Case Partial oculomotor nerve palsy due to a basilar tip aneurysm

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1 Case Partial oculomotor nerve palsy due to a basilar tip aneurysm Schepers Christophe 1, Schepers Steven2 1 Medical Student, KU Leuven. UZ Leuven, UZ Gasthuisberg, Herestraat 49, 3000 Leuven; cschepers18@gmail.com 2 Department of Radiology, Jessa Ziekenhuis Hasselt, Stadsomvaart 11, 3500 Hasselt stevenschepers@gmail.com UZ Leuven Section: Neuroradiology Published: 2016, Sep. 4 Patient: 72 year(s), female Clinical History A 72-year-old female patient consulted the neurologist because of ptosis of her left eyelid. This ptosis had aggravated over several months. There was no significant alteration of the pupil. Several investigations were planned including laboratory examination, thoracic X-ray, CT-angiography of the carotid arteries, MRI brain and electromyogram with Jolly-test. Imaging Findings The chest X-ray did not show any tumours in both lungs. The MRI-scan of the brain showed the presence of a saccular basilar tip aneurysm. The diameter of this saccular aneurysm is ± 5.2 mm. Dimensions of the neck are 2.3 mm to 2.2 mm. This aneurysm is folded backwards and because of this configuration it impresses the root entry zone of the left oculomotor nerve. This causes the clinical partial oculomotor nerve palsy.

2 The CT-angiography of the carotid arteries, initially intended to rule out an acute dissection of the left internal carotid artery, didn't show any acute dissection of the left internal carotid artery. Besides confirmation of the saccular aneurysm and its proportions, it also shows a tortuous course of the internal carotid arteries with short stenoses and adjacent dilatations, more pronounced on the right side. This so-called string-of-beads" aspect is typical for fibromuscular dysplasia (FMD). Discussion In the case described above an aneurysm of the basilar artery caused a pupil-sparing oculomotor nerve palsy. In complete oculomotor nerve palsy mydriasis of the pupil can be expected. In this case, however, the pupil was spared which means that the parasympathetic fibres originating from the Edinger-Westphal nucleus in the mesencephalon are not yet compressed by the intracranial aneurysm. Ajtai B et al. suggested that because of the topographical relationship between the basilar artery and the oculomotor nerve, an aneurysm of the basilar artery will push first on the ventral-medial aspect of the nerve and thereby spare the parasympathetic fibres innervating the ciliary and sphincter pupillae muscle. Indeed, it is widely accepted that these fibres are not equally distributed on the surface of the oculomotor nerve but form a distinct bundle on the nerve's dorsomedial-medial aspect. [1] Also at the carotid arteries, signs of fibromuscular dysplasia were demonstrated, which can explain the cause of the aneurysm. Fibromuscular dysplasia is an uncommon pathology of intermediate-sized arteries. It is characterized by segmental and non-atherosclerotic disease of arteries in different parts of the body, including intracranial and cervical arteries. The prevalence of FMD in these head and neck arteries is estimated between 0.3 and 3% which is less than its most frequent affected site, in particular the renal arteries. The disease is predominantly female. Many specialists believe this prevalence is underestimated because FMD is mostly asymptomatic. [2, 3] Symptoms that are associated to the disease are due to complications such as spontaneous dissection, severe stenosis or intracranial aneurysm. The symptoms accompanying these complications are highly variable and logically depend on the exact localization and the type of the lesion. No formal radiological diagnostic criteria for FMD exist, although the finding of a string-of-beads aspect of the renal or cervico-encephalic arteries on CT- or MR- angiography is very suggestive of FMD. A web-like" defect at the origin of the internal carotid artery is another suggestive finding. With the renal and cervico-encephalic arteries as main sites, the finding of suggestive aspects compatible with FMD at one site should consecutively be followed by CT- or MR-angiography examination of the other site. [2] Final Diagnosis Basilar tip aneurysm with compression of the oculomotor nerve and underlying fibromuscular dysplasia. Differential Diagnosis List Partial Horner's syndrome, Partial palsy of the oculomotor nerve, Myasthenia gravis

3 Figures Figure 1 3D T1-weighted vibe image after injection of gadolinium Basilar tip aneurysm (1) pressing on the root-entry zone of the left oculomotor nerve (2) Area of Interest: Cardiovascular system; Neuroradiology brain; Vascular; Imaging Technique: MR; Procedure: Diagnostic procedure; Special Focus: Aneurysms; Figure 2 Curved MPR image of CTA Carotid Arteries Tortuous course of the internal carotid arteries (area between arrows) contributing to the String-of-beads" aspect of the right internal carotid artery. Area of Interest: Arteries / Aorta; Cardiovascular system; Head and neck; Imaging Technique: CT; CT-Angiography; Procedure: Computer Applications-Detection, diagnosis; Contrast agent-intravenous;

4 Diagnostic procedure; Special Focus: Dysplasias; Pathology; Figure 3 Volume rendering of 3D Time-of-Flight image of Circle of Willis Basilar tip aneurysm. Area of Interest: Arteries / Aorta; Neuroradiology brain; Imaging Technique: CT; CT-Angiography; Procedure: Computer Applications-Detection, diagnosis; Contrast agent-intravenous; Special Focus: Aneurysms; References [1] Ajtai B, Fine EJ, Lincoff N. (2004) Pupil-sparing, painless compression of the oculomotor nerve by expanding basilar artery aneurysm: a case of ocular pseudomyasthenia. Arch Neurol 61: [2] Varennes L, Tahon F, Kastler A, Grand S, Thony F, Baguet JP, et al. (2015) Fibromuscular dysplasia: what the radiologist should know: a pictorial review. Insights Imaging 6: [3] Touzé E, Oppenheim C, Trystram D, Nokam G, Pasquini M, Alamowitch S, et al. (2010) Fibromuscular dysplasia of cervical and intracranial arteries. Int J Stroke 5(4): Citation Schepers Christophe 1, Schepers Steven2 1 Medical Student, KU Leuven. UZ Leuven, UZ Gasthuisberg,

5 Herestraat 49, 3000 Leuven; 2 Department of Radiology, Jessa Ziekenhuis Hasselt, Stadsomvaart 11, 3500 Hasselt (2016, Sep. 4) Partial oculomotor nerve palsy due to a basilar tip aneurysm {Online} URL: