Disclosures: Acute Aortic Syndrome. A. Michael Borkon, M.D. Director of CV Surgery Mid America Heart Institute Saint Luke s Hospital Kansas City, MO
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1 Acute Aortic Syndrome Disclosures: A. Michael Borkon, M.D. Director of CV Surgery Mid America Heart Institute Saint Luke s Hospital Kansas City, MO No financial relationships to disclose 1
2 Acute Aortic Syndrome Objectives 1. Define pathology 2. Identify risk factors 3. Identify patients at risk 4. Critical symptoms and signs 5. Discuss Imaging 6. Current appropriate Treatment Scientific American August 2005 Acute Aortic Syndrome Definition Sudden-onset chest pain with contained disruption in aortic wall To reduce mortality 1. Recognize patients with at risk aortas 2. Identify and urgently treat patients with acute aortic syndrome 2
3 Acute Aortic Syndrome Causes Acute Aortic Syndrome Penetrating Aortic Ulcer 1. Acute 2. Intramural Aortic Hematoma 3. Penetrating Aortic Wall Ulcer 4. Contained Aortic Aneurysm Rupture 5. Traumatic Aortic Disruption All Life-threatening All Time Sensitive All Mortal consequences Disrupted atherosclerotic plaques that can penetrate the aortic wall and lead to contained rupture 3
4 Acute Aortic Syndrome Intramural Aortic Hematoma Sudden collection of blood within the aortic wall that occurs without an obvious intimal tear that can grow and result in classic dissection Acute Aortic Syndrome Vulnerable Aorta 1. Acquired risk factors 1. Aortic size 2. Age 3. Tobacco use 4. Hypertension 5. Iatrogenic 6. Pregnancy 7. Cocaine 8. Weight lifting 2. Genetic risk factors 1. Marfan Syndrome 2. Familial TAAD 3. Bicuspid aortic valve PapeLA, Tsai TT, IsselbacherEM, Oh JK, et al. Aortic diameter 5.5 cm is not a good predictor of type A aortic dissection observations from the International Registry of Acute (IRAD). Circulation 2007;116:
5 Spontaneous intimal tear allows redirection of blood flow from aortic true lumen through the defect into the medial of the aortic wall = false lumen Classification Incidence Most frequently recognized lethal condition of the aorta Occurs nearly 3 times as frequently as AAA rupture 5
6 Incidence Pape, LA, et al, Presetnation, diagnosis, and outcomes of acute aortic dissection J Am Coll Cardiol 2015;66:350-8 IRAD TYPE A TYPE B # % % AGE MALE % % MARFAN 122 5% 56 4% H/O HTN % % ANEURYSM % % IRAD Database 12/26/95-2/6/2013 Pathogenesis Direct Mechanical Forces Hypertension 75% Iatrogenic/trauma Hypervolemia of pregnancy Aortic Wall Composition & Size Connective tissue disorders Aortitis Bicuspid aortic valve Cystic medial necrosis Intramural hematoma Although the role of increased aortic wall strain is intuitive, the mechanism by which hypertension actually leads to dissection is unclear 6
7 Complications Complications Malperfusion Rupture Pericardial tamponade Aortic Regurgitation TYPE A Renal 23-75% = Renal Failure Extremities 25-60% = Limb ischemia Abdominal viscera 10-20% = Bowel ischemia Cerebral 3-13% = Stroke Coronary 5-11% = MI Spinal 2-9% = Spinal paralysis 7
8 Complications Symptoms Ascending/Arch Development of a Chronic Aneurysm Made worse by: Patent or partially thrombosed false lumen Hypertension Connective tissue disorder 1. 40% die at onset 2. 30% misdiagnosed thought to be MI 3.Sudden onset of chest pain 1.Ripping/tearing/migratory 2.Location indicates aortic tear 4. Stroke 5. Paralysis 6. Abdominal pain Ascending Descending 8
