Developing the DAISI (Devices for Acute Ischemic Stroke Intervention) Coordinated Registry Network: A NEST Development Project
|
|
- Ilene Lambert
- 5 years ago
- Views:
Transcription
1 Travelling through the NETs of the NEST: Toward Collective, Collaborative Intelligence via Continuum of Evidence Generation Developing the DAISI (Devices for Acute Ischemic Stroke Intervention) Coordinated Registry Network: A NEST Development Project Murray Sheldon, MD; Carlos Peña, PhD Center for Devices and Radiological Health U.S. Food and Drug Administration MDEpiNet Annual Meeting 2017 White Oak, Maryland October 20, 2017
2 Why Acute Ischemic Stroke? Burden of Stroke Approximately 795,000 Americans suffer a new or recurrent stroke each year and stroke kills nearly 129,000 people a year. Introduction of Neurothrombectomy devices Neurothrombectomy devices (primarily stent retrievers and aspiration catheters) have been cleared for revascularization by removal of thrombus in AIS patients who are ineligible or who failed IV t-pa (drug therapy). Limited opportunities to collect additional clinical evidence Data needed for expanded indications and other uses may be difficult to obtain for marketed devices that have become standard of care Challenging study designs in some circumstances where new device development and new clinical studies are needed Study design and evaluation of outcomes are complicated due to complexity of the neurovasculature While RCT studies may still be needed to answer some questions, the cost can be burdensome to industry and in some cases, may be answered through RWE 2
3 Historical Perspective 1996 CDER approves IV t-pa for AIS (<3 hours) 2004 CDRH clears Merci Retriever [510(k)] for contraindications to or failure of t-pa Current marketed mechanical thrombectomy devices cleared with a revascularization indication for use: Merci Retriever Penumbra system Solitaire Revascularization Device Trevo Retriever Capture Revascularization Device 3
4 Current Device Examples Stent Retrievers Solitaire Trevo Aspiration Devices Penumbra Aspiration System 4
5 The Ah-Ha Moment! (2015) Publications of five prospective randomized trials Marketed mechanical thrombectomy devices Endovascular Therapy (ET) in combination with pharmacotherapy IV tpa within hours from symptom onset proximal large vessel occlusion (LVO) stroke in the anterior circulation (M1 Middle Cerebral Artery (MCA) segment with or without concomitant Internal Carotid Artery (ICA) occlusion) All studies showed superior clinical outcomes in the ET treatment arm compared to patients who only received best medical management, typically IV t-pa alone. Based on this data, the American Heart Association- American Stroke Association added ET using stentretrievers as a first-line treatment to its clinical guidelines for the early management of patients with acute ischemic stroke. 5
6 Regulatory Pathway September 2016 FDA granted a de novo classification request to allow marketing of the Concentric Medical Inc. Trevo Pro Vue Retrievers based on clinical data. FDA established a new classification regulation (21 CFR ) with product code, POL for neurovascular mechanical thrombectomy devices intended for acute ischemic stroke treatment with mandatory special controls. These special controls include performance data to demonstrate improvement in clinical outcomes of reduction in disability. 6
7 DAISI Coordinated Registry Network: Devices for Acute Ischemic Stroke Intervention Partnering with Stakeholders for Success The Beginning, February 2, 2017
8 Professional Societies American Association of Neurological Surgeons American Heart Association Congress of Neurological Surgeons Neuropoint Alliance Society of NeuroInterventional Surgery Society of Vascular and Interventional Neurology Contract Research Organizations The Emmes Corporation Boston Biomedical Associates Stakeholder Attendees Industry Boston Scientific Cardinal Health Codman Neuro Cook Medical Johnson & Johnson Medtronic MicroVention, Inc. MIVI Neuroscience Neuravi Limited WL Gore & Associates Penumbra Inc. Pulse Therapeutics Stryker Neurovascular Other (MDIC) Hospital Corporation of America Academia Cleveland Clinic Columbia University Dartmouth-Hitchoock Medical Center Duke-Margolis Center for Health Policy George Washington University Oklahoma State University UCLA University at Buffalo, Jacobs Institute Weill Cornell Medicine Government FDA NIH National Library Medicine AHRQ 8
