Scientists Profile: Name: Titilayo Oyelola FAKEYE. Tel: 234(0) SHORT C.

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1 Scientists Profile: Name: Titilayo Oyelola FAKEYE Tel: 234(0) SHORT C.V Research Interests: Drug/herb utilization and Interaction; Medicine-use related problems among chronically ill patients with emphasis on herb use and related issues; Implementation research in Pharmacy Practice Current research focus: The areas of my research focus have been on the biological evaluation of commonly used herbs, drug utilization in different populations with emphasis on drug-herb use and interaction, pharmacist-led interventions in management of chronic diseases with emphasis on diabetes mellitus, and implementation research in pharmacy practice. In collaboration with other research scientists, I have been able to establish the anti-inflammatory and antimicrobial properties of the basic fraction of the methanol extract of Picralima nitida towards developing the fraction as a drug candidate in inflammation and fungal infections. The cream formulation of the basic fraction was found effective in human dermatomycosis. I have worked extensively on drug use among different populations, attitude of patients populations to use of herbal agents, and tendency to co-administer western drugs and herbal medicines. The series of studies carried out showed gross deficiency and illogical assumptions by the users on basic issues of rational drug use. The results highlighted the need for healthcare providers especially pharmacists to take cognizance of herb use when a patient s drug medication history is being taken; and for ambulatory patients, proper counselling of patients on herb use when drugs are dispensed. Studies evaluating the mechanism of interactions between some of the herbs and drugs have established activities of cytochrome P450 isozymes. Our studies have shown that pharmacists and physicians were found deficient regarding herbal agents usually sold in Nigeria suggesting that they require more training in order to counsel patients adequately.

2 As a result of unearthing extensive herb use among diabetes patients, studies to evaluate the effect of coadministration of herbs including Moringa oleifera, Vernonia amygdalina, Ocimum gratisimum with selected oral hypoglycemic agents have been completed. Some of the studies also seek to propose the mechanism of interactions of these two classes of agents. Also, in vivo interaction of water beverage of Hibiscus sabdariffa with drugs, and the outcome on therapy in hypertension, diabetes and dyslipidemia are almost completed using animal models and healthy human volunteers. Research work on pharmacist-led interventions in treatment adherence among poorly controlled type 2 diabetes in Nigerian hospitals showed that pharmacist, especially with clinical orientation, can help diabetes patients in understanding their regimen exercise, diet and drugs; identify and resolve various treatment non-adherence problems leading to the achievement of blood glucose goals. Studies are on-going evaluating the impact of pharmacist-led interventions in the management of other chronic diseases. Several studies have shown that the Nigerian pharmacist is capable of making positive impact on health care of the patient. Concurrently with other research studies, my research team is also evaluating the factors responsible for the non-implementation of some of these practices in the day-to-day duties of the pharmacist, proposing solutions and making efforts to implement these skills in pharmacies real-time through implementation studies. Selected Publications: 1. Fakeye TO, Adisa R, Erhun WO. ( 2017). Developing a model for teaching and learning clinical pharmacy components of the pharmacy curriculum in Nigeria. Pharmacy Education. 17 (1): Fakeye, TO, Adisa R, Olukotun RT, & Morawo PK. (2017). Hospital and community pharmacists perception of the scope, barriers and challenges of pharmacy practice-based research in Nigeria. Pharmacy Practice. 15(1): Adisa R, Olajide OO, & Fakeye, TO. (2017). Social Support, Treatment Adherence and Outcome among Hypertensive and Type 2 Diabetes Patients in Ambulatory Care Settings in southwestern Nigeria. Ghana Medical Journal. 51(2): Showande JS, Igbinoba IS, Fakeye TO, Adegbolagun MO. In vivo pharmacodynamic and pharmacokinetic interactions of Hibiscus sabdariffa calyces extracts with simvastatin. Journal of Clinical Pharmacy and Therapeutics. DOI: /jcpt (In press) 5. Adedeji WA, Igbinoba SI, Fakeye TO, Oladosu IA, Fehintola FA, Ma Q, Morse GD. (2017). Evaluation of CYP2D6 phenotype in the Yoruba Nigerian population. Expert Review of Clinical Pharmacology, 10(10): Adisa R, Fakeye TO. (2016) Do diabetes-specialty clinics differ in management approach and outcome? A cross-sectional assessment of ambulatory type 2 diabetes patients in two teaching hospitals in Nigeria. Ghana Medical Journal. 50 (2): Adisa R, Aderemi JO, Fakeye TO (2015). Evaluation of prescription pattern and patients opinion on healthcare practices in selected primary healthcare facilities in Ibadan, South-Western Nigeria. West African Journal of Pharmacy: 26 (2)

