preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute. Circulation.

Transcription

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2 Hobbs FDR, Kenkre JE, Roalfe AK, Davis RC, Hare R, Davies MK. Impact of heart failure and left ventricular systolic dysfunction on quality of life: a cross-sectional study comparing common chronic cardiac and medical disorders and a representative adult population. Eur Heart J. 2002;23(23): Fuster V, O Rourke RA, Walsh R, Poole-Wilson P. Hurst s the heart, 12th edition. Vol 2007.; 2007: Fauci A, Braunwald E, Kasper D, Hauser S, Longo D, Jameson J, et al. Harrison s principles of internal medicine, 17th edition.; 2008: Heart failure Risk factors - Mayo Clinic. Accessed December 10, Kumar V, Abbas AK, Fausto N, Mitchell R. Robbins basic pathology, 8th edition.; 2007: Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG et al Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed. J Am Coll Cardiol. 2009;53(15):e1-e He J, Ogden LG, Bazzano LA, Vupputuri S, Loria C, Whelton PK. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. Arch Intern Med. 2001;161(7): Doggrell SA. CHARMed the effects of candesartan in heart failure. Expert Opin Pharmacother. April Redfield MM, Jacobsen SJ, Burnett JC, Mahoney DW, Bailey KR, Rodeheffer RJ, et al. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA. 2003;289(2): Lee DS, Gona P, Vasan RS, Larson MG, Benjamin EJ, Wang TJ, et al. Relation of disease pathogenesis and risk factors to heart failure with

3 56 preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute. Circulation. 2009;119(24): Russell SD, Saval MA, Robbins JL, Ellestad MH, Gottlieb SS, Handberg EM, et al. New York Heart Association functional class predicts exercise parameters in the current era. Am Heart J. 2009;158(4 Suppl):S24-S Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, et al ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013;128(16):e240-e Madhok V, Falk G, Rogers A, Struthers AD, Sullivan FM, Fahey T, et al. The accuracy of symptoms, signs and diagnostic tests in the diagnosis of left ventricular dysfunction in primary care: a diagnostic accuracy systematic review. BMC Fam Pract. 2008;9: Jimeno Sainz A, Gil V, Merino J, García M, Jordán A, Guerrero L, et al. ity of Framingham criteria as a clinical test for systolic heart failure. Rev cli nica espan ola. 2006;206(10): Maestre A, Gil V, Gallego J, Aznar J, Mora A, Martín-Hidalgo A, et al. Diagnostic accuracy of clinical criteria for identifying systolic and diastolic heart failure: cross-sectional study. J Eval Clin Pract. 2009;15(1): Watson RD, Gibbs CR, Lip GY. ABC of heart failure. Clinical features and complications. BMJ. 2000;320(7229): Wilkins LW, Tajik AJ, M.D., et al. Cardiovascular physiology concepts 2nd ed. Lippincott Williams & Wilkins; 2013: Ciampi Q, Villari B. Role of echocardiography in diagnosis and risk stratification in heart failure with left ventricular systolic dysfunction. Cardiovasc Ultrasound. 2007;5: Naik MM, Diamond GA, Pai T, Soffer A, Siegel RJ. Correspondence of left ventricular ejection fraction determinations from two-dimensional echocardiography, radionuclide angiography and contrast cineangiography. J Am Coll Cardiol. 1995;25(4):

4 Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification. Eur J Echocardiogr. 2006;7(2): Cella DF. Quality of life: concepts and definition. J Pain Symptom Manage. 1994;9(3): CDC - Concept - HRQOL. Accessed January 15, Indonesia U, Suharsono T, Keperawatan FI, Magister P, Keperawatan I. Universitas Indonesia.Dampak home based exercise training terhadap kapasitas fungsional dan kualitas hidup pasien Lam CL, Lauder IJ. The impact of chronic diseases on the health-related quality of life (HRQOL) of Chinese patients in primary care. Fam Pract. 2000;17(2): Dunderdale K, Thompson DR, Miles JN V, Beer SF, Furze G. Quality-of-life measurement in chronic heart failure: do we take account of the patient perspective? Eur J Heart Fail. 2005;7(4): Dahlan MS. Statistik untuk kedokteran dan kesehatan. 6th ed. Jakarta: Epidermiologi Indonesia; 2014: Sakata Y, Shimokawa H. Epidemiology of heart failure in asia. Circ J. 2013;77(9): WHO Definition of an older or elderly person. Accessed May 30, Lam CSP. Heart failure in southeast asia: facts and numbers. ESC Hear Fail. 2015;2(2): Keteyian SJ, Piña IL, Hibner BA, Fleg JL. Clinical role of exercise training in the management of patients with chronic heart failure. J Cardiopulm Rehabil Prev. 30(2): Juenger J, Schellberg D, Kraemer S, Haunstetter A, Zugck C, Herzog W, et al. Health related quality of life in patients with congestive heart failure: comparison with other chronic diseases and relation to functional variables.

