Having entered the industry in 2012 as Turkey s first brand of nutritional supplements, Zade Vital continues its studies with its vision to become a

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Mildred Cross
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4 Having entered the industry in 2012 as Turkey s first brand of nutritional supplements, Zade Vital continues its studies with its vision to become a global pharmaceutical company developing and manufacturing pharmaceutical products. With its 130 years of deep-rooted history, the Helvacızade Group stands in the back of Zade Vital having achieved to obtain the Ministry of Health registration of medicinal products for human use under the traditional herbal medicinal products for the first time in Turkey. Zade Vital continues its operations with its mission to protect public health level, enhance health level and reduce treatment costs and makes differences with its R-D centers, science team and manufacturing facilities.

About Helvacızade Group Being among Turkey s 500 largest establishments the Helvacızade Group today

Being one of the world s leading manufacturers in the edible vegetable oil industry, Helvacızade

Helvacızade, which has been conducting R-D and P-D studies in the health industry since the 2000 s,

knowledge and facilities of the universities and the industry together in the pharmaceutical

5 About Helvacızade Group Being among Turkey s 500 largest establishments the Helvacızade Group today operates in three main fields of business. Being one of the world s leading manufacturers in the edible vegetable oil industry, Helvacızade sends its products to 65 countries around the world as well as Turkey under the brand Zade. Helvacızade, which has been conducting R-D and P-D studies in the health industry since the 2000 s, has developed and manufactured Turkey s first healthy living brand Zade Vital bringing the knowledge and facilities of the universities and the industry together in the pharmaceutical industry requiring heavy R-D investment. Having Anatolia s largest logistics centre, Helvacızade operates in the field of distributorship products as the third field of business. 2

6 HELVACIZADE GROUP Zade & Zade Vital Avicenna R-D Center, Konya / Turkey Natural Products R-D Center, DÜAMER, Konya / Turkey Ege University Center For Drug R-D and Pharmacokinetic Applications, ARGEFAR İzmir / Turkey İde.EGE.TGB Ege University Technopark Zade Vital 2015 İzmir / Turkey Zade Vital Drug Manufacturing Facilities Konya / Turkey General Headquarters Konya / Turkey General Headquarters (Sales & Marketing) İstanbul / Turkey Zade Edible Vegetable Oil Refinery Facilities, Konya / Turkey 3

7 TH Center f or D rug R&D a nd Pharmacokinetic Applications 4

8 HELVACIZADE GROUP in the center of technology... R-D AND INNOVATION CENTERS 5

Center for Drug R&D and Pharmacokinetic Applications Leadership in the University-Industry R-D Collaborations The R-D studies performed at the Zade Laboratories

Zade Vital offers services with its R-D centers to the health industry in Turkey and in the world.

and Pharmacokinetic Applications, ARGEFAR. Zade Vital maintains its R-D collaboration with Ege University in the Ege University s Technopark ideege.

9 Center for Drug R&D and Pharmacokinetic Applications Leadership in the University-Industry R-D Collaborations The R-D studies performed at the Zade Laboratories from 1994 until today turned into many national and international publications and products and many new grounds were broken. Zade Vital offers services with its R-D centers to the health industry in Turkey and in the world. The Helvacızade Group has developed and manufactured Turkey s first healthy living brand Zade Vital in cooperation with the Ege University Center for Drug R&D and Pharmacokinetic Applications, ARGEFAR. Zade Vital maintains its R-D collaboration with Ege University in the Ege University s Technopark ideege. Product R-D Ministry of Health-registered medicinal products for human use Traditional herbal medicinal products Aromatherapy products Cosmetic-dermocosmetic products Natural drugs Biotechnological products Pilot manufacturing services in compliance with GMP standards 6

