Colorectal Surgery SSI Prevention Bundle and ERAS. NYSPFP Webinar
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1 Colorectal Surgery SSI Prevention Bundle and ERAS NYSPFP Webinar Christopher Mantyh, MD Duke University Medical Center Professor of Surgery Chief of Colorectal Surgery Chief of Quality
2 Who Cares About Quality in Surgery? The Government CMS ties reported outcomes to payment or penalties medicare.gov/hospitalcompare, Health Grades Current reported surgical outcomes Lower extremity bypass outcomes Colon surgery outcomes Outcomes in operations in patients > 65 years Insurance companies Using follow CMS on reimbursements New bundle payments for a disease state Complications will negatively effect this
3 Who Cares About Quality in Surgery? Hospitals Directly compare hospitals in an location: patient shoppers, referral shoppers Reimbursement: currently a bonus, soon penalties Change from Volume=Quantity/Cost based purchasing to Value=Quality/Cost based purchasing Surgeons Self-realization that surgical complications can be prevented Save money, morbidity, mortality American College of Surgeons established NSQIP to accurately compare outcomes It is the right thing to do Patients
4 Increasing Financial Penalty for HAIs 100% 80% 60% 40% 20% 0% VBP Domain Weights Clinical Process Patient Experiences Outcome Efficiency 6% AMI = acute myocardial infarction; HAC = hospital-acquired condition; HF = heart failure; RRP = Readmission Reduction Program; VBP = Value-Based Purchasing Program. 1. CMS. Hospital-Acquired Conditions. Available at: Accessed July 21, CMS. Hospital Value-Based Purchasing Program Fact Sheet. Available at: Network-MLN/MLNProducts/downloads/Hospital_VBPurchasing_Fact_Sheet_ICN pdf. Accessed August 4, CMS. Readmissions Reduction Program. Available at: Accessed August 4, Arkansas Foundation for Medical Care, Quality Improvements Organization. Available at: Accessed August 20, CareFusion Corporation or one of its subsidiaries. All rights reserved. 4
5 Improvement Initiative for NSQIP: Colorectal SSI Peri-operative bundle Increase laparoscopy ERAS Wound VAC over open cases Wound classification: critically important in risk stratification Use as a model system for general surgery Identify high risk SSI operations Liver, pancreas, gastric, groin node dissections, HIPEC
6 Colorectal Peri-operative Bundle Pre-operative Chlorhexidine (CHG) shower * Chart review- 61% of patients documented to have received pre-op scrub and 91% of those patients completed pre-operative scrub Mechanical bowel prep + oral antibiotics + pre-operative IV antibiotics CHG 70% alcohol prep Intra-operative Antibiotic: Ertapenem (no re-dosing) or Cipro + Flagyl Normothermia Alexis wound protectors (open cases) Change gown and gloves follow anastomosis or at fascial closure Wound closure tray Limit OR traffic *RN CIRCULATORS APPLYING SURGICAL SCRUB AND FOLEY PLACEMENT AS OF SEPTEMBER 2012
7 Peri-operative Bundle (cont.) Post-operative No re-dosing of antibiotics unless clearly documented reason Leave sterile dressings on for 48 hrs CHG wipes daily after dressing removal Strip VACs (trial)
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9 Bundle Reduced SSI Post-op sepsis LOS Variable direct costs
10 Enhance Recovery After Surgery (ERAS)
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12 Surgical Stress
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14 Duke CRS ERAS Protocol
15 Duke CRS ERAS PREOP HOLDING, day of operation -IDENTIFY fast track patients and initiate protocol -THROMBOPROPHYLAXIS timed with epidural -EPIDURAL anesthesia placement INTRAOP -ANTIBIOTICS PROPHYLAXIS before skin incision -SCD s on before induction -GOAL-DIRECTED IVF THERAPY with ESOPHAGEAL MONITORING -TEMPERATURE regulation -NG/OG discontinued before leaving OR POSTOP -IDENTIFY ERAS patients for protocol participation -DIET begins night of surgery -AMBULATION begins night of surgery -HOB at 30 degrees at all times -IVF </= 1L/24hrs (70kg) -EPIDURAL and SCD continuation -post-op THROMBOPROPHYLAXIS begins POD 1
16 Goal Directed Fluid Management Reduce bowel edema Decreases POI Reduces pulmonary complications Especially useful in long procedures with expected extubation Is NOT fluid restrictive