5 58 Heart. 2002;87(3): Joseph SM, Novak E, Arnold SV, Jones PG, Khattak H, Platts AE, et al. Comparable performance of the kansas city cardiomyopathy questionnaire in patients with heart failure with preserved and reduced ejection fraction. Circ Heart Fail. 2013;6(6): Heo S, Lennie TA, Okoli C, Moser DK. Quality of life in patients with heart failure: ask the patients. Heart Lung. 2009;38(2): Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med. 2006;355(3): Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators. N Engl J Med. 1991;325(5): Packer M, Coats AJ, Fowler MB, Katus HA, Krum H, Mohacsi P, et al. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med. 2001;344(22): Moss AJ, Zareba W, Hall WJ, Klein H, Wilver DJ, Dannom DS, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 2002;346(12):

6 Lampiran 1. Ethical Clearance

7 Lampiran 2. Surat izin penelitian

8 Lampiran 3. Informed consent

9

10 Lampiran 4. Data hasil penelitian No. Nama (Akronim) No. RM LVEF (dalam %) MLHFQ dimensi Fisik MLHFQ dimensi Umum MLHFQ dimensi Emosi Skor total MLHFQ 1. Pu C Su C La C St C MZ C TD C SSp C SSb C SSm C Sj C SN C KD C IT C GT C Sn C Rb C Snn C KS C Tj C JS C Uw C Dj C NS C AS C Sr C SP C AN C DS C DY C Ag C ADL C Ms C

11 Lampiran 5. Hasil analisis statistik SPSS versi 21 Jenis Kelamin Frequency Cumulative Perempuan 19 59,4 59,4 59,4 Laki-laki 13 40,6 40,6 100,0 Umur Frequency Cumulative ,1 3,1 3, ,1 3,1 6, ,1 3,1 9, ,1 3,1 12, ,1 3,1 15, ,1 3,1 18, ,3 6,3 25, ,1 3,1 28, ,1 3,1 31, ,1 3,1 34, ,5 12,5 46, ,4 9,4 56, ,4 9,4 65, ,3 6,3 71, ,1 3,1 75, ,3 6,3 81, ,3 6,3 87, ,1 3,1 90, ,1 3,1 93, ,3 6,3 100,0

12 NYHA Frequency Cumulative NYHA kelas I 15 46,9 46,9 46,9 NYHA kelas II 13 40,6 40,6 87,5 NYHA kelas III 4 12,5 12,5 100,0 LVH Frequency Cumulative Tidak 12 37,5 37,5 37,5 Ya 20 62,5 62,5 100,0 Diuretik Frequency Cumulative Tidak 12 37,5 37,5 37,5 Ya 20 62,5 62,5 100,0 Beta Blocker Frequency Cumulative Tidak 16 50,0 50,0 50,0 Ya 16 50,0 50,0 100,0 Ca channel Blocker Frequency Cumulative Tidak 26 81,3 81,3 81,3 Ya 6 18,8 18,8 100,0

13 Digoxin Frequency Cumulative Tidak 25 78,1 78,1 78,1 Ya 7 21,9 21,9 100,0 Antiplatelet Frequency Cumulative Tidak 19 59,4 59,4 59,4 Ya 13 40,6 40,6 100,0 Nitrat Frequency Cumulative Tidak 14 43,8 43,8 43,8 Ya 18 56,3 56,3 100,0 ACE inhibitor Frequency Cumulative Tidak 19 59,4 59,4 59,4 Ya 13 40,6 40,6 100,0

