Office of the Executive Vice President and University Provost UNIVERSITY LOUISVILLE.

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1 UNIVERSITY OF LOUISVILLE. Office of the Executive Vice President and University Provost Memorandum of Understanding in Research, Education and Training Programs Between the University of Louisville Department of Pharmacology and Toxicology (USA), and Ain Shams University, Egypt The Department of Pharmacology and Toxicology of the University of Louisville and Ain Shams University intend to enhance relations between the two universities by developing an academic and cultural exchange in teaching, research and other activities. This agreement describes a MS and PhD partnership in which students can enter and complete an MS program at Ain Shams University and then transfer to the University of Louisville to complete the requirements for the PhD in Pharmacology. The agreement will be coordinated by Dr. Osama EI-Tawil (Cairo University), Dr. Lobna Foad Abdelaziz (Ain Shams University), and Dr. Steven Myers (University of Louisville). ARTICLE I Students from Ain Shams University applying directly into the MS program at the University of Louisville will be required to successfully complete all requirements for the MS degree, including coursework as applicable at the University of Louisville for the MS degree. Courses taken at Ain Shams University will be evaluated on a case-by-case basis for substitution of required courses for obtaining a MS degree at the University of Louisville. Initial evaluations will be conducted by the program coordinators and their recommendations forwarded to the Department of Pharmacology and Toxicology graduate admissions committee at the University of Louisville for final decision. ARTICLE II Students from Ain Shams University applying to the PhD program at the University of Louisville will be required to have an existing MS degree from the Ain Shams University or the University of Louisville. Upon completion of the MS in Pharmacology or Toxicology to be awarded at Ain Shams University (or the University of Louisville), top students will be recommended to apply for transfer to the PhD program in Pharmacology and Toxicology at the University of Louisville. Students will be reviewed for eligibility and acceptance into the graduate program in Pharmacology and Toxicology at the University of Louisville by the graduate admissions committee and by the program coordinators. Courses taken at Ain Shams University will be evaluated on a case-by-case basis for substitution of courses required for a PhD degree at the University of Louisville. Upon transfer to the University of Louisville, students will be required to complete presentation/communication courses as well as the remaining required coursework for the PhD in Pharmacology research ethics). Students will be required and Toxicology (scientific writing, seminar, to pass applicable qualifying exams, including preparation, presentation, submission, and defense of their PhD dissertation proposal. successful defense of their PhD proposal, students will engage in research towards the preparation, presentation, and defense of their PhD dissertation. Upon Following successful completion of all required courses at the University of Louisville and successful defense of their PhD dissertation, the student will be awarded the PhD in Pharmacology and Toxicology from the University of Louisville. University of Louisville Louisville, KY Ph: F:

2 ARTICLE III The projected number of students successfully entering the program at the University of Louisville will depend upon the quality of the students applying to the program (based on GRE scores, transcripts, letters of recommendation) and the capacity of University of Louisville Department of Pharmacology and Toxicology faculty members to incorporate these students into their laboratory research programs. All students who apply for admission to graduate programs at the University of Louisville are eligible to apply for financial assistance from the University of Louisville and elsewhere. Financial assistance from the University of Louisville for students enrolling in Department of Pharmacology and Toxicology graduate programs is awarded on a highly competitive basis through the Integrated Programs in the Biomedical Sciences (IPIBS) gateway. Applicants who apply for advanced academic standing through established partnership agreements are rarely competitive for financial assistance via the IPIBS gateway and should seek financial assistance from other government sources or individual faculty research grants relevant to their dissertation research project. ARTiClE IV Requirements for transfer of students from Ain Shams University into the PhD program in Pharmacology and Toxicology at the University of louisville include: 1. A Letter of application from the student acknowledging that the student is responsible for all required tuition and fees including health insurance to be paid to the University of Louisville. 2. For transfer into the MS or PhD program at the University of Louisville students must provide an official transcript detailing with coursework and grades completed at Ain Shams University. 3. For transfer into the PhD program at the University of Louisville students must provide an Electronic copy of MS thesis awarded from Ain Shams University when available. 4. Results ofthe general Graduate Record Exam or suitable alternative. 5. A minimum of two recommendation letters that include assessment of applicant's competency in written and spoken English as well as student's research skills and applicability for the MS or PhD program. 6. Students will be subject to compliance with entry and visa requirements of Egypt and the United States with assistance provided by the International Center at the University of Louisville. ARTICLE V The present Memorandum of Understanding shall be effective for a period of five years from the date it is signed by both parties. It may be renewed unless written notice is given one year before the termination by one of the two parties.

3 ARTICLE VI Courses taken at Ain Shams University in Pharmacology or Toxicology can substitute courses at the University of Louisville, in either the MS or PhD programs. Evaluation of these courses will be conducted on a case-by-case basis by the program coordinators, who are currently Dr. Osama EI-Tawil (Cairo University), Dr. Lobna Foad Abdelaziz (AinShams University), and Dr. Steven Myers (University of Louisville) as well as the graduate admissions committee at the University of Louisville. Students transferring into the PhD program in Pharmacology and Toxicology at the University of Louisville will be expected to have completed the following course work at the Ain Shams University. Credit hours of each specific course are dependent on the student's major at Ain Shams University. for Course Credit Description Hours General toxicology 3 Dose-response relationship, Factors affecting toxic action, Absorption, distribution, excretion, Metabolism, Bioactivation, Mechanistic toxicology, Diagnosis of poisoning, Treatment of poisoning, Antidotes Pharmacology I 3 Recent concepts in Pharmacology, Drugs acting on the different body systems; their actions, mechanisms of actions, side effects, therapeutic uses, and drug interactions Pharmacology II 3 Studying the antimicrobial drugs, the drugs used for combating internal and external parasites, antiseptics and disinfectants, antifungal drugs, antiviral drugs, growth promoters, drug residues in food of animal origins Physiology 3 Students will explore in details the function of the nervous the endocrine, the reproductive and the digestive system as well their integration to achieve homeostasis. Students will integrate physiological data and mechanisms with the ongoing basic sciences of anatomy, histology and biochemistry and their clinical applications and follow the rapidly changing and details about Molecular physiology and genetics. Biochemistry 3 The course deals with the study of Biological oxidation that includes the bioenergetics, electron transport chain and oxidative phosphorylation and reactive oxygen species. Carbohydrate chemistry and metabolism that include the oxidation of glucose under aerobic (Krebs cycle) and anaerobic condition (glycolysis), glycogen synthesis and conversion of dietary carbohydrates into important metabollc intermediates in the body. Study of Hormones, which include the mechanism of hormone action, hormones chemistry, metaboltc and biologic effects of different classes such as peptide hormones (pituitary and pancreatic hormones), steroidal hormones, and hormones derived from tyrosine amino acid. Integration of metabolism is also studied.

