BIOMARKER ELISAs for CLINICAL RESEARCH
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1 BIOMARKER s BIOMARKER s for CLINICAL RESEARCH QUANTITATIVE EASY-TO-USE RELIABLE Features & Benefits Characterized epitope-mapped antibodies Validated for clinical samples according to ICH and FDA guidelines Human serum based calibrators & controls Proprietary products - in-house R&D and production Personal and competent customer service SERVICE MEASUREMENTS available BIOMEDICA Medizinprodukte GmbH & Co KG Divischgasse Vienna Austria EUROPE T F export@bmgrp.com
2 BIOMEDICA produces internationally recognized, high quality s for clinical research in the field of cardiorenal diseases as well as bone and mineral disorders. Our customers include numerous top ranking scientific institutions worldwide, well-known CROs and laboratories in the pharmaceutical industry. We are setting the standard for clinical research using serum-based calibrators and controls, thus enabling researchers to collect biologically reliable data. The provided immunoassays are fully validated. Biomedica s experienced and qualified team of professionals provides technical and scientific support. The majority of our assays are marked and ready for use in IVD. The company s manufacturing processes comply with ISO 9001:2015 management system standards and conform to GMP/GLP guidelines. For specific markers, Biomedica has become a market leader with a continuously growing portfolio. A worldwide distribution network has been established for these products as well as an analytical service, which offers customers in-house diagnostic analysis of their samples.
3 FULLY VALIDATED s for CLINICAL RESEARCH QUANTITATIVE EASY-TO-USE RELIABLE C-terminal FGF23 Cat. No. BI Sclerostin Cat. No. BI Bioactive Sclerostin Cat. No. BI DKK-1 Cat. No. BI Periostin Cat. No. BI bone and phosphate metabolism, nephrology, cardiovascular homeostasis Related diseases: hypophosphatemia, vitamin D disorders, autosomal dominant hypophosphatemia (ADHR), X-linked hypophosphatemia (XLH), fibrous dysplasia of the bone intact and the C-terminal fragment of FGF23 human serum and plasma (EDTA, citrate, heparin) overnight assay 50µl / well marked - for IVD use in the EU 9 (product specific) bone and mineral metabolism Related diseases: bone and vascular disease, osteoporosis, cancer induced bone diseases, renal disorders Wnt-signalling antagonist Sclerostin (SOST) human serum and plasma (EDTA, heparin), cell culture and urine protocol overnight assay 20µl / well 100+ (product specific) bone and mineral metabolism Related diseases: bone and vascular disease, osteoporosis, cancer induced bone diseases, renal disorders bioactive Sclerostin and Sclerostin fragments; antibody binding occurs in loop 2, the binding region to the LRP5/6 complex human serum and plasma (EDTA, citrate), cell culture and urine protocol 3.5 hrs 20µl / well bone and mineral metabolism Related diseases: osteoporosis, rheumatoid arthritis, cancer induced bone diseases, vascular calcification, diabetes Wnt-signalling antagonist Dickkopf-1 human serum 3.5 hrs 20µl / well marked - for IVD use in the EU 45 (product specific) bone homeostasis, tissue development and repair Related diseases: osteoporosis, cardiovascular diseases, hypertension, respiratory diseases all known isoforms of human Periostin human serum and plasma (EDTA, citrate, heparin), cell culture and urine protocol 5.5 hrs 10µl / well 2 (product specific) SETTING THE STANDARD FOR CLINICAL RESEARCH export@bmgrp.com
4 FULLY VALIDATED s for CLINICAL RESEARCH QUANTITATIVE EASY-TO-USE RELIABLE Free srankl Cat. No. BI Osteoprotegerin (OPG) Cat. No. BI Soluble Semaphorin 4D Cat. No. BI Total Soluble bone and mineral metabolism, thermoregulation Related diseases: osteoporosis, diseases with locally increased resorption activity, arthritis, type 2 diabetes, cancer induced bone diseases soluble, uncomplexed receptor RANKL (receptor activator of NF-κB) human serum and plasma (heparin) overnight assay 150µl / well marked - for IVD use in the EU 100+ (product specific) bone and mineral metabolism Related diseases: osteoporosis, arthritis, diseases with locally increased resorption activity, cardiovascular disease, vascular calcification monomeric and dimeric Osteoprotegerin human serum and plasma (EDTA, heparin, citrate) 5.5 hrs 20µl / well 96 (product specific) bone homeostasis, immune response, cell migration, vascularisation, neural connectivity, tumor progression Related diseases: osteoporosis, arthritis, type 2 diabetes, cancer related bone diseases, neurological diseases soluble SEMA4D/CD100 human plasma (EDTA, citrate, heparin), cell culture protocol 4.5 hrs 10µl / well immunology, osteology, cardiology, nephrology, oncology Related diseases: kidney disease, cardiovascular disease, cancer Neuropilin-1 Cat. No. BI Human Endostatin Cat. No. BI total soluble NRP1 human serum and plasma (EDTA, citrate, heparin) 4 hrs 10µl / well angiogenesis, cardiovascular homeostasis Related diseases: artherosclerosis, chronic kidney disease (CKD), ischemia, stroke, micro-vascular injury, renal fibrosis, preeclampsia angiogenesis inhibitor Endostatin human serum and plasma (EDTA, citrate, heparin) 4.5 hrs 10µl / sample SETTING THE STANDARD FOR CLINICAL RESEARCH export@bmgrp.com