9 Clinical Working Groups Core data element Common definitions Informatics and Methodology Central vs. distributed model Data sharing structure and interoperability Sustainability and Value Governance structure to assure value Funding structure Data use agreements 9
10 Current Stroke Registries in US NeuroVascular Quality Initiative (NVQI) Society of Neurointerventional Surgeons Get with the Guidelines-Stroke Database American Stroke Association/ American Heart Association Paul Coverdell National Acute Stroke Registry CDC INterventional Stroke Therapy Outcomes Registry (INSTOR) 10
11 What s Next? Capture data on Real World use of these devices A few potential examples Core infarct volume Imaging criteria for patient selection for treatment Use with other interventional devices during the surgical procedure Use in additional areas of the vasculature Coordinate Registry Networks as an infrastructure for additional data capture 11
UPDATES IN INTRACRANIAL INTERVENTION Jordan Taylor DO Metro Health Neurology 2015
UPDATES IN INTRACRANIAL INTERVENTION Jordan Taylor DO Metro Health Neurology 2015 NEW STUDIES FOR 2015 MR CLEAN ESCAPE EXTEND-IA REVASCAT SWIFT PRIME RECOGNIZED LIMITATIONS IV Alteplase proven benefit
More informationMechanical Thrombectomy of Large Vessel Occlusions Using Stent Retriever Devices
Mechanical Thrombectomy of Large Vessel Occlusions Using Stent Retriever Devices Joey English MD, PhD Medical Director, Neurointerventional Services California Pacific Medical Center Hospitals, San Francisco,
More informationMechanical thrombectomy in Plymouth. Will Adams. Will Adams
Mechanical thrombectomy in Plymouth Will Adams Will Adams History Intra-arterial intervention 1995 (NINDS) iv tpa improved clinical outcome in patients treated within 3 hours of ictus but limited recanalisation
More informationStroke Clinical Trials Update Transitioning to an Anatomic Diagnosis in Ischemic Stroke
Stroke Clinical Trials Update Transitioning to an Anatomic Diagnosis in Ischemic Stroke Alexander A. Khalessi MD MS Director of Endovascular Neurosurgery Surgical Director of NeuroCritical Care University
More informationUpdate on Early Acute Ischemic Stroke Interventions
Update on Early Acute Ischemic Stroke Interventions Diana Goodman MD Lead Neurohospitalist Maine Medical Center Assistant Professor of Neurology, Tufts University School of Medicine I have no disclosures
More informationDisclosure. Advances in Interventional Neurology. Disclosure. Natural History of Disease 3/15/2018. Vishal B. Jani MD
Advances in Interventional Neurology Disclosure Vishal B. Jani MD Medical Director Vascular Neurology Consultant Interventional Neurology CHI Health Assistant Professor, Creighton University School of
More information5/31/2018. Interventional Therapies that Expand Time Windows for Acute Ischemic Stroke Treatment. Disclosures. Impact of clot burden
Good Outcome (%) Rankin 0-2 at 90 days 5/31/2018 Interventional Therapies that Expand Time Windows for Acute Ischemic Stroke Treatment Disclosures Cerenovus: I am on Executive Committee for ARISE2 Trial
More informationThe DAWN of a New Era for Wake-up Stroke
The DAWN of a New Era for Wake-up Stroke Alan H. Yee, D.O. Stroke and Critical Care Neurology Department of Neurology University of California Davis Medical Center Objectives Review Epidemiology and Natural
More informationInterventional Stroke Treatment
Interventional Stroke Treatment Vishal B. Jani MD Medical Director Vascular Neurology Consultant Interventional Neurology CHI Health Assistant Professor, Creighton University School of Medicine Omaha,
More informationBroadening the Stroke Window in Light of the DAWN Trial
Broadening the Stroke Window in Light of the DAWN Trial South Jersey Neurovascular and Stroke Symposium April 26, 2018 Rohan Chitale, MD Assistant Professor of Neurological Surgery Vanderbilt University
More informationSolitaire FR Revascularization Device
Solitaire FR Revascularization Device FEATURING PARAMETRIC DESIGN Restore. Retrieve. Revive. 5 Revolutionizing Mechanical Thrombectomy with Parametric Design Solitaire FR Device The Solitaire FR revascularization
More informationAdvances in Neuro-Endovascular Care for Acute Stroke
Advances in Neuro-Endovascular Care for Acute Stroke Ciarán J. Powers, MD, PhD, FAANS Associate Professor Program Director Department of Neurological Surgery Surgical Director Comprehensive Stroke Center
More informationNew Stroke Interventions. Scott L. Zuckerman M.D. Vanderbilt Neurosurgery
New Stroke Interventions Scott L. Zuckerman M.D. Vanderbilt Neurosurgery Agenda Clot Retrieval Devices Merci Penumbra Stent Retrievers Solitaire Trevo New Technology Funnel ReCover MERCI Retriever (2004)