3 8. Adisa R, Fakeye TO, Aindero VO (2015). Evaluation of outpatient prescriptions in a Universitybased healthcare facility in Ibadan. African Health Sciences. 15(4): Adisa R, Agbom NN, Fakeye TO. (2015) Medication Use in Pregnancy: A Cross-Sectional Assessment of Pregnant Women at Antenatal Clinic of Adeoyo Maternity Teaching Hospital, Ibadan, Southwestern Nigeria. Nigerian Journal of Pharmaceutical Research. 11 (1): Adisa R, Aderemi JO and Fakeye TO (2015). Evaluation of prescription pattern and patients opinion on healthcare practices in selected primary healthcare facilities in Ibadan, South-Western Nigeria. West African Journal of Pharmacy: 26 (2) 11. Adisa R, Fakeye TO and Aindero VO (2015). Evaluation of outpatient prescriptions in a University-based healthcare facility in Ibadan. African Health Sciences. 15(4): Saka SA and Fakeye TO (2015). A retrospective study of adherence to malaria treatment guidelines for children in rural health facilities of southwest Nigeria. Annals of Health Research.1 (1): Adisa R, Agbom N. N., and Fakeye TO (2015). Medication Use in Pregnancy: A Cross-Sectional Assessment of Pregnant Women at Antenatal Clinic of Adeoyo Maternity Teaching Hospital, Ibadan, Southwestern Nigeria. Nigerian Journal of Pharmaceutical Research. 11 (1): Adisa R, Fakeye TO (2014). Treatment non-adherence among patients with poorly controlled type 2 diabetes in ambulatory care settings in southwestern Nigeria. African Health Sciences 14(1): Adisa R, Fakeye TO, and Aindero VO. (2014). Drug prescription patterns and knowledge of dispensing process among health workers in primary healthcare facilities in Ibadan, southwestern Nigeria. International Journal of Pharmacy Practice 22 (Suppl 1): Adisa R, Abayomi-Bero and Fakeye TO. (2014). Clients perception of pharmacist-provided medication counseling and contemporary roles in patient care in Ibadan, southwestern Nigeria. West African Journal of Pharmacy 25(2): Aje AA, Idowu PA and Fakeye TO (2014). Potential dangers of administering undiscarded paracetamol syrup Nigerian Journal of Pharmacy 48 (1): Fakeye TO, Omotayo S, Adisa R. (2013): Knowledge and Treatment Recommendations of Community Pharmacists for cases of diarrhoea, migraine headache, and malaria in a metropolitan city in southwestern Nigeria. International Journal of Pharmacy Practice Vol. 21. Suppl 1, ) 19. Diobi K, Fakeye TO, Adisa R (2013) Community Pharmacists Perception of the Relevance of Drug Package Insert as Source of Drug Information in Southwestern Nigeria. Tropical Journal of Pharmaceutical Research 12 (3): Showande SJ, Fakeye TO, Tolonen A, Hokkanen J (2013) In Vitro inhibitory activities of the extract of Hibiscus sabdariffa L. (Family Malvaceae) on Selected Cytochrome P450 isoforms. African Journal of Traditional Complementary & Alternative Medicine. 10(3):

4 21. Adisa R, Fakeye TO. (2013). Effects of number and type of antidiabetes medications on adherence and glycaemia of ambulatory type 2 diabetes patients in southwestern Nigeria Pharmacy Practice 11(3): Sanya E, Fakeye TO, Adisa R, Showande S (2013). Use of antibiotics among non-medical undergraduate students in a Nigeria University. African Health Sciences 13(4): Fakeye TO, Adisa R, Showande SJ (2012) Attitude and opinion of Nigerian community pharmacists to self medication practices. African Journal of Pharmacy and Pharmacology Vol. 6(15), pp Adisa R, Fakeye TO, Fasanmade AO (2011). Medication adherence among ambulatory patients with type 2 diabetes in a tertiary health care setting in southwestern Nigeria. Pharmacy Practice Apr-Jun; 9(2): Fakeye TO, Adisa R, Olatunji (2010) A. Self medication among hospitalized patients in selected secondary health facilities in south western Nigeria. Pharmacy Practice 8(4): Adisa R, Fakeye TO, Okorie L (2010). Knowledge, Attitude, Self-management practices among ambulatory type 2 diabetes patients in Ibadan, Nigeria. Ethiopian Journal of Pharmaceutical Sciences 28(2): Nwako SO, Fakeye TO. (2009) Evaluation of use of herbal medicines among ambulatory hypertensive patients attending a secondary health care facility in Nigeria International Journal of Pharmacy Practice; 17(2), (5) 28. Fakeye TO, Adisa R, Ismail ME (2009). Attitude and use of herbal medicines among pregnant women in Nigeria BMC Complementary and Alternative Medicine; 9:53 ( 29. Fakeye TO, Pal A, Yadav N, Bawankule D, Khanuja SPS (2009). Toxic effect of oral administration of dried calyx of Hibiscus sabdariffa Linn (Malvaceae). Phytotherapy Research; 23(3), Fakeye TO, Onyemadu O (2008) Evaluation of knowledge base of hospital pharmacists and physicians on herbal medicines in Southwestern Nigeria. Pharmacy Practice; 6(2): Fakeye TO, Abu T, Adebisi O (2007) A survey of the use of herbs among patients attending secondary health care facilities in Southwestern Nigeria. Journal of Herbal Pharmacotherapy; 7(3-4): Fakeye TO, Oladipupo T, Showande O, Ogunremi Y (2007) Effects of co administratio n of extract of Carica papaya Linn (family Cariaceae) on activity of two oral hypoglycemic agents. Tropical Journal of Pharmaceutical Research; 6 (1): Fakeye TO, Adegoke AO, Omoyeni OC, Famakinde AA (2007) Effect of water extract of Hibiscus sabdariffa, Linn (Malvaceae) Roselle on excretion of a diclofenac formulation Phytotherapy Research, 21(1):96-8.

