Dennis Mathews, O.D. Partner, ESG Board Certified, ABO

Transcription

1 Dennis Mathews, O.D. Partner, ESG Board Certified, ABO

2 Define migraine disorders Signs and symptoms of migraine disorders Differential diagnosis Management

3 A JOKE!!!

4

5 Sensory neurons from trigeminal ganglion Sensory neurons from upper cervical dorsal root Innervate vascular structures intracranially Project to trigeminocervical complex Nerve fibers from trigeminal nucleus caudalis project to the thalamus and then sensory cortex

6 Pain signals are modulated by hyothalamus, periaqueductal gray, pontine locus coeruleus, and nucleus raphe magnus

7

8 Self propagating wave of cellular depolarization that spreads across the cerebral cortex Depressed neuronal bioelectrical activity and altered brain function occurs Activates neurons in the trigeminal nucleus caudalis leading to inflammatory changes in meningeal vascular structures producing headache, upregulating MMP

9 Nociceptive neurons become more sensitive to stimulus due to reduced threshold, increased response magnitude, expansion of receptive field, and development of spontaneous neuronal activity

10 Neurologic symptoms, temporary, unilateral Headaches moderate to severe Pulsating, unilateral, nausea vomiting, light sensitivity, sound sensitivity, smell sensitivity Classical with prodromes, one third of cases Common without prodromes, two third of cases

11 2 hours to 2 days before headache Altered mood, irritability, depression or euphoria Fatigue, stiff neck Cravings for foods Constipation or diarrhea Sensitivity to smell and noise

12 Transient focal neurological phenomenon Gradual development lasting 1 hour Visual, sensory, motor Visual usually scintillating scotoma Sensory pins-and-needles on side of headache with numbness at mouth Motor as hemiplegia Auditory as hallucinations

13 Unilateral, throbbing, moderate to severe 40% with bilateral headaches Pain lasts 4-22 hours in adults, 1 hour in children Basilar with world spinning, light headedness, bilateral visual obscurations Aura may be without headache

14 Sore feeling in area of migraine Impaired thinking Tired or hung over Stomach problems Mood changes

15 Genetic factors, gene markers in familial cases Triggers stress, hunger, fatigue hormonal around menstration not during late stages of pregnancy no clear evidence of food trigers

16 Neurovascular- perhaps high levels of serotonin Possible activation of NMDA receptors Blood flow to cortex decreased Pain caused from intracranial neuropathy and extracranial vasodilation with inflammation

17

18 Four out of five symptoms including pulsating headache, duration of 4-22 hours, pain on one side of head, nausea, symptoms that interfere with life, 92% probability of migraine Fewer than three symptoms, 17% probability of migraine

19 Muscle traction headache Increased ICP Temporal arteritis Cluster headache Acute glaucoma Meningitis Subarachnoid hemorrhage TIA MS

20 Trigeminal nerve- intracranial and extracranial blood vessels, venous sinuses, extracranial muscles, mucous membranes, meninges, the cornea, intraocular structures, and anterior facial skin Cervical nerves 2 and 3- occipital region Intracranial parenchyma has no sensation

21 Stress related Soreness radiation up over the back of neck and head, or tight band feeling around head Prolonged muscle contraction causing spasm Supranuclear suppression of normal reflex depression of prolonged muscle stimulation normally acquired from spindle muscle fibers

22 Bilateral dull, boring pain the temporal or occipital areas Develops as the day progresses Stress in life Treat with oral analgesics, life style changes

23 Tumor Venous Sinus Thrombosis Stenotic Transverse Sinuses IIH Papilledema Diffuse headache, worse when leaning down Nuchal rigidity, vision changes

24

25

26

27

28

29

30

31

32

33 Acute vision loss with ION Temporal headache, tenderness Jaw claudication Joint pain High sed rate, CRP, platelet count

34

35 Awakes patient at night Histaminic HA Four hour duration Unilateral Recurrent, clusters Transient Horner s Pupil

36

37 Narrow angles High spikes in IOP Blurred vision, corneal edema Gonioscopy required Watch for plateau iris

38

39

40 Nuchal rigidity Fever Nausea Elevated WBC WBC in CSF Medical emergency

41

42 Acute, debillitating, HA Nuchal rigidity Tersion s syndrome Comma Dilated and fixed pupils from brainstem compression

43 Transient vision loss Monocular- anterior cerebral circulation Binocular- posterior cerebral circulation May present with flashes of light Differentiate from basilar migraine equivalent