9 Symptoms & Signs IRAD Database 2/24/10-2/6/13 IRAD TYPE A TYPE B Worse pain % % Anterior pain % % Tearing pain 72 24% 51 30% Syncope 93 22% 13 6% HTN % % Pulse deficit 75 32% 33 24% Physical Findings Type A (ascending) Acutely ill appearing Hypertension Shock Pericardial tamponade Aortic regurgitation Stroke symptoms Extremity ischemia Pape, LA, et al, Presetnation, diagnosis, and outcomes of acute aortic dissection J Am Coll Cardiol 2015;66:
10 Imaging Initial Treatment Chest X-ray EKG MRI ECHO Aortogram CT best Quick and easy 99% sensitive & Specific Chest-abdomen-pelvis Consult CV surgery ICU/CVOR Anti-impulse therapy Beta-blockers Hydralazine 10
11 Type A Repair Operative Mortality 20% Non-operative mortality >60% 11
12 Type A Repair Complicated Acute Type B Dissection Endovascular repair Malperfusion Obliteration false lumen Roselli et al. Ann thorac Surg 2018; 105: Operative mortality 30% if need TEVAR Medical management alone 7-12% 12
13 Complicated Acute Type B Dissection Endovascular repair Size isn t everything! Dissection can occur in the small diameter aorta PapeLA, Tsai TT, IsselbacherEM, Oh JK, et al. Aortic diameter 5.5 cm is not a good predictor of type A aortic dissection observations from the International Registry of Acute (IRAD). Circulation 2007;116:
14 Aortic Aneurysm Size is everything! Risk of rupture increases over 6 cm diameter Large aorta thousands-fold greater risk of dissection Aortic Aneurysm Rupture and/or dissection are Increased in ascending aorta > 6 cm All aortic aneurysm need to be referred to Aortic Program To be followed by knowledgeable team Indications for operation ascending aorta Symptoms >5.5 cm Rapid growth Operative coincidence Elefteriades JA & Farkas, E.A, Thoracic aortic aneurysm, Clinically pertinent controversies and uncertaintiesj Am Coll Cardiol 2010;55:
15 Marfan Syndrome Marfan Syndrome 1 in 5000 persons 53 distinct genetic patterns Autosomal Dominant 50% transmission 25% spontaneous mutation Indications for operation ascending aorta or aortic root >4.5 cm 15
16 Bicuspid Aortic Valve % of population Bicuspid Aortic Valve BAV aortopathy 25-30% Aneurysm risk is 80-fold > Tricuspid AR 10-times > risk of for dissection vs. AS Marfan risk of dissection is 10-fold > BAV! Marfan BAV Aortic repair for size: No aortic risk factors > 5.5 cm Aortic risk factors >5.0 cm Low patient-risk >5.0 cm Concomitant AVR >4.5 cm Aortic arch resection > 5.5 cm Root > Presence of aortic root involvement is concerning 16
17 Acute Aortic syndrome Dissection is NOT random Aortic wall damaged over time Emotional/ Physical stress Susceptibility to aortic aneurysm and dissection is set from birth by genetics Aortic Dissection Aorta enlarges loosing distensibility Excess wall tension Acute hypertensive event exceeds tensile limit of wall Emotional stress or physical exertion 66% Hatzaras I.S., et al. (2007) Role of exertion or emotion as inciting events for acute aortic dissection. Am J Cardiol 100: Ritter Rules High index of suspicion 1. Urgent need for diagnosis and repair 2. Severe, sudden onset, severe pain #1 symptom 3. Often misdiagnosed, always rule out aortic dissection 4. Get the right scan: CTA 5. Know the risk factors: 1. Enlarged aorta 2. Family history aortic disease 3. Genetic syndromes prone to aortic disease 4. Bicuspid aortic valve 6. Triggers 1. Lifestyle 2. Trauma 3. Hypertension 4. Pregnancy 7. Immediate referral to CV surgery 17
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