Effect of prophylactic drugs on vestibular evoked myogenic potential in migraine patients

Transcription

1 Audiol. 2012;21(3): Research Article Effect of prophylactic drugs on vestibular evoked myogenic potential in migraine patients Marziyeh Moallemi 1, Fahimeh Hajiabolhassan 1, Jamileh Fatahi 1, Mansoureh Togha 2, Roya Abolfazli 3, Shohre Jalaie 4, Fatemeh Khamseh Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Iran 2 - Department of Neurology, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Iran 3 - Department of Neurology, Amir Alam Hospital, School of Medicine, Tehran University of Medical Sciences, Iran 4 - Department of Statistics, School of Rehabilitation, Tehran University of Medical Sciences, Iran 5 - Department of Neurology, Faculty of Medicine, Islamic Azad University, Medical Sciences Branch of Tehran, Iran Received: 24 December 2011, accepted: 29 May 2012 Abstract Background and Aim: In many migraine patients prophylactic drugs are effective in reducing attacks and symptoms such as vestibular complaints. Therefore, related neural pathways are probably also affected. This study aimed to compare vestibular evoked myogenic potential in migraine patients under treatment with prophylactic drugs and those without any treatment. Methods: Subjects included 46 patients with migraine. They were evaluated in two groups; those under treatment with prophylactic drugs (21 subjects) and those without treatment (25 subjects). The age range of patients was years. The vestibular evoked myogenic potential were recorded with 500 Hz tone bursts at 95 db nhl. Results: Mean of amplitude ratio (p=0.02), and interpeak latency values in the right ear (p=0.03) and left ear (p=0.001) were higher in patients with prophylactic therapy than the group without therapy; this difference was statistically significant. There was no statistical difference between the two groups in terms of mean of latency of p13 and n23 peaks, and absolute amplitude (p>0.05). Conclusion: Prophylactic drugs probably improve mean of main response parameters of vestibular evoked myogenic potential in migraine patients with prophylactic therapy. Keywords: Vestibular evoked myogenic potential, prophylactic drugs, vestibular system, migraine Corresponding author: Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Nezam Alley, Shahid Shahnazari St., Madar Square, Mirdamad Blvd., Tehran, , Iran. Tel: , abolhassani@sina.tums.ac.ir

2 : :. nhl p=0/001 p=0/03 p=0/02 : n23 p13..(p>0/05). : : (91/3/9 : 90/10/3 : )...(3 2)...(1) : abolhassani@sina.tums.ac.ir : :

3 VEMP 64.(10) (11). VEMP VEMP... ( 3 22) 25 10/44. 4/9 15 ) 21. 7/0. ( 6 6/3 12/ / (International 1988 Headeache Society1988: HIS-1988)..(4 2).(5) ( ). (Vestibular Evoked Myogenic Potential: VEMP) VEMP. (Sternocleidomastoid: SCM) VEMP...(6) p13-n23 VEMP Young Liao. VEMP 2004 VEMP Roceanu.(7) VEMP (2008) (2009) Baier.(8) VEMP. ( ) (2010).(9) VEMP

4 SCM.(3) ( ) SCM.(10) VEMP ICS CHARTR EP. GN otometrics nhl PA-800 ER-3A 5/1. p13-n23 n23 p13. 11/5 SPSS. t.. n23 p13 VEMP VEMP.. VEMP.. 8/56 37/42 35/79. 10/19. ( ) ) ( ( ) ) ) ( (. ( ) (3) ( ) ( ). VEMP. 24 SCM. SCM

5 VEMP 66 VEMP 1 p (n=25) (n=21) VEMP 0/03 7/43 (1/65) 8/49 (1/57) (ms) 0/001 6/86 (1/00) 8/10 (1/22) 0/02 0/12 (0/10) 0/24 (0/21) (µv).(p<0/05)... VEMP. p13. n23 p13.. p13-n23 p13 p13 1/24 16/03. 2/15 16/38 n23 1/30 24/62. 2/33 24/49 16/70 p13 17/07 1/86. 2/41 1/79 24/14 n23. 2/14 23/94 n23 p13.(p>0/05) VEMP 76/47 166/42. 81/87 168/25 133/98 143/57 79/42. 75/29.(p>0/05) 1

6 67..(14). VEMP.. 4/9 7/6 7/0 6/3... 0/3. (6) 0/24.. VEMP..(9 3)..(12) n23 p13.. VEMP..(13) p13 p13..(7-10 3) p13.. VEMP. VEMP VEMP..(6).(7) ( ). VEMP. ( )

7 VEMP 68 VEMP.(7 2 4) ) VEMP (.(3)...(15 3 4).(4 2). VEMP.. VEMP

8 69 ) (. p13. VEMP VEMP. REFERENCES 1. Dash AK, Panda N, Khandelwal G, Lal V, Mann SS. Migraine and audiovestibular dysfunction: is there a correlation? Am J Otolaryngol. 2008;29(5): Baloh RW. Neurotology of Migraine.Headache. 1997;37(10): Allena M, Magis D, De Pasqua V, Schoenen J.Bisdorff AR. The vestibulo-collic reflex is abnormal in migraine. Cephalalgia. 2007;27(10): Galletti F, Cupini LM, Corbelli I, Calabresi P, Sarchielli P. Pathophysiological basis of migraine prophylaxis. Prog Neurobiol. 2009;89 (2): Harno H, Hirvonen T, Kaunisto MA, Aalto H, Levo H, Isotalo E, et al. Subclinical vestibulocerebellar dysfunction in migraine with and without aura. Neurology. 2003;61(12): Hall JW. New handbook of auditory evoked responses. 2 nd ed. Boston: Pearson education Inc; Liao L, Young YH. Vestibular evoked myogenic potentials in basilar artery migraine. Laryngoscope. 2004;114(7): Roceanu A, Allena M, De Pasqua V, Bisdorff A, Schoenen J. Abnormalities of the vestibulo-collic reflex are similar in migraineurs with and without vertigo. Cephalalgia. 2008;28(9): Baier B, Stieber N, Dieterich M. Vestibularevoked myogenic potentials in vestibular migraine. J Neurol. 2009;256(9): Moallemi M, Hajiabolhassan F, Fatahi J, Abolfazli R, Jalaie Sh, Khamseh F. Vestibular evoked myogenic potentials in migraine patients. Audiol. 2011;20(1): Persian. 11. Baier B, Winkenwerder E, Dieterich M. "Vestibular migraine": effects of prophylactic therapy with various drugs. J Neurol. 2009;256(3): Wang SJ, Yeh TH, Chang CH, Young YH. Consistent latencies of vestibular evoked myogenic potentials. Ear Hear. 2008;29(6); Murofushi T, Ozeki H, Inoue A, Sakata A. Does migraine-associated vertigo share a common pathophysiology with Meniere's disease? Study with vestibular-evoked myogenic potential. Cephalalgia. 2009;29(12): Afridi SK, Matharu MS, Lee L, Kaube H, Friston KJ, Frackowiak RS, et al. A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain. 2005;128(4): Hamel E. Serotonin and migraine: biology and clinical implications. Cephalalgia. 2007;27(11):