More informationAcute Stroke Treatment: Current Trends 2010
Acute Stroke Treatment: Current Trends 2010 Helmi L. Lutsep, MD Oregon Stroke Center Oregon Health & Science University Overview Ischemic Stroke Neuroprotectant trials to watch for IV tpa longer treatment
More informationBenjamin Fox, MD Medical Director: Neurointerventional Radiology (NIR) DRMC Medical Director: Neurosurgery & Neurovascular, Intermountain Healthcare
Update on neurointerventional (NIR) services at Dixie Regional Medical Center and in the Southwest Region Benjamin Fox, MD Medical Director: Neurointerventional Radiology (NIR) DRMC Medical Director: Neurosurgery
More informationEndovascular Neurointervention in Cerebral Ischemia
Endovascular Neurointervention in Cerebral Ischemia Beyond Thrombolytics Curtis A. Given II, MD Co-Director, Neurointerventional Services Baptist Physician Lexington 72 y/o female with a recent diagnosis
More informationEndovascular Treatment of Ischemic Stroke
Endovascular Treatment of Ischemic Stroke William Thorell, MD Associate Professor Neurosurgery UNMC Co-Director Stroke and Neurovascular Center Nebraska Medicine Overview Definitions of terms Review basic
More informationStroke Update Elaine J. Skalabrin MD Medical Director and Neurohospitalist Sacred Heart Medical Center Stroke Center
Stroke Update 2015 Elaine J. Skalabrin MD Medical Director and Neurohospitalist Sacred Heart Medical Center Stroke Center Objectives 1. Review successes in systems of care approach to acute ischemic stroke
More informationMechanical Thrombectomy: Where Are We Now? T. Adam Oliver, MD Tallahassee Neurological Clinic Tallahassee, Florida TMH Neurosymposium June 11, 2016
Mechanical Thrombectomy: Where Are We Now? T. Adam Oliver, MD Tallahassee Neurological Clinic Tallahassee, Florida TMH Neurosymposium June 11, 2016 none DISCLOSURES Where did we come from? Spiotta, et
More informationEndovascular Treatment for Acute Ischemic Stroke: Curtis A. Given II, MD Co-Director, Neurointerventional Services Baptist Physician Lexington
Endovascular Treatment for Acute Ischemic Stroke: Curtis A. Given II, MD Co-Director, Neurointerventional Services Baptist Physician Lexington Disclosures: SWIFT PRIME site (Medtronic) Physician Proctor
More informationBGS Spring Conference 2015
Neuroradiology in hyperacute stroke: what is the UK position? Dr Shelley Renowden Bristol NICE HIS July, 2013 The current evidence on mechanical clot retrieval for treating acute ischaemic stroke shows
More informationEndovascular Treatment for Acute Ischemic Stroke
ular Treatment for Acute Ischemic Stroke Vishal B. Jani MD Assistant Professor Interventional Neurology, Division of Department of Neurology. Creighton University/ CHI health Omaha NE Disclosure None 1
More informationInterventional Neuroradiology. & Stroke INR PROCEDURES INR PROCEDURES. Dr Steve Chryssidis. 25-Sep-17. Interventional Neuroradiology
Interventional Neuroradiology Interventional Neuroradiology & Stroke Dr Steve Chryssidis Interventional Neuroradiology (INR) is a subspecialty within Radiology INR -- broadly defined as treatment by endovascular
More informationEndovascular Stroke Therapy
Endovascular Stroke Therapy Update with Emphasis on Practical Clinical and Imaging Considerations Sachin Kishore Pandey, MD, FRCPC Disclosures I have no relevant financial disclosures or conflict of interest
More informationHow to Interpret CT/CTA for Acute Stroke in the Age of Endovascular Clot Retrieval
How to Interpret CT/CTA for Acute Stroke in the Age of Endovascular Clot Retrieval Peter Howard MD FRCPC Disclosures No conflicts to disclose How to Interpret CT/CTA for Acute Stroke in the Age of Endovascular
More informationStudying Aneurysm Devices in the Intracranial Neurovasculature
Studying Aneurysm Devices in the Intracranial Neurovasculature The benefits and risks of treating unruptured aneurysms depend on the anatomical location. One approach to studying devices to treat unruptured
More informationMechanical thrombectomy beyond the 6 hours. Mahmoud Rayes, MD Medical Director, Stroke program Greenville Memorial Hospital
Mechanical thrombectomy beyond the 6 hours Mahmoud Rayes, MD Medical Director, Stroke program Greenville Memorial Hospital Disclosures None Worldwide statistics 1 IN 6 people will have a stroke at some
More information12/4/2017. Disclosures. Study organization. Stryker Medtronic Penumbra Viz Route 92. Data safety monitoring board Tudor G.