4 Cellular/Molecular 3 The course deals with various metabolic disorders such as those Biology concerning carbohydrate metabolism, lipid and lipoproteins as well as protein metabolism. It also includes a satisfactory understanding about clinical enzymology demonstrating enzyme markers of various diseases. In addition, it involves a full explanation about liver and renal functions and tests evaluating such functions. Mineral metabolism and endocrine system disorders are also covered during the course. Regulation of gene expression, recombinant DNA technology along with a comprehensive classification of tumor markers and their clinical uses are included. Statistics 3 Students will learn the basics of statistical analysis of data, including t- test, ANOVA, chi-square, probability, power analysis, sample size, variance, populations Skills and Ethics of 3 Searching and selection of the points of interest, scientific design of the Scientific Research research experiments, treating experimental animals, How to use library and web net for searching for information, different search enginesevaluation of the published materials - bases for good scientific writingmethods of Data Views - scientific publications- Methods of scientific citation. Students at Ain Shams University will take courses in order to fulfill requirements for the Masters degree in either Pharmacology or Toxicology. These courses will consist of core content courses that will prepare selected students for eligibility to transfer to the University of Louisville Department of Pharmacology and Toxicology for completion of their studies for the PhD. Core content courses for the Masters degree awarded at Ain Shams University will consist of courses specific in either Pharmacology or Toxicology. Detailed information regarding these courses as well as credit hours and course descriptions are provided in the attachment. Curricular requirements to be taken at the University of Louisville for students transferring to the PhD program in pharmacology and toxicology are shown below (steps 1-4 will be completed in the first year of residency at the University of Louisville). 1. Communication in English (3 credits) 2. Scientific Writing (2 credits) 3. Research Ethics (1 credit) 4. Seminar (1 credit) 5. Defense of dissertation proposal (Final Qualifying Exam) 6. Presentation and Defense of PhD dissertation 7. Award of the PhD in pharmacology and toxicology from the University of Louisville

5 ARTICLE VII All instruction and coursework, presentations, examinations and defenses at the University of Louisville are in English. Curricular requirements at the University of Louisville may be revised as needed. Program quality and effectiveness will be assessed through faculty teaching and course evaluations, and through the program review process required of all graduate programs at the University of Louisville. Faculty members from both the University of Louisville and Ain Shams University will be encouraged to travel to the partner University to meet with students, faculty, and administrators to discuss curriculum, course quality, students and logistical issues regarding the successful implementation continuation of this agreement. ARTICLE VIII Students transferring from Ain Shams University will have access to the full complement of services available to students enrolled at the University of Louisville, including health, sports and recreation, the arts, advising, entertainment, and housing. The International Center at the University of Louisville provides comprehensive information and serves all international students at the University of Louisville, including those transferring from Ain Shams University. ARTICLE IX Originals of this Memorandum of Understanding will be prepared in both the Arabic and English languages, and both versions shall be signed by both parties, with each institution to retain an original agreement in Arabic and in English. Notwithstanding the foregoing, both parties agree the English language version of the Memorandum of Understanding is the definitive statement of the agreement between the parties, and is therefore the official version of the Memorandum of Understanding to resolve any issues of interpretation that may arise during the term of the agreement.

6 Signatures for University of Louisville zt;fy Steven R. Myers, Ph.D. Professor Associate Chair for Professional Education Program coordinator Department of Pharmacology and Toxicology dtv d David W. Hein, Ph.D. Professor and Chair Department of Pharmacology and Toxicology Vice Provost for Academic Strategy Toni M. Ganzel, M.D., M.B.A. Dean of the School of Medicine Professor of Otolaryngology University of Louisville School of Medicine Beth A. Boehm, Ph.D. Vice Provost for Graduate Affairs Dean, School of Interdisciplinary and Graduate Studies ~=e~~ Vice Provost for Diversity and International Affairs

7 ...,--- Signatures for AinShams University Prof. Dr. AbdelWahab Wzzat Acting President Ain Shams University Khalifa EI-Maamon st. Abbasiya o ela ntal Chair (Pharmacology) Faculty of Medicine, Ain Shams University Cairo, Egypt Prof. Mona AIKotB Departmental Chair (Forensic and clinical Faculty of Medicine, Ain Shams University Cairo, Egypt Ay-((alt( Lg May Hamza, MB BCh, MSc, MD Associate Professor of Pharmacology Faculty of Medicine, Ain Shams University Cairo, Egypt toxicology)

8 Egyptian Coordinator of Academic Exchange Programs with University of Louisville Osama S. EI-Tawil, Ph.D. Professor and Chair Department of Toxicology and Forensic Medicine Faculty of Veterinary Medicine Egypt University Program coordinator

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