MARK D. GORRELL PhD CURRICULUM VITAE

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1 MARK D. GORRELL PhD CURRICULUM VITAE January /2/14 Page 1 of 27

2 CURRICULUM VITAE Mark Douglas GORRELL BSc(Hons) PhD Molecular Hepatology Group, Liver Injury and Cancer Program, Centenary Institute Affiliated with the Royal Prince Alfred Hospital and the University of Sydney Medical School Telephone Facsimile Address Centenary Institute, DO6, University of Sydney NSW Australia URL Born 1956 in New South Wales, Australia Nationality Australian QUALIFICATIONS Bachelor of Science [Honours], Australian National University conferred Doctor of Philosophy, Australian National University conferred PRESENT CLASSIFICATION Associate Professor of the University of Sydney. University of Sydney employee. Associate Faculty and Molecular Hepatology unit leader in the Centenary Institute. RESEARCH INTERESTS Understanding the functions of the prolyl oligopeptidase gene family, and the molecular pathogenesis of chronic liver disease. APPOINTMENT HISTORY Feb 2007 Associate Professor AW Morrow Gastroenterology and Liver Centre Discipline of Medicine Central Clinical School Sydney Medical School The University of Sydney Nov 2007 Associate Faculty and Molecular Hepatology unit leader, Liver Immunobiology Program Centenary Institute, Sydney Medical School, University of Sydney Appointment history in the University of Sydney 1995 to 2007 June 2005 Feb 2007 Principal Research Fellow Aug1999 to Jun 2005 Senior Research Fellow Jun 1995 to Aug 1999 Research Fellow AW Morrow Gastroenterology and Liver Centre Discipline of Medicine Central Clinical School Faculty of Medicine The University of Sydney Appointment history in the Royal Prince Alfred Hospital 1994 to 2007 April 2004 Feb 2007 Principal Hospital Scientist Nov 2002 to April 2004 Senior Hospital Scientist Jun 1995 to Nov 2002 Senior Research Fellow Jan 1994 to Jun 1995 Senior Research Officer AW Morrow Gastroenterology and Liver Centre Royal Prince Alfred Hospital Sep 1991 to Dec 1993 Senior Research Associate Neurovirology Laboratories 9/2/14 Page 2 of 27

3 The Johns Hopkins University School of Medicine Baltimore, MD, USA Nov 1989 to Sep 1991 Jul 1988 to Nov 1989 Mar 1984 to Jun 1988 Feb 1982 to Feb 1984 Senior Research Fellow Retrovirus Biology Laboratory Division of Comparative Medicine The Johns Hopkins University School of Medicine Baltimore, MD, USA Senior Hospital Scientist A.W. Morrow Gastroenterology and Liver Centre Royal Prince Alfred Hospital, Camperdown, Australia Research Fellow Centre for Animal Biotechnology School of Veterinary Science The University of Melbourne at Parkville Senior Scientist (project leader) Australian Monoclonal Development Pty Ltd. [a small biotech] 65 Dickson Ave, Artarmon, NSW, Australia EDUCATION 1978 to 1981 Doctor of Philosophy, conferred April Department of Zoology, Australian National University. PhD Thesis: "Monoclonal Antibodies to Fasciola hepatica". Supervisor: Dr M.J. Howell 1977 Honours Thesis: "Antigenic Analysis of Fasciola hepatica" to 1976 Bachelor of Science, Australian National University. Majors: Parasitology, Vertebrate Zoology, Biochemistry. The three major impacts of my research: 1. My discovery, with Dr Abbott, of two enzymes, DPP8 and DPP9, enabled the Merck Corporation to counter screen on these enzymes when developing the first compound, sitagliptin, that selectively inhibits DPP4 but not DPP8 or DPP9. This selective inhibitor is and the most successful type 2 diabetes therapy of the 21 st century. Many other pharmaceutical companies now market similarly selective, safe and effective DPP4 inhibitors. Some such companies licensed DPP8 and contracted me as a consultant or to evaluate DPP4 selectivity. DPP4 inhibitors obtained FDA approval in the USA in 2006 and entered the Australian Public Benefit Scheme in My recent discovery that DPP9 enzyme deficiency is lethal in young mice [Gall et al 2013] confirms that DPP4 selectivity is essential. 2. Our pioneering establishment in Australia of DNA microarray analysis of gene expression in diseased liver led to the novel identification of many disease-associated genes. These discoveries, such as roles for WNT, DDR1, Hedgehog, CD147 and T cells, have been built upon by us and many labs to better understand chronic liver disease. These projects were funded by the peak bodies of both Australia and USA, NHMRC (358398; McCaughan, Gorrell) and NIH (RFA/DK/98.017; Farrell, McCaughan, George). 3. Both DPIV and the DPIV-related enzyme fibroblast activation protein [FAP] are made by tumour stromal fibroblasts. We discovered that FAP is also readily detected in diseased but not healthy liver and that its abundance is proportional to scarring severity. FAP has since been found in other fibrotic diseases. We have shown that FAP influences cell adhesion, migration and death in vitro. Many labs worldwide are now examining potential FAP-targetted disease therapies. RESEARCH GOALS My primary long-term goal is to progress towards an understanding of disease pathogenesis and to learn to harness this knowledge to improve disease outcomes. To this end I have been studying leukocyte phenotypes and the kinetics of local immune responses, comparing effective and ineffective immune responses, biochemical and serological analyses of the glycoproteins of pathogens and mammals. While advancing toward this goal I have accumulated extensive experience in cell biology, immunology and protein biochemistry. My focus has been the pathogenesis of liver diseases, tumours, 9/2/14 Page 3 of 27

4 parasites, bacteria and viruses, in particular immune responses. I am now primarily interested in the pathogenesis of cirrhosis and the roles of a specific class of peptidases, the prolyl oligopeptidases, which includes dipeptidyl peptidase (DPP) 4, DPP8, DPP9 and FAP (fibroblast activation protein). PRODUCTIVITY SUMMARY Income average per scientist per year in the last 3 years: $95,000. Table: Research income ($ thousands) Year Program grant* Project grants Travel awards Applied research ** Annual Totals Scholarships Equipment *** Cummulative Totals , ,029 2, , , , , , , , , ,813 Totals 1,123 2, ,501 6,791 * Amounts are allocations to my group from the NHMRC Program Grants and **Research funds from companies. *** Equipment grants >$30,000 were generally awarded to consortia of many academics. Supervision of PhD Completions: 13 Supervision of Masters of Medicine / MPhil Completions: two Scholarships awarded to students: 13 (6 NHMRC, 6 APA, 1 UPA, 2 SydUni) Current supervision of postgraduate research students: three Current supervision of employees: three Current Collaborations: Centenary Inst, Univ Sydney, interstate, international PUBLICATIONS Parameter Total mean per year mean per paper Year 2013 All publications 26 years *Citations Peer-reviewed publications Book chapters/reviews 33 3 Editorial / commentary 7 0 Patents 5 0 Papers having an IF Impact Factor [IF] Papers in journals of IF Papers in journals of IF 3 to Citations per IF > two years post-publication * Data collected November Impact Factors [IF] are 2013 data. 9/2/14 Page 4 of 27