5 34. Fakeye TO, Itiola OA, Dunkwu A (2006) Biological Activity and In Vivo Disposition Profile of the Stem Bark of Picralima Nitida (Family Apocy naceae). Recent Progress in Medicinal Plants in BIOPHARMACEUTICALS Vol 14. Editors JN Govil, VK Singh & Khalil Ahmad. Studium Press, LLC Texas, USA. pp Fakeye TO, Itiola OA, George AO, Odelola HA (2004) Antimicrobial Property of Picralima nitida Stem Bark Extract in Cream Formulations. Pharmaceutical Biology; 42 (4-5), Fakeye TO, Fehintola FA, Ademowo GA, Walker O (2002) Therapeutic monitoring of chloroquine in pregnant women with malaria. West African Journal of Medicine. 21(4): Fakeye TO, Itiola OA, Odelola HA, Adeniji AO (1999) Use of non-narcotic analgesics by the working population in a Nigerian city. Nigerian Quarterly Journal of Hospital Medicine. 9 (4), Fakeye TO, Itiola OA, Akinlade O. (1997). Drug utilization in a university community. Nigerian Quarterly Journal of Hospital Medicine 7(3),

6 SHORT CV Name FAKEYE Titilayo O Position Reader EDUCATION/TRAINING Institution & Location Degree Year(s) Specialty West African Postgraduate FPCPharm 2013 Clinical Pharmacy College of Pharmacists University of Ibadan Ph.D 1998 Pharmaceutical Microbiology University of Ibadan M.Sc 1992 Pharmacology & Therapeutics Obafemi Awolowo University, Ile-Ife B.Pharm 1988 Pharmacy EMPLOYMENT/WORK EXPERIENCE Employment history and administrative assignments DURATION ASSIGNMENT 2012 till date Associate Lecturer, Centre for Childhood & Adolescent Mental Health, College of Medicine, University of Ibadan March 2009 July 2016 Ag. Head, Department of Clinical Pharmacy & Pharmacy Administration Ag. Head, Department of Clinical Pharmacy & Pharmacy Administration Ag. Head, Department of Pharmaceutical Microbiology & Clinical Pharmacy 2013 till date Professor Reader Senior Lecturer Lecturer I Lecturer II Assistant Lecturer HONORS, AWARDS AND SCHOLARSHIPS DURATION September March 2006 July September, 2007 March 2008 December 2010 May June 2011 July August 2013 POSITION Postdoctoral Fellow, Central Institute of Medicinal & Aromatic Plants, Lucknow. India Visiting Scholar, Shanghai Institute of Modernization of Traditional Medicine, Shanghai Institute of Materia Medica, Shanghai. China Visiting Lecturer, Department of Clinical Pharmacy & Pharmacy Administration, Obafemi Awolowo University Visiting Scholar, Translational Pharmacology Research Core, State University of New York at Buffalo, NY. USA Pharmabridge Fellow, Skaggs School of Pharmacy, University of Colorado, Denver, CO. USA

7 OTHER SCIENTIFIC ACTIVITIES 1991 till date Member, Pharmaceutical Society of Nigeria 1995 till date Member, Association of Lady Pharmacists 2006 till date Member, National Association of Pharmacists in Academia Reviewer, African Journal of Medicine & Medical Sciences Reviewer, Journal of Herbal Pharmacotherapy 2009 till date Reviewer, BMC Complementary & Alternative Medicine African Health Sciences Tropical Journal of Pharmaceutical Research Nigerian Journal of Pharmaceutical Research West African Journal of Pharmacists Clinical Pharmacology & Therapeutics External Examiner, Clinical Pharmacy & Pharmacy Administration, Olabisi Onabanjo University External Examiner, Clinical Pharmacy & Pharmacy Administration, Obafemi Awolowo University 2015 till date UI/UCH Institutional Review Board