10 R-D AND INNOVATION CENTERS 7

11 Zade & Zade Vital Avicenna Research and Development Center Zade & Zade Vital Avicenna R-D Center is certified to be Turkey s 200 th R&D Center by the Ministry of Science, Industry and Technology and is the first R-D Center in Turkey in the field of natural healthcare products. Natural Products Research and Development Center DÜAMER The Natural Products Research and Development Center DÜAMER is a multicenter R-D and P-D project of cooperation with Selçuk University and Ege University. Any kind of analyses can be carried out at the Zade and Zade Vital R-D laboratories with high technology infrastructure provided by different devices. At the centers where the research and development studies for the endemic, medicinal, aromatic and oily seed plants are conducted, new product studies continue in the fields of nutraceuticals and medicines, particularly natural products. At the R-D Centers, full-scope R-D and P-D services are offered to the industries of biotechnology, pharmaceuticals, chemistry, food, feed, agriculture, veterinary medicine, pharmaceutics, medicine and environment. 8

12 R-D AND INNOVATION CENTERS 9

13 10 the sign for technologic excellence...

14 R-D AND INNOVATION CENTERS ZADE & ZADE VITAL FACILITIES 11

Zade Vital Drug Manufacturing Facilities: The Zade Vital Facilities that were built using

productions under GMP (Good Manufacturing Practices) standards.

manufacturing capacity of 1 billion capsules.

15 Zade Vital Drug Manufacturing Facilities: The Zade Vital Facilities that were built using state-of-the-art technology are Europe s largest soft capsule manufacturing facility that can carry out productions under GMP (Good Manufacturing Practices) standards. Having gone into operation in 2015, the Zade Vital Drug Manufacturing Facilities have an annual manufacturing capacity of 1 billion capsules. Having received the Drug Manufacturing Site Permit, the Zade Vital Facilities broke new ground in Turkey and in the world and were certified with the Cold Press method GMP certificate being the first in Turkey and around the world. 12

16 ZADE & ZADE VITAL FACILITIES At the Zade Vital Drug Manufacturing Facilities, soft capsules, liquid and semi-solid pharmaceutical forms are manufactured under GMP standards. 13

Soft Capsule Manufacturing At the facilities, soft capsules are manufactured in

Primary and secondary packaging in all products is performed with machinery with

At the Zade Vital Facilities where bicolored soft capsules can also be

For the first time in Turkey, four different types of products are blistered

17 Soft Capsule Manufacturing At the facilities, soft capsules are manufactured in different forms and dosages and as halal-certified. Primary and secondary packaging in all products is performed with machinery with the highest technology under GMP standards. At the Zade Vital Facilities where bicolored soft capsules can also be manufactured, product names and logos can also be printed on soft capsules. For the first time in Turkey, four different types of products are blistered together and released to market under the name Combo. The Zade Vital Facilities have the capacity to manufacture different packaging forms with the large device course. 14

18 ZADE & ZADE VITAL FACILITIES 15

19 16

20 SOFT CAPSULE MANUFACTURING 17

Products formularized specially for different age groups are available in pharmacies throughout Turkey and the world and public

21 Liquid Forms Manufacturing At the Facilities, any kind of liquid products including Cold Pressed oils and Omega 3 fish oil in emulsion and suspension forms can be manufactured and packaged. Products formularized specially for different age groups are available in pharmacies throughout Turkey and the world and public health is supported at high standards. Semi-solid Pharmaceutical Forms Manufacturing Semi-solid pharmaceutical forms include creams, pomades and gel products are manufactured at the Zade Vital Facilities. 18

22 LIQUID FORMS MANUFACTURING 19

requirements such as the Deionized Water System conforming to the US and European Pharmacopeia, HVAC and network systems are

23 Technical Support Units The stability monitoring rooms have largest m 2 s used in the pharmaceutical industry. The Zade Vital Facilities that are designed as two-storey have Building Management System Automation ; all infrastructure requirements such as the Deionized Water System conforming to the US and European Pharmacopeia, HVAC and network systems are provided at high standards. Operational facility is provided in storage and shipment operations at the facilities having large storage areas. 20

24 ZADE & ZADE VITAL FACILITIES 21

Zade Edible Vegetable Oil Refinery Facilities Zade Facilities operate in an outdoor area of 200.

