ANAHIT MEHRABYAN, MD. Medical Doctor, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia, 8/1988-8/1994

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1 ANAHIT MEHRABYAN, MD EDUCATION Medical Doctor, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia, 8/1988-8/1994 PROFESSIONAL TRAINING AND EXPERIENCE University of North Carolina, Chapel Hill, NC Clinical Assistant Professor, Division of Neuromuscular Disorders, Department of Neurology, 10/2017- present Resident, Adult Neurology (PGY4), Department of Neurology, University of North Carolina Hospitals, 9/2012-9/2016 Research Associate, Department of Radiology and Neurology, 1/2012-9/2012 Research Fellow, Department of Neurology, 7/2009-9/2010 Research Supervisor: William Powers, MD, H. Houston Merritt Distinguished Professor and Chair of Neurology Department PI of the Projects: Detection of white matter changes by Diffusion Tensor Imaging (DTI) in patients with decreased level of consciousness due to non-traumatic supratentorial hemorrhage. Description: This was a pilot study to detect white matter changes in patients with intracerebral hemorrhage (ICH) and their correlation with depressed level of consciousness and functional outcome of patients after 3 months of first clinical symptoms. Data analysis of brain MRI scans obtained from patients during and prior to their hospitalization for the acute non-traumatic intracerebral hemorrhage. Description: This was a retrospective study designed to review MRI images for any possible diffuse changes of the brain in patients with intracerebral hemorrhage (ICH) in comparison with the normal brain MRI scans obtained from the same subject within 4 years prior to ICH. Postdoctoral Research Associate, Neurosensory Disorders Center, School of Dentistry, 12/2006-6/2009 Research supervisor: Gregory Essick, D.D.S., PhD, Professor, Department of Prosthodontics Description: The project was designed to study sensation and perception of different sensory modalities such as vibration, pressure, temperature in healthy population.

2 Postdoctoral Fellow, Department of Cell and Molecular Physiology, 9/ /2006 Research Supervisor: Robert Sealock, PhD, Professor, Department of Cell and Molecular Physiology Descrption: RNA interference is a unique way of gene silencing; quicker and cheaper method and can be introduced to the restricted group of desirable cells. The project was designed to use short hairpin RNA (shrna), the more natural way of sirna induction. The aim was the introduction of shrna to the skeletal muscles to knockdown proteins of neuromuscular junction. Penn State, Milton S. Hershey Medical Center, Hershey, PA Fellow, Neuromuscular Medicine (PGY5), Department of Neurology, Division of Neuromuscular Medicine, 9/2016 Eastern Virginia medical School, Norfolk, VA Postdoctoral Fellow, Jones Institute for Reproductive Medicine, 7/2004-9/2005 Research Supervisor: Andrei Zalensky, DSci, Associate Professor of Obstetrics and Gynecology Description: Core histones are main proteins of chromatin. They have dual function enabling DNA to become a compact strand, as well as regulating DNA function by their own modification. Our interest was a specific subclass of histones, associated with human testes and sperm cells. Clinical Research Fellowship in Diabetic Neuropathies, Department of Internal Medicine, Division of Diabetes, Endocrinology, and Metabolic diseases, 7/2002-6/2004 Research supervisor: Aaron Vinik, MD, PhD, FCP, FACP, Diabetes Research Institute Scientific Director Project: Small Fiber Neuropathies in Metabolic Syndrome and Newly Diagnosed Diabetes. Description: The project was devoted to a new technique that allows detection of small fiber lesion in the skin. (Immunohistochemistryof intraepidermal nerve fiber). I was involved in neurological evaluation of diabetic patients for detection and follow up of diabetic neuropathies; Nerve Conduction Studies; Skin Biopsy with quantitative analysis of skin small nerve fibers by confocal microscopy International Experience Austria Internship in Neurology, Department of Clinical Neurology, University Hospital of Vienna, Vienna, 9/2001 Internship in Neurology, Department of Neurology, the Landesnervenklinik Salzburg, 7/1999

3 Armenia Resident, Adult Neurology, Department of Neurology, Yerevan State Medical University, Yerevan, 10/ /1997 Staff Neurologist specialized in Neurophysiology, Private practice, Prom Test Laboratories, Yerevan, 9/ /2011 Staff Neurologist specialized in Neurophysiology, Neurology Clinic and Republic Epilepsy Center, Erebouni Medical Center, Yerevan, 10/1997-7/2002 Seminars and Additional Trainings The Fifth Annual Nationwide Children s Hospital/OSU/Wellstone Myology Course, Columbus, OH, 2016 Diabetes Seminars, Endocrine Fellows Foundation, Austin, Texas, 2003 Salzburg Cornell Seminars in Neurology, Cornell University Medical College, Salzburg, Austria, 1997 Workshop in Health Service Management, Yerevan, Armenia, 1997 AWARDS Recipient, Clinical Research Fellowship in Diabetic Neuropathies, American Diabetes Association, 2002 Recipient, Internship in Neurology, American Austrian Foundation, 2001 Recipient, Internship in Neurology, American Austrian Foundation, 1999 CERTIFICATION Neuromuscular Medicine Certification, October 2017 License, Physician License Certificate, NC, May 2017(active Adult Neurology Residency Certification, September 2016 License, Medical Physician and Surgeon, PA, July 2016 (active) ECFMG Certification, April 2008 License in Neurology, Ministry of Health, Yerevan, Armenia, October 1997 Certification of Health Services Management USAID/AIHA/AUPHA, Yerevan, Armenia, May 1997