17 Multi-modality Pain Management Previously opioids more opioids additional opioids American Society of Anesthesia 2004 Task Force: Opioid dose-sparing effects (reduced opioid-related adverse events) can be achieved via the use of non-opioid agents and regional blocks. Recommended all patients receive around the clock regimen of a non-opioid agent NSAIDs COXIBs Acetaminophen Consider supplemental regional anesthesia techniques Anesthesiology 2004, 100:
18 Duke Peri-operative Pain Management: Low Thoracic Epidurals T10 region Give test dose once sited as normal 5000U SC heparin can be given immediately after placement Hydromorphone 0.4mg-0.6mg before induction of anesthesia Lidocaine bolus at least 10 minutes pre-incision (40-100mg) 1 g IV acetaminophen prior to incision Run infusion of 0.25% bupivacaine throughout case (3-6 ml/hr) No intraoperative iv opioids after induction without discussion with Attending Anesthesiologist Switch to bupivacaine 0.125%/hydromorphone 10mcg/ml in epidural pump before leaving for PACU at end of case. Settings: Infusion 4-6 ml/hour; 2ml bolus every 30 minutes Max dose set for infusion over 4 hours + 6 boluses (12ml) (example - infusion 5ml/hr; max 32ml over 4 hours)
19 Peri-operative Pain Management Post-operative Continue epidural for 2-3 days (bowel function) IV acetaminophen until tolerating orals Oral opioids with d/c epidural If tolerating liquids, solids move to oral acetaminophen Ibuprofen PRN Ketorolac used sparingly Dry, or elderly patients can push into kidney failure Gastric bleeding Surgical bleeding
20 OBJECTIVE The purpose of this study was to examine the impact of the implementation of the enhanced recovery pathway (ERP) and preventative surgical site infection bundle (SSIB) on colorectal surgery (CRS) outcomes at a single institution. Kennan et al, J Am Coll Surg. 221: , 2015
21 THE PREVENTIVE SSI BUNDLE Kennan et al, J Am Coll Surg. 221: , 2015
22 THE ENHANCED RECOVERY PATHWAY Kennan et al, J Am Coll Surg. 221: , 2015
23 COMPLIANCE Kennan et al, J Am Coll Surg. 221: , 2015
24 Duke ERAS Results Oral intake on the day of surgery 65.5% of ERAS patients vs. 18.8% (p <0.0001). Eating solids on POD1 49% of ERAS patients vs. 12.5% (p< 0.001). Ambulating on POD1 70% of ERAS patients were ambulating. Bowel movement 2.4 days in the ERAS group vs. 3.4 days (p=0.008).
25
26 30-day Post-Operative Outcomes of ACS-NSQIP Sampled Patients Who Underwent Major, Elective Colorectal Surgery, Stratified by the Presence of the Enhanced Recovery Pathway and/or Preventative Surgical Site Infection Bundle 30-day Post-Operative Outcomes Total Cohort 9/2006-3/2013 (n = 787) Pre-ERP/Bundle 9/2006-1/2010 (n = 337) Post-ERP/Pre-Bundle 2/2010-6/2011 (n = 165) Post-ERP/Bundle 7/2011-3/2013 (n = 285) p-value Length of stay (median, Q1, Q3) 5 (4, 8) 6 (4, 8) 5 (4, 8) 5 (3, 7) < Mortality 7 (0.9%) 2 (0.6%) 1 (0.6%) 4 (1.4%) Unplanned reoperation 37 (4.7%) 24 (7.1%) 4 (2.4%) 9 (3.2%) Wound complication 150 (19.1%) 96 (28.5%) 32 (19.4%) 22 (7.7%) < Superficial SSI 132 (16.8%) 83 (24.6%) 31 (18.8%) 18 (6.3%) < Deep SSI 6 (0.8%) 5 (1.5%) 1 (0.6%) 0 (0%) Organ space SSI 46 (5.8%) 28 (8.3%) 10 (6.1%) 8 (2.8%) Deep venous thrombosis 10 (1.3%) 3 (0.9%) 7 (4.2%) 0 (0%) < Pulmonary embolism 5 (0.6%) 1 (0.3%) 2 (1.2%) 2 (0.7%) Stroke/CVA 6 (0.8%) 0 (0%) 3 (1.8%) 3 (1.1%) Unplanned reintubation 17 (2.2%) 9 (2.7%) 4 (2.4%) 4 (1.4%) Pneumonia 18 (2.3%) 10 (3%) 5 (3%) 3 (1.1%) Myocardial infarction 9 (1.1%) 2 (0.6%) 3 (1.8%) 4 (1.4%) Cardiac arrest 1 (0.1%) 0 (0%) 0 (0%) 1 (0.4%) Sepsis 55 (7%) 30 (8.9%) 20 (12.1%) 5 (1.8%) < Septic shock 11 (1.4%) 8 (2.4%) 2 (1.2%) 1 (0.4%) Urinary tract infection 42 (5.3%) 25 (7.4%) 9 (5.5%) 8 (2.8%) 0.039
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28 J Am Coll Surg. 221: , 2015
29 Kennan et al, J Am Coll Surg. 221: , 2015
30 DISCUSSION This study is the first examine the combined effect of the ERP and SSIB Our experience exemplifies how the process of quality improvement in surgery must be an ongoing effort, and that sequential adoption of separately studied care protocols can provide incremental improvements in patient care. Not only did patient outcomes improve with the introduction of the ERP and SSIB, but these measures also provided cost-savings in the care of CRS patients. Continual assessments and updates of existing evidence based care protocols such as the ERP and SSIB will lead to continual improvement in post-operative outcomes and increased value of care delivered.