000 tonnes/year with 12 different alternatives based on the chemical properties of each product.

25 Zade Edible Vegetable Oil Refinery Facilities Zade Facilities operate in an outdoor area of m 2 and an indoor area of m 2. The refining of vegetable oils is carried out at the facilities having a capacity of tonnes/year with 12 different alternatives based on the chemical properties of each product. The Zade Facilities is the first and only facility to have 17 different quality and system certificates in its field. 22

The manufacturing is completed in seven fundamental stages in which foreign substances contained in raw

26 ZADE & ZADE VITAL FACILITIES The manufacturing process at the Zade Facilities is controlled by the PLC Automation systems that can ensure the same high quality continuously free from human error. The manufacturing is completed in seven fundamental stages in which foreign substances contained in raw materials are fully removed. About 400 analyses per day are carried out on samples taken from 17 different units of the facility. 23

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28 we support you, naturally... ZADE VITAL HEALTHY LIFE SERIES 25

Zade Vital Natural Nutritional Supplements Zade Vital is developed with the cooperation of ARGEFAR; Ege University Center for Drug R&D and Pharmacokinetic Applications and their quality is also

The Zade Vital Natural Nutritional Supplements provide the world s richest product range in the field of cold pressed herbal nutritional supplements with its soft capsules and liquid forms.

29 Zade Vital Natural Nutritional Supplements Zade Vital is developed with the cooperation of ARGEFAR; Ege University Center for Drug R&D and Pharmacokinetic Applications and their quality is also tested by ARGEFAR. The Zade Vital Natural Nutritional Supplements provide the world s richest product range in the field of cold pressed herbal nutritional supplements with its soft capsules and liquid forms. Also the Zade Vital range includes Omega 3 fish oil soft capsules and syrups. Helvacızade has achieved to obtain the Ministry of Health-Authorization of Medicinal Product for Human Use in the field of traditional herbal medicinal products with Zade Vital Nigelin for the first time in Turkey. It continues being a leader in this field with its newly authorized products, Zade Vital Cucurmin, Zade Vital Corvital, Zade Vital Punimin and Zade Vital Rotavin. Center f or D rug R&D a nd Pharmacokinetic Applications 26

30 ZADE VITAL HEALTHY LIFE SERIES 27

31 PRODUCTS WITH MINISTRY OF HEALTH REGISTRATION IN TURKEY Zade Vital Nigelin Zade Vital Cucurmin Zade Vital Corvital Zade Vital Rotavin Zade Vital Punimin Allergic Rhinitis/Blood Lipid Levels/Immune System Prostate Health Herbal Omega 3 / Cadiovascular Health Cardiovascular Health Diabetes / Menopause 28