4 PUBLICATIONS Book Chapters 1. Vinik, A.I., Mehrabyan, A.C., Johnson, D.A. (2004) Gastrointestinal Disturbances" Therapy for Diabetes mellitus and Related Disorders 4 th Edition, Harold E. Lebovitz, American Diabetes Association, Chapter 44 (pp ) 2. Vinik, A.I., Mehrabyan A. (2004) Diabetic Monoradiculopathy/Amyoradiculopathy, Therapy for Diabetes mellitus and Related Disorders 4 th Edition, Harold E. Lebovitz, American Diabetes Association, Chapter 43 (pp ) 3. Vinik, A.I., Pittenger, G., Barlow, P., Mehrabyan A. (2004) Diabetic Neuropathy: An Overview of Clinical Aspects, Pathogenesis, and Treatment Diabetes Mellitus 3 rd Edition, Derek LeRoith, Simeon Taylor and Jerrold Olefsky, Lippincott Williams and Wilkins, Philadelphia, PA, Chapter 91, pp Peer Reviewed Publications 1. Guest, S., Essick, G., Mehrabyan, A., Dessirier, J., McGlone, F. Effect of hydration on the tactile and thermal sensitivity of the lip Physiology & Behavior 01/2014; 123: PMID# Guest, S., Ma, A., Mehrabyan, A., Essick, G., Hopkinson, A., McGlone, F. Perception of the fluids with divers rheology applied to the underarm versus forearm skin Somatosensory & Motor Research 07/2012; 29(3):89-10 PMID# Mehrabyan, A., Guest, S., Essick, G., McGlone, F., Thermal and tactile sensitivity of the scalp Somatosensory & Motor Research 09/2011; 28(3-4):31-47 PMID# Pittenger, G.L, Mehrabyan, A.C., Simmons, K., Rice, A., Dublin, C., Barlow, P., Vinik., A. (2005) Small Fiber Neuropathy is Associated with the Metabolic Syndrome Metabolic Syndrome and Related Disorders, Vol.3, N2, PMID# Vinik, A.I., Mehrabyan, A.C. (2004) Diabetic Neuropathy Medical Clinics of North America, Vol.88, N4, PMID# Vinik, A.I., Mehrabyan, A.C., Colen, L., Boulton, A. (2004) Focal Entrapment Neuropathies in Diabetes Diabetes Care, Vol.27, N7, PMID# Mehrabyan, A.C., Pittenger, G.L., Burcus, N.I., Simmons, K., Vinik, A.I (2004) Polyneuropathy in Patients with Dysmetabolic Syndrome and Newly Diagnosed Diabetes Abstract, Diabetes, Vol.53, N6 8. Vinik, A.I., Mehrabyan, A.C. (2004) Understanding Diabetic Neuropathies Emergency Medicine, Vol.36, N5, Vinik A.I., Mehrabyan, A.C. (2003) Diagnosis and Management of Diabetic Autonomic Neuropathy, Comprehensive Therapy Vol.29 NO.2/3, PMID#

5 Presentations at Professional Meetings 1. Mehrabyan, A.C., Chahin, N., Karam, C. Occurrence of Anti-Hu and Lambert-Eaton Myasthenic Syndromes in a patient with small cell lung cancer Poster presentation at AANEM 62nd Annual Meeting in Honolulu, Hawaii, October 28, Mehrabyan, A.C., JulieAnne G. McGregor, Caroline J. Poulton et al. In-depth analysis of neurologic complications of ANCA vasculitis in a large inception cohort reveals novel associations Oral presentation, The 17 th International Vasculitis &ANCA Workshop, April 2015, London, UK 3. Mehrabyan, A.C, Karam, C., Chahin, N. Neuromuscular case presentation, Inaugural UNC Colloquium on Neuromuscular Disorders, Chapel Hill, NC, February 7, Mehrabyan, A.C., Churikov, D., and Zalensky, A.O. Identification and Localization of the Novel Human Germline-Specific Histone H2B- 175, Research Day, EVMS, Norfolk, VA, October Mehrabyan, A.C., Pittenger, G.L., Burcus, N.I., Simmons, K., Vinik, A.I. Epidermal Nerve Fiber Alterations in Patients with Dysmetabolic Syndrome (DMS) and Type 2 Diabetes (T2D) and Neuropathy 14 th Annual Neurodiab Meeting, Regensburg, Germany, September Vinik, A.I., Mehrabyan, A.C., Stransberry, K.B., Pittenger, G.L., Skin Biopsy in Diabetes and Metabolic Syndrome: External Validation By Comparison With Other Neurologic Tests And Metabolic Parameters. Journal of the Peripheral Nervous System Vol. 8, N3, Sept 2003 (184) 6 th IDF International Symposium on Diabetic Peripheral Neuropathy and Neurodiab Meeting, Sant Malo, France, September ORGANIZATIONAL AFFILIATIONS Member of American Academy of Neurologists Member of American Stroke Association PERSONAL AND OTHER DATA Languages: Armenian (fluent), Russian (fluent), English (fluent)