12/4/2017 Update on Stroke Trials:Extending the Window DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo NP001713
More informationStroke Treatment Beyond Traditional Time Windows. Rishi Gupta, MD, MBA
Stroke Treatment Beyond Traditional Time Windows Rishi Gupta, MD, MBA Director, Stroke and Neurocritical Care Endovascular Neurosurgery Wellstar Health System THE PAST THE PRESENT 2015 American Heart Association/American
More informationSEE IT. BELIEVE IT. THE CONFIDENCE OF CLARITY. Solitaire Platinum. Revascularization Device
SEE IT. BELIEVE IT. THE CONFIDENCE OF CLARITY. Revascularization THE CONFIDENCE OF CLARITY. The key features that make the device effective have been retained including our unique Parametric overlapping
More informationNeuro-vascular Intervention in Stroke. Will Adams Consultant Neuroradiologist Plymouth Hospitals NHS Trust
Neuro-vascular Intervention in Stroke Will Adams Consultant Neuroradiologist Plymouth Hospitals NHS Trust Stroke before the mid 1990s Swelling Stroke extension Haemorrhagic transformation Intravenous thrombolysis
More informationAcute Stroke Identification and Treatment
Acute Stroke Identification and Treatment James S. McKinney, MD, FAHA Medical Director, NHRMC Stroke Center SE NC is located in the buckle of the Stroke Belt, seeing the highest stroke incidence and mortality
More informationDrano vs. MR CLEAN Review of New Endovascular Therapy for Acute Ischemic Stroke Patients
Drano vs. MR CLEAN Review of New Endovascular Therapy for Acute Ischemic Stroke Patients Peter Panagos, MD, FACEP, FAHA Associate Professor Emergency Medicine and Neurology Washington University School
More informationIschemic Stroke Therapies: Resource Guide
Ischemic Stroke Therapies: Resource Guide Ischemic Stroke Therapies Table of Contents Introduction...1 Stroke Protocol Roadmap...2 Public Awareness...3-4 Emergency Medical Services... 5-6 Emergency Department
More informationBest medical therapy (includes iv t-pa in eligible patients)
UDATE ON REVASCAT: (Randomized Trial Of Revascularization With Solitaire FR Device Versus Best Medical Therapy In The Treatment Of Acute Stroke Due To Anterior Circulation Large Vessel Occlusion Presenting
More informationEndovascular Procedures (Angioplasty and/or Stenting) for Intracranial Arterial Disease (Atherosclerosis and Aneurysms)
Endovascular Procedures (Angioplasty and/or Stenting) for Intracranial Arterial Disease (Atherosclerosis and Aneurysms) Policy Number: 2.01.54 Last Review: 11/2018 Origination: 4/2006 Next Review: 11/2019
More informationSingle Pass MCA Revascularization with Trevo
Single Pass MCA Revascularization with Trevo By Concentric Medical ProVueTM Retriever Case Reported By Sascha Prothmann, MD Klinikum rechts der Isar, Munich, Germany Images contained herein courtesy of
More informationMechanical Endovascular Reperfusion Therapy
Get With the Guidelines Stroke Mechanical Endovascular Reperfusion Therapy February 1, 2017 Speaker Lee H. Schwamm, MD Executive Vice Chairman and Director of Stroke/TeleStroke Services, Department of
More informationHistorical. Medical Policy
Medical Policy Subject: Mechanical Embolectomy for Treatment of Acute Stroke Policy #: SURG.00098 Current Effective Date: 01/01/2016 Status: Revised Last Review Date: 08/06/2015 Description/Scope This
More informationStroke Cart Improves Efficiency in Acute Ischemic Stroke Intervention
Stroke Cart Improves Efficiency in Acute Ischemic Stroke Intervention MR Amans, F Settecase, R Darflinger, M Alexander, A Nicholson, DL Cooke, SW Hetts, CF Dowd, RT Higashida, VV Halbach Interventional
More informationIntra-arterial Stroke Therapy: 2018 Update
Intra-arterial Stroke Therapy: 2018 Update Expanding the Treatment Window Parita Bhuva, M.D. Medical Director Enrolling investigator Stryker Neurovascular (DAWN trial) Disclosures Most common large vessel
More informationComparison of Five Major Recent Endovascular Treatment Trials