5 PUBLICATIONS since 1999 Parameter Total mean per year mean per paper Publications in the last 15 years Papers having an Impact Factor Impact Factor *Citations occurring since Hirsch s h-index = 31. i10 index = Hirsch Index for the last 5 years is 25 Citations; 3506 Citations in last 5 years [ ]; Hirsch Index = 26; 2011 Hirsch Index = 26; 2010 Hirsch Index = 24; 2009 Hirsch Index = 23; 2008 Hirsch Index = 22; 2007 Hirsch Index = 22. The six most-cited papers: 325, of Oravecz 1997; 252 of Cox 2003; 217 of Gorrell 2001; 197 of Abbott 2000; 168, of Gorrell 2005; 165, of Levy PERSONAL INTERESTS Tennis, gardening, travel. GRANTS AND AWARDS Australian Wool Corporation Postgraduate Scholarship Australian Wool Corporation project grant, MD Rickard, MR Brandon & MD Gorrell "Cellular immune responses to cysticercosis". $150,000 over 3 years NHMRC project grant, GW McCaughan & MD Gorrell: Structure and Function of Dipeptidyl Peptidase IV (CD26). $211,000 over 3 years NHMRC equipment grant, GA Bishop, MD Gorrell & GW McCaughan: Ultra-low temperature freezer. $13, RK Baird Travel Award $700. MD Gorrell 1996 Human Leucocyte Differentiation Antigen Congress Travel Bursary $1,600. MD Gorrell NHMRC project grant, GW McCaughan & MD Gorrell: Molecular analysis of the multifunctional glycoprotein dipeptidylpeptidase IV. $234,000 over 3 years RIEF (Australian Research Council). Member of Consortium led by A/Prof. R. I. Christopherson, Univ. Sydney. Recombinant Protein Facility. $185, Wellcome Trust. Member of Consortium led by A/Prof. R. Christopherson, Univ. Sydney. Identification and characterisation of purified recombinant proteins by high pressure liquid chromatography-mass spectrometry. $517, RIEF (Australian Research Council). Member of Consortium led by Prof. R. Raison, UTS. A facility for the analysis of biomolecular interactions. $254, The Clive and Vera Ramaciotti Foundation. Member of Centenary Institute consortium. Automated cell counter. $20, Ramaciotti Foundation. Member of Centenary Institute consortium. Multi-label plate reader. $40, Anonymous Philanthropic grant. Inflammation of the gut and liver. MD Gorrell $150,780 over 3 years Australian Brewers' Foundation project grant; Microarray analysis of intrahepatic gene expression in alcoholic liver disease. P. Haber, M. Gorrell, G. McCaughan, R. Batey $40, NHMRC project grant ; The Role of Fibroblast activation protein in Chronic Liver Injury. GW McCaughan, MD Gorrell $255,000 over NHMRC equipment grant; Incubator for insect cell culture. MD Gorrell, J Rasko, C Demangel, GW McCaughan, $9, University of Sydney Sesqui grant; Microarray analysis of intrahepatic gene expression in alcoholic liver disease. P. Haber, M. Gorrell, G. McCaughan $30, Rebecca L. Cooper Foundation: Functional Genomics in Liver and Lung Diseases. GW McCaughan, MD Gorrell, B. Saunders. $9, NHMRC equipment grant; Nucleic Acid Extraction Facility. MD Gorrell, GA Bishop, GM Halliday, WJ Britton $7,510. 9/2/14 Page 5 of 27