44

45

46

47

48 Transit vision loss Unilateral or bilateral Look for other symptoms of demyelination MRI of brain and cervical spine LP

49

50

51

52 Unilateral headache Increases in intensity with time Pounding pain changing to dull Can continue for days Nausea, vimiting, polyuria, diarrhea, chills, prostration History childhood car sickness

53 Visual prodromes of scintillating scotomas or temporary visual blackouts Other neurologic symptoms possible Pulsating unilateral pain changing to dull pain lasting 6-8 hours Nausea, vomiting, and prostration may occur

54 Causes by vasoconstriction of internal carotid artery branches supplying the intracranial tissues with dilation of the extracranial vessels of the scalp branches of the external carotid artery Vasoconstriction may be neurogenic resulting from stress or other stimuli with resulting hypoxia and acidosis of tissue

55 Acidosis causes secondary dilation of extracranial arteries releasing vasoactive substances and causing a perivascular edema and inflammation Serotonin, bradykinins, histamine, slow reacting substance of anaphylaxis, prostaglandins, and platelet aggregation changes have been associated with migraine

56 Ergotamine vasodilates and can be used to abort the migraine headaache Propanolol, antihistamines, corticosteroids, clonidine, methysergide have also been used to treat Imetrex, aborts pain by blocking pain receptors in the brain

57 First triptan available in US, 1991 Structurally similar to seratonin (5-HT) Agonist for some seratonin receptors, those on cranial arteries and veins Reduces inflammation and causes vasoconstriction of dilated arteries in the brain Reduces activity of trigeminal nerve

58 Dosed oral tablets of 25, 50, 100 mg, nasal spray, injections, and transdermal electrophloresis, injection best Metabolized by monoamine oxidase Side effects include atypical sensations, chest pains, vertigo, malise, sleep disorders, seriouis side effects heart with cornary artery vasospasm

59 Member of family of ergots, is alkaloid which originates in ergot family of fungus Used in combination with caffeine(cafergot) Has been used to treat post-partum hemorrhaging Similar structure of neurotransmitters such as serotonin, dopamine, and epinephrine acting as agonist to these molecules

60 Causes constriction of intracranial extracerebral blood vessels through 5-HT-1B receptor, and inhibits trigeminal neurotransmission by 5-HT-1D receptors Effects D2 dopamine and 5-HT-1A receptors as well Side effects include nausea and vomiting, coronary arterial spasm, dangerous in patients with Raynauds, renal disease, pregnancy

61 Topamax Anticonvulsant drug Available in US since 1996 Effective for treatment of migraine due to effect on cerebral blood vessels Used off label for a number of conditions including IIH, with CAI effect, and cluster headaches Also used to treat diabetic neuropathy

62 Nustagmus Blurred vision Diplopia Vertigo Tinnitus Epistaxis Cognitive disorders Memory impairment

63 Angle closure glaucoma Maculopathy Eye movement disorders Epidermal necrolysis Allergic edema Conjunctival edema Dilated pupils

64 Chemical structure of monosaccharide, similar to fructose Effect on voltage gated sodium channels Effect on high voltage activated calcium channels Effect on GABA-A receptors Effect on AMPA/kainite receptors Effect on Carbonic Anhydrose isoenzymes

65 Valproic acid Used to treat bipolar disorder, epilepsy, and migraine headaches First made 1881 Began use in US in 1962 for seizure disorders

66 Nausea Drowsiness Dizziness Vomiting Weakness Bleeding Suicidal behavior

67 Aspirin, benzodiazepines, cimetidine, erythromycin, felbamate, mefloquine, oral contraceptives, primidone, rifampin, warfarin, zidovudine

68 Protects against a seizure-induced reduction in phosphatidylinositol(3,4,5)triphosphate(pip3) Blockage of voltage dependent sodium channels Increased levels of GABA(gama-aminobutyric acid) Histone deacetylase-inhibiting effects having neuro-protective effects

69 Injections are done in the upper neck Effect is to inhibit muscle spasm at the back of the head Reduces the evolution of headache 31 injections given in seven specific regions of the head and neck Repeat every 3 months Chronic defined as 14 days of headache per month

70

71

72

73

74 Tic douloureux Burning, sharp pain along trigeminal nerve territories Trigger points, activated by touching such as brushing teeth, combing hair, etc. Etiopathic MS HZV Posterior fossa tumor

75 Complete eye exam with dilated fundus Visual fields Neuro eye exam Consider ascultation for bruits Look for orbital signs History to differentiate type of headache Blood pressure Localization of pain- focal possible tumor Check for dry eyes and sinusitis