31 DUH Variable Direct Cost/Case by Cost Group Inpatient Colectomy Primary Procedure Discharges COST_GROUP FY11 FY12 FY13 THRU FP9 % CHG F.SURGERY SVC % A.INTERMEDIATE SVC % C.PHARMACY SVC % B.INTENSIVE NRS SVC % J.LABS % O.BLOOD % I.RAD SVCS % G.RESP CARE % H.PT OT SPEECH SVCS % E.OTHER DIAG AND THERA % K.ER TRANSP % D.CARDIO SVC % M.MED SURG SUPPL % N.OP CLINIC % TOTAL VAR DIR COST/CASE % ALOS % DISCHARGES % 50% 40% 30% 20% 10% 0% % of FY13 Total VDC/Case 48% 22% 10% 6% 5% 2% 2% 1% 1% 1% 9/3/ Data source = DSR/EPSI
32 ALOS and Variable Direct Cost by Primary Surgeon, FY12-FY13 YTD thru FP9, Colectomy Discharges MD DISCHARGES ALOS MEDIAN LOS AVG VAR DIR COST MEDIAN VAR DIR COST MD $13,018 $10,019 MD ,982 7,686 MD ,577 9,343 MD ,524 13,653 MD ,541 15,946 MD ,206 12,757 ALL OTHERS Colorectal surgeons Non colorectal surgeons OVERALL /3/
33 30-day Post-Operative Outcomes of ACS-NSQIP Sampled Patients Who Underwent Major, Elective Colorectal Surgery in Pre-ERP/Bundle Vs. Post-ERP/Bundle Period After Inverse Proportional Weighting Characteristic Pre-ERP/Bundle 9/2006-1/20120 Post-ERP/Bundle 7/2011-3/2013 p-value Length of stay 7.9+/ /-5.5 <0.001 Mortality (30 d) 0.7% 1.9% Unplanned reoperation 6.9% 2.8% Wound complication 26.3% 8.3% <0.001 Superficial SSI 22.5% 7.1% <0.001 Deep SSI 1.5% 0.0% Organ space SSI 7.6% 2.5% Deep venous thrombosis 1.0% 0.0% Pulmonary embolism 0.3% 0.7% Stroke/CVA 0.0% 1.3% Unplanned reintubation 2.7% 0.8% Pneumonia 2.9% 1.0% Myocardial infarction 0.5% 1.4% Cardiac arrest 0.0% 0.5% Sepsis 8.9% 1.7% <0.001 Septic shock 2.4% 0.5% Urinary tract infection 7.6% 2.8% 0.008
34 HCAHPS: Duke Colorectal Surgery Trend in Pain Management 38% improvement since 2011
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37 Do ERAS/Bundles Matter? National data Published studies NSQIP, STS Institutional data LOS Costs Readmissions Bundles/ERAS will succeed Incremental changes are unlikely to succeed
38 Pearls from ERAS/Bundles ERAS works Reduces LOS Reduces narcotics if use multimodality therapy Reduces wound infections Reduces overall complications May improve patient satisfaction It is coming to a hospital near you It usually involves tweaking the system, not reinventing the wheel
39 Pearls from ERAS/Bundles Each hospital/surgeon/group different Use what you have and what will work Need buy in from everyone ERAS is plastic: mold it Review every 6 months Talk to your administration, be pro-active Present your data Show the bad data and how to fix it
40 Getting Buy-In: Team Approach Anesthesia Pain management Epidurals, axial blocks Multi-modal treatment Peri-op IV fluids Normothermia, normoglycemia Surgical partners: Need to do collectively to avoid confusion with rest of support OR nurses OR time out (check list), wound classification Prep patient, Foley placement Floor Nurses Wound management Foley removal Ambulation, VTE prophylaxis Discharge education (prevent re-admissions)
41 The Hurdle: Why and How? Am I or we (division/institution) practicing best medicine? Avoid the buts my patients are sicker my partners are set in their ways too complicated, never work here I don t have time Establish a core group Surgeon, anesthesiologist, nurse (s) Database to track (NSQIP, institutional) Engage administration Set modest goals Present data as it comes in Be malleable and be patient! Celebrate success
42 The Hurdle: Why and How? The data Share it early and often What is working, what is not Administration Hospital Compare etc. Joint Commission Bundled cost to insurance Are your competitors doing this? Be diligent What is your compliance with bundles/eras? Tract LOS, complications, costs
43 ERAS/Bundles Conclusions Biggest advance in surgery over the last 20 years Cost (yes) Length of stay (yes) Return to work/daily activities (yes) Pain (yes) Reduction in complications (yes) SSI UTI VTE Patient satisfaction (probably) Poorly measured Survival (probably) Stay tuned studies coming
44 Thank You, Acknowledgements, Questions Surgery Julie Thacker, MD John Migaly, MD Jeff Sun, MD Jeff Keenan, MD Anesthesia Tim Miller, MD Nursing Regina Woody, RN Jill Haslam, RN
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