell cycle progression and survival of pancreatic 12. Salma, U.S., Sheehy, R.M., Schab, A.M., Hagen, J., Reilly, J.E., Tiwari, N., Nteeba, J., Sherman, S.K., Keck, K.J., O Dorisio, T., Howe, J.R., Bellizzi, A.M., Darbro, B.W., Quelle, D.E. RABL6A, a novel critical regulator of Akt-mTOR signaling in pancreatic 13. Hammond, E., Quelle, D.E., Abou Alaiwa, M.H., Stark, K., Saylor, M., Hogue, S., Rohret, F., Newell Jr., J.D., Sheehy, R.M., Salma, U.S., Meyerholz, D.K., Darbro, B.W., Rogers,

5 Page 5 C.S., Sieren, J.C. Development of a lung cancer pig model: non-invasive characterization with computed tomography. ATS 2017 conference. 14. Salma, U.S., Reilly, J., Hagen, J., Tiwari, N., Sheehy, R.M., Zhan, F., O Dorisio, T.M., Howe, J.R., Bellizzi, A.M., Darbro, B.W., Quelle, F.W., Quelle, D.E. RABL6A, a Novel Critical Regulator of Akt-mTOR Signaling in Pancreatic Neuroendocrine Tumor Cells. AACR annual meeting Washington, D.C. 15. Sheehy, R.M., Schab, A.M., Salma, U.S., Hagen, J., Keck, K.J., O Dorisio, T., Howe, J.R., Darbro, B.W., Bellizzi, A.M., Quelle, D.E. RABL6A-dependent regulation of c-myc expression and activity is essential for cell-cycle progression and survival of pancreatic neuroendocrine cells. University of Iowa Research week 2017, poster presentation.