32 ZADE VITAL HEALTHY LIFE SERIES NATURAL NUTRITIONAL SUPPLEMENTS SERIES Safflower Oil Walnut Oil Black Cumin Seed Oil Pumpkin Seed Oil Flax Seed Oil Pomegranate Seed Oil Wheat Germ Oil /Daily Grape Seed Oil Bitter Melon With Extra Virgin Olive Oil M Milk Thistle Seed Oil Nettle Seed Oil Coriander Seed Oil Sesame Seed Oil Coconut Oil Celery Oil Fig Seed Oil Fennel Oil Anise Oil Camelina Oil Poppy Seed Oil Cottonseed Oil R N.Extra Virgin Olive Oil Pistachio Oil Hemp Seed Oil Peanut Oil R Hazelnut Oil R Canola Oil St. John s Wort Oil M Terebinth Oil Sour Cherry Kernel Oil Green Coffee Oil Bay Seed Oil Almond Oil Apricot Kernel Oil Chia Seed Oil Red Palm Oil R Weight Control / CLA Mental Health Immune System Prostate Health Herbal Omega 3 / Cardiovascular Health Omega 5 Source Energy Source Cardiovascular Health Support For Ulcer and Diabetes Treatment Protecting Liver Health Hairy Skin / Dandruff / Seborrhea Support For Anxiety Treatment Skin Health MCT / Joint Health / Natural Cosmetic Support For Treatment of Parkinson Disease Eye / Liver Health Support For Menstrual Pain Treatment Support For of Flatulence, Bloating, Indigestion Treatment Support For Cardiovascular Health Antioxidant Source Digestive System Cardiovascular Health Vitamin Support Support to Dermatitis Treatment Cholestrol Balance Skin Moisturizer Cholesterol Balance/Cardiovascular Heart Health Wound / Burn Injury Support For Treatment of Periodontal Diseases Support Against Skin Blemishing Skin Dryness Foot Health Skin Moisturizer Support Against Skin Blemishes Metabolic Syndrome Support to Reduce Paralysis Riskin M: Maceration : Cold Pressed R: Refined 29

ZADE VITAL COSMECEUTICALS TWIST OFF SOFT CAPSULES St.

Oil Pomegranate Seed Oil Sesame Seed Oil Grape Seed Oil Coconut Oil Bay Seed Oil Almond Oil Apricot Kernel Oil N.

Athlete s Foot Support For Treatment of Periodontal Diseases Support Against Skin Blemishing Support For Skin Dryness Support For Eczema Treatment

33 ZADE VITAL COSMECEUTICALS TWIST OFF SOFT CAPSULES St. John s Wort Oil Fennel Oil Anise Oil Coriander Seed Oil Terebinth Oil Sour Cherry Kernel Oil Green Coffee Oil Milk Thistle Seed Oil Black Cumin Seed Oil Pomegranate Seed Oil Sesame Seed Oil Grape Seed Oil Coconut Oil Bay Seed Oil Almond Oil Apricot Kernel Oil N.Extra Virgin Olive Oil Chia Seed Oil Red Palm Oil M R Wound / Burn Injury Support For Cellulite Treatment Skin Health Support For Treatment of Athlete s Foot Support For Treatment of Periodontal Diseases Support Against Skin Blemishing Support For Skin Dryness Support For Eczema Treatment Support For Psoriasis and Eczema Treatment Anti-aging Herbal Sun Protection Dark Circles Under The Eyes Natural Cosmetic Foot Care/Health Skin Moisturizer Support Against Skin Blemishes Skin Health Itching / Dryness / Peeling off Anti-aging / Hair - Nail Health M: Maceration : Cold Pressed 30

ZADE VITAL HEALTHY LIFE SERIES COMBO SERIES Combo Woman / Special for Women Combo Man / Special for Men Combo Performance / Energy Source Combo Mental / Mental Health Combo Teens / Special for

for Ketogenic Dieters Combo Metabolic / Health Support Black Cumin Seed Oil, Omega 3 Fish Oil For Adults, Pomegranate Seed Oil, Flax Seed Oil Grape Seed Oil, Omega 3 Fish Oil For Adults, Pumpkin Seed