6 2003 Rebecca L. Cooper Foundation: Nucleic Acid Extraction Facility. GW McCaughan, MD Gorrell, GA Bishop, GM Halliday $16, NHMRC / Department of Veterans Affairs project grant ; Microarray analysis of intrahepatic gene expression in alcoholic liver disease. P. Haber, M. Gorrell, G. McCaughan $255,000 over Ernest Heine Foundation. Equipment grant; Cryostat for the study of human liver diseases. G. McCaughan, M. Gorrell, A. Basten. $46, Rebecca L. Cooper Foundation: Localising gene expression. GW McCaughan, MD Gorrell, B. Saunders. $16, NHRMC Equipment grant. Recombinant Protein Facility. Mark D Gorrell, Alexandra F Sharland, Dr Paul S Haber, Dr G Alex Bishop, Prof Geoffrey W McCaughan. $16, NHMRC project grant ; Roles of the dipeptidyl peptidase IV gene family in Human Liver Disease. MD Gorrell, GW McCaughan, $79, Clive and Vera Ramaciotti Foundation. High speed centrifuge for DNA preparation. AF Sharland, RD Allen, GA Bishop, S Chadban, JM Eris, H Wu, C Wang, GW McCaughan, MD Gorrell, A Abendroth $30, Applied research grants from Pharma. Compound selectivity for DPIV. M. Gorrell. $46, Anonymous Philanthropic grant. What are the biological or disease outcomes of lacking DP8 or DP9. MD Gorrell $174,402 over 3 years [58.14K pa] Applied research grants from Pharma. Compound selectivity for DPIV. M. Gorrell. $66, NHMRC Program grant Molecular and cellular pathogenesis of human liver disease. G. Farrell, G. McCaughan, J. George (CIs) and Principal Investigators Gorrell, Bertolino, Teoh, Shackel, Bowen, Leclerq. $4.6 million over 5 years. [$926,000 in 2005, $938,000 in 2006 etc] 2005 University of Sydney R & D grant. Human biology of dipeptidyl peptidases. GW McCaughan, M Gorrell. $49, Ferring Research Ltd, Southhampton, UK. Project grant. Liver fibrosis, M. Gorrell. $79, Rebecca L. Cooper Foundation. HPLC protein separation. W. Britton, G. W. McCaughan, M. Gorrell, J. Allen. $16, University of Sydney Equipment grant. High performance liquid chromatography protein separation. Consortium led by Prof W. Britton. $45, University of Sydney Equipment grant. FACS Aria. Consortium led by A/Prof Nick King. $248, NHMRC Equipment grant. Cooled gradient palm cycler and rotor-shake genie. GA Bishop, AF Sharland, S Chadban, RDM Allen, MD Gorrell $10, Perpetual Trustees Equipment grant. HPLC protein separation. W. Britton, G. W. McCaughan, M. Gorrell, J. Allen. $17, Cancer Institute NSW Research Infrastructure Grant. Gel imaging facility. John Allen, Mark Gorrell, Rosetta Martiniello-Wilks, Stephen Clarke, Jonathon Arnold. $60, Interactions between porcine ligands and the human lymphocyte activating receptor NKG2D AF Sharland, MD Gorrell, M Sandrin, D Christiansen. ID: Roche Organ Transplantation Research Foundation. $220,000 over 3 years. [$71,000 in 2007] 2006 Applied research grants from Pharma including Boehringer Ingelheim, Glenmark and Servier. Compound selectivity for DPIV. M. Gorrell. $52, NHMRC Equipment grant. G. W. McCaughan, Mark Gorrell, Alexandra Sharland, Paul S. Haber, Bret W. Church, Patrick Bertolino Refrigerated Incubator and Analytical Apparatus $29, Probiomics Ltd. Probiotics and immune responses. Mark Gorrell, $10, Univ Sydney Equipment grant. W Britton, B Fazekas, GW McCaughan, M Gorrell, J Rasko, J Triccas, A Abendroth, B Saunders. Assessing cell proliferation. $50, Clive and Vera Ramaciotti Foundation. W Britton, B Fazekas, GW McCaughan, M Gorrell, J Rasko, J Triccas, B Saunders. Assessing cell proliferation. $25, Anonymous Philanthropic grant. Prolyl oligopeptidases in the pathobiology of chronic liver injury. MD Gorrell $195,021 over 3 years [$65,007 pa] Applied research grants from Pharma. Compound selectivity for DPIV. M. Gorrell. $12, DPIV expression and nanospheres. Ceramisphere Ltd. M. Gorrell. $10, ARC LIEF LE awarded to University of Sydney consortium led by Bret Hambly: BD Hambly, S Bao; GA Bishop; J Black; IL Campbell; Q Dong; MD Gorrell; GE Grau; NH Hunt; NJ King; R Markham; DJ Marsh; KL McDonald; SV McLennan; KJ Rodgers; D Seth. Dako ACIS III Cellular Image Acquisition and Analysis System. $150, NHMRC project grant ; Therapeutic potential of the dipeptidyl peptidase IV gene family. MD Gorrell, $458,750. [153 pa] 2008 NHMRC Equipment grant. Mark Gorrell, Christopher Semsarian, Pu Xia, John Allen, Mika Jormakka, Geoffrey W. McCaughan, John Rasko, Mathew Vadas, Fiona Warner, Devanshi Seth, 9/2/14 Page 6 of 27

7 Tatiana Tsoutsman, Jeff Holst, Silvia Ling. Advanced multiparameter quantitation station. $37, NHMRC Equipment grant awarded to University of Sydney consortium led by Prof Nick King: NJ King, BD Hambly, S Bao; GA Bishop; J Black; IL Campbell; Q Dong; MD Gorrell; GE Grau; NH Hunt; R Markham; DJ Marsh; KL McDonald; SV McLennan; KJ Rodgers; D Seth. Dako ACIS III Cellular Image Acquisition and Analysis System. $24, Perpetual Trustees Clive and Vera Ramaciotti Equipment grant. Fluorescence polarization reader with high performance luminescence. CI: Mathew Vadas. Co-investigators: Mark Gorrell, Christopher Semsarian, Pu Xia, John Allen, Mika Jormakka, Geoffrey McCaughan, John Rasko, Warwick Britton, Barbara Fazekas, Wolfgang Weninger, Jennifer Gamble, Nicholas West, Fiona Warner, Chris Jolly, Devanshi Seth, Charles Bailey, Jeff Holst. $30, Rebecca L Cooper Foundation Equipment grant. Fluorescence polarization reader with high performance luminescence. M Gorrell, P Xia, GW McCaughan, J Rasko, M Vadas, B Fazekas, W Weninger, J Gamble, M Jormakka, C Jolly, F Warner, D Seth, C Bailey, J Holst. $20, NHMRC Equipment grant awarded to University of Sydney consortium led by Prof Nick King: Flow Cytometry, $200, NHMRC Equipment grant awarded to Centenary Institute consortium led by Prof Wolfgang Weininger: Inverted Multiphoton, $75, Anonymous Philanthropic grant. Dipeptidyl peptidases in biology. MD Gorrell $220,521 over 3 years [$73,507 pa] Perpetual Trustees Clive and Vera Ramaciotti Equipment grant. Live cell imaging. CI: Mathew Vadas. Centenary Institute Consortium led by N Haass & N Shackel. $50, Rebecca L Cooper Medical Research Foundation Ltd Equipment grant. Human protein production at 27 degrees. M D Gorrell, WB Church, AF Sharland $20, NHMRC Project grant Diabetes exacerbates non-alcoholic steato-hepatitis (NASH). A/Pr S Twigg A/Pr S McLennan A/Pr M Gorrell. $545,500 [$136,375 to MDG] NHMRC Program Grant awarded to M Vadas, GW McCaughan, J Gamble, P Bertolino, P Xia provides some funds for my research NHMRC Equipment grant awarded to a University-wide consortium led by Dr Mika Jormakka. Automated storage, retrieval, and UV imaging system of protein crystallization, $45,000. CIs Mika Jormakka, Jennifer Gamble, Chris Semsarian, John Rasko, Mathew Vadas, Pu Xia, Mark D Gorrell, Ronald Clarke, Megan Maher, Jeff Holst, W. Bret Church University of Sydney bridging grant. Therapeutic uses of DPP-IV and related proteins. MD Gorrell $50, Diabetes Australia Research Trust General Grant. Targeting proteases for a novel therapy for type 2 diabetes and liver complications. MD Gorrell $59, Anonymous Philanthropic grant. DPP-IV and FAP in Chronic Liver Disease. MD Gorrell $272,160 over 3 years [$90,720 pa] Group of Eight Australia - Germany Joint Research Co-operation Scheme funded by DAAD [Deutscher Akademischer Austauschdienst]. A novel approach to understanding tumour development. O. Schilling 18,000Euro, MD Gorrell $18, Australian Centre for HIV and Hepatitis Virology Research (ACH2) MD Gorrell, A Zekry, GW McCaughan, A Lloyd. Novel outcome predictors in HCV post-liver transplant. $193, Perpetual Trustees Equipment grant. Automated electrophoresis. Consortium led by C. Jolly $30, University of Sydney Equipment Grant Scheme. F. Braet, A. Weiss, N. King, C. dos Remedios, D. Traini, M.B. Graeber, C. Murphy, G. Grau, L. Soon, T.P. Newsome, C. Goldsbury, M. Lovelace, M.D. Gorrell, C. Pollock. Wide field super-resolution microscopy with ground state depletion Exploring nanoscopic life in chronic diseases. USYD $89, Rebecca L Cooper Medical Research Foundation Ltd Equipment grant. Protease therapies for diabetes-associated liver disease. M D Gorrell, F M Keane, A Cook, N A Shackel, D Seth, Jinbiao Chen, C Jolly, N Hare, G W McCaughan. Grant $22,000 Licensing income to University from developed IP: Non-exclusive license fees paid to the University for DP8 and DP9 patents and expenses are managed by the University Business Office (Sydnovate). The primary use of the patents is to measure the selectivity of Dipeptidyl Peptidase IV inhibitors being used for type 2 diabetes therapy. Regarding significance see UniNews item, Sydney s key role in diabetes success by E. Heath. March 21, Maintaining this IP including responses to patent office reports, associated commercial projects and liason with Sydnovate continues to occupy my significant attention. 9/2/14 Page 7 of 27