Comparison of Five Major Recent Endovascular Treatment Trials Sample size 500 # sites 70 (100 planned) 316 (500 planned) 196 (833 estimated) 206 (690 planned) 16 10 22 39 4 Treatment contrasts Baseline
More informationDistal Mechanical Thrombectomy in Acute Ischemic Stroke Method and Benefit. Hans Henkes, Wiebke Kurre Stuttgart, Germany
Distal Mechanical Thrombectomy in Acute Ischemic Stroke Method and Benefit Hans Henkes, Wiebke Kurre Stuttgart, Germany 1 Thrombectomy... with stent-retrievers is an evidence based therapy for intracranial
More informationInterventional Treatment of Stroke
Interventional Treatment of Stroke Andrew F. Ducruet, MD Barrow Neurological Institute 2018 BNI Stroke Rehab Symposium October 13, 2018 Disclosures Consultant: Medtronic, Penumbra, Cerenovus Lecture Overview
More informationPr Roman Sztajzel Service de Neurologie HUG
Pr Roman Sztajzel Service de Neurologie HUG Conflict of interest: none IV THROMBOLYSIS AND ENDOVASCULAR THROMBECTOMY approved treatments of acute stroke main criteria time (delay) IV thrombolysis radiological
More informationOverview. Introduction. New Interventions for Acute Stroke. New Approaches to hemorrhagic Strokes
Overview New Interventions for Acute Stroke Paula Eboli, MD Department of Neurosurgery Rockwood Clinic, Deaconess Hospital Introduction New Approaches to hemorrhagic Strokes New Approaches to Ischemic
More informationCarotid artery stents and embolic protection
Regulation of Carotid Artery Stents and Embolic Protection Devices in the United States A history of, and perspectives on, FDA regulation of carotid stents and associated embolic protection devices over
More informationACUTE ISCHEMIC STROKE. Current Treatment Approaches for Acute Ischemic Stroke
ACUTE ISCHEMIC STROKE Current Treatment Approaches for Acute Ischemic Stroke EARLY MANAGEMENT OF ACUTE ISCHEMIC STROKE Rapid identification of a stroke Immediate EMS transport to nearest stroke center
More informationVivek R. Deshmukh, MD Director, Cerebrovascular and Endovascular Neurosurgery Chairman, Department of Neurosurgery Providence Brain and Spine
Vivek R. Deshmukh, MD Director, Cerebrovascular and Endovascular Neurosurgery Chairman, Department of Neurosurgery Providence Brain and Spine Institute The Oregon Clinic Disclosure I declare that neither
More informationEndovascular Treatment Updates in Stroke Care
Endovascular Treatment Updates in Stroke Care Autumn Graham, MD April 6-10, 2017 Phoenix, AZ Endovascular Treatment Updates in Stroke Care Autumn Graham, MD Associate Professor of Clinical Emergency Medicine
More informationSignificant Relationships
Opening Large Vessels During Acute Ischemic Stroke Significant Relationships Wade S Smith, MD, PhD Director UCSF Neurovascular Service Professor of Neurology Daryl R Gress Endowed Chair of Neurocritical
More informationStrokecenter Key lessons of MR CLEAN study
Strokecenter Key lessons of MR CLEAN study Diederik Dippel Disclosures Funded by the Dutch Heart Foundation Nominal, unrestricted grants from AngioCare BV Medtronic/Covidien/EV3 MEDAC Gmbh/LAMEPRO Penumbra
More informationRBWH ICU Journal Club February 2018 Adam Simpson
RBWH ICU Journal Club February 2018 Adam Simpson 3 THROMBOLYSIS Reperfusion therapy has become the mainstay of therapy for ischaemic stroke. Thrombolysis is now well accepted within 4.5 hours. - Improved
More informationEndovascular Treatment for Acute Ischemic Stroke: Considerations from Recent Randomized Trials
Published online: March 13, 2015 1664 9737/15/0034 0115$39.50/0 Review Endovascular Treatment for Acute Ischemic Stroke: Considerations from Recent Randomized Trials Manabu Shirakawa a Shinichi Yoshimura
More informationEVOLUTION IN SYSTEMS OF STROKE CARE RIDWAN LIN, MD, PHD STROKE & INTERVENTIONAL NEUROLOGY BROWARD HEALTH
EVOLUTION IN SYSTEMS OF STROKE CARE RIDWAN LIN, MD, PHD STROKE & INTERVENTIONAL NEUROLOGY BROWARD HEALTH STROKE SYSTEMS OF CARE: 7. Secondary prevention 1. Primary prevention Patient 3. Emergency transport
More informationIs there even a time window?
