Curriculum Vitae. Stephan Gielen, MD, FESC. Place and Date of Birth. Present Position and Address. Training and Education. Post Graduate Degrees

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1 Curriculum Vitae Stephan Gielen, MD, FESC Place and Date of Birth November 16th, 1967, Dortmund, Germany Present Position and Address Director, Dept. of Cardiology, Angiology and Intensive Care Medicine Klinikum Lippe, Röntgenstr. 18, Detmold, Germany Extraordinary Professor of Medicine, Medical Faculty, Martin- Luther-University Halle-Wittenberg, Germany Secretary, Project Group on Prevention of the German Cardiac Society National Coordinator for Prevention, Germany Training and Education , Halle/Saale, Germany: Deputy Director, Dept. of Internal Medicine III (Cardiology, Angiology), Director, Cardiac Catheterization Laboratory, Director, Heart Failure Clinic, University Hospital, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany , Leipzig, Germany: Senior Staff Physician ( Oberarzt ), Dept. of Internal Medicine/Cardiology, Heart Center, University of Leipzig, Leipzig, Germany Director, Heart Failure Clinic, Assistant Professor, Medical Faculty, University of Leipzig , Leipzig, Germany: Residency in Internal Medicine & Cardiology Dept. of Internal Medicine/Cardiology, Heart Center, University of Leipzig, Leipzig, Germany , Heidelberg, Germany: Residency in Internal Medicine Ruprecht-Karls-University Heidelberg, Dept. of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg, Germany 1997 United States Medical Licensing Examination (USMLE, ECFMG) 1996 State License (Ärztliche Approbation) 1994 Medical State Examination Medical School - Ruhr-Universität Bochum, Bochum, Germany - Harvard Medical School, Boston, MA, USA - Baylor College of Medicine, Houston, TX, USA Post Graduate Degrees 2014 Certification by the State of Saxony-Anhalt as Extraordinary Professor

2 of the University of Halle 2014 Board certification for Internal Intensive Care Medicine 2006 Venia legendi, Internal Medicine 2002 Board certification for Internal Medicine (6 years) 2002 Board Certification for Cardiology 2000 Certification for Emergency Medicine European Society of Cardiology Activities President of the European Association for Cardiovascular Prevention and Rehabilitation (EACPR) Board Member, European Society of Cardiology (ESC), Member of the Executive Board, EACPR Treasurer of the EACPR ( ) Chair-elect, Section of Exercise Physiology, EACPR ( ) ESC Spokesperson for Exercise Physiology (since 2008) Member of the Training & Research Committee, ESC Member of the 2011 ACS/NSTEMI Guideline Task Force, ESC Other International Scientific Committee Participation Germany Society of Cardiology, Cardiovascular Research - Secretary, Project Group on Prevention - 1st Speaker, Working Group 14 "Preventive Cardiology nd Speaker, Working Group 29 "Heart Diseases in Aging German Society for Prevention and Rehabilitation of Cardiovascular Diseases e.v. - Congress President of the 37th Annual Conference in Berlin Member of the guideline commission "Resistance exercise in cardiac rehabilitation - Member of the guideline commission "Secondary prevention of cardiovascular diseases German Heart Foundation (Deutsche Herzstiftung, e.v.) - Member of the scientific council of the German Heart Foundation Editorial Boards European Journal of Preventive Cardiology (since 2014) Journal of Cardiopulmonary Rehabilitation & Prevention European Cardiology Fellowships / Honours Fellow of the European Society of Cardiology Wilhelm P. Winterstein Prize of the German Heart Foundation 2012 Grant of the German Research Foundation (DFG-Stipendium GI-535/1-1) Roland-Ernst-Grant together with Prof. Dr. D. Teupser Grant from the German National Scholarship Foundation (Studienstiftung des deutschen Volkes ( ))