8 Postgraduate student scholarships awarded to supervised students NHMRC scholarship; PhD: Miriam T. Levy. Hepatic stellate cells in human cirrhosis NHMRC scholarship; M. Med.: Colin Ong. Expression of DPPIV, FAP and CD13 in human skin cancer NHMRC scholarship; PhD: Nicholas A. Shackel. Differential gene expression in human cirrhosis. Primary supervisor Prof G. McCaughan APA scholarship; PhD: Xiao Xuan {Jane} Huang. Pathogenesis of human cirrhosis UPA scholarship; PhD: Joohong Park. Expression, purification and characterisation of dipeptidyl peptidase 8 and DPIV NHMRC scholarship #219707; PhD: Denise MT. Yu. Functional studies of Dipeptidyl Peptidase 8 (DP8) and DP NHMRC scholarship; PhD: Xin {Maggie} Wang. Fibroblast activation protein in cell biology and liver fibrosis NHMRC scholarship #307818; PhD: Katerina Ajami. Dipeptidyl Peptidase 9 expression and action APA scholarship; PhD: Peter Tran. Porcine NKG2D ligands. Primary supervisor Dr A.F. Sharland APA scholarship; PhD: Naveed Ahmed Nadvi. Epitope tags in structural biology. Primary supervisor W. Bret Church of Pharmacy APA scholarship; PhD: Tsun-Wen {Sheena} Yao. Fibroblast activation protein and DPP International scholarship; PhD: Yiqian Chen. Dipeptidyl Peptidase gene expression APA scholarship; PhD: Elisabeth J. Hamson. Endopeptidase substrates APA scholarship; PhD: Yuan Zhou Zheng. Dipeptidyl Peptidases in chronic liver injury APA scholarship; PhD: Hui [Emma] Zhang. Functions and biochemistry of Dipeptidyl Peptidase Sydney Medical School scholarship; PhD: Margaret G. Gall. In vivo function of Dipeptidyl Peptidase 9. TEACHING THESIS Examinations / student guidance University of Melbourne. PhD theses 1996, 1999, University of South Australia (Flinders). MSc thesis Honours MSc thesis University of Sydney. 1 Masters of Medicine, 10 honours theses, 2 PhD theses Monash University PhD thesis 2005, 2010, University of Adelaide. PhD thesis Australian National University. PhD thesis University of Sydney Medicine Central Clinical School Postgraduate Student Review Committee membership University of Sydney Medicine Central Clinical School Postgraduate Student Co-ordinator [acting] Oct Centenary Institute Postgraduate Student Midpoint Review Committees 2002 onwards. [chair x5]. Centenary Institute Higher Degree Committee since Teaching postgraduate students of the University of Sydney Thirteen completions, ten as primary supervisor PhD: Catherine A. Abbott (BSc). Molecular studies of human glycoprotein DPIV/CD26. Primary supervisor Prof GW McCaughan PhD: Miriam T. Levy (MB BS, FRACP). Hepatic stellate cells in human cirrhosis M. Med.: Colin Ong (MB BS). Expression of DPIV, FAP and CD13 in human skin cancer PhD: Nicholas A. Shackel (MB BS, FRACP). Differential gene expression in human cirrhosis. Primary supervisor Prof G.W. McCaughan PhD: Xiao Xuan {Jane} Huang (MD, M. Med.). Pathogenesis of human cirrhosis PhD: Joohong Park (BSc, M Sc). Expression, purification and characterisation of dipeptidyl peptidase 8 and DPIV PhD: Denise Ming Tse Yu (B Med Sci (Hons)). Functional studies of Dipeptidyl Peptidase 8 (DP8) and DP9. 9/2/14 Page 8 of 27