Is there even a time window? A brief summary of key 2018 trials: DAWN and DEFUSE-3 For Neurosciences Update Conference, February 22, 2018 Maxim D. Hammer, M.D. Executive Summary Based on DAWN and DEFUSE-3,
More informationMR RESCUE: Primary Results
MR RESCUE: Primary Results (Mechanical Retrieval and REcanalization of Stroke Clots Using Embolectomy) Funded by NIH-NINDS UCLA SPOTRIAS Grant: P50 NS044378 Clinical Trials.gov Number NCT00389467 FDA IDE
More informationSentinel Stroke National Audit Programme (SSNAP) Based on stroke patients admitted to hospital for thrombectomy between April 2016 and March 2017
Thrombectomy Sentinel Stroke National Audit Programme (SSNAP) Thrombectomy Report for April 2016 - March 2017 National results July 2017 Based on stroke patients admitted to hospital for between April
More informationPatient selection for i.v. thrombolysis and thrombectomy
3 rd Congress of the European Academy of Neurology Amsterdam, The Netherlands, June 24 27, 2017 Teaching Course 8 Acute treatment and early secondary prevention of stroke Level 2 Patient selection for
More informationCode Stroke Intervention: Endovascular Therapies for Stroke J. DIEGO LOZANO MD INTERVENTIONAL NEURORADIOLOGY
Code Stroke Intervention: Endovascular Therapies for Stroke J. DIEGO LOZANO MD INTERVENTIONAL NEURORADIOLOGY Disclosures None Part A. Objectives Epidemiology of AIS and of ELVO Concept: Acute Ischemic
More informationPRISM Trial. Retrospective Case Review of Technical Success Using the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery
PRISM Trial Retrospective Case Review of Technical Success Using the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery George L. Adams, MD, MHS, FACC, FSCAI Clinical Associate Professor
More informationNeurothrombectomy Devices for Treatment of Acute Ischemic Stroke Executive Summary
Technical Brief Number 4 Effective Health Care Program Neurothrombectomy Devices for Treatment of Acute Ischemic Stroke Executive Summary Background Acute ischemic strokes are associated with poor outcomes
More informationSupplementary Online Content
Supplementary Online Content Lapergue B, Blanc R, Gory B, et al; ASTER Trial Investigators. Effect of endovascular contact aspiration vs stent retriever on revascularization in patients with acute ischemic
More informationTechniques for Treating Chronic Carotid Occlusion
Techniques for Treating Chronic Carotid Occlusion Adnan H. Siddiqui, MD, PhD Professor & Vice-Chairman Dept. Neurosurgery, UB Director Neurosurgical Stroke Service, Kaleida Health Chief Medical Officer,
More informationCase 1 5/26/2017 ENDOVASCULAR MECHANICAL THROMBECTOMY IN PATIENTS WITH ACUTE ISCHEMIC STROKE
ENDOVASCULAR MECHANICAL THROMBECTOMY IN PATIENTS WITH ACUTE ISCHEMIC STROKE Rhonda Whiteman Racing Against the Clock Workshop June 1, 2017 Objectives To discuss the hyperacute ischemic stroke management
More informationHow to Manage LVO Stroke with Access Blocked by Cervical Carotid Occlusion
How to Manage LVO Stroke with Access Blocked by Cervical Carotid Occlusion November 1 st, 2017 Johanna T. Fifi, MD Director, Endovascular Ischemic Stroke Associate Professor of Neurology, Neurosurgery,
More informationCVA Updates Karen Greenberg, DO, FACOEP. Director Neurologic Emergency Department Crozer Chester Medical Center
CVA Updates 2018 Karen Greenberg, DO, FACOEP Director Neurologic Emergency Department Crozer Chester Medical Center Disclosure I have the following financial relationship with the manufacturer of any commercial
More informationRegistry Assessment of Peripheral Interventional Devices (RAPID)
Registry Assessment of Peripheral Interventional Devices (RAPID) Adding Data Sources May 2, 2018 W. Schuyler Jones, MD Duke Clinical Research Institute Duke Heart Center Disclosures Research Grants: Agency
More informationFigures for Draft Response to IMS III, MR RESCUE, and SYNTHSESIS Trials
Figures for Draft Response to IMS III, MR RESCUE, and SYNTHSESIS Trials Figure 1: Lay Press Judgment May Belie a Deeper Examination of the Data. Truman ultimately defeated Dewey for the Presidency Subject
More informationENDOVASCULAR THERAPIES FOR ACUTE STROKE
