BIOGRAPHICAL SKETCH. NAME: Eric Rivas. era COMMONS USER NAME (credential, e.g., agency login): ERICRIVAS1

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1 OMB No and (Rev. 11/16 Approved Through 10/31/2018) NAME: Eric Rivas BIOGRAPHICAL SKETCH era COMMONS USER NAME (credential, e.g., agency login): ERICRIVAS1 POSITION TITLE: Assistant professor, Exercise Physiology EDUCATION/TRAINING INSTITUTION AND LOCATION DEGREE Start Date Completion Date FIELD OF STUDY Texas A&M University, Kingsville, TX BS 08/ /2004 Kinesiology & Education Texas A&M University, Kingsville, TX MS 08/ /2005 Kinesiology Univ. of Texas Southwestern Med Ctr Predoc 08/ /2015 Integrative Physiology Texas Woman s Univ., Denton, TX PhD 08/ /2015 Exercise Physiology Univ. of California, Irvine, CA Postdoc 09/ /2016 Pediatric Obesity Univ. of TX Med Branch, Galveston, TX Postdoc 09/ /2017 Translational Burns A. Personal Statement I am an exercise and thermal physiologist with extensive training in integrative cardiovascular physiology. My research experiences have honed my skills and desire to conduct high-quality research on a variety of clinically relevant questions with greater impact to the general public. I have followed the traditional path of obtaining extramural funding at each stage of my early career. I obtained a prestigious American Heart Association pre-doctoral fellowship during my training at the Thermal and Vascular Laboratory at the Institute for Exercise and Environmental Medicine, University of Texas Medical Center, Dallas that focused on hyperthermia therapy on acute hypotensive response and glycemic control in adults with diabetes. I then joined a nationally recognized NIH T32 postdoctoral fellowship training program for exercise rehabilitation scientists at the University of California-Irvine, School of Medicine which provided training in pediatric exercise physiology and obesity. I then completed the postdoctoral translational burns fellowship program at the University of Texas Medical Branch and Shriners Hospitals for Children at Galveston, where I obtained an NIH Diversity Supplement funded by Eunice Kennedy Institute of Child Health and Human Development to Promote Diversity in Health- Related Research. This work allowed for exceptional training in randomized control trials, exercise science, cardiovascular and metabolism research in clinical populations. I subsequently was awarded a Ruth L. Kirschstein National Research Service Award (F32), funded by the National Heart Lung and Blood Institute. Further, I am a current scholar (cohort 6) in the Program to Increase Diversity in Cardiovascular Health-Related Research (PRIDE-CVD) sponsored by the National Heart, Lung, and Blood Institute, which aims to support minority scientist that focus on addressing cardiovascular disease health disparities research. My previous training has also involved exercise training and its adaptations at the whole-body level (body composition, strength, aerobic capacity) and at the metabolic and cellular level (mitochondrial function, glycemic control, and protein synthesis) in burned populations. Much of this work established exercise rehabilitation prescription guidelines for burn populations. At Texas Tech University I am a tenure-track Assistant Professor of Exercise Physiology and the director of the newly developed Exercise and Thermal Integrative Physiology Laboratory, in which we aim to study environmental factors and nutrition that affect cardiovascular health. 1. Rivas E, Herndon DN, Beck K, Suman OE Burn injury impairs cardiac output during submaximal aerobic exercise in children. Medicine and Science in Sport and Exercise 2017 PMCID:PMC Rivas E, McEntire SJ, Herndon DN, Suman OE Resting β-adrenergic blockade does not alter exercise thermoregulation in children with burn injury: a randomized control trial. Journal of Burn Care and Research PMID: Rivas E, Rao M, Casselberry T., Ben-Ezra V. The change in metabolic heat production is a primary mediator of heat acclimation in adults. Journal of Thermal Biology PMID: Rivas E, Herndon DN, Porter C, Suman OE Short-term metformin and exercise training effects on strength, aerobic capacity, glycemic control and mitochondrial function in burn children. American Journal of Physiology Endocrinology and Metabolism PMID:

2 B. Positions and Honors Positions and Employment Texas Certified Physical Education Teacher, Waco & Aransas County, TX Graduate Teaching Fellow, Dept. of Kinesiology & Biol., Texas Woman s University, Denton TX Research Associate, Thermal and Vascular Physiology lab., IEEM & UTSW, Dallas TX Am. Heart Assoc. Predoc Fellow, Thermal and Vascular Physiology lab., IEEM, Dallas TX NIH T32 Postdoc Fellow, Uni. of California & Inst. for Clinical & Translational Sci., Irvine CA NIH Minority Suppl. Postdoc Research Fellow, Uni. of TX Med. Branch & Shriners Hosp. for Children, Galveston TX Assistant Professor, Dept. of Kinesiology and Sport Mgt., Lubbock TX Other Experience and Memberships 2010 Member, Texas Regional Chapter of the American College of Sports Medicine 2010 Member, American College of Sports Medicine 2011 Member, The American Physiological Society 2012 Member, The Obesity Society 2014 Member, The American Heart Association 2016 Member: The American Burn Association Honors 2013 Research Development Award, Texas Regional Chapter of the American College of Sports Medicine 2013 Carl V. Gisolfi Grant Award, The American College of Sports Medicine 2013 Sanborn Scholarship Award, Texas Woman s University 2014 Predoctoral Fellowship Award, The American Heart Association 2014 Minority Travel Fellowship Award, The American Physiological Society, Experimental Biology 2014 Military Physiology Predoctoral Award, The American Physiological Society 2014 Research grant award, National Swimming Pool Foundation 2014 Outstanding Doctoral Kinesiology Student Award, Texas Woman s University 2014 Minority Travel Award, The Federation of American Societies for Experimental Biology 2015 Student Poster Award, Texas Regional Chapter of the American College of Sports Medicine 2015 Student Manuscript Award, Texas Regional Chapter of the American College of Sports Medicine 2015 Mentee, American Heart Association Council on Hypertension Advisory and Mentoring Program 2017 NIH Diversity Supplement, Eunice Kennedy Institute of Child Health and Human Development to Promote Diversity in Health-Related Research Minority travel fellowship Award, The American Physiological Society, Experimental Biology 2017 Mead Johnson Research Award, The American Physiological Society Endocrinology & Metabolism Section at Experimental Biology Conference 2017 NIH F32 NRSA Individual Postdoctoral Fellowship (declined award), National Heart, Lung, and Blood Institute 2017 Scholar (cohort 6), Program to Increase Diversity in Cardiovascular Health-Related Research (PRIDE- CVD) sponsored by the National Heart, Lung, and Blood Institute 2017 The American College of Sports Medicine Level 3 Leadership & Diversity Award C. Contributions to Science Graduate Career ( ): My doctoral research occurred in two laboratories: 1) Exercise and Biochemistry Laboratory at Texas Woman s University focused on nutrition and exercise perturbations on metabolism in obese type 2 diabetic adults, and 2) The Institute for Exercise and Environmental Medicine, Thermal and Vascular Physiology Laboratory at UTSW focused on temperature regulation in healthy young and aged and burned adult survivors. 1. Nutrition, exercise and passive hyperthermia on metabolism. My research identified that omega-3 supplementation improved lipid profiles; however, did not contribute to post-exercise insulin sensitivity responses. We also reported that acute bouts of passive hyperthermia increased plasma leptin while acutely reducing arterial blood pressure in obese type 2 diabetics. This work highlights the importance of exercise and the novel use of hyperthermia therapy for improving metabolic and vascular function in obese and

3 diabetic populations. Lastly, we showed heat acclimation under uncompensible heat stress is mediated by primary alterations in metabolic heat production. a) Rivas E, Newmire DE, Ben-Ezra V. Obese type 2 diabetics have a blunted hypotensive response to acute hyperthermia therapy that does not affect the perception of thermal stress or physiological strain compared to healthy adults. Physiology & behavior. 2016;165: PMID: b) Rivas E, Newmire DE, Crandall CG, Hooper PL, Ben-Ezra V. An acute bout of whole body passive hyperthermia increases plasma leptin, but does not alter glucose or insulin responses in obese type 2 diabetics and healthy adults. Journal of thermal biology. 