14 Trombolitik Frequency Cumulative Tidak 16 50,0 50,0 50,0 Ya 16 50,0 50,0 100,0 Umur Statistics 32 N Missing 0 Mean 52,41 Median 55,00 Mode 54 Std. Deviation 10,191 Minimum 24 Maximum 66 Case Processing Summary Cases Missing Total N N N LVEF ,0% 0 0,0% ,0% Dimensi Fisik ,0% 0 0,0% ,0% Dimensi Umum ,0% 0 0,0% ,0% Dimensi Emosi ,0% 0 0,0% ,0% MLHFQ total ,0% 0 0,0% ,0% Descriptives Statistic Std. Error Mean 60,56 2,957 95% Confidence Interval for Mean Lower Bound 54,53 Upper Bound 66,59 LVEF 5% Trimmed Mean 61,30 Median 64,00 Variance 279,738 Std. Deviation 16,725

15 Minimum 16 Maximum 87 Range 71 Interquartile Range 23 Skewness -0,796 0,414 Dimensi Fisik Dimensi Umum Dimensi Emosi Kurtosis 0,431 0,809 Mean 11,94 1,503 95% Confidence Interval for Lower Bound 8,87 Mean Upper Bound 15,00 5% Trimmed Mean 11,51 Median 9,00 Variance 72,319 Std. Deviation 8,504 Minimum 1 Maximum 32 Range 31 Interquartile Range 12 Skewness 0,711 0,414 Kurtosis -0,412 0,809 Mean 12,81 1,389 95% Confidence Interval for Lower Bound 9,98 Mean Upper Bound 15,65 5% Trimmed Mean 12,44 Median 12,50 Variance 61,770 Std. Deviation 7,859 Minimum 3 Maximum 30 Range 27 Interquartile Range 10 Skewness 0,717 0,414 Kurtosis -0,434 0,809 Mean 6,94 1,029 95% Confidence Interval for Lower Bound 4,84 Mean Upper Bound 9,04 5% Trimmed Mean 6,60 Median 6,00 Variance 33,867 Std. Deviation 5,820 Minimum 0 Maximum 21 Range 21

16 Interquartile Range 7 Skewness 0,789 0,414 Kurtosis -0,013 0,809 Mean 31,78 3,531 95% Confidence Interval for Mean Lower Bound 24,58 Upper Bound 38,98 5% Trimmed Mean 30,68 Median 22,00 Variance 398,886 MLHFQ total Std. Deviation 19,972 Minimum 9 Maximum 74 Range 65 Interquartile Range 28 Skewness 0,946 0,414 Kurtosis -0,166 0,809 Tests of Normality Shapiro-Wilk Statistic df Sig. LVEF 0, ,085 Umur 0, ,004 NYHA 0, ,000 a. Lilliefors Significance Correction Correlations LVEF Dimensi Fisik Dimensi Emosi MLHFQ total Pearson Correlation 1-0,057 0,099-0,046 LVEF Sig. (2-tailed) 0,757 0,589 0,804 N Dimensi Fisik Dimensi Emosi MLHFQ total Pearson Correlation -0, ,669 ** 0,951 ** Sig. (2-tailed) 0,757 0,000,000 N Pearson Correlation 0,099 0,669 ** 1 0,795 ** Sig. (2-tailed) 0,589 0,000 0,000 N Pearson Correlation -0,046 0,951 ** 0,795 ** 1 Sig. (2-tailed) 0,804 0,000 0,000 N **. Correlation is significant at the 0.01 level (2-tailed).

17 Lampiran 6. Kuesioner Minnesota Living with Heart Failure

18 Lampiran 7. Dokumentasi penelitian

19 Lampiran 8. Biodata Mahasiswa BIODATA MAHASISWA Identitas Nama : Alfredo NIM : Tempat/tanggal lahir : Jakarta, 10 Maret 1994 Jenis kelamin : laki-laki Alamat : Jl. Gondang Timur IV No. 66B, Semarang Nomor HP : paulusalfredo@gmail.com Riwayat Pendidikan Formal 1. SD : SD San Marino, Jakarta. Lulus tahun : SMP : SMP San Marino, Jakarta. Lulus tahun : SMA : SMAN 2 Jakarta. Lulus tahun : FK UNDIP : Masuk tahun : 2012