5 FULLY VALIDATED s for CLINICAL RESEARCH QUANTITATIVE EASY-TO-USE RELIABLE Mouse, Rat Endostatin angiogenesis, cardiovascular homeostasis Related diseases: artherosclerosis, chronic kidney disease (CKD), ischemia, stroke, micro-vascular injury, renal fibrosis, preeclampsia Cat. No. BI-20742MR angiogenesis inhibitor Endostatin in mouse and rats mouse and rat serum and plasma (EDTA, citrate, heparin) 2.5 hrs 5µl / sample for pre-clinical use NT-proCNP Cat. No. BI proanp Cat. No. BI NT-proBNP Cat. No. SK-1204 angiogenesis, growth, skeletal development, cardiovascular homeostasis Related diseases: cardiovascular disease, renal disorders, sepsis, SIRS, preeclampsia C-type natriuretic peptide precursor (AA 24-73) human serum and plasma (EDTA, citrate, heparin), protocol for cell culture supernatant, urine, and non-human samples 4 hrs 20µl / well 13 (product specific) cardiovascular homeostasis, cardiotoxicity in preclinical studies Related diseases: cardiovascular disease, heart failure, transplants, sepsis NT-proANP (1-98) human, rat, mouse, cat and dog serum and plasma (EDTA, heparin), cell culture supernatant, urine 3.5 hrs 10µl / well 62 (product specific; 5 references: CV safety biomarker in rats) cardiovascular and renal homeostasis, regulation of fatty acid metabolism Related diseases: obesity, diabetes, renal failure, cardiac impairment, acute myocardial infarction, secondary hypertension NT-proBNP (1-76) human serum and plasma (EDTA) 3.5 hrs 50µl / well 57 (product specific) BNP fragment Cat. No. BI-20852W cardiovascular homeostasis, renal homeostasis, regulation of fatty acid metabolism Related diseases: obesity, diabetes, renal failure, cardiac impairment, acute myocardial infarction, secondary hypertension NT-proBNP (1-76) and all fragments containing AA 8-29 of the NT-proBNP (1-76 peptide) human serum and plasma (EDTA, citrate, heparin) overnight assay 30µl / well 52 (product specific) SETTING THE STANDARD FOR CLINICAL RESEARCH export@bmgrp.com
6 FULLY VALIDATED s for CLINICAL RESEARCH QUANTITATIVE EASY-TO-USE RELIABLE Endothelin (ET 1-21) regulation of vascular homeostasis Related diseases: arterial hypertension and cardiovascular disorders, cardiac hypertrophy, cerebral vasospasm Cat. No. BI bioactive Endothelin (1-21), a potent vasoconstrictor human serum and plasma (EDTA) overnight assay 50µl / well 46 (product specific) Big Endothelin-1 Cat. No. BI-20082H regulation of vascular homeostasis Related diseases: arterial hypertension and cardiovascular disorders, cardiac hypertrophy, cerebral vasospasm Big Endothelin-1 (Big Endothelin 1-38) human serum and plasma (EDTA, citrate, heparin) 5.5 hrs 50µl / well 13 (product specific) Human olab (Anti oxidized LDL autoantibodies) Cat. No. BI oxidative stress, cardiology Related diseases: cardiovascular diseases autoantibodies to oxidized human low density lipoprotein (LDL) human serum 2 hrs 20µl / well 30 (product specific) OxyStat Cat. No. BI-5007 oxidative stress, cardiology, neurology Related diseases: cardiovascular disease, artherosclerosis, sepsis, carcinogenesis, inflammatory processes, neurodegenerative disease biological peroxidess human serum, EDTA plasma, biological fluids 15 min 10µl / well 19 (product specific) Human MDA-oxLDL Cat. No. BI oxidative stress, cardiology Related diseases: cardiovascular diseases malondialdehyde (MDA)-modified ApoB LDL human serum and plasma (EDTA, citrate, heparin) 3.5 hrs 20µl / well 6 (product specific) SETTING THE STANDARD FOR CLINICAL RESEARCH export@bmgrp.com
7 Analytical Testing Service Biomedica offers a comprehensive testing service for all our proprietary s. As an experienced assay developer and manufacturer in the heart of Europe, our staff contribute to every step in the making of our s, thereby gaining a unique understanding of the assays' performance. Using our analytical custom testing service, even customers without access to a fully equipped laboratory or skilled staff are able to obtain reliable biomarker results from samples of both human and animal origin. Advantages Applications High-quality services Experienced, trained staff Expert sample handling Comprehensive results presented in an analytical report Clinical studies Pre-clinical studies Custom applications
8 WORLDWIDE AVAILABILITY global distribution for reliable results SUPERIOR QUALITY QUALIFIED CUSTOMER SERVICE we for you Don t compromise. Maximise. in-house R&D and production PROPRIETARY PRODUCTS GUARANTEED PERFORMANCE rigorous validation and QC characterized antibodies and reagents HIGHLY SPECIFIC PL BIOMEDICA Medizinprodukte GmbH & Co KG Divischgasse Vienna Austria EUROPE T F export@bmgrp.com
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