9 PhD: Sunmi Song (BSc (Hons). Molecular pathogenesis of fibrosis PhD: Xin {Maggie} Wang (BSc, MMed). Fibroblast activation protein in cell biology and liver fibrosis PhD: Katerina Ajami. (B Med Sci (Hons)). Functional characterisation of DP8 and DP PhD: Peter Tran (B Med Sci (Hons)). Porcine NKG2D ligands. Primary supervisor Dr AF Sharland. Withdrew from degree PhD: Lisa Wing-Yee Lo (B Med Sci (Hons)). Roles of profibrotic cytokines in liver fibrosis in diabetes. Primary supervisor Pr S. Twigg PhD: Naveed A. Nadvi (BSc (Hons). Epitope tags in structural biology. Primary supervisor W. Bret Church of Pharmacy. Submitted Awarded Dec PhD: Tsun-Wen Yao B. Biotech, M. App. Biotech. FAP and DPP9. Submitted Awarded Graduated Dec M Med: Sumaiya Chowdhury BSc (Hons). DPIV and FAP in metabolism. Awarded Graduated Apr Cosupervisor Dr D. Yu PhD: Yiqian Chen BSc MSc. Dipeptidyl Peptidase gene expression and substrates. Cosupervisor Dr D. Yu PhD: Elizabeth J. Hamson B. Med. Sci. (Hons): Proteinase degradomes. Cosupervisor Dr F. Keane PhD: Yuan Zhou Zheng BSc (Hons) (Univ Sydney). Withdrew from degree. Cosupervisor Pr S. Twigg PhD: Hui [Emma] Zhang B Pharm (China) M Appl Sci (Univ Sydney). Functions and biochemistry of Dipeptidyl Peptidase 9. Cosupervisor Dr F. Keane PhD: Margaret G. Gall BSc MSc (Univ Sydney). In vivo function of Dipeptidyl Peptidase 9. Cosupervisor Dr F. Keane. Teaching Honours research students of the University of Sydney Fourteen honours thesis completions, six as primary supervisor B. Med. Sci. Honours Class 1: Loubnah Zaydan-Slaitini. Effects of soluble CD26 on T cell proliferation B. Sci. Molec. Biol. Honours Class 1: Denise Yu. Cloning a novel prolyl oligopeptidase. Primary supervisor Dr C Abbott B. Med. Sci. Honours Class 1+ University medal: Vanessa Gysbers. The adenosine deaminase binding activity of CD B. Med. Sci. Honours Class 1: Katerina Ajami. Cloning novel prolyl oligopeptidases. Primary supervisor Dr C. Abbott B. Med. Sci. Honours Class 1: Mina Obradovic. Characterisation of a novel dipeptidyl peptidase, DP8. Primary supervisor Dr C. Abbott B. Med. Sci. Honours Class 1: Yvonne Brennan. Pathogenesis of alcoholic liver disease. Primary supervisor Dr D. Seth B. Med. Sci. Honours Class 1+ University medal: Sarah Richardson. Role of EMMPRIN in liver disease. Primary supervisor Dr N. Shackel B. Med. Sci. Honours Class 2: Jamai Rahim. Osteopontin in alcoholic liver disease. Primary supervisor Dr D. Seth B. Med. Sci. Honours Class 1: Betty Chow. ACE2 biochemistry in liver disease. Primary supervisor Dr F. Warner B. Sci. Honours Class 1: Naveed Nadvi. KAT-1 biochemistry. Primary supervisor W. B. Church of Pharmacy B. Med. Sci. Honours Class 2: Sumaiya Chowdhury. DPIV family expression in the immune system. Cosupervisors Dr D. Yu, Dr S. Song B. Med. Sci. Honours Class 1: Elizabeth Hamson. Fibroblast activation protein. Cosupervisor Dr F. Keane B. Sci. Honours Class 1: Alastair Duly. DPIV gene family polymorphisms. Cosupervisors Dr D. Yu, Dr R. Bagnall B. Pharm. Honours Class 1: Zainab Reslan. Structure based drug design. Primary supervisor Dr W B Church B. Pharm. Honours Class 1: Amanda Elaro. Prolyl endopeptidase. Primary supervisor Dr W B Church GMP / MBBS Honours. Pok Fai Wong B.Med.Sci. Substrates of FAP and DPP-IV. Cosupervisor Dr FM Keane. 9/2/14 Page 9 of 27

10 Teaching Postgraduate students: supervision of short Masters research projects Sarah Boustany. Primary supervisor Dr G. Cox. Mr Min Hooi Tai Associate supervisor Ms Denise Yu. Ms Tsun-Wen Yao Associate supervisor Ms Sunmi Song. Ms Jené Roestorf Associate supervisor Dr Denise Yu. Mrs Margaret G. Gall Associate supervisor Dr Denise Yu. Ms Priscilla Tourany Associate supervisor Dr Denise Yu. Teaching Undergraduate students: supervision of research experience Nearly all were students of the University of Sydney Mr Lim, Mr Yeo were enrolled in the University of Sydney Molecular Biotechnology Program. Ms Reikhoff was here as an essential course requirement for her medical degree (University of Gröningen, Holland). Stephanie Seelk was a student in Diploma in Biochemistry and Molecular Biology, Friedrich-Schiller- University, Jena, Germany. Marja Kornhuber was a student in Biochemistry, Free-University, Berlin, Germany. Mr N. Narayan 1990 Mr C. Chin 1993 Ms Denise M.T. Yu 1996 Ms Belinda Creighton 1997 Ms Jennifer Ho 1998 Ms Hannah J.D. North 1999, Mr Kenny Wan 2000, Ms Francine Portelli 2000/1, Ms Konsita Kuswara Ms Souraya Hijazi 2001/02, Ms Lisa Lim 2001/02. Ms Netke Reikhoff Ms Valerie Tan 2002/03. Ms Wimonrat Hoasawadut Mr Ricky Lim Mr Jiun Tzen Yeo Libby Hamson Kaitlyn Preece Stephanie Seelk Marja Kornhuber Lectures for postgraduate teaching courses Immune responses to viruses in the central nervous system. Postgraduate Course in Immunology. Centenary Institute of Cancer Medicine and Cell Biology. June Manufacturing recombinant glycoproteins in mammalian cell culture. Postgraduate Course in Molecular Biology, University of Sydney Faculty of Medicine. August, Liver Inflammation. Postgraduate Course in Immunology. Centenary Institute of Cancer Medicine and Cell Biology. June 1998 and Pathogenesis of Chronic Liver Diseases. Postgraduate Course. Centenary Institute of Cancer Medicine and Cell Biology. Sept Biology of Prolyl Oligopeptidases. Pharmacy. March Supervision of Research Assistants (external funding) Katerina Ajami, B Med Sci (Hons) (Univ Sydney) Xin (Maggie) Wang, BSc (Peking), MSc (Univ Sydney) Kathryn A. Evans, B Med Sci (Hons) (James Cook University) Brenna Osborne, BSc (Hons) (Univ Sydney) Margaret G. Gall BSc MSc (Univ Sydney) Ana Júlia Vieira de Ribeiro BSc MSc (Universidade Federal do Rio de Janeiro) Sumaiya Chowdhury BSc (Hons) M Med (Univ Sydney) Supervision of postdoctoral research fellows (external funding) Catherine A Abbott, BSc PhD (Univ Sydney). Primary supervisor Prof GW McCaughan Devanshi Seth, BSc, PhD. Primary supervisor A/Prof PS Haber Rohan B Williams, BSc, PhD (UNSW). Primary supervisor Prof W. Britton Heather M Knott, BSc (Hons) PhD (Univ Sydney) Joohong Park, BSc, M Sc, and PhD (Univ Sydney) Denise MT Yu, B Med Sci (Hons) PhD (Univ Sydney) Xin (Maggie) Wang, BSc (Peking), MSc (Univ Sydney) PhD (Univ Sydney) Sunmi Song (BSc (Hons) PhD (Univ Sydney) Fiona M. Keane BSc PhD (Dublin) Yiqian Chen BSc MSc PhD (Univ Sydney). 9/2/14 Page 10 of 27