34 ZADE VITAL HEALTHY LIFE SERIES COMBO SERIES Combo Woman / Special for Women Combo Man / Special for Men Combo Performance / Energy Source Combo Mental / Mental Health Combo Teens / Special for Juniors Combo +50 / Special for Adults Combo Fit / Healthy Body Combo Sport / For Athletes Combo Derma / For Taking Care of the Skin Combo Cardio /Support Cardiovascular Health Combo Ketone / Special for Ketogenic Dieters Combo Metabolic / Health Support Black Cumin Seed Oil, Omega 3 Fish Oil For Adults, Pomegranate Seed Oil, Flax Seed Oil Grape Seed Oil, Omega 3 Fish Oil For Adults, Pumpkin Seed Oil, Wheat Germ Oil Walnut Oil, Hazelnut Oil, Peanut Oil, Wheat Germ Oil Walnut Oil, Omega 3 Fish Oil For Adults, Coconut Oil, Wheat Germ Oil Walnut Oil, Omega 3 Fish Oil For Kids, Black Cumin Seed Oil, Peanut Oil Fig Seed Oil, Coconut Oil, Pumpkin Seed Oil, Grape Seed Oil Black Cumin Seed Oil, Coconut Oil, Flax Seed Oil, Safflower Oil Wheat Germ Oil, Flax Seed Oil, Safflower Oil, Omega 3 Fish Oil For Adults Nettle Seed Oil, Black Cumin Seed Oil, Pomegranate Seed Oil, Wheat Germ Oil Black Cumin Seed Oil, Camelina Oil, Grape Seed Oil, Omega 3 Fish Oil For Adults Black Cumin Seed Oil, Flax Seed Oil, Wheat Germ Oil, Omega 3 Fish Oil For Kids Chia Seed Oil, Black Cumin Seed Oil, Milk Thistle Seed Oil, Omega 3 Fish Oil For Adults VITAMINS, MINERAL Vitamin A Vitamin D3 Vitamin E Likopen Likopen Plus Nyctotyphlosis Rachitism, Osteomalacia Retinopathy, Cataract, Macular Degeneration Immunity, Cardiovascular Health BPH, Prostatitis 31

ZADE VITAL HEALTHY LIFE SERIES OMEGA 3 FISH OIL SERIES Omega 3 Fish Oil Soft Capsule Premium

Kids Omega 3 Fish Oil Soft Capsule Premium Breastfeeding Omega 3 Fish Oil Soft Capsule Premium

Orange Flavored Fish Oil Syrup Premium Adults Omega 3 Natural Mint Flavored Fish Oil Syrup For

35 ZADE VITAL HEALTHY LIFE SERIES OMEGA 3 FISH OIL SERIES Omega 3 Fish Oil Soft Capsule Premium Adults Omega 3 Fish Oil Soft Capsule Premium Pregnancy Omega 3 Fish Oil Soft Capsule Premium Kids Omega 3 Fish Oil Soft Capsule Premium Breastfeeding Omega 3 Fish Oil Soft Capsule Premium Premium Kids Omega 3 Natural Strawberry Flavored Fish Oil Syrup Premium Kids Omega 3 Natural Orange Flavored Fish Oil Syrup Premium Adults Omega 3 Natural Mint Flavored Fish Oil Syrup For Adults For Pregnancy For Kids For Breastfeeding Mothers General Support For Kids For Kids For Adults 32

36 Helvacızade Food Pharma & Chemicals Inc. İstanbul Headquarter Şerifali Mah. Aptekin Yolu Köroğlu İş Merkezi No:73 K: Yukarıdudullu, Ümraniye, İstanbul, Türkiye T.: F.: General Headquarter Fevzi Çakmak Mah. Ankara Yolu 6. km Karatay, Konya, Türkiye T.: F.: Zade Facilities Zade Vegetable Oil Refinery Facilities Konya Organize Sanayi Bölgesi, Güzel Konak Sk. No: 8, Konya, Türkiye T.: F.: Zade Vital Drug Manufacturing Facilities Zade & Zade Vital Avicenna (İbni Sina) R-D Center DÜAMER Natural Products R-D Center Konya Organize Sanayi Bölgesi, Güzel Konak Sk. No: 10, Konya, Türkiye T.: T.:

Center for Drug R&D and Pharmacokinetic Applications. Natural Nutritional Supplements

Center for Drug R&D and Pharmacokinetic Applications. Natural Nutritional Supplements Natural Nutritional Supplements BM-16-04-481 APRIL 2016 As the first nutritional supplement brand of Turkey, we are proud to offer you the best products with over 128 years of experience. 128 years of