3 Major Publications Landmesser U, Chapman MJ, Farnier M, Gencer B, Gielen S, Hovingh GK, Lüscher TF, Sinning D, Tokgözoglu L, Wiklund O, Zamorano JL, Pinto FJ, Catapano AL; European Society of Cardiology (ESC); European Atherosclerosis Society (EAS). European Society of Cardiology/European Atherosclerosis Society Task Force consensus statement on proprotein convertase subtilisin/kexin type 9 inhibitors: practical guidance for use in patients at very high cardiovascular risk. Eur Heart J Aug 1;38(29): Sandri M, Viehmann M, Adams V, Rabald K, Mangner N, Höllriegel R, Lurz P, Erbs S, Linke A, Kirsch K, Möbius-Winkler S, Thiery J, Teupser D, Hambrecht R, Schuler G, Gielen S. Chronic heart failure and aging - effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study. Eur J Prev Cardiol Mar;23(4): Arena R, Guazzi M, Lianov L, Whitsel L, Berra K, Lavie CJ, Kaminsky L, Williams M, Hivert MF, Cherie Franklin N, Myers J, Dengel D, Lloyd-Jones DM, Pinto FJ, Cosentino F, Halle M, Gielen S, Dendale P, Niebauer J, Pelliccia A, Giannuzzi P, Corra U, Piepoli MF, Guthrie G, Shurney D; AHA Writing Group, Arena R, Berra K, Dengel D, Franklin NC, Hivert MF, Kaminsky L, Lavie CJ, Lloyd-Jones DM, Myers J, Whitsel L, Williams M; ESC/EACPR Writing Group, Corra U, Cosentino F, Dendale P, Giannuzzi P, Gielen S, Guazzi M, Halle M, Niebauer J, Pelliccia A, Piepoli MF, Pinto FJ; ACPM Writing Group, Guthrie G, Lianov L, Shurney D. Healthy lifestyle interventions to combat noncommunicable disease-a novel nonhierarchical connectivity model for key stakeholders: a policy statement from the American Heart Association, European Society of Cardiology, European Association for Cardiovascular Prevention and Rehabilitation, and American College of Preventive Medicine. Eur Heart J Aug 14;36(31): Gielen S, Laughlin MH, O'Conner C, Duncker DJ. Exercise training in patients with heart disease: review of beneficial effects and clinical recommendations. Prog Cardiovasc Dis Jan-Feb;57(4): Gielen S, Landmesser U. The Year in Cardiology 2013: cardiovascular disease prevention. Eur Heart J Feb;35(5): Gielen S, Sandri M, Kozarez I, Kratzsch J, Teupser D, Thiery J, Erbs S, Mangner N, Lenk C, Hambrecht R, Schuler G, Adams V. Anti-Catabolic Effects of Exercise Training in Patients with Chronic Heart Failure in Different Age Strata: The Randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Catabolism Study. Circulation. 2012; 125(22): Sandri M, Kozarez I, Adams V, Mangner N, Höllriegel R, Erbs S, Linke A, Möbius-Winkler S, Thiery J, Kratzsch J, Teupser D, Mende M, Hambrecht R, Schuler G, Gielen S. Age-related Effects of Exercise Training on Diastolic Function And Markers of Myocardial Fibrosis in Chronic Heart Failure Patients and Healthy Subjects with Reduced Ejection Fraction The Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) Diastolic Dysfunction Study Eur Heart J. 2012;33: Mangner N, Adams V, Sandri M, Hoellriegel R, Hambrecht R, Schuler G, Gielen S. Muscle function and running activity in mouse models of hereditary muscle dystrophy: impact of double

4 knockout for dystrophin and the transcription factor MyoD. Muscle Nerve Apr;45(4): Gielen S, Schuler G, Adams V. Cardiovascular effects of exercise training: molecular mechanisms. Circulation. 2010;122(12): Gielen S, Adams V, Linke A, Erbs S, Möbius-Winkler S, Schubert A, Schuler G, Hambrecht R. Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle. Eur J Cardiovasc Prev Rehabil Aug;12(4): Gielen S, Adams V, Möbius-Winkler S, Linke A, Erbs S, Yu J, Kempf W, Schubert A, Schuler G, Hambrecht R. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol Sep 3;42(5): Gielen S, Schuler G, Hambrecht R. Exercise training in coronary artery disease and coronary vasomotion. Circulation Jan 2;103(1):E1-6. Review. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, Schoene N, Schuler G. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med Feb 17;342(7): Textbooks: ESC Textbook on Preventive Cardiology, 1st edition. Editors: S. Gielen, D. Wood, G. de Backer, M. Piepoli Lead Author: Physical Activity and Inactivity. Oxford University Press, Oxford, 2014 ESC Textbook of Cardiovascular Medicine, 1st & 2nd Edition Editors: J.A. Camm, T.F. Lüscher, P. Serruys S. Gielen*, A. Mezzani, R. Hambrecht, H. Saner (* Lead Author) Chapter 25: Cardiac Rehabilitation, Oxford University Press, Oxford, 2009 Cardiovascular Prevention and Rehabilitation Editors: J. Perk, P. Mathes, H. Gohlke, C. Monpère, I. Hellemans, H. McGee, P. Sellier, H. Saner. S. Gielen, J. Niebauer, R. Hambrecht. Chapter 19: Exercise training in heart failure. Springer, Heidelberg, 2007 Major Research Interest Exercise interventions in heart failure Lipid lowering Secondary prevention Structural heart disease interventions

5 Motivation Letter Dear colleagues: Cardiovascular medicine is currently at a stage of major transformations: The introduction of novel preventive interventions and medications which may halt or even reverse the progression of atherosclerosis The introduction of many subspecialities within the field of cardiovascular medicine, which reflect the dynamic development in heart failure, rhythmology, interventional therapy, and congenital heart disease to name just a few. As President of the EACPR I had the opportunity to experience the strength and vision of the ESC to lead our field into the future. During my presidency I launched the ESC textbook series on Preventive Cardiology and continue as editor of our European Journal of Preventive Cardiology. What motivates me to be a candidate for the office of Councillor of the ESC is to promote a patient-centered outcome-oriented perspective on cardiovascular medicine. The rapid sequence of technical and pharmaceutical innovations in cardiology call for a professional industry-independent and credible organization like the ESC to prioritize novel treatments based on prognostic benefits and cost-benefit ratio. Additionally, I believe that prevention is better than cure. Preventive cardiology needs to become an essential part of our clinical work rather than be delegated to rehabilitation institutions. With our clear lifestyle recommendations and the novel drugs on the horizon we are now closer than ever to drastically reduce the burden of atherosclerotic disease in Europe and beyond. I see the ESC as a leader in prevention and we should work towards this goal together with WHF and WHO. Digital technology will be key to leverage and promote prevention to professionals and patients, however, health apps should not only be industry-driven. We as professionals need to have our own agenda and priorities for the digital age and influence the developments in this fast-growing area through partnership and certification. Finally, despite all our subspeciality skills I would like us to preserve the unity of cardiovascular medicine. Subspeciality certifications are necessary but should be anchored around a core cardiovascular curriculum. Patients deserve disease- and outcome-focused treatment recommendations which require a broad general knowledge. The young cardiologists of tomorrow are our door to the next generation of cardiologists. The ESC has a unique opportunity to guide these young talents to become excellent general cardiologists before they focus on a subspeciality area. I envision the ESC as the international postgraduate cardiology school for the next generation of cardiologists and will work to harmonize and coordinate the multiple initiatives for young cardiologists within the ESC. Thank you for supporting my candidacy for the office of Councillor of the ESC. With best regards, Stephan Gielen, MD, FESC Apl. Prof. of Medicine, University of Halle/Saale, Germany Director, Dept. of Cardiology, Angiology, and Intensive Care Medicine Klinikum Lippe, Detmold, Germany