11 RESEARCH COOPERATION: 1. Dr Thilo Kaehne & Professor Dr Siegfried Ansorge, Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany. Epitope mapping antibodies to CD26 using a peptide library, Physiological significance and mechanism of action of DP IV in T cell proliferation Drs Wolfgang Rettig and Andreas Schnapp, Boehringer Ingelheim Pharma KG, Biberach-an-der- Riss, Germany [then Vienna, Austria]. Comparison of Dipeptidyl peptidase IV with Fibroblast Activation Protein: Expression and role in liver cirrhosis Professor Gary Halliday, Department of Dermatology, University of Sydney. Comparison of DP IV with Fibroblast Activation Protein: Expression and role in human skin cancer Dr W. Bret Church, Faculty of Pharmacy, University of Sydney. Modelling structures in the DPP-IV gene family , Professor Ronald Dickinson, Royal Brisbane Hospital. "Adduct formation by DP IV in zomepirac treated rodents" Associate Professor Charles Collyer, Molecular and Microbial Biosciences, University of Sydney. Structure of Dipeptidyl Peptidases Dr George Marinos, St George Hospital. Markers of fibrosis in hepatitis C virus infected human liver Professor Paul Haber, Drug Health Services, RPAH, "Pathogenesis of alcoholic liver disease" University of Sydney HCV Pathogenesis Consortium, including Prof. Geoff Farrell & Professor Jacob George of Storr Liver Unit, Westmead Hospital and Prof. Geoff McCaughan Dr Catherine Abbott, Flinders University of South Australia. Biology and Biochemistry of DPP10, DPP8 and DPP A/Pr Guy Cox, Electron Microscope Unit, Univ Sydney. Novel method to image collagen fibers , Professor Dr Ingrid De Meester, University of Antwerp, Belgium. Enzymology of dipeptidyl peptidase Associate Professor Ossama El Kabbani, Victorian College of Pharmacy, Monash University, Melbourne. Structure of DPP-IV Dr Rohan Williams, UNSW Dept Biotechnology, and Dr Josiah Poon, Univ Sydney Computer Science. Text recognition for understanding microarray data Dr Robert Brink, Centenary Institute. Dipeptidyl peptidase gene deficient animals Dr Alex Sharland, Transplant Surgery, University of Sydney. NK cell surface proteins Professor Stephen Twigg and A/Pr Sue McLennan, Endocrinology Centre, University of Sydney. Chronic liver disease in diabetes Dr W Bret Church, Faculty of Pharmacy, University of Sydney. Biochemistry of recombinant human Kynurenine Aminotransferase Professor Christopher M. Overall, University of British Columbia Centre for Blood Research, Departments of Oral Biological and Medical Sciences and Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada. DPP8 substrates Prof Eileen McLaughlin, Reproductive Science Group, ARC Centre of Excellence in Biotechnology and Development, and School of Environmental and Life Sciences, University of Newcastle. DPPs in testis. 21. Dr Kemal Topaloglu, Cukurova University, Faculty of Medicine, Department of Pediatric Endocrinology and Metabolism, Balcalı, Adana, TURKEY. Structure function in DPPs Dr P. Bertolino and Dr C. Jolly, Centenary Institute. Lymphocytes in DPP knockout mice Professor John Prins, Diamantina Institute, University of Queensland. DPP-IV in adipose tissue Dr Soon Lee, RPAH Pathology Dept. DPP9 expression Professor William Bachovchin, Tufts University, Boston. Dipeptidyl peptidase targeting for therapy and measurement for diagnosis Professor Chris Semsarian, Centenary Institute. DPP polymorphisms Associate Professor Pu Xia, Centenary Institute. DPPs in cell signalling DPP4 in liver cancer Dr Devanshi Seth, Centenary Institute and Drug Health Services, RPAH. DPPs in humans Dr Oliver Schilling, Institute for Molecular Medicine and Cell Research, University of Freiburg. Protease substrates /2/14 Page 11 of 27

12 30. Dr Chuck Bailey, Gene Therapy, Centenary Institute. Protease expression in immortalised fibroblasts Dr Andrew Stephens, Ovarian Cancer Biomarker Research, Prince Henrys Institute for Medical Research, Melbourne, Prof Andrew Lloyd, Dr Amany Zekry, UNSW and St George Hospital, University of New South Wales. DPP-IV in HCV Prof Nicholas Manolios, Dr Wendy Rhee [Lau], Dr Rani Sinnathurai. Westmead Hospital. DPPs in arthritis Dr Derek Spielman. Veterinary Science, University of Sydney. DPP9 knockout mouse pathology Professor Dr Pieter van der Veken and colleagues, University of Antwerp, Belgium. Dipeptidyl peptidase inhibition OTHER PROFESSIONAL ACTIVITIES MEMBERSHIP OF ONLINE ASSOCIATIONS ORCHID. Linkedin Research Gate Service on Institutional Committees University of Sydney Genomics and Bioinformatics Consultative Committee Chair Prof Ron Trent & Prof Tim Littlejohn University of Sydney Institutional Strengths Stream in Microbiology, Infectious Diseases, Immunology and Host Defences Committee Chair Prof W. Britton Centenary Institute Equipment Committee Chair Dr Nicholas Pearce Centenary Institute Major Equipment Committee Chair Prof Antony Basten Centenary Institute Safety Committee Chair Mr Jeffrey Crosbie Centenary Institute Research Strategy Committee (occasional attendance by invitation) Chair Prof Antony Basten. University of Sydney Discipline of Medicine Central School Postgraduate Student Review Committee 2003-present. Chair Prof Colin Sullivan. Centenary Institute Senior Academics Committee (occasional attendance by invitation) 2006 Chair Prof David Burke. Centenary Institute Senior Scientist Committee present. Chair Prof Mathew Vadas. Centenary Institute Postgraduate Studies Committee Chair Prof C Semsarian. Centenary Institute Equipment Committee. Chair A/Prof Mark Gorrell present. Charles Perkins Centre for Obesity Diabetes and Cardiovascular Diseases building user planning committee NHMRC Research Translation Faculty. Aug Service on Conference Committees Treasurer, International Congress on Differentiation and Cell Biology Treasurer, Hunter Cellular Biology Meeting. [An annual conference] Co-convenor of Liver Forum 11 Oct Sydney. Reviewer of Gastroenterological Society of Australia conference abstracts 2004-onwards. International Proteolysis Society 2009: meeting organisation committee member. International Proteolysis Society 2013: meeting organisation committee member. Co-convenor of OMICS conference on Diabetes Nov USA. Reviewer of APASL conference abstracts Conference Session Chair Hunter Cellular Biology Meeting Royal Prince Alfred Hospital Medical Officers Association Reunion Week June College of Health Sciences Conference, Leura, NSW, November The Australian Health and Medical Research Congress, Sydney, November International Congress on Dipeptidyl Amino Peptidases. Magdeburg, Germany College of Health Sciences Conference, Leura, NSW, November Australian Liver Association Apr Qld. OMICS conference on Diabetes Aug Chicago. OMICS conference on Translational and personalised medicine. Aug Chicago. 9/2/14 Page 12 of 27