2016;59: PMID: c) Rivas E, Wooten JS, Newmire DE, Ben-Ezra V. Omega-3 fatty acid supplementation combined with acute aerobic exercise does not alter the improved post-exercise insulin response in normoglycemic, inactive and overweight men. European journal of applied physiology. 2016;116(6): PMID: d) Rivas E, Rao M, Castleberry T, Ben-Ezra V. The change in metabolic heat production is a primary mediator of heat acclimation in adults. Journal of thermal biology. 2017;70: PMID: Temperature regulation burned adults and simulated hemorrhage in healthy young adults. We reported that adult burn survivors have low aerobic exercise capacity that may increase the risk for cardiovascular disease. It is often recommended that burned individuals not exercise in the heat, due to damaged skin from burn and grafting. Our work showed similar abilities to tolerate heat stress and heat acclimation as non-burned individuals. In addition to utilizing stimulated hemorrhage model, we provided the U.S. Department of Defense valuable information on passive and exercise-heat stress and hemorrhage on cardiovascular function. a) Ganio MS, Pearson J, Schlader ZJ, Brothers RM, Lucas RA, Rivas E, Kowalske KJ, Crandall CG. Aerobic Fitness Is Disproportionately Low in Adult Burn Survivors Years After Injury. Journal of burn care & research 2015;36(4): PMCID: PMC b) Schlader ZJ, Ganio MS, Pearson J, Lucas RA, Gagnon D, Rivas E, Kowalske KJ, Crandall CG. Heat acclimation improves heat exercise tolerance and heat dissipation in individuals with extensive skin grafts. Journal of applied physiology. 2015;119(1): PMCID: PMC c) Gagnon D, Schlader ZJ, Adams A, Rivas E, Mulligan J, Grudic GZ, Convertino VA, Howard JT, Crandall CG. The Effect of Passive Heat Stress and Exercise-Induced Dehydration on the Compensatory Reserve During Simulated Hemorrhage. Shock. 2016;46(3 Suppl 1): PMID: Postdoc Fellowship: : My post-doctoral training occurred in two laboratories: 1) The University of California Irvine (UCI), Galassetti laboratory focused on pediatric obesity and exercise, and 2) Shriners Hospitals for Children (SCH) and The University of Texas Medical Branch at Galveston (UTMB), Metabolism and Pediatric Exercise Physiology laboratory that focused on translational burns in children. 1. UCI: Exercise capacity in obese children. This training strengthened my understanding of obesity and pediatric exercise physiology. We found that peak exercise capacity test examined by allometric scaling and normalized oxygen uptake to kg of lean body suggest obesity reduced cardiorespiratory fitness independent of biological maturation (i.e., puberty) and sex. However, submaximal exercise is affected differently by puberty status in boys and girls. The following manuscripts are in preparation or currently under preparation: 1) Allometric scaling and normalization to lean body mass suggest obesity and metabolic syndrome are associated with reduced peak aerobic capacity in children, and 2) Central role of inflammation on cardiovascular disease progression in obesity, type 1 and type 2 diabetes from children to adults. a) Rivas E, Huynh H, Galassetti, PR Obesity affects relative peak oxygen uptake-heart rate relationship and exercise economy differently in pre and postpubescent boys and girls International Journal of Exercise Science 2. SHC & UTMB: Clinical translational research in burn children. This training provided an exceptional experience with randomized placebo-controlled trials that involved drug (propranolol and metformin) and exercise interactions in clinical populations, and understanding the pathophysiology of hypermetabolism from burn injury. We published several important findings from this work that may help advance exercise science and burn care in burn populations. 1) We found that propranolol (a drug that reduces hypermetabolism) did

