Christine Herde, MD, FACOG

Transcription

1 Christine Herde, MD, FACOG Vice Chair, Department of OB/GYN CareMount Medical, Mount Kisco, NY Assistant Director of OB/GYN, Mount Sinai Health System at CareMount Medical 1. OSE presumption that Ovarian Cancer arised from the ovary or even the ovarian surface epithelium (OSE) 2. Prophylactic Oophorectomy became a treatment option for High Risk Patients. 3. This theory was challenged by: the absence of a clearly defined precursor lesion in the ovary or OSE and the recognition of Primary Peritoneal Cancer predominantly in high risk patients with a history of oophorectomy. Greene M, Mai P, Cancer Prev Res. 2015; 8 (5)

2 4. RRSO Prophylactic Oophorectomy to Risk- Reducing Salpingo-oophorectomy- 1994/1995- BRCA1/BRCA2- tubal malignancy was included in the group of malignancies. The beginning of The suggestion for a cure. 5. BSOR Bilateral Salpingectomy with Ovarian Retention maintain ovarian function in patients not yet ready, decrease long term risks of premature menopause. Greene M, Mai P, Cancer Prev Res. 2015; 8(5) Minimal additional Surgical Time 2. No excess re-hospitalization 3. No excess blood transfusion 4. Increase in the proportion of hysterectomies being performed laparoscopically. 5. Cost benefit analysis cost effective 6. Estimated decrease in ovarian CA risk by 38% if done with hysterectomy. 7. Estimated decrease in ovarian CA risk by 29% if done in place of tubal ligation. Kwon JS, McAlpine JN, Hanley GE, et al. Obstet Gynecol. 2015; 125:

3 Debated in the literature however; Rates of BS increased among women undergoing hysterectomy as well as those undergoing interval tubal ligation Randomized controlled trials are needed to support the validity of this approach to reduce the incidence of ovarian cancer. The approach to hysterectomy or sterilization should not be influenced by the theoretical benefit of salpingectomy Focuses on hysterectomy and laparoscopic sterilization procedures 3

4 Should we consider salpingectomy at the time of Cesarean Section or postpartum tubal ligation. The Gravid Uterus Changes in Vasculature -The diameter of the main uterine artery doubles in size. -Change in the uterine vascular resistance. -Smaller arcuate and radial arteries remodel in a similar pattern with enlargements in lumenal caliber from 25 to 220%. -Smaller arcuate and radial arteries have either no change or an increase in wall thickness. -Veins also enlarge substantially Palmer SK, Zamudio S, Coffin C, Parker S, Stamm E, Moore LG. Quantitative estimation of human uterine artery blood flow and pelvic blood flow redistribution in pregnancy. Obstet Gynecol 80: ,

5 Parkland Method Pomeroy Method Irving Method Uchida Method 5

6 Complete vs. Partial Salpingectomy Partial Salpingectomy: Removal of the distal 1/3: Fimbria Infundibulum Portion of Ampulla US Birth Rates and Population Growth Estimates 4 Million Births in the US 8 to 9% of all US Live Births will result in Postpartum Tubal Sterilization Anticipated to be more than 50% of all sterilizations Estimated Tubal Ligation C/S and postpartum: 320,000 annually. 6

7 Permanent sterilization with likely decrease in failure rate Decrease risk of ectopic pregnancy if failure Decrease in post ablation tubal sterilization syndrome Primary prevention of epithelial carcinoma of the fallopian tube, ovary or peritoneum. Permanent No option for reversal No study has compared the contraceptive efficacy or risk of complications with complete or partial salpingectomy for PP sterilization Blood loss/hemorrhage Cautery complication 7

8 Legal and Ethical Responsibility to provide adequate information Bring the patient into the Medical Decision Making Process Must disclose Material Facts relevant to the decision making process Must answer truthfully Documentation is Key Berg JW, Appelbaum PS, Lidz CW, et al. Oxford University Press, New York No data regarding long term impact. At least 10 years to see if it creates a definite decrease risk in Cancer. 8

9 What is new? Where are we going? Three to five years later: longterm effects of prophylactic bilateral salpingectomy on ovarian function Preliminary Data on PBS (Prophylactic Bilateral Salpingectomy) Observational Study for Premature Surgical Menopause 79 patient from 9/2010 9/ /79 patients with follow up Venturella R, Lico D, Borelli M, Imbrogno MG, Cevenini G, Zupi E, Zullo F, Morelli M, Three to five years later: long-term effects of prophylactic bilateral salpingectomy on ovarian function, The Journal of Minimally Invasive Gynecology (2016), doi: /j.jmig

10 The addition of PBS to TLH in the late reproductive years does not modify the ovarian age of treated women up to 3 to 5 years after surgery 10

11 -Paul Kalanithi, MD 11