13 International Proteolysis Society 2013 meeting, Capetown. OMICS conference on Diabetes Nov USA. Editorial Board Membership World Journal of Gastroenterology Open access. Papers reviewed: 38. World Journal of Diabetes Open access. The Open Enzyme Inhibition Journal Open access. Gastroenterology and Hepatology Open access. WebMedCentral faculty member Open access. Open Access Publishing Assess manuscripts for Journals Journals : Nature Structural Biology Lancet Protein Science x2. Clinical Sciences 1999 [review]. Human Immunology. Journal of Gastroenterology and Hepatology. Electrophoresis. GH & IGF (Growth hormone and insulin-like growth factor). BMC Genomics. EMBO Reports. Biotechniques. Cytokine. Journal of Insect Cell Science. Cancer Investigation. Clinical Chemistry Journals 2006: Current Medicinal Chemistry [review]. Liver International [x2]. EMBO Journal [x2]. Acta Pharmacologica Sinica. Cellular and Molecular Life Sciences [review]. World Journal of Gastroenterology. Journal of Neurovirology. Journals 2007: World Journal of Gastroenterology [x10]. Journal of Neurovirology. FEBS Journal. Journal of Investigative Dermatology. Medicine Today. Acta Pharmacologica Sinica. Liver International. Expert Opinion on Medical Diagnostics [Informa Healthcare]. Journals 2008: Trends in Immunology. Acta Biochimica et Biophysica Sinica. World Journal of Gastroenterology [x3]. Liver International. Biochimica et Biophysica Acta - Proteins and Proteomics. Expert Opinion on Pharmacotherapy [Informa Healthcare]. Journal of Cell Communication and Signaling. FEBS Journal. EMBO Reports. Journal of Pathology. Journals 2009: Acta Pharmacologica Sinica. World Journal of Gastroenterology [x4]. FEBS Journal [x2]. Liver International. Journal of Biomedicine and Biotechnology. Diabetes Obesity and Metabolism. Molecular Cancer. Journals 2010: World Journal of Gastroenterology [x6]. Acta Pharmacologica Sinica [x2]. Liver International. European Journal of Pharmacology. Inflammation & Allergy Drug Targets. Journal of Molecular Biology. Biological Chemistry. Advances in Clinical Chemistry. Expert Opinion on Drug Discovery. Journals 2011: World Journal of Gastroenterology [x6]. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery. Expert Opinion on Drug Discovery. Cancer Epidemiology. Biomarkers and Prevention. Journal of Medicinal Chemistry. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery. Journal of Endocrinology. Current Medicinal Chemistry. Regulatory Peptides. Scandinavian Journal of Immunology. Expert Opinion on Therapeutic Patents. Disease Markers. Journal of Physiology and Pharmacology. Liver International. Diabetes/Metabolism Research and Reviews. Current Molecular Medicine. Journals 2012: European Journal of Histochemistry. World Journal of Gastroenterology x3. Acta Pharmacologica Sinica x2. Protein & Peptide Letters. American Journal of Physiology: Gastrointestinal and Liver Physiology. BioMedCentral Cell Biology. Reviews in Medicinal Chemistry. Regulatory Peptides. Endocrinology. Journals 2013: International Journal of Cardiology. Clinical and Experimental Immunology. World Journal of Gastroenterology x 3. World Journal of Diabetes. World Journal of Hepatology. Journal of Molecular Histology. BMC Cell Biology. Biofactors. Micron. Cellular and Molecular Life Sciences. Scandinavian Journal of Immunology, Journal of the Royal Society Interface. Biomed Research. Journals 2014: World Journal of Gastroenterology. Acta Pharmacologica Sinica. Contemporary Oncology. Assess grants for funding bodies since 1999 Grants: NHMRC of Australia , Diabetes Australia Wellcome Trust (UK; ), USA Department of Agriculture (USDA; ), Leo and Jenny Foundation, Auckland Medical Research Foundation, International Federation of Science (Sweden; since 2005), Cure Cancer Australia 2005, Raine Medical Research Foundation of Western Australia Netherlands Organisation for Scientific Research. National Medical Research Council (Singapore) , Austrian Science Fund (FWF). Czech Science Foundation. Institute Mérieux. Croation Science 9/2/14 Page 13 of 27