4 not negatively affect skin blood flow response at rest in hot conditions or affect temperature regulation during exercise and therefore did not place children at greater risk for hyperthermia; 2) We are also the first to report that severely burn children have heart failure-like characteristics such as attenuated cardiac output and stroke volume during submaximal exercise and exercise intolerance; 3) For the first time, we found that glycemic control is improved after exercise training in burned children; and 4) Lastly, we reported that children with burn injury when compared to age-sex matched non-burned children, have attenuated strength and cardiorespiratory fitness 4 years post burn, suggesting a continued exercise rehabilitation may be needed years after burn injury. a) Rivas E, McEntire SJ, Herndon DN, Suman OE Resting β-adrenergic blockade does not alter exercise thermoregulation in children with burn injury: a randomized control trial. Journal of Burn Care and Research PMID: b) Rivas E, Herndon DN, Beck K, Suman OE Burn injury impairs cardiac output during submaximal aerobic exercise in children. Medicine and Science in Sport and Exercise 2017 PMCID:PMC c) Rivas E, Herndon DN, Porter C, Suman OE Short-term metformin and exercise training effects on strength, aerobic capacity, glycemic control and mitochondrial function in burn children American Journal of Physiology Endocrinology and Metabolism PMID: d) *Cambiaso-Daniel J, *Rivas E, Carson JS, Hundeshagen G, Nunez Lopez, O, Glover SQ, Herndon DH, Suman OE Cardiorespiratory capacity and strength remains attenuated at 4 years post-burn injury in children. The Journal of Pediatrics. * indicates co-first author PMID: Complete List of Published Work in My Bibliography: nding D. Additional Information: Research Support Current Research Support: Texas Tech startup funds 09/01/ Funds used on purchasing new equipment and disposables. Texas Tech University Internal Research Proposal Support Program 04/01/ This grant will cover the cost of collecting pilot data that includes subject compensation and the purchase of disposables for 6 weeks of heat therapy and omega 3 on micro- and microvasculature in Hispanics with Obesity. Completed Research Support: Texas Chapter of The American College of Sports Medicine 08/01/ The goal of the project is to investigate the influence of heat stress at rest on glycemic control in healthy individuals and type 2 diabetics. Carl V. Gisolfi Memorial Fund, American College of Sports Medicine 08/01/ The goal of this project is to investigate the influence of heat stress at rest and during exercise on glycemic control in healthy individuals and type 2 diabetics. #14PRE American Heart Association Predoctoral Fellowship 07/01/ The purpose of this fellowship project was to investigate the influence of heat stress at rest and during exercise on glycemic control and blood pressure responses in healthy individuals and type 2 diabetics. Role: Predoctoral Fellowship (mentor: Craig Crandall, Ph.D., IEEM & UTSW) National Swimming Pool Foundation grant 08/01/ This project assessed the impact of increasing body temperature via warm water immersion at rest and during exercise on glycemic control, insulin sensitivity and acute blood pressure responses.

5 #71006 Shriners Hospitals for Children Suman (PI) 07/01/ Amino acid supplementation in recovery from severe burn The major goal of this Shriners Hospitals for Children funded study was to determine if amino acid supplementation combined with exercise training leads to greater improvements in liver and plasma lipid concentrations and muscle lipid metabolism than exercise alone during rehabilitation in burn children #2T322AR A1 Caiozzo (PI) 07/01/ The major goal of this NIH Clinical Translational Science Award (CTSA) program was to assist in developing the next generation of exercise scientists in exercise and rehabilitation medicine. Role: Postdoc Fellowship (mentor: Pietro Galassetti, M.D., Ph.D., UCI) # 3R01HD S1 Oscar Suman (PI) 01/01/ One Bout of Exercise (one day before the start of exercise training program) and One Bout of Exercise Repeated at the End of the 12-wk Exercise Training Program; Effects of Exercise plus Oxandrolone on Glucose Tolerance and Incretin Response in Burned Children. The major goal of this parent grant diversity supplement was to provide financial support for postdoctoral training fellowship to study projects investigating the metabolism and exercise in burned children. #F32HL Rivas (PI) (declined award) 07/01/17 Cardiovascular, Perception, and Thirst on Exercise Tolerance in Hot Conditions in Burned Children The major goal of this project was to identify whether impaired cardiovascular responses, temperature regulation, and hydration status place burned children at an increased risk for heat-related injury.