ENDOVASCULAR THERAPIES FOR ACUTE STROKE Cerebral Arteriogram Cerebral Anatomy Cerebral Anatomy Brain Imaging Acute Ischemic Stroke (AIS) Therapy Main goal is to restore blood flow and improve perfusion
More informationDISCLOSURES. Learning Objectives. David Lee Gordon, MD, FAHA Update in Stroke 2007 FINANCIAL DISCLOSURE UNLABELED/UNAPPROVED USES DISCLOSURE
Acute Stroke Care and the Role of EMS Ryan Hakimi, DO, MS April 30, 2015 Assistant Professor Director, Critical Care Neurology Department of Neurology University of Oklahoma Health Sciences Center DISCLOSURES
More informationACUTE ISCHEMIC STROKE
ENDOVASCULAR MECHANICAL THROMBECTOMY IN PATIENTS WITH ACUTE ISCHEMIC STROKE HHS Stroke Annual Review March 7 and March 8, 2018 Objectives To review the stroke endovascular mechanical thrombectomy evidence
More informationEndovascular Procedures for Intracranial Arterial Disease (Atherosclerosis and Aneurysms)
Last Review Status/Date: December 2016 Page: 1 of 49 Arterial Disease (Atherosclerosis and Description Intracranial arterial disease includes thromboembolic events, vascular stenoses, and aneurysms. Endovascular
More informationPlace for Interventional Radiology in Acute Stroke
Place for Interventional Radiology in Acute Stroke Dr Lakmalie Paranahewa MBBS, MD(Radiology), FRCR Consultant Interventional Radiologist Asiri Group of Hospitals Objectives Imaging in Stroke Neurovascular
More informationframework for flow Objectives Acute Stroke Treatment Collaterals in Acute Ischemic Stroke framework & basis for flow
Acute Stroke Treatment Collaterals in Acute Ischemic Stroke Objectives role of collaterals in acute ischemic stroke collateral therapeutic strategies David S Liebeskind, MD Professor of Neurology & Director
More informationImaging Stroke: Is There a Stroke Equivalent of the ECG? Albert J. Yoo, MD Director of Acute Stroke Intervention Massachusetts General Hospital
Imaging Stroke: Is There a Stroke Equivalent of the ECG? Albert J. Yoo, MD Director of Acute Stroke Intervention Massachusetts General Hospital Disclosures Penumbra, Inc. research grant (significant) for
More informationIn acute ischemic stroke, recanalization of an occluded cerebral
ORIGINAL RESEARCH INTERVENTIONAL Double Solitaire Mechanical Thrombectomy in Acute Stroke: Effective Rescue Strategy for Refractory Artery Occlusions? J. Klisch, V. Sychra, C. Strasilla, C.A. Taschner,
More informationPerils of Mechanical Thrombectomy in Acute Asymptomatic Large Vessel Occlusion
Perils of Mechanical Thrombectomy in Acute Asymptomatic Large Vessel Occlusion Aman B. Patel, MD Robert & Jean Ojemann Associate Professor Director, Cerebrovascular Surgery Director, Neuroendovascular
More informationTreatment with intravenous rtpa has proved successful in
ORIGINAL RESEARCH INTERVENTIONAL Mechanical Embolectomy for Acute Ischemic Stroke in the Anterior Cerebral Circulation: The Gothenburg Experience during 2000 2011 A. Rentzos, C. Lundqvist, J.-E. Karlsson,
More informationAlex Abou-Chebl, MD Associate Professor of Neurology and Neurosurgery Director of Neurointerventional Services Director of Vascular and
Alex Abou-Chebl, MD Associate Professor of Neurology and Neurosurgery Director of Neurointerventional Services Director of Vascular and Interventional Neurology Fellowships University of Louisville School
More informationAdvances in Acute stroke Management
Advances in Acute stroke Management Sandra Ripper-Brown, DNP Neuroscience Nurse Practitioner St. Mary s Medical Center WPB, FL Palm Beach County Nurse Practitioner Council Annual Conference APRNs: Agents
More informationACUTE STROKE TREATMENT IN LARGE NIHSS PATIENTS. Justin Nolte, MD Assistant Profession Marshall University School of Medicine
ACUTE STROKE TREATMENT IN LARGE NIHSS PATIENTS Justin Nolte, MD Assistant Profession Marshall University School of Medicine History of Presenting Illness 64 yo wf with PMHx of COPD, HTN, HLP who was in
More informationISA consensus statement: Recommendations for the Early Management of Acute Ischemic Stroke with Endovascular Treatment.
ISA consensus statement: Recommendations for the Early Management of Acute Ischemic Stroke with Endovascular Treatment. 1. Endovascular Treatment of Ischemic Stroke: Early reperfusion is crucial for the
More informationFilters versus Occlusion Balloons during CAS Is there a clear preference?
Washington TCT 2005 Filters versus Occlusion Balloons during CAS Is there a clear preference? K. Mathias Department of Radiology Teaching Hospital of Dortmund - Germany Presenter Disclosure Information
More informationAcute Ischemic Stroke Imaging. Ronald L. Wolf, MD, PhD Associate Professor of Radiology
Acute Ischemic Stroke Imaging Ronald L. Wolf, MD, PhD Associate Professor of Radiology Title of First Slide of Substance An Illustrative Case 2 Disclosures No financial disclosures Off-label uses of some
More informationAbout 700,000 Americans each year suffer a new or recurrent stroke. On average, a stroke occurs every 45 seconds
UCLA Stroke Center Stroke Facts About 700,000 Americans each year suffer a new or recurrent stroke On average, a stroke occurs every 45 seconds Stroke kills more than 150,000 people a year (1 of every
More informationFrom interventional cardiology to cardio-neurology. A new subspeciality
From interventional cardiology to cardio-neurology. A new subspeciality in the future? Prof. Andrejs Erglis, MD, PhD Pauls Stradins Clinical University Hospital University of Latvia Riga, LATVIA Disclosure
More informationACUTE STROKE INTERVENTION: THE ROLE OF THROMBECTOMY AND IA LYSIS
Associate Professor of Neurology Director of Neurointerventional Services University of Louisville School of Medicine ACUTE STROKE INTERVENTION: THE ROLE OF THROMBECTOMY AND IA LYSIS Conflict of Interest
More informationNational and International Efforts to Generate RWE. Danica Marinac Dabic, MD, PhD, MMSc, FISPE Director, Division of Epidemiology, CDRH
National and International Efforts to Generate RWE Danica Marinac Dabic, MD, PhD, MMSc, FISPE Director, Division of Epidemiology, CDRH Outline FDA Vision and Strategic Priorities National Evaluation System
More informationDisclosures. CREST Trial: Summary. Lecture Outline 4/16/2015. Cervical Atherosclerotic Disease
Disclosures Your Patient Has Carotid Bulb Stenosis and a Tandem Intracranial Stenosis: How Do SAMMPRIS and Other Evidence Inform Your Treatment? UCSF Vascular Symposium 2015 Steven W. Hetts, MD Associate
More informationCerebral Revascularization For Stroke
Cerebral Revascularization For Stroke If you are looking for the ebook Cerebral Revascularization for Stroke in pdf form, then you've come to loyal site. We present full edition of this ebook in txt, doc,
More informationEndovascular Therapy for Acute Ischemic Stroke: Reducing Door-to-puncture Time
DOI: 10.5797/jnet.oa.2016-0140 Endovascular Therapy for Acute Ischemic Stroke: Reducing Door-to-puncture Time Yoichi Morofuji, 1,2 Nobutaka Horie, 1,2 Yohei Tateishi, 2,3 Minoru Morikawa, 4 Eisaku Sadakata,
More informationWHY TIMELINESS MATTERS. W&M Wren Association Lecture Series
WHY TIMELINESS MATTERS April 10, 2018 W&M Wren Association Lecture Series Pankajavalli Ramakrishnan, M.D., Ph.D. Stroke Neurologist and Neurointerventionalist Riverside Regional Medical Center Comprehensive
More informationAMSER Case of the Month: March 2019
AMSER Case of the Month: March 2019 62 year-old male with left-sided weakness Ashley Graziano OMS IV, Lake Erie College of Osteopathic Medicine Erik Yannone MD, Charles Q. Li MD, Warren Chang MD, Matthew
More informationEndovascular Procedures for Intracranial Arterial Disease (Atherosclerosis and Aneurysms)
Endovascular Procedures for Intracranial Arterial Disease (Atherosclerosis and Aneurysms) Policy Number: Original Effective Date: MM.05.010 02/01/2013 Line(s) of Business: Current Effective Date: HMO;
More informationUpdates on Endovascular Therapy
Updates on Endovascular Therapy 5 th Annual Intermountain Stroke Conference October 16, 2017 M. Shazam Hussain, MD, FRCP(C), FAHA Director, Cerebrovascular Center Associate Professor, CCLCM Staff, Vascular
More informationEvidence for Mechanical ThrombectomyFor Acute Ischemic Stroke. Kenneth V Snyder MD PhD SUNY Buffalo, NY
Evidence for Mechanical ThrombectomyFor Acute Ischemic Stroke Kenneth V Snyder MD PhD SUNY Buffalo, NY Disclosure Speaker name:... I have the following potential conflicts of interest to report: Honorarium
More informationUNIVERSITY HOSPITAL UDINE/ITALY A SINGLE CENTRE EXPERIENCE IN STROKE TREATMET WITH EMBOTRAP II. TECHNOLOGY BASE ON CLOT RESEARCH
UNIVERSITY HOSPITAL UDINE/ITALY A SINGLE CENTRE EXPERIENCE IN STROKE TREATMET WITH EMBOTRAP II. TECHNOLOGY BASE ON CLOT RESEARCH Massimo Sponza, Vladimir Gavrilović RIPERFUSION THERAPY Intraovenous thrombolysis
More informationAcute brain vessel thrombectomie: when? Why? How?
Acute brain vessel thrombectomie: when? Why? How? Didier Payen, MD, Ph D Université Paris 7 Département Anesthesiologie-Réanimation Univ Paris 7; Unité INSERM 1160 Hôpital Lariboisière AP-HParis current
More informationDisclosures. Anesthesia for Endovascular Treatment of Acute Ischemic Stroke. Acute Ischemic Stroke. Acute Stroke = Medical Emergency!
Disclosures Anesthesia for Endovascular Treatment of Acute Ischemic Stroke I have nothing to disclose. Chanhung Lee MD, PhD Associate Professor Anesthesia and perioperative Care Acute Ischemic Stroke 780,000
More information