14 Foundation. Medical Research Council of Portugal. Zurich Cancer League. National Science Centre of Poland. Service to industry Consultant in biotechnology to three firms during the years 1987 to Honorary consultant to Cryosite Ltd regarding ATCC cell lines Advisor on dipeptidyl peptidase IV inhibitor selectivity to pharmaceutical research companies: Seven companies since 2003, including Takeda, Forest, Sanofi-Aventis, Glenmark, Lupin, Torrent, Boehringer Ingelheim. Consultant on dipeptidyl peptidases to Bristol-Meyers Squibb and to Boehringer Ingelheim Other Service Personal computing: Established Apple local area network (LAN) and internet access at Neurovirology, Johns Hopkins Univ Manage Apple PCs in the Liver Lab Cosupervision of numerous PhD students and research assistants since , in addition to those listed above. Treasurer, Australia & New Zealand Society for Cell and Developmental Biology Advisory Board member, International Federation of Science International Advisory Panel for the 8th General Meeting of the IPS Research Committee, Gastroenterological Society of Australia (GESA) MEMBERSHIP OF PROFESSIONAL SOCIETIES American Society for Virology [life member 2005-] American Association for the Advancement of Science Australia & New Zealand Society for Cell and Developmental Biology (ANZSCDBI) (Governing Committee member , Treasurer ). Australian Society for Biochemistry and Molecular Biology (ASBMB) Australian Society for Immunology Gastroenterological Society of Australia Research Committee member International Proteolysis Society Treasurer and Governing Council member The Sydney Protein Group New York Academy of Sciences Australian Society for Medical Research The Immunology Council, The Johns Hopkins University Australian Society for Veterinary Pathology European Association for the Study of Diabetes RESEARCH EXPERIENCE I have trained in immunology, biochemistry, virology, liver disease pathogenesis, and serology. I was primarily in veterinary research until re-training into medical research at Johns Hopkins University I am now primarily interested in the pathogenesis of cirrhosis and the roles of dipeptidyl peptidase (DPP) 4, DPP8, DPP9 and FAP (fibroblast activation protein). From 1977 to 1981 during my Honours and PhD research on fascioliasis I became familiar with the technologies of monoclonal antibody (MAb) production and characterization, serology and protein biochemistry. In 1982 and 1983 I applied this experience to commercial research at Australian Monoclonal Development Pty Ltd. in Sydney. The primary achievements of the team I led were in the production, characterization and application to immunodiagnosis of highly specific MAbs to strains of Brucella abortus and to bovine immunoglobulins. In 1984 I made and characterized MAbs to sommatotropins. These MAbs were applied to academic and commercial research on recombinant growth hormones. In 1985 I moved my career into academic research. From 1985 to 1988 I oversaw the MAb laboratory in what is now The Centre for Animal Biotechnology, headed by Dr Mal Brandon. The Centre has been at the forefront of sheep immunology since In this position I worked on producing, characterizing and using MAbs to sheep leukocyte cell surface differentiation antigens. We studied lymphocyte phenotypes in the liver, abomasum, intestine, lungs, skin, mammary glands, lymph nodes and blood of normal and diseased sheep and cattle. I was involved in studying infections of Taenia hydatigena, Haemonchus contortus, Fasciola hepatica, Trichostrongylus colubriformis and 9/2/14 Page 14 of 27

15 Mycobacterium bovis. Our most significant discovery was that the normal liver contains large numbers of CD8 lo CD5 - lymphocytes. In 1988 and 1989 I worked with Dr Geoff McCaughan, Director of Research in the A. W. Morrow Gastroenterology and Liver Centre and Physician in Charge of Transplant Hepatology, Australian National Liver Transplant Unit. My focus was on rat dipeptidyl peptidase IV (DP-IV; CD26). We discovered that the liver antigen gp110 is DP-IV, is on B cells (in addition to T cells, bile canaliculi, endothelium, epithelium, kidney tubules and acinar cells), is a homodimer, and that it is upregulated both on rat T cells following activation and in rat serum during liver regeneration. In 1989 I moved to the Johns Hopkins University School of Medicine to study the pathogenesis of sheep lentivirus with the research group that discovered this virus. With Professor Opendra Narayan DVM PhD and colleagues (1) I determined that Visna virus does not infect T cells, (2) we contrasted the immunopathology of virus isolates causing low and high levels of inflammation in brain, and (3) we studied cytokine production by cocultures of SIV-infected macrophages with T cells. This work contrasts the sheep lentivirus, which does not involve immunodeficiency, with the primate lentiviruses SIV and HIV. From 1991 to 1993 I worked with the eminent expert in viral pathogenesis, Professor Diane Griffin MD PhD. I studied a rodent encephalitic alphavirus model, Sindbis virus, examining the role of the four nonstructural virus proteins in pathogenesis. I found that recombinant Sindbis nonstructural proteins, derived from vaccinia but not from E. coli, can confer protective immunity upon mice by an antibodyindependent, possibly T cell dependent, mechanism. We also compared the cytokine profiles of brains and spinal chords from immune and nonimmune mice. Like hepatitis C virus, Sindbis is a small negative strand RNA virus. In 1994 I returned to the Gastroenterology and Liver Centre to examine CD26/DP IV in more detail. I am using knowledge of the CD26 gene cloned and sequenced in the Liver Centre. We stably transfected CHO cells and purified both wild-type and catalytically inert recombinant soluble human CD26. We dissected out structure/function relationships of CD26. We identified two residues essential for binding to the ligand adenosine deaminase and two residues essential for enzyme activity. In collaboration with Dr Bret Church I modelled the 3D structure of CD26. We are comparing DP IV with other dipeptidyl peptidases such as fibroblast activation protein (FAP) and the novel enzymes DP8 and DP9 that we have cloned. We make and purify enzymes in this work. We have found that FAP is expressed on activated hepatic stellate cells in proportion to the degree of liver injury. The collagen digesting activity of FAP and ligand binding are probably involved in the stellate cell mediated pathogenesis of cirrhosis. We use gene knockout mice in these studies. I have become more directly involved in studying the pathogenesis of chronic liver diseases since Using gene arrays, we have identified novel molecules of interest and are studying some in detail. Since 2005 I have focussed on functions of the DPP-IV enzyme family and their roles in chronic liver injury and diabetes. This work involves many collaborations; those colleagues are listed above. My diverse experience in biochemistry, cell biology, liver disease pathogenesis, HIV-like brain viruses, parasites, immunity and diabetes is being applied to several projects. My research group is focussed upon understanding and improving therapies in the fields of diabetes and chronic liver diseases. PUBLICATIONS Total number of citations: 3,506 to Measured by Google Scholar. [Measured By ISI: 2,604 to ,029 to ,835 to ,603 to to to 2006] Papers with >100 citations: nine papers that are shaded. Papers with >30 citations within 5 years: nine papers since The topics of the most cited papers are: DPP4, DPP8, chemokines, FAP in liver, liver collagen / Second Harmonic Generation. 2006; Oravecz 1997, Levy 1999, Abbott : Oravecz 1997, Abbott 2000, Ajami 2008, and some reviews. 2010: Oravecz 1997, Abbott 2000, Cox 2003, and some reviews. 2011: Oravecz 1997, Abbott 2000, Cox 2003, and some reviews. 2012: Cox 2003, and some reviews. 2013: Oravecz 1997, Levy 1999, Cox 2003 and some reviews. First author publications: 24 9